0. DOCID:27880 SCORE: 0.00211147758172746
DOCNO: 11776752
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sentinel Lymph Node Biopsy
QUALIFIER: pathology
QUALIFIER: diagnosis
AUTHOR: R J Bold RJ
AUTHOR: M Schlieman M
AUTHOR: B N Fahy BN
AFFILIATION: Department of Surgery, Division of Surgical Oncology, University of California, Davis Cancer Center, 4501 X Street, Sacramento, CA 95817, USA. richard.bold@ucdmc.ucdavis.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer biotherapy & radiopharmaceuticals.
COUNTRY: United States
TITLE: Sentinel lymph node biopsy for breast cancer.
PUBDATE: 20011001
Sentinel lymph node biopsy (SLNB) is an emerging surgical technique to improve lymph node staging for breast cancer. Despite the rapid development of this technique, there remain aspects of SLNB that need to be further defined to provide a standardized approach. Variables, including patient selection, technical details for the performance of SLNB, extent of pathologic evaluation of the sentinel lymph node, and the impact of micrometastases, are areas of controversy. This paper reviews the controversies and discusses available data as well as personal experience and opinion.

1. DOCID:27123 SCORE: 0.0020029033437485
DOCNO: 11551135
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
QUALIFIER: surgery
AUTHOR: D F Dargent DF
AFFILIATION: Department of Gynecologic Oncology, Hospital Edouard Herriot, Lyon, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Surgical clinics of North America.
COUNTRY: United States
TITLE: Laparoscopic surgery in gynecologic oncology.
PUBDATE: 20010801
Laparoscopy found its first application in the field of gynecology. Today, laparoscopy benefits the general gynecologist because of its minimally invasive nature. Benign procedures, such as oophorectomies and hysterectomies, have become practically outpatient procedures. The learning curve for laparoscopy in gynecologic cancer operations is obviously steeper, more time consuming, and training-dependent. With increased operative time, cost, and the questions of safety in malignant conditions, laparoscopy has quite a burden of proof before it becomes widely accepted. This article reviews the current applications of laparoscopy in gynecologic oncology with available data and offers future directions best suited for laparoscopy in this subspecialty.

2. DOCID:26660 SCORE: 0.00190693841648069
DOCNO: 11200504
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
AUTHOR: T Wu T
AUTHOR: S Xu S
AUTHOR: J Shen J
AUTHOR: A Song A
AUTHOR: S Chen S
AUTHOR: M Zhang M
AUTHOR: T Shen T
AFFILIATION: Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing.
PUBTYPE: Journal Article
JOURNALTITLE: Anti-cancer drug design.
COUNTRY: England
TITLE: New potential photodynamic therapeutic anti-cancer agents: synthesis and characterization of demethoxy amino-substituted hypocrellins.
PUBDATE: 20000801
A novel method was used to obtain demethoxy amino-substituted hypocrellin derivatives. The reaction condition was mild and amino substitution occurred at position 2 or 11 of hypocrellins with high yield. The photophysical and photochemical properties of the amino-substituted hypocrellins derivatives were investigated, and their significantly enhanced red absorptivities and strong active oxygen-generating functions qualified them as promising photodynamic therapeutic anti-cancer agents.

3. DOCID:27913 SCORE: 0.00188062358781652
DOCNO: 11014091
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: M Matter M
AUTHOR: M Dusmet M
AUTHOR: F Chevalley F
AFFILIATION: Service de chirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne. Maurice.Matter@chuv.hospvd.ch
PUBTYPE: Journal Article
JOURNALTITLE: Revue médicale de la Suisse romande.
COUNTRY: SWITZERLAND
TITLE: [The place of surgery in the treatment of advanced localized, recurrent and metastatic breast cancer]
PUBDATE: 20000601
In the multidisciplinary treatment of locally advanced and metastatic breast cancer, aggressive surgical options can be chosen in selected cases. They may allow: survival to be prolonged by the resection of metastases (liver, ovary, lung), symptomatic treatment (bone pain, local recurrence, infiltration of the chest wall), prevention of potentially disabling complications (pathologic fractures, medullary compression), exclusion of another tumoural or non tumoural diseases. The decision to perform surgery has to be discussed between the surgeon and the oncologist so as to optimise its timing. Surgical treatment can follow induction therapy or can precede chemo- or hormonotherapy.

4. DOCID:27664 SCORE: 0.00184492598489288
DOCNO: 11218389
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: T Nakazawa T
AFFILIATION: Yamaguchi University School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: Japan
TITLE: [Progress of molecular bacteriological studies on Helicobacter pylori]
PUBDATE: 20010201
To understand pathogenesis of H. pylori in stomach diseases including gastric cancer, molecular bacteriological studies are important. The studies are greatly advanced by information of the whole genome sequence of this bacterium in 1997. Various methods of gene manipulation to identify the genes involved in pathogenesis are now available such as transformation followed by construction of knockout mutants, complementation using H. pylori-E. coli shuttle vectors, random insertion mutagenesis, and RT-PCR or proteome analysis of in vivo-expressed genes. The molecular mechanism of persistent infection of H. pylori is discussed in light of recent findings on molecular mechanisms of bacterial attachment and colonization as well as on gastric physiology.

5. DOCID:27905 SCORE: 0.00176512137442102
DOCNO: 11192793
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: M Hut'an M
AUTHOR: M Salapa M
AUTHOR: J Bandzák J
AUTHOR: P Baláz P
AFFILIATION: Chirurgické oddelenie NsP Ruzinov, Bratislava, Slovenská republika.
PUBTYPE: Journal Article
JOURNALTITLE: Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti.
COUNTRY: Czech Republic
TITLE: [The current method of staging gastrointestinal (GIT) tumors]
PUBDATE: 20001001
The authors analyzed in a retrospective study the stage of carcinomas of the stomach and colorectum in their material. In 1996-1998 they operated 35 patients with gastric tumours and 77 patients with colorectal cancer. In both groups they operated more than 50% of the patients in the IIIrd or more advanced stage of the disease. 22.8% gastric tumours and 19.5% colorectal tumours were operated in the acute stage. The situation in the group is alarming, it is essential to improve the early diagnosis and thus also treatment in all links of the chain: patient--attending physician--surgeon--society.

6. DOCID:27765 SCORE: 0.00174235400645359
DOCNO: 12066020
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: nursing
QUALIFIER: complications
QUALIFIER: methods
AUTHOR: S Brown S
AUTHOR: L F Degner LF
AFFILIATION: Faculty of Nursing, University of Manitoba, Winnipeg, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of palliative nursing.
COUNTRY: England
TITLE: Delirium in the terminally-ill cancer patient: aetiology, symptoms and management.
PUBDATE: 20010601
Delirium is a frequent and serious clinical problem in the terminally ill cancer patient. Multiple dimensions of delirium make definition, measurement, and assessment of it challenging in clinical nursing practice. Assessment and management of delirium requires knowledge of the diagnostic criteria for it, aetiology, signs and symptoms, and nursing interventions. Four delirium assessment scales determined to be useful in assessing patients with terminal illness are reviewed. The use of a delirium assessment instrument in routine nursing assessments would be important for the nurse's early detection of delirium so that interventions to reverse the causes of delirium could immediately be implemented.

7. DOCID:26607 SCORE: 0.00173622557584259
DOCNO: 9989206
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: S Narod S
AFFILIATION: Department of Medicine, Women's College Hospital, Toronto, Ont., Canada. narod@ftn.net
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: NETHERLANDS
TITLE: Genetic epidemiology of prostate cancer.
PUBDATE: 19990101
A family history of prostate cancer is a consistent risk factor for prostate cancer, and can also be used to predict the presence of prostate cancer among asymptomatic men who undergo PSA screening. Approximately 5% of cases of prostate cancer have a familial component. The genetic epidemiology of prostate cancer is complex, and genes on chromosome 1 and X chromosome contribute to familial aggregation. Neither of these prostate cancer susceptibility genes have been identified, but are the subject of an active search. Hereditary prostate cancer resembles non-hereditary cancer in terms of age of onset, pathologic appearance and grade.

8. DOCID:27507 SCORE: 0.00172932800709038
DOCNO: 9723580
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: therapy
AUTHOR: M J Carey MJ
AUTHOR: G M Rodgers GM
AFFILIATION: Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of hematology.
COUNTRY: UNITED STATES
TITLE: Disseminated intravascular coagulation: clinical and laboratory aspects.
PUBDATE: 19980901
Disseminated intravascular coagulation (DIC) is a complex acquired coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetrical complications, sepsis, cancer, and trauma. Numerous laboratory tests are available to monitor DIC, but most patients are adequately managed using only routine hemostasis screening tests, and assays for fibrinogen and D-dimer. Treatment of DIC should focus on reversing the underlying disorder initiating the coagulopathy. Novel treatments are being investigated for treating DIC; many of these experimental modalities target the excessive TF activity that characterizes DIC.

9. DOCID:26365 SCORE: 0.00172745604538964
DOCNO: 11797393
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: genetics
AUTHOR: R Kushima R
AFFILIATION: Department of Clinical Laboratory Medicine, (Central Clinical Laboratory), Shiga University of Medical Science, Ohtsu 520-2192.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Rinsho byori. The Japanese journal of clinical pathology.
COUNTRY: Japan
TITLE: [Relationship and role of morphological diagnosis and gene diagnosis of cancer (1) tumors in the gastrointestinal tract]
PUBDATE: 20011201
At present histopathological examination based on clinical findings is the most important and definitive method of diagnosing gastrointestinal tumors. In this field, gene analysis is sometimes used as a supplemental diagnosis. However, fruitful analyses of gene abnormalities in gastrointestinal tumors have facilitated thoughtful morphological diagnosis. Gene diagnosis is expected to play an important role in the grading of malignancy, examining sensitivity for chemotherapy and discovering micrometastases, in cases of cancers definitively diagnosed by histopathology.

10. DOCID:26988 SCORE: 0.00166516336562829
DOCNO: 9750488
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: K Okada K
AUTHOR: Y Yamanaka Y
AUTHOR: T Hachiya T
AUTHOR: H Ishida H
AFFILIATION: Department of Urology, Nihon University School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Clinical staging of prostate cancer]
PUBDATE: 19980801
Clinical staging of prostate cancer was reviewed on the basis of TNM classification edited by UICC in 1997. In this revision, (1) T1c was newly categorized among T1 for cases of high PSA level without any abnormal sign of DRE, (2) T2 was subdivided into T2a and T2b in accordance with unilateral or bilateral nodule in the prostate, respectively, (3) T3 was also subdivided into T3a with capsular invasion and T3b with seminal vesicle invasion. It is hoped that present classification will become useful tools for the detection of the tumor burden cancer patients.

11. DOCID:26708 SCORE: 0.00160838956473639
DOCNO: 9589072
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Depsipeptides
QUALIFIER: pharmacology
QUALIFIER: antagonists & inhibitors
AUTHOR: T Kurome T
AUTHOR: K Takesako K
AUTHOR: I Kato I
AFFILIATION: Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Japan.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of antibiotics.
COUNTRY: JAPAN
TITLE: Aureobasidins as new inhibitors of P-glycoprotein in multidrug resistant tumor cells.
PUBDATE: 19980301
Cyclic depsipeptide antibiotic aureobasidin A (AbA) and its analogs were tested for the inhibitory activity of P-glycoprotein in multidrug resistant cancer cells as well as for the antifungal activity. Some analogs with lower antifungal activity than AbA showed higher inhibition of P-glycoproteins indicating difference of the structure-activity relationships between the two activities. Among AbA analogs tested, [D-beta-hydroxy-methylvalyl9]-AbA newly prepared by chemical synthesis, which had much lower antifungal activity than AbA, showed 10-fold higher inhibitory activity of P-glycoprotein than AbA.

12. DOCID:26640 SCORE: 0.00159222460960897
DOCNO: 11550935
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Biometry
QUALIFIER: prevention & control
AUTHOR: Y Shen Y
AUTHOR: J Cai J
AFFILIATION: Department of Biostatistics, M. D. Anderson Cancer Center, University of Texas, Houston 77030, USA. yushen@odin.mdacc.tmc.edu
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: United States
TITLE: Maximum of the weighted Kaplan-Meier tests with application to cancer prevention and screening trials.
PUBDATE: 20010901
A class of maximum weighted Kaplan-Meier test statistics is described where the weight functions are chosen from a family of smooth functions. The investigated test statistic is robust and sensitive to a variety of alternatives that are often observed in cancer prevention and screening trials. A simulation study is performed to compare the size and power properties between the proposed test statistics and some existing ones. We illustrate the procedure using data from a clinical trial of a breast cancer screening program.

13. DOCID:27564 SCORE: 0.00154574072004707
DOCNO: 11068590
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: H J Feldmann HJ
AFFILIATION: Klinik für Radioonkologie-Strahlentherapie Klinikum Fulda. hjfeldmann.raz@klinikum-fulda.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al].
COUNTRY: GERMANY
TITLE: [Split-course radiotherapy or treatment interruption]
PUBDATE: 20001001
BACKGROUND: Experimental and clinical studies have shown that a prolonged overall treatment time is associated with a decrease in local tumor control. METHODS: In a brief review, the clinical data of radiotherapy with split-course or treatment interruption were collected. RESULTS AND CONCLUSION: There was a detrimental effect of the treatment interruption on overall or disease-specific survival in patients with locally advanced head and neck cancer or non-small-cell lung cancer in particular in patients with good prognostic factors and well to moderate differentiated tumors. Therefore, interruption of radiotherapy in patients with curative treatment should be avoided.

14. DOCID:26834 SCORE: 0.00151921072026425
DOCNO: 11320350
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: methods
AUTHOR: K M Freund KM
AFFILIATION: Boston University School of Medicine, Boston, Massachusetts, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Medscape women's health [electronic resource].
COUNTRY: United States
TITLE: Rationale and technique of clinical breast examination.
PUBDATE: 20001101
Despite the advances in breast imaging, there are clear indications for the need of clinical breast examination as part of breast cancer screening for all women. The article reviews the technique for clinical breast examination and assessment of its results. The main goal of the clinical breast examination is to differentiate normal physiologic nodularity from a discrete breast mass. If a discrete mass is identified, evaluation is mandatory in all cases to exclude breast cancer. This evaluation is guided by the features of the clinical findings, the age of the woman, and her personal risk for breast cancer.