0. DOCID:22777 SCORE: 0.00211208804099457
DOCNO: 9426472
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: antagonists & inhibitors
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: C A Omer CA
AUTHOR: N E Kohl NE
AFFILIATION: Department of Cancer Research, Merck Research Laboratories, West Point, PA 19486, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in pharmacological sciences.
COUNTRY: ENGLAND
TITLE: CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents.
PUBDATE: 19971101
For Ras oncoproteins to transform mammalian cells, they must be post-translationally farnesylated in a reaction catalysed by the enzyme farnesyl-protein transferase (FPTase). Inhibitors of FPTase have therefore been proposed as anti-cancer agents. In this review Charles Omer and Nancy Kohl discuss the development of FPTase inhibitors that are kinetically competitive with the protein substrate in the farnesylation reaction. These compounds are potent and selective inhibitors of the enzyme that block the tumourigenic phenotypes of ras-transformed cells and human tumour cells in cell culture and in animal models.


1. DOCID:23335 SCORE: 0.00193126147630325
DOCNO: 8741691
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
DESCRIPTOR: Viral Proteins
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: T Mashima T
AUTHOR: M Naito M
AUTHOR: S Kataoka S
AUTHOR: T Tsuruo T
AFFILIATION: Institute of Molecular and Cellular Biosciences, University of Tokyo.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Cancer chemotherapy and apoptosis]
PUBDATE: 19960701
Tumor cells undergo apoptotic cell death when treated with several chemotherapeutic agents. Since these agents, acting on different cellular targets, induce a similar pattern of cell death (apoptosis), it is suggested that a common signaling pathway of apoptosis could exist and that apoptosis resistance could cause a new form of multi-drug resistance in tumor cells. Although the mechanisms of apoptosis are not fully understood, the involvement of ICE/ced-3 family proteases in chemotherapy-induced apoptosis is strongly suggested. Identification of factors directly acting on these apoptosis pathway will offer new strategies in cancer chemotherapy.


2. DOCID:23467 SCORE: 0.00191198658719837
DOCNO: 7820825
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Medicine, Traditional
DESCRIPTOR: Perception
QUALIFIER: psychology
AUTHOR: I A Nwoga IA
AFFILIATION: Florida A & M University School of Nursing, Tallahassee 32307.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer nursing.
COUNTRY: UNITED STATES
TITLE: Traditional healers and perceptions of the causes and treatment of cancer.
PUBDATE: 19941201
The observation that some Nigerian patients use alternative health care services when they perceive that one medical system has failed them provided the impetus for this survey. The purpose of the survey was to understand why some Nigerian patients rely on traditional healers for cure of cancer by exploring the perceptions of Igbo traditional healers from Anambra State of Nigeria about the causes and treatment of cancer. Implications of the different meanings of illness and disease to patients and physicians provided the theoretical framework for understanding the cultural context of the study. Findings have ethical, moral, and cultural implications for professional nursing practice, education, and research.


3. DOCID:23109 SCORE: 0.00190543497433208
DOCNO: 9450418
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: nursing
QUALIFIER: complications
AUTHOR: A Acheson A
AUTHOR: D MacCormack D
AFFILIATION: Manitoba Cancer Treatment and Research Foundation, Winnipeg.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Canadian oncology nursing journal = Revue canadienne de nursing oncologique.
COUNTRY: CANADA
TITLE: Dyspnea and the cancer patient--an overview.
PUBDATE: 19971101
Dyspnea, a distressing subjective symptom common in patients with advanced cancer, has been vastly under-reported. It can be directly caused from the tumour such as in superior vena cava obstruction; indirectly caused from debilitating conditions such as pneumonia or pulmonary embolism; or related to treatment such as surgery or radiation therapy. Nursing assessment and diagnosis are discussed. The authors present strategies for the management of dyspnea that nurses will find helpful when confronted with this symptom. Nurses play an important role in helping patients and their families to cope with dyspnea and to maintain as normal a lifestyle as possible.


4. DOCID:23622 SCORE: 0.00188716957616772
DOCNO: 8902488
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Respiration, Artificial
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: P Foucher P
AUTHOR: M Merati M
AUTHOR: N Baudouin N
AUTHOR: O Reybet-Degat O
AUTHOR: P Camus P
AUTHOR: L Jeannin L
AFFILIATION: Dept of Pulmonary Diseases, University Hospital, Dijon, France.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology.
COUNTRY: DENMARK
TITLE: Fatal ball-valve airway obstruction by an extensive blood clot during mechanical ventilation.
PUBDATE: 19961001
A ball-valve airway obstruction by a blood clot cast of almost the whole bronchial tree occurred in a small-cell lung cancer patient, who had been on mechanical ventilation for 9 days. Chest radiographs revealed overinflated lungs. Attempts to remove the cast via fibreoptic bronchoscopy were unsuccessful and the patient died. A postmortem extraction of the clot was performed with a rigid tube. This case is rare because of absence of severe haemoptysis and lung volume reduction.


5. DOCID:23502 SCORE: 0.00184912785539589
DOCNO: 9315960
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adaptation, Psychological
DESCRIPTOR: Cognitive Therapy
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: S B Dunbar SB
AUTHOR: J G Summerville JG
AFFILIATION: Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of cardiovascular nursing.
COUNTRY: UNITED STATES
TITLE: Cognitive therapy for ventricular dysrhythmia patients.
PUBDATE: 19971001
Living with a serious ventricular dysrhythmia and its treatment poses certain psychological stressors including anxiety, depression, fear, and a sense of loss of control. Additional stressors related to side effects and technology issues may be present depending on whether the patient is treated with antidysrhythmic medications, an internal cardioverter defibrillator, or both. Cognitive therapy has been used with some success to reduce patient fear and improve psychological outcomes in some patient populations with illnesses characterized by loss of control including cancer and epilepsy. This article outlines a cognitive therapy approach for use with patients who have a serious ventricular dysrhythmia.


6. DOCID:23711 SCORE: 0.00179360752805473
DOCNO: 9421447
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: therapy
QUALIFIER: pathology
QUALIFIER: therapy
AUTHOR: P F Schellhammer PF
AUTHOR: D F Lynch DF
AFFILIATION: Department of Urology and the Virginia Prostate Center of Eastern Virginia Medical School and Sentara Cancer Institute, Norfolk, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in urologic oncology.
COUNTRY: UNITED STATES
TITLE: Are monotherapy options reasonable for T3 prostate cancer?
PUBDATE: 19971101
In 1997, we believe that either surgery, radiation, or hormonal monotherapy are unlikely to be adequate therapy alone for clinical stage T3 prostate cancer and that primary treatment strategies should use combination therapy. Combination therapies have been investigated in an effort to lessen the impact of monotherapy failure, and combination therapy trials have been shown to diminish the incidence of local failure and increase the time to progression. To gauge the role that irradiation or surgical monotherapy may play in clinical stage T3 disease, this article analyzes series that report local and distant disease control.


7. DOCID:23798 SCORE: 0.00170860570831072
DOCNO: 7774935
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 17
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: Y Miki Y
AUTHOR: J J Swensen JJ
AUTHOR: M R Hobbs MR
AUTHOR: B S DeHoff BS
AUTHOR: P R Rosteck PR
AUTHOR: M H Skolnick MH
AUTHOR: S L Neuhausen SL
AFFILIATION: Department of Medical Informatics, University of Utah Medical School, Salt Lake City 84108, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Genomics.
COUNTRY: UNITED STATES
TITLE: A physical map encompassing GP2B, EPB3, D17S183, D17S78, D17S1183, and D17S1184.
PUBDATE: 19950101
The q21 region of chromosome 17 contains the gene BRCA1, which is involved in familial early-onset breast and ovarian cancers. A physical map of a region that extends from a distal boundary of the BRCA1 region, D17S78, to GP2B has been constructed. The map consists of 30 STSs, including 2 new short tandem repeat polymorphic markers. The contig is composed of a mixture of 7 YACs, 5 P1 plasmids, and 14 cosmids and was ordered by STS-content mapping.


8. DOCID:22805 SCORE: 0.00167109856651389
DOCNO: 8813117
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: A Biegon A
AUTHOR: M Brewster M
AUTHOR: H Degani H
AUTHOR: E Pop E
AUTHOR: D Somjen D
AUTHOR: A M Kaye AM
AFFILIATION: Pharmos, Ltd., Kiryat Weizmann, Rehovot, Israel.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: A permanently charged tamoxifen derivative displays anticancer activity and improved tissue selectivity in rodents.
PUBDATE: 19961001
A quaternized form of tamoxifen (TAM), tamoxifen methiodide (TMI), was shown to demonstrate very low brain uptake compared to TAM and, unexpectedly, was considerably less estrogenic than TAM in the uterus. The agonist activity of TMI in the bone was similar to that of TAM. TMI manifested significant dose-dependent tumoricidal activity with a rapid onset of action against MCF-7 human breast cancer implants in nude mice and a mean reduction in tumor size of 60% over six weeks.


9. DOCID:23332 SCORE: 0.00166988363722265
DOCNO: 8865475
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug effects
QUALIFIER: drug therapy
AUTHOR: G J Gormley GJ
AFFILIATION: Merck Research Laboratories, Rahway, NJ 07065, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in urologic oncology.
COUNTRY: UNITED STATES
TITLE: Evaluation of men on finasteride.
PUBDATE: 19960801
Finasteride, an orally active type II 5 alpha-reductase (5 alpha R) inhibitor, blocks conversion of testosterone (T) to dihydrotestosterone (DHT). The utility of finasteride in effectively managing benign prostatic hyperplasia has been documented. Use of the drug results in reduced prostate volume and serum levels. Patients receiving finasteride should be monitored with periodic digital-rectal examination (DRE) and serum PSA measurement. Patients with a sustained increase in serum PSA or an abnormal DRE require additional evaluation. There is no evidence that use of finasteride has an adverse effect on prostate cancer detection, if the drug's effect on serum PSA is recognized and accounted for.


10. DOCID:23194 SCORE: 0.00163391664013174
DOCNO: 8052876
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: N van Zandwijk N
AUTHOR: O Dalesio O
AFFILIATION: Department of Pulmonary Oncology, The Netherlands Cancer Institute, Amsterdam.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Platinum-based chemotherapy in non-small cell lung cancer: the experience of the European Organization for the Research and Treatment of Cancer.
PUBDATE: 19940601
The history of chemotherapy for non-small cell lung carcinoma is one of very slow progress. Consequently, the categories of patients who will ultimately benefit from this modality are still debated. Recent European Organization for Research and Treatment of Cancer studies show that there is less concern about the importance of platinum as an ingredient of combination regimens or as an adjunct to radiotherapy. The presence of cisplatin is related to better response and survival in patients with locoregional and distant metastatic disease.


11. DOCID:23025 SCORE: 0.00160127062527827
DOCNO: 8071521
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
AUTHOR: M M Mahon MM
AUTHOR: O F James OF
AFFILIATION: Department of Medicine (Geriatrics), School of Clinical Medical Sciences, Medical School, Newcastle upon Tyne, England.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical gastroenterology.
COUNTRY: UNITED STATES
TITLE: Liver disease in the elderly.
PUBDATE: 19940601
While there are no liver diseases specific to advanced age, the presentation, clinical course and management of liver diseases in the elderly may differ in important respects from younger individuals. The management of older patients with specific liver diseases should be informed by these differences. Alcoholic liver disease presents at a more advanced stage, drug induced liver disease and viral hepatitis may also be more severe. It is increasingly recognised that primary hepatocellular cancer arises in elderly cirrhotics regardless of the etiology of the cirrhosis, the risk highest in hemochromatosis and cirrhosis arising from hepatitis B and C.


12. DOCID:22527 SCORE: 0.00159872511666787
DOCNO: 9385536
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: A Brzezinski A
AUTHOR: J G Schenker JG
AFFILIATION: Department of Obstetrics and Gynecology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
COUNTRY: ENGLAND
TITLE: Induction of ovulation and risk of breast cancer: an overview and perspectives.
PUBDATE: 19971001
The modern techniques for assisted reproduction have exposed many women to potent follicular stimulation regimens. Follicular stimulation is associated with an exposure to potent fertility drugs and abnormal estrogen, progesterone and human chorionic gonadotropin (hCG) concentrations. These treatments and hormones might affect the proliferation of epithelial breast cells and thus the risk of breast cancer. The possible effects of ovarian stimulation on the incidence and course of human breast cancer, and the need for long-term cohort studies is discussed.


13. DOCID:22634 SCORE: 0.00159772839437294
DOCNO: 8773505
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Life
QUALIFIER: therapy
AUTHOR: J A Talcott JA
AFFILIATION: Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Quality of life in early prostate cancer. Do we know enough to treat?
PUBDATE: 19960601
Informed consent is especially important for patients with early (nonmetastatic) prostate cancer. Because it occurs in older men and usually grows slowly, most newly diagnosed patients are likely to live many years and most likely will die without symptoms of metastatic cancer. The complications of treatment, however, may begin within months and be permanent. Recent studies using modern survey techniques are beginning to provide accurate information on treatment complications. A careful, thorough discussion between doctor and patient is necessary to identify the best available therapy for each patient.


14. DOCID:22934 SCORE: 0.00159085869366941
DOCNO: 7927112
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Tashiro H
AUTHOR: A Omura A
AUTHOR: S Ozeki S
AUTHOR: Y Higuchi Y
AUTHOR: M Shinohara M
AFFILIATION: First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University, Fukuoka.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Fukuoka igaku zasshi = Hukuoka acta medica.
COUNTRY: JAPAN
TITLE: Squamous cell carcinoma of the oral cavity consisting of band-like nests.
PUBDATE: 19940801
Four squamous cell carcinomas of the oral cavity shared common histological and clinical characteristics. The primary lesion was situated at the floor of the mouth or the tongue. The cancer cell nests were band-like. The border between nests and stroma was smooth and distinct, with the continuity of the basement membrane being well maintained. The response to preoperative chemoradiotherapy was relatively poor. Although the lesion was locally advanced, no cervical metastasis was detected. No recurrence has occurred after the operation.