0. DOCID:27880 SCORE: 0.00211147758172746
DOCNO: 11776752
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sentinel Lymph Node Biopsy
QUALIFIER: pathology
QUALIFIER: diagnosis
AUTHOR: R J Bold RJ
AUTHOR: M Schlieman M
AUTHOR: B N Fahy BN
AFFILIATION: Department of Surgery, Division of Surgical Oncology, University of California, Davis Cancer Center, 4501 X Street, Sacramento, CA 95817, USA. richard.bold@ucdmc.ucdavis.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer biotherapy & radiopharmaceuticals.
COUNTRY: United States
TITLE: Sentinel lymph node biopsy for breast cancer.
PUBDATE: 20011001
Sentinel lymph node biopsy (SLNB) is an emerging surgical technique to improve lymph node staging for breast cancer. Despite the rapid development of this technique, there remain aspects of SLNB that need to be further defined to provide a standardized approach. Variables, including patient selection, technical details for the performance of SLNB, extent of pathologic evaluation of the sentinel lymph node, and the impact of micrometastases, are areas of controversy. This paper reviews the controversies and discusses available data as well as personal experience and opinion.


1. DOCID:27123 SCORE: 0.0020029033437485
DOCNO: 11551135
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
QUALIFIER: surgery
AUTHOR: D F Dargent DF
AFFILIATION: Department of Gynecologic Oncology, Hospital Edouard Herriot, Lyon, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Surgical clinics of North America.
COUNTRY: United States
TITLE: Laparoscopic surgery in gynecologic oncology.
PUBDATE: 20010801
Laparoscopy found its first application in the field of gynecology. Today, laparoscopy benefits the general gynecologist because of its minimally invasive nature. Benign procedures, such as oophorectomies and hysterectomies, have become practically outpatient procedures. The learning curve for laparoscopy in gynecologic cancer operations is obviously steeper, more time consuming, and training-dependent. With increased operative time, cost, and the questions of safety in malignant conditions, laparoscopy has quite a burden of proof before it becomes widely accepted. This article reviews the current applications of laparoscopy in gynecologic oncology with available data and offers future directions best suited for laparoscopy in this subspecialty.


2. DOCID:26660 SCORE: 0.00190693841648069
DOCNO: 11200504
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
AUTHOR: T Wu T
AUTHOR: S Xu S
AUTHOR: J Shen J
AUTHOR: A Song A
AUTHOR: S Chen S
AUTHOR: M Zhang M
AUTHOR: T Shen T
AFFILIATION: Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing.
PUBTYPE: Journal Article
JOURNALTITLE: Anti-cancer drug design.
COUNTRY: England
TITLE: New potential photodynamic therapeutic anti-cancer agents: synthesis and characterization of demethoxy amino-substituted hypocrellins.
PUBDATE: 20000801
A novel method was used to obtain demethoxy amino-substituted hypocrellin derivatives. The reaction condition was mild and amino substitution occurred at position 2 or 11 of hypocrellins with high yield. The photophysical and photochemical properties of the amino-substituted hypocrellins derivatives were investigated, and their significantly enhanced red absorptivities and strong active oxygen-generating functions qualified them as promising photodynamic therapeutic anti-cancer agents.


3. DOCID:31936 SCORE: 0.00188784917497012
DOCNO: 12419914
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: Megumi Sumino M
AUTHOR: Toshikazu Sekine T
AUTHOR: Nijsiri Ruangrungsi N
AUTHOR: Kazuei Igarashi K
AUTHOR: Fumio Ikegami F
AFFILIATION: Graduate School of Pharmaceutical Sciences, Chiba University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: Japan
TITLE: Ardisiphenols and other antioxidant principles from the fruits of Ardisia colorata.
PUBDATE: 20021101
Novel alkylphenols, ardisiphenols A-C (1-3) and a novel bergenin derivative, demethoxybergenin (10) were isolated from the fruits of Ardisia colorata (Myrsinaceae), together with known alkylresorcinols (4-6), embelin (7), myricetin (8), quercetin (9), bergenin (11), norbergenin (12), kaempferol (13), quercetin-3-O-beta-D-glucopyranoside (14) and gallic acid (15). Their structures were determined by NMR, MS(/MS) analyses and other spectroscopic methods. Ardisiphenols showed moderate scavenging activities toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and showed cytotoxicity against the murine breast cancer cell line, FM3A.


4. DOCID:27913 SCORE: 0.00188062358781652
DOCNO: 11014091
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: M Matter M
AUTHOR: M Dusmet M
AUTHOR: F Chevalley F
AFFILIATION: Service de chirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne. Maurice.Matter@chuv.hospvd.ch
PUBTYPE: Journal Article
JOURNALTITLE: Revue médicale de la Suisse romande.
COUNTRY: SWITZERLAND
TITLE: [The place of surgery in the treatment of advanced localized, recurrent and metastatic breast cancer]
PUBDATE: 20000601
In the multidisciplinary treatment of locally advanced and metastatic breast cancer, aggressive surgical options can be chosen in selected cases. They may allow: survival to be prolonged by the resection of metastases (liver, ovary, lung), symptomatic treatment (bone pain, local recurrence, infiltration of the chest wall), prevention of potentially disabling complications (pathologic fractures, medullary compression), exclusion of another tumoural or non tumoural diseases. The decision to perform surgery has to be discussed between the surgeon and the oncologist so as to optimise its timing. Surgical treatment can follow induction therapy or can precede chemo- or hormonotherapy.


5. DOCID:27664 SCORE: 0.00184492598489288
DOCNO: 11218389
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: T Nakazawa T
AFFILIATION: Yamaguchi University School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: Japan
TITLE: [Progress of molecular bacteriological studies on Helicobacter pylori]
PUBDATE: 20010201
To understand pathogenesis of H. pylori in stomach diseases including gastric cancer, molecular bacteriological studies are important. The studies are greatly advanced by information of the whole genome sequence of this bacterium in 1997. Various methods of gene manipulation to identify the genes involved in pathogenesis are now available such as transformation followed by construction of knockout mutants, complementation using H. pylori-E. coli shuttle vectors, random insertion mutagenesis, and RT-PCR or proteome analysis of in vivo-expressed genes. The molecular mechanism of persistent infection of H. pylori is discussed in light of recent findings on molecular mechanisms of bacterial attachment and colonization as well as on gastric physiology.


6. DOCID:31693 SCORE: 0.00177229367105133
DOCNO: 12470982
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Climacteric
DESCRIPTOR: Neoplasms
QUALIFIER: drug therapy
AUTHOR: Mark Clemons M
AUTHOR: Andrew Clamp A
AUTHOR: Beverley Anderson B
AFFILIATION: Division of Medical Oncology, Toronto-Sunnybrook Regional Cancer Centre, Ont., Canada. mark.clemons@tsrcc.on.ca
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer treatment reviews.
COUNTRY: England
TITLE: Management of the menopause in cancer survivors.
PUBDATE: 20021201
The consequences of premature menopause are of great importance to cancer survivors. Oestrogen replacement therapy (with and without added progestins) is the most extensively researched agent for the treatment and prevention of menopausal problems. While this may be appropriate for symptom control in patients with tumours that are not hormone responsive, patients with hormone dependent tumours will require safe and effective alternative treatments for menopausal symptoms. This paper will discuss both the short-term and long-term consequences of the menopause in cancer survivors and will also offer various management strategies.


7. DOCID:31574 SCORE: 0.00177168047648427
DOCNO: 12324259
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: methods
QUALIFIER: trends
AUTHOR: Sanjay Tickoo S
AUTHOR: Steven Russell S
AFFILIATION: Department of Genetics, University of Cambridge, UK. s.tickoo@gen.cam.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in pharmacology.
COUNTRY: England
TITLE: Drosophila melanogaster as a model system for drug discovery and pathway screening.
PUBDATE: 20021001
Although the freakish nightmare world of Mr Samsa may seem completely divorced from our view of the real world, the comparisons between the Drosophila and human genomes indicate that we are a lot closer to insects than we like to think. The use of sophisticated genetic approaches combined with emerging genomics technologies suggest that the fly has much to offer as a tool for understanding basic cellular processes and provides an attractive and complex model system for exploring the molecular basis of human diseases such as cancer, Alzheimer's disease and Huntington's disease.


8. DOCID:30872 SCORE: 0.00176617674793824
DOCNO: 12087588
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug effects
AUTHOR: Les Lockridge L
AUTHOR: Rose J Papac RJ
AUTHOR: Mark A Perazella MA
AFFILIATION: Department of Medicine, Section of Oncology and Section of Nephrology, Yale University, New Haven, CT 06529-8029, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of kidney diseases : the official journal of the National Kidney Foundation.
COUNTRY: United States
TITLE: Pamidronate-associated nephrotoxicity in a patient with Langerhans's histiocytosis.
PUBDATE: 20020701
Pamidronate is used frequently to treat malignancy-associated hypercalcemia and osteolytic lesions. This widely used bisphosphonate has been noted to cause nephrotoxicity in patients with multiple myeloma and metastatic breast cancer. We encountered a patient with Langerhans's histiocytosis who developed nephrotic syndrome and renal failure after pamidronate therapy. We describe the clinical and renal biopsy findings in this patient.


9. DOCID:27905 SCORE: 0.00176512137442102
DOCNO: 11192793
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: M Hut'an M
AUTHOR: M Salapa M
AUTHOR: J Bandzák J
AUTHOR: P Baláz P
AFFILIATION: Chirurgické oddelenie NsP Ruzinov, Bratislava, Slovenská republika.
PUBTYPE: Journal Article
JOURNALTITLE: Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti.
COUNTRY: Czech Republic
TITLE: [The current method of staging gastrointestinal (GIT) tumors]
PUBDATE: 20001001
The authors analyzed in a retrospective study the stage of carcinomas of the stomach and colorectum in their material. In 1996-1998 they operated 35 patients with gastric tumours and 77 patients with colorectal cancer. In both groups they operated more than 50% of the patients in the IIIrd or more advanced stage of the disease. 22.8% gastric tumours and 19.5% colorectal tumours were operated in the acute stage. The situation in the group is alarming, it is essential to improve the early diagnosis and thus also treatment in all links of the chain: patient--attending physician--surgeon--society.


10. DOCID:31993 SCORE: 0.00176249836734449
DOCNO: 16222146
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: James J Mezhir JJ
AUTHOR: Hank Schmidt H
AUTHOR: Bakhtiar Yamini B
AUTHOR: Neil N Senzer NN
AUTHOR: Mitchell C Posner MC
AUTHOR: Donald W Kufe DW
AUTHOR: Ralph R Weichselbaum RR
AFFILIATION: Departments of aSurgery bRadiation Oncology, University of Chicago Hospitals, Chicago, Illinois, USA cMary Crowley Medical Research Center, Sammons Cancer Center, Dallas, Texas, USA dDana Farber Cancer Institute, Boston, Massachusetts, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: England
TITLE: Chemoinducible gene therapy.
PUBDATE: 20051101
Chemoinducible cancer gene therapy is a potential new treatment for solid tumors that may in part enhance the anti-tumor effects of chemotherapy while minimizing toxicity. This approach combines viral vectors expressing cytotoxic transgenes that can be transcriptionally activated by DNA-damaging agents. The development of chemoinducible gene therapy has numerous implications for the treatment of both localized and metastatic disease in patients with solid tumors.


11. DOCID:27765 SCORE: 0.00174235400645359
DOCNO: 12066020
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: nursing
QUALIFIER: complications
QUALIFIER: methods
AUTHOR: S Brown S
AUTHOR: L F Degner LF
AFFILIATION: Faculty of Nursing, University of Manitoba, Winnipeg, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of palliative nursing.
COUNTRY: England
TITLE: Delirium in the terminally-ill cancer patient: aetiology, symptoms and management.
PUBDATE: 20010601
Delirium is a frequent and serious clinical problem in the terminally ill cancer patient. Multiple dimensions of delirium make definition, measurement, and assessment of it challenging in clinical nursing practice. Assessment and management of delirium requires knowledge of the diagnostic criteria for it, aetiology, signs and symptoms, and nursing interventions. Four delirium assessment scales determined to be useful in assessing patients with terminal illness are reviewed. The use of a delirium assessment instrument in routine nursing assessments would be important for the nurse's early detection of delirium so that interventions to reverse the causes of delirium could immediately be implemented.


12. DOCID:26607 SCORE: 0.00173622557584259
DOCNO: 9989206
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: S Narod S
AFFILIATION: Department of Medicine, Women's College Hospital, Toronto, Ont., Canada. narod@ftn.net
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: NETHERLANDS
TITLE: Genetic epidemiology of prostate cancer.
PUBDATE: 19990101
A family history of prostate cancer is a consistent risk factor for prostate cancer, and can also be used to predict the presence of prostate cancer among asymptomatic men who undergo PSA screening. Approximately 5% of cases of prostate cancer have a familial component. The genetic epidemiology of prostate cancer is complex, and genes on chromosome 1 and X chromosome contribute to familial aggregation. Neither of these prostate cancer susceptibility genes have been identified, but are the subject of an active search. Hereditary prostate cancer resembles non-hereditary cancer in terms of age of onset, pathologic appearance and grade.


13. DOCID:27507 SCORE: 0.00172932800709038
DOCNO: 9723580
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: therapy
AUTHOR: M J Carey MJ
AUTHOR: G M Rodgers GM
AFFILIATION: Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of hematology.
COUNTRY: UNITED STATES
TITLE: Disseminated intravascular coagulation: clinical and laboratory aspects.
PUBDATE: 19980901
Disseminated intravascular coagulation (DIC) is a complex acquired coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetrical complications, sepsis, cancer, and trauma. Numerous laboratory tests are available to monitor DIC, but most patients are adequately managed using only routine hemostasis screening tests, and assays for fibrinogen and D-dimer. Treatment of DIC should focus on reversing the underlying disorder initiating the coagulopathy. Novel treatments are being investigated for treating DIC; many of these experimental modalities target the excessive TF activity that characterizes DIC.


14. DOCID:26365 SCORE: 0.00172745604538964
DOCNO: 11797393
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: genetics
AUTHOR: R Kushima R
AFFILIATION: Department of Clinical Laboratory Medicine, (Central Clinical Laboratory), Shiga University of Medical Science, Ohtsu 520-2192.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Rinsho byori. The Japanese journal of clinical pathology.
COUNTRY: Japan
TITLE: [Relationship and role of morphological diagnosis and gene diagnosis of cancer (1) tumors in the gastrointestinal tract]
PUBDATE: 20011201
At present histopathological examination based on clinical findings is the most important and definitive method of diagnosing gastrointestinal tumors. In this field, gene analysis is sometimes used as a supplemental diagnosis. However, fruitful analyses of gene abnormalities in gastrointestinal tumors have facilitated thoughtful morphological diagnosis. Gene diagnosis is expected to play an important role in the grading of malignancy, examining sensitivity for chemotherapy and discovering micrometastases, in cases of cancers definitively diagnosed by histopathology.