0. DOCID:18710 SCORE: 0.00257064583460039
DOCNO: 8096359
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 17
DESCRIPTOR: Proto-Oncogenes
QUALIFIER: genetics
QUALIFIER: methods
AUTHOR: S Mazoyer S
AUTHOR: P Lalle P
AUTHOR: S A Narod SA
AUTHOR: Y J Bignon YJ
AUTHOR: F Courjal F
AUTHOR: B Jamot B
AUTHOR: B Dutrillaux B
AUTHOR: D Stoppa-Lyonnett D
AUTHOR: H Sobol H
AFFILIATION: Unité d'Oncologie Génétique, Centre Léon Bérard, Lyons, France.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of human genetics.
COUNTRY: UNITED STATES
TITLE: Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers.
PUBDATE: 19930401
Nineteen French breast and breast-ovarian cancer families were tested for linkage with five chromosome 17q markers. The five breast-ovarian cancer families as a group give positive evidence for linkage, whereas the 14 breast cancer-only families do not. Heterogeneity of linkage of breast and breast-ovarian cancers is significant in France and supports the existence of more than one susceptibility gene.


1. DOCID:19039 SCORE: 0.00244239436840433
DOCNO: 1561952
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: K Ishikura K
AUTHOR: M Hasegawa M
AUTHOR: K Nomura K
AUTHOR: T Okamoto T
AUTHOR: T Ujiie T
AUTHOR: K Kumagai K
AUTHOR: T Fujioka T
AUTHOR: T Kubo T
AFFILIATION: Department of Urology, School of Medicine, Iwate Medical University.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Sarcomatoid renal cell carcinoma: 3 case reports]
PUBDATE: 19920201
We report 3 cases of sarcomatoid renal cell carcinoma, which is an uncommon neoplasm consisting of a typical renal cell carcinoma associated intimately with a sarcomatoid component. All patients were symptomatic at hospitalization and underwent nephrectomy. Two patients died of metastatic renal cancer within a year, and another is alive without evidence of metastasis for 12 months after the surgery. Because sarcomatoid renal cell carcinoma has a highly malignant behavior and poor prognosis, an adjuvant treatment effective in controlling the disease is awaited.


2. DOCID:19640 SCORE: 0.00228797798739507
DOCNO: 2303289
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
AUTHOR: R Berndt R
AUTHOR: P Nischan P
AUTHOR: K Ebeling K
AFFILIATION: Humboldt University, Berlin, GDR.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: UNITED STATES
TITLE: Screening for lung cancer in the middle-aged.
PUBDATE: 19900201
A screening programme for lung diseases has been in operation in the German Democratic Republic for more than 3 decades. The programme is based on biennial chest X-rays (70 x 70 mm posterior-anterior) of the population 40 years of age or over. With respect to lung cancer the results show that, for the population under 60 years of age, the adjusted relative risk of dying from lung cancer among subjects who took part in the last screening round compared with subjects who did not but were screened at least once during the preceding 10-year period was 0.93 (95% confidence interval 0.65-1.33).


3. DOCID:19565 SCORE: 0.00217332801977667
DOCNO: 1434663
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: pathology
AUTHOR: S M Gitt SM
AUTHOR: P Flint P
AUTHOR: C H Fredell CH
AUTHOR: G L Schmitz GL
AFFILIATION: Department of Surgery, University of Michigan Medical Center, Ann Arbor.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Bowel perforation due to metastatic lung cancer.
PUBDATE: 19921201
Lung cancer infrequently metastasizes to the bowel. When this occurs, the symptoms may vary from mild to emergent in nature. Three patients are presented illustrating the life threatening complications that may occur due to bowel metastases of lung carcinoma. A review of the literature reveals that only four of 24 reported patients have survived bowel perforation due to metastatic lung carcinoma. One of the three patients presented herein survived to be discharged home. Patients with known lung carcinoma who develop abdominal complaints should be investigated aggressively to prevent life-threatening complications by early intervention.


4. DOCID:19478 SCORE: 0.00214460318833521
DOCNO: 1434028
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: K Yokoi K
AUTHOR: N Miyazawa N
AUTHOR: J Muraki J
AUTHOR: M Nakazono M
AUTHOR: G Imura G
AUTHOR: K Shimamura K
AFFILIATION: Division of Thoracic Diseases, Tochigi Cancer Center, Utsunomiya.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Japanese journal of clinical oncology.
COUNTRY: JAPAN
TITLE: Penile metastasis from lung cancer.
PUBDATE: 19920801
A case of metastatic tumor of the penis from lung cancer is reported. The patient, who had received a right pneumonectomy 17 months previously for a squamous cell carcinoma of the lung, complained of urinary retention and painful erection of the penis. He underwent an emergency suprapubic cystostomy. Twenty days after the procedure, he died of disseminated lung carcinoma. The autopsy demonstrated massive metastasis to the penis from squamous cell carcinoma of the lung. Penile metastasis from lung cancer is a very rare condition and only 14 cases of this secondary carcinoma have been reported.


5. DOCID:22777 SCORE: 0.00211208804099457
DOCNO: 9426472
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: antagonists & inhibitors
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: C A Omer CA
AUTHOR: N E Kohl NE
AFFILIATION: Department of Cancer Research, Merck Research Laboratories, West Point, PA 19486, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in pharmacological sciences.
COUNTRY: ENGLAND
TITLE: CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents.
PUBDATE: 19971101
For Ras oncoproteins to transform mammalian cells, they must be post-translationally farnesylated in a reaction catalysed by the enzyme farnesyl-protein transferase (FPTase). Inhibitors of FPTase have therefore been proposed as anti-cancer agents. In this review Charles Omer and Nancy Kohl discuss the development of FPTase inhibitors that are kinetically competitive with the protein substrate in the farnesylation reaction. These compounds are potent and selective inhibitors of the enzyme that block the tumourigenic phenotypes of ras-transformed cells and human tumour cells in cell culture and in animal models.


6. DOCID:18822 SCORE: 0.00205555950266183
DOCNO: 2076633
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: Y Zheng Y
AFFILIATION: Second Hospital, Henan Medical College, Zhengzhou.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [Plasma estrogen level in patients with cervical cancer]
PUBDATE: 19901101
Plasma estrone (E1), estradiol (E2) and estriol (E3) levels were determined in 51 cases of cervical cancer and 52 normal postmenopausal women. It was found that the plasma E1, E2 and E3 levels in cervical cancer patients were higher than those in normal postmenopausal women. There was a significant difference in E1 and E3 between the two groups (P less than 0.05). E1/E2, E2/E3, E1/E3 and E1/E2 + E3 were measured in the two groups. E1/E2 ratio in cervical cancer patients was higher than that in normal postmenopausal women (P less than 0.05).


7. DOCID:19371 SCORE: 0.00201937767105877
DOCNO: 8491958
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: standards
QUALIFIER: standards
QUALIFIER: diagnosis
AUTHOR: J E White JE
AUTHOR: L Begg L
AUTHOR: N W Fishman NW
AUTHOR: B Guthrie B
AUTHOR: J K Fagan JK
PUBTYPE: Journal Article
JOURNALTITLE: Journal of gerontological nursing.
COUNTRY: UNITED STATES
TITLE: Increasing cervical cancer screening among minority elderly. Education and on-site services increase screening.
PUBDATE: 19930501
Older women participate in cervical cancer screening less regularly than do younger women. As a consequence, more lesions are found in more advanced and less curable stages in older women. Elderly black and Hispanic women have had lower rates of participation in cervical cancer screening than white women. There is a marked, inverse relationship between the stage of cervical cancer at diagnosis and the 5-year survival rate. The rate of cervical cancer screening among older women can be increased by offering education about Pap tests and onsite cervical cancer screening in housing for the elderly.


8. DOCID:17779 SCORE: 0.00200654965326393
DOCNO: 2145004
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: etiology
AUTHOR: B L Andersen BL
AFFILIATION: Department of Psychology, Ohio State University, Columbus.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: How cancer affects sexual functioning.
PUBDATE: 19900601
Significant sexual morbidity occurs in the majority of cancer patients. In the assessment of sexual functioning, the health-care provider needs to survey sexual behavior, sexual desire, excitement, orgasm, and resolution (i.e., the sexual response cycle), and the occurrence of sexual dysfunction(s). Data are available documenting sexual disruption for the major sites of disease, including breast, colorectal, bladder, and the genitals, as well as for those with Hodgkin's disease. The author includes a brief model (ALARM) to assist the health professional in assessing sexual functioning in cancer patients.


9. DOCID:19568 SCORE: 0.00198226359205345
DOCNO: 1383517
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hospitals, District
DESCRIPTOR: Hospitals, General
DESCRIPTOR: Hospitals, Teaching
QUALIFIER: mortality
QUALIFIER: surgery
AUTHOR: R D Kingston RD
AUTHOR: S Walsh S
AUTHOR: J Jeacock J
AFFILIATION: Department of Clinical Studies, Trafford General Hospital, Manchester, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Royal College of Surgeons of Edinburgh.
COUNTRY: SCOTLAND
TITLE: Colorectal surgeons in district general hospitals produce similar survival outcomes to their teaching hospital colleagues: review of 5-year survivals in Manchester.
PUBDATE: 19920801
A study of 578 patients treated for colorectal cancer in the North-west region comparing survival after surgery in teaching and non-teaching hospitals was performed. All patients had a minimum of 5 years follow-up. A greater proportion of elderly and emergency patients were treated in the non-teaching hospitals. The number of operative mortalities and 5-year survival figures for all causes of death and for colorectal deaths alone were similar in teaching and non-teaching hospital patients.


10. DOCID:18543 SCORE: 0.00197028084623198
DOCNO: 8490206
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pharmacology
AUTHOR: T Hasegawa T
AUTHOR: H Nishino H
AUTHOR: A Iwashima A
AFFILIATION: Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: Isothiocyanates inhibit cell cycle progression of HeLa cells at G2/M phase.
PUBDATE: 19930401
To analyze the inhibitory effects of isothiocyanates on the growth of human cancer cells, the effects of these compounds on the cell cycle progression of HeLa cells were studied by flow cytometry. The accumulation of cells at G2/M phase was observed at 16 h after treatment with 10 microM allyl isothiocyanate, 2.5 microM benzyl or phenethyl isothiocyanate, at which concentrations the cell growth was inhibited to 41-79% of control. These results suggest that isothiocyanates delay the cell cycle progression of HeLa cells, leading to inhibition of cell growth.


11. DOCID:23335 SCORE: 0.00193126147630325
DOCNO: 8741691
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
DESCRIPTOR: Viral Proteins
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: T Mashima T
AUTHOR: M Naito M
AUTHOR: S Kataoka S
AUTHOR: T Tsuruo T
AFFILIATION: Institute of Molecular and Cellular Biosciences, University of Tokyo.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Cancer chemotherapy and apoptosis]
PUBDATE: 19960701
Tumor cells undergo apoptotic cell death when treated with several chemotherapeutic agents. Since these agents, acting on different cellular targets, induce a similar pattern of cell death (apoptosis), it is suggested that a common signaling pathway of apoptosis could exist and that apoptosis resistance could cause a new form of multi-drug resistance in tumor cells. Although the mechanisms of apoptosis are not fully understood, the involvement of ICE/ced-3 family proteases in chemotherapy-induced apoptosis is strongly suggested. Identification of factors directly acting on these apoptosis pathway will offer new strategies in cancer chemotherapy.


12. DOCID:23467 SCORE: 0.00191198658719837
DOCNO: 7820825
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Medicine, Traditional
DESCRIPTOR: Perception
QUALIFIER: psychology
AUTHOR: I A Nwoga IA
AFFILIATION: Florida A & M University School of Nursing, Tallahassee 32307.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer nursing.
COUNTRY: UNITED STATES
TITLE: Traditional healers and perceptions of the causes and treatment of cancer.
PUBDATE: 19941201
The observation that some Nigerian patients use alternative health care services when they perceive that one medical system has failed them provided the impetus for this survey. The purpose of the survey was to understand why some Nigerian patients rely on traditional healers for cure of cancer by exploring the perceptions of Igbo traditional healers from Anambra State of Nigeria about the causes and treatment of cancer. Implications of the different meanings of illness and disease to patients and physicians provided the theoretical framework for understanding the cultural context of the study. Findings have ethical, moral, and cultural implications for professional nursing practice, education, and research.


13. DOCID:19672 SCORE: 0.00190917226954003
DOCNO: 1451586
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vegetables
QUALIFIER: pharmacology
QUALIFIER: toxicity
AUTHOR: Z Z Zhao ZZ
AUTHOR: M T Huang MT
AFFILIATION: Hebei Cancer Institute, Shijiazhuang.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].
COUNTRY: CHINA
TITLE: [A SOS induction test screening study for vegetables inhibiting mutagenicity caused by antineoplastic drugs]
PUBDATE: 19920301
Using mutational and anti-mutational synchronous in SOS inductest (+/- S9), We found that 7 out of 11 kinds of commonly eaten vegetables had the ability to inhibit mutagenicity caused by chemical drugs such as Mitomycin C, Bleomycinia, Fluorouracil, Cis-Diaminodichloroplatinum, Arabinosylcytosin and mustargen, They were garlic, green Chinese onion, onion, garlic bulb, tomato, cucumber and water radish. The other 4 lacking this ability were rape, chinese toon, ginger and asparagus lettuce stalk. We believe that our results can be helpful in the preparation. of cancer patients' diet, who are receiving chemotherapy and in the prevention of cancer.


14. DOCID:23109 SCORE: 0.00190543497433208
DOCNO: 9450418
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: nursing
QUALIFIER: complications
AUTHOR: A Acheson A
AUTHOR: D MacCormack D
AFFILIATION: Manitoba Cancer Treatment and Research Foundation, Winnipeg.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Canadian oncology nursing journal = Revue canadienne de nursing oncologique.
COUNTRY: CANADA
TITLE: Dyspnea and the cancer patient--an overview.
PUBDATE: 19971101
Dyspnea, a distressing subjective symptom common in patients with advanced cancer, has been vastly under-reported. It can be directly caused from the tumour such as in superior vena cava obstruction; indirectly caused from debilitating conditions such as pneumonia or pulmonary embolism; or related to treatment such as surgery or radiation therapy. Nursing assessment and diagnosis are discussed. The authors present strategies for the management of dyspnea that nurses will find helpful when confronted with this symptom. Nurses play an important role in helping patients and their families to cope with dyspnea and to maintain as normal a lifestyle as possible.