0. DOCID:27523 SCORE: 0.00311463266275269
DOCNO: 10893179
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: metabolism
QUALIFIER: genetics
QUALIFIER: metabolism
QUALIFIER: physiology
QUALIFIER: cytology
AUTHOR: C Frei C
AUTHOR: S M Gasser SM
AFFILIATION: Swiss Institute for Experimental Cancer Research (ISREC) Ch. des Boveresses 155, CH-1066 Epalinges/Lausanne, Switzerland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of cell science.
COUNTRY: ENGLAND
TITLE: RecQ-like helicases: the DNA replication checkpoint connection.
PUBDATE: 20000801
The eukaryotic homologues of the Escherichia coli RecQ DNA helicase play conserved roles in the maintenance of genome stability. Results obtained in yeast and mammalian systems are beginning to form a coherent picture about what these helicases do to ensure normal cell division and why humans who lack these enzymes are cancer prone. Recent data suggest that the yeast enzyme Sgs1p, as well as two human homologues, which are encoded by the Bloom's and Werner's syndrome genes, function during DNA replication and possibly in a replication checkpoint specific to S phase.


1. DOCID:27311 SCORE: 0.00307154460076831
DOCNO: 9750496
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: diagnosis
QUALIFIER: blood
AUTHOR: H Akino H
AUTHOR: Y Suzuki Y
AUTHOR: K Okada K
AFFILIATION: Department of Urology, Faculty of Medicine, Fukui Medical University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Clinical significance of prostate specific antigen and gamma-seminoprotein ratio for diagnosing prostate cancer]
PUBDATE: 19980801
It has been reported that prostate specific antigen and gamma-seminoprotein ratio (PSA/gamma-Sm ratio) is an useful means for distinguishing benign prostatic hyperplasia and prostate cancer if serum PSA is measured by Eiken-PSA method. We studied the clinical significance of PSA/gamma-Sm ratio when using Markit-M-PSA method. PSA/gamma-Sm ratio had no superiority over PSA alone for detecting prostate cancer. The present results suggest that the clinical significance of PSA/gamma-Sm ratio can be varied by various PSA-assay kits.


2. DOCID:26707 SCORE: 0.00302057624235851
DOCNO: 9640530
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Repair
QUALIFIER: genetics
AUTHOR: T A Prolla TA
AFFILIATION: Department of Genetics, University of Wisconsin-Madison 53706, USA. taprolla@facstaff.wisc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in cell biology.
COUNTRY: UNITED STATES
TITLE: DNA mismatch repair and cancer.
PUBDATE: 19980601
Mutations in DNA mismatch repair (MMR) genes have been associated with hereditary nonpolyposis colorectal cancer. Studies in bacteria, yeast and mammals suggest that the basic components of the MMR system are evolutionarily conserved, but studies in eukaryotes also imply novel functions for MMR proteins. Recent results suggest that mutations in MMR genes lead to tumorigenesis in mice, but DNA replication errors appear to be insufficient to initiate intestinal tumorigenesis in this model system. Additionally, MMR-deficient cell lines display a mutator phenotype and resistance to several cytotoxic agents, including compounds widely used in cancer chemotherapy.


3. DOCID:27115 SCORE: 0.00299477241154641
DOCNO: 11851197
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Minority Groups
DESCRIPTOR: Societies, Medical
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: P L Rayford PL
PUBTYPE: Addresses
JOURNALTITLE: Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians.
COUNTRY: United States
TITLE: Alcohol, tobacco (nicotine) and pancreatic pathophysiology.
PUBDATE: 20010301
Current knowledge indicates that chronic use of alcohol is implicated in the etiology of chronic pancreatitis and probably in pancreatic cancer and that chronic use of tobacco is associated with pancreatic cancer and probably pancreatitis. Studies by others, and by us, support this knowledge. In addition, our studies suggest that nicotine, which is a major component and an additive component of tobacco, is probably a major factor in these pathological effects. The possibility exists that nicotine may also play a role in tobacco induced diseases of other organs of the body.


4. DOCID:26883 SCORE: 0.00290238281087692
DOCNO: 9866475
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude of Health Personnel
DESCRIPTOR: Clinical Nursing Research
DESCRIPTOR: Oncologic Nursing
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: M E Dorion ME
AUTHOR: H B Porter HB
AFFILIATION: Systemic Therapy Department, Windsor Regional Cancer Centre, Ontario.
PUBTYPE: Journal Article
JOURNALTITLE: Canadian oncology nursing journal = Revue canadienne de nursing oncologique.
COUNTRY: CANADA
TITLE: The research experience: reflections of a novice researcher.
PUBDATE: 19981101
The oncology nurses at the Windsor Regional Cancer Centre (WRCC), like other health professionals, realize that professional proficiency can be improved through systematic strategies designed to enhance and streamline patient care. For this reason, all nurses in the systemic therapy department of the WRCC agreed to take part in a research study called "Effectiveness and Efficiency of Nurse-Given Cancer Patient Education" (Porter, 1998). Their opinions, accomplishments and feelings about this research experience are recorded under selected headings of the research process.


5. DOCID:27253 SCORE: 0.00287097852665703
DOCNO: 11229776
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: antagonists & inhibitors
AUTHOR: S Sasaki S
AUTHOR: T Ehara T
AUTHOR: I Sakata I
AUTHOR: Y Fujino Y
AUTHOR: N Harada N
AUTHOR: J Kimura J
AUTHOR: H Nakamura H
AUTHOR: M Maeda M
AFFILIATION: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. sasaki@phar.kyushu-u.ac.jp
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry letters.
COUNTRY: England
TITLE: Development of novel telomerase inhibitors based on a bisindole unit.
PUBDATE: 20010201
Telomerase is the enzyme that elongates telomere repeat at the ends of a chromosome. As high telomerase activity is observed in most cancer cells, inhibitors of human telomerase have been expected as new chemotherapeutic agents for cancer. We describe here the discovery of novel inhibitors with IC50 values in the submicromolar range. The structure of the novel inhibitors will be useful as a scaffold for construction of the library in the search for telomerase inhibitors.


6. DOCID:26397 SCORE: 0.00280018270261477
DOCNO: 10938662
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: H P Howaldt HP
AUTHOR: H Vorast H
AUTHOR: J C Blecher JC
AUTHOR: M Reicherts M
AUTHOR: M Kainz M
AFFILIATION: Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Uniklinik Giessen.
PUBTYPE: Journal Article
JOURNALTITLE: Mund-, Kiefer- und Gesichtschirurgie : MKG.
COUNTRY: GERMANY
TITLE: [Results of the DOSAK tumor register]
PUBDATE: 20000501
The German-Swiss-Austrian Group on Maxillofacial Tumors (DOSAK) has been performing observational studies in oral cancer. Since 1989, approximately 1600 cases of tumor of the head and neck per years has been collected in a central tumor registry. The database consists of more than 16,000 patients from 71 clinics; almost two-thirds are primary cases of squamous cell carcinoma. The data show great differences in patho-anatomical findings, therapy concepts, and five-year survival rates among the hospitals.


7. DOCID:27914 SCORE: 0.00279685484187071
DOCNO: 10969593
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Length of Stay
QUALIFIER: economics
QUALIFIER: therapy
QUALIFIER: economics
AUTHOR: M Muto M
AUTHOR: T Konishi T
AFFILIATION: Dept. of Surgery, National Nagano Hospital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Critical paths and economical efficiency on cancer therapy]
PUBDATE: 20000801
The critical paths of cancer patient care are discussed. The number of cancer institutes which have introduced critical paths into patient care has been increasing in the past few years. The effect of critical paths is to standardize the patient care process, shorten the length of the hospital stay of cancer patients, reduce the cost of care, have a well-managed cancer care team, and satisfy patients with full information on the care schedule. Combined with clinical practice guidelines, protocols and algorithms, critical paths are a more powerful tool with which to improve the efficiency and quality of cancer patient management in hospital care.


8. DOCID:26792 SCORE: 0.00278766910220246
DOCNO: 9574480
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hand
DESCRIPTOR: Kidney Pelvis
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: F Grados F
AUTHOR: E Houvenagel E
AUTHOR: G Cayrolle G
AUTHOR: R Bellony R
AUTHOR: P Fardellone P
AUTHOR: J L Sebert JL
AFFILIATION: Rheumatology Department, North Teaching Hospital, Amiens, France.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue du rhumatisme (English ed.)
COUNTRY: FRANCE
TITLE: Two new cancer locations accompanied with palmar fasciitis and polyarthritis.
PUBDATE: 19980301
Only 35 cases of cancer with palmar fasciitis and polyarthritis have been published to date. We report two new cases, one with a transitional cell carcinoma of the renal pelvis and the other with an adenocarcinoma of the uterus. Neither of these locations has been reported in association with palmar fasciitis and polyarthritis. Palmar fasciitis with polyarthritis can occur in a wide range of cancers and warrants extensive investigations for a malignant tumor.


9. DOCID:26818 SCORE: 0.00267651628888686
DOCNO: 11597455
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quantitative Structure-Activity Relationship
QUALIFIER: chemistry
AUTHOR: S B Mekapati SB
AUTHOR: W A Denny WA
AUTHOR: A Kurup A
AUTHOR: C Hansch C
AFFILIATION: Department of Chemistry, Pomona College, Claremont, CA 91711, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: England
TITLE: QSAR of anticancer compounds. Bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides).
PUBDATE: 20011101
QSAR have been developed for the anticancer activity (growth inhibition) of various tumor cells by bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides). Of the seven QSAR, positive hydrophobic interactions are found in only two examples: bis(naphthalimides) versus human colon cancer cells. This is consistent with other QSAR of anticancer compounds where hydrophobic interactions are found to be unimportant.


10. DOCID:27246 SCORE: 0.00264606663816675
DOCNO: 11397132
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Immunological
DESCRIPTOR: Nutrition
QUALIFIER: pathology
QUALIFIER: immunology
QUALIFIER: pathology
AUTHOR: D Eichler D
AFFILIATION: Dept. of Physics, Ben Gurian University, Beer Sheva, Israel.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of theoretical biology.
COUNTRY: England
TITLE: Slow proliferation as a survival advantage: an attempt to resolve a paradox.
PUBDATE: 20010601
A model is proposed for immunological high zone- and self-tolerance that is based on the concept of overstimulation of replication: It is demonstrated that if proliferation is hindered by delayed response to nutritional deficiency, then under competitive conditions slower proliferation can become a survival advantage. This offers a resolution of the paradox that self-antigens promote both positive and negative selection in the development of lymphocytes. It also suggests that maintaining nutrition and caloric intake at a minimal level can prolong the survival of cancer patients if the cancer cells replicate more rapidly than healthy ones.


11. DOCID:27018 SCORE: 0.00260300079489715
DOCNO: 11482220
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Postoperative Complications
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: Iu V Dumanskiĭ IuV
AUTHOR: S A Shtutin SA
AUTHOR: V F Zagorodnskiĭ VF
AUTHOR: I N Morgunova IN
AUTHOR: A N Zaika AN
AUTHOR: O Iu Stoliarova OIu
PUBTYPE: Journal Article
JOURNALTITLE: Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukraïny, Naukove tovarystvo khirurhiv Ukraïny.
COUNTRY: Ukraine
TITLE: [The complications in surgical treatment of gastric cancer in elderly and senile patients]
PUBDATE: 20010301
Causes of the perioperative complications occurrence in 736 elderly and senile patients, operated on for gastric cancer, were studied. It was established that the complications frequency and mortality were depended on the concomitant diseases presence, on the main disease complications, duration and volume of operation as well, but not from their age. The operation performance method and anesthesiological support perfection would permit to widen indications for the radical surgical intervention performance and raise the treatment of patients efficacy.


12. DOCID:26945 SCORE: 0.00255551370874176
DOCNO: 10831324
AUTHOR: G M Kayajanian GM
AFFILIATION: 1600 South Joyce Street, Suite 1411, Arlington, Virginia 22202, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Ecotoxicology and environmental safety.
COUNTRY: UNITED STATES
TITLE: Southeast Asia, promotability and dioxin's relationship to cancer incidence in operation ranch hand veterans.
PUBDATE: 20000601
Significant increases in systemic, melanoma, and presumedly total skin cancers are observed in Operation Ranch Hand veterans unexposed to dioxin. The spiked increase of excess systemic cancers and skin cancer incidence is the pattern expected from a 2- to 3-year exposure to cancer initiators in Southeast Asia during tours of duty coupled with brief or full promotability of initiated cells later in the United States. A discussion of promotability is undertaken. The exposure of these airmen to both Southeast Asia and dioxin is associated with a significant reduction of elevated systemic cancers and total skin cancers.


13. DOCID:27896 SCORE: 0.00249383772687085
DOCNO: 11374234
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Chest X-Ray
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
AUTHOR: G Hillerdal G
AUTHOR: C Henschke C
AUTHOR: S Sone S
AFFILIATION: Lungkliniken, Akademiska sjukhuset, Uppsala, samt lungkliniken, Karolinska sjukhuset, Stockholm. gunnar.hillerdal@lung.uas.lul.se
PUBTYPE: Journal Article
JOURNALTITLE: Läkartidningen.
COUNTRY: Sweden
TITLE: [Screening for lung cancer--new possibilities with new methods!]
PUBDATE: 20010401
Screening for lung cancer has been regarded as unwarranted for many years. With new techniques, this is no longer the case. Screening with low dose CT scanning has been used in Japan and New York, among many places, for a number of years. We here describe some results. New lung cancers were found in 0.6 per cent of all participants in both studies at the yearly repeat scan. The tumors have been very small, almost all in Stage I, and survival is very good. Thus, the results are promising, and trials in Sweden will hopefully begin before long.


14. DOCID:27567 SCORE: 0.00246820825871241
DOCNO: 11001068
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neovascularization, Pathologic
QUALIFIER: blood supply
AUTHOR: P Carmeliet P
AUTHOR: R K Jain RK
AFFILIATION: The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Belgium. peter.carmeliet@med.kuleuven.ac.be
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature.
COUNTRY: ENGLAND
TITLE: Angiogenesis in cancer and other diseases.
PUBDATE: 20000901
Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases. Concentrated efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interactions among these molecules and how they affect vascular structure and function in different environments are now beginning to be elucidated. This integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases. But owing to several unanswered questions, caution is needed.