0. DOCID:23821 SCORE: 0.00380925993382779
DOCNO: 9275681
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Papovaviridae Infections
DESCRIPTOR: Tumor Virus Infections
QUALIFIER: analysis
QUALIFIER: isolation & purification
QUALIFIER: virology
AUTHOR: Q Ding Q
AUTHOR: Y Zhang Y
AUTHOR: S Sun S
AFFILIATION: Huashan Hospital, Shanghai Medical University.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua wai ke za zhi [Chinese journal of surgery].
COUNTRY: CHINA
TITLE: [Role of PCR and dot bolt hybridization in the detection of human papillomavirus of the penile cancer]
PUBDATE: 19960101
Human papillomavirus (HPV), a oncogenicpotential, may be carcinogenic effectors in variety of genital tract malignancies. We examined the association of human papillomavirus type 16 and 18 in 28 penile cancers by the highly sensitive polymerase chain reaction and dot bolt hybridization. Human papillomavirus type 16 was found in 14 of 28 penile cancers (50%), whereas type 18 was identified in 3 of 28 penile cancers (10.6%). Our results suggest humanpapillomavirus type 16 may play a role in the development of this tumor and associate with smoking and ages of patients.


1. DOCID:22686 SCORE: 0.00346539025718881
DOCNO: 7973921
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: therapy
AUTHOR: A Routh A
AUTHOR: T Khansur T
AUTHOR: B T Hickman BT
AUTHOR: D Bass D
AFFILIATION: Department of Radiotherapy, University of Mississippi, Jackson.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Management of brain metastases: past, present, and future.
PUBDATE: 19941201
Brain metastasis is an important cause of morbidity and mortality in cancer patients. Because most of these patients die of systemic disease, the primary therapeutic goal is to improve the quality of life. Conventional therapy for brain metastases is usually whole-brain irradiation. Chemotherapy often results in regression of brain metastases in chemosensitive tumors. We review our institutional experience in the treatment of brain metastasis with both radiation and chemotherapy. In the future, improvement in the management of brain metastases will depend on improved chemotherapy, radiosensitizers, and radiotherapy techniques such as stereotactic radiosurgery.


2. DOCID:22710 SCORE: 0.00339719858897166
DOCNO: 8931062
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms
DESCRIPTOR: Quality of Life
AUTHOR: S Donnelly S
AUTHOR: D Walsh D
AFFILIATION: Palliative Care Program, Cleveland Clinic Foundation, Ohio, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Palliative medicine.
COUNTRY: ENGLAND
TITLE: Quality of life assessment in advanced cancer.
PUBDATE: 19961001
Our purpose is to examine how applicable current quality of life instruments are in advanced cancer. Quality of life (QOL) is difficult to define and measure; it is a multidimensional, dynamic and subjective concept. An acceptable QOL instrument for advanced disease should be simple to administer and easy to explain, complete and analyse. In our view, the present instruments used in oncology do not serve the needs of advanced cancer patients. Based on our review, we believe a single question posed on a linear or categorical scale should be used to assess QOL in advanced cancer in preference to other available methods.


3. DOCID:23931 SCORE: 0.00336426928597898
DOCNO: 8877630
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J E Richter JE
AUTHOR: G W Falk GW
PUBTYPE: Editorial
JOURNALTITLE: Journal of clinical gastroenterology.
COUNTRY: UNITED STATES
TITLE: Barrett's esophagus and adenocarcinoma. The need for a consensus conference.
PUBDATE: 19960901
The fear of cancer has evoked calls for intensive surveillance programs in Barrett's esophagus. Two evolving issues are fueling this fire: (a) the rising risk of adenocarcinoma of the esophagus over the past 20 years and (b) the coincidental increase in the recognized prevalence of Barrett's esophagus in the general population. However, these sobering statistics must be carefully weighed against the lack of adverse effects on survival and the cost of an extensive surveillance program for adenocarcinoma in Barrett's esophagus, the latter estimated at between $(300) and $(1,500) million per year. Barrett's esophagus and its associated cancer risk represent a crisis in gastroenterology. A consensus conference of leading basic and clinical scientists is needed in this area.


4. DOCID:21249 SCORE: 0.0033386773043209
DOCNO: 7855452
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Job Description
QUALIFIER: organization & administration
QUALIFIER: organization & administration
AUTHOR: M E Cooley ME
AUTHOR: E M Lin EM
AUTHOR: S W Hunter SW
AFFILIATION: Philadelphia Veterans' Affairs Medical Center, PA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: UNITED STATES
TITLE: The ambulatory oncology nurse's role.
PUBDATE: 19941101
The increasing complexity of cancer care in the ambulatory setting results in the role of the ambulatory oncology nurse being pivotal to ensuring quality health care. Nurses have created a variety of multifaceted roles that include the staff nurse, advanced practice nurse, clinical trials nurse, office nurse, and the head nurse or nurse manager. Common issues encountered by the ambulatory oncology nurse are telephone triage, limitation of time, and transition of care.


5. DOCID:21982 SCORE: 0.00317478090468393
DOCNO: 9370077
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: antagonists & inhibitors
QUALIFIER: pharmacology
AUTHOR: S Sebti S
AUTHOR: A D Hamilton AD
AFFILIATION: H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9497, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Inhibitors of prenyl transferases.
PUBDATE: 19971101
Because farnesylation of Ras is required for its cancer-causing activity, several classes of farnesyl transferase inhibitors have recently been developed as potential anticancer drugs. During the last 12 months, important advances have been made in this field. In this review, we focus on three topics: targets of farnesyl transferase inhibitors other than Ras, alternative prenylation of K-Ras by the closely related prenyl transferase, geranyl geranyl transferase I, and the effects of geranyl geranyl transferase I inhibitors on cell cycle, apoptosis, and human tumor growth.


6. DOCID:22197 SCORE: 0.0031419590201069
DOCNO: 9183625
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: T Maekawa T
AFFILIATION: Department of Hygiene, Kyoto Prefectural University of Medicine, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Human cell : official journal of Human Cell Research Society.
COUNTRY: JAPAN
TITLE: [Prospects for antisense therapy of human leukemias]
PUBDATE: 19960301
Recent progress in cloning of pathogenic genes and technical advance in the synthesis of antisense oligodeoxynucleotides (AS ODN) analogues have spurred a research effort dedicated to the development of antisense therapy for cancer and viral diseases. We have reported that phosphorothioate AS ODN could effectively inhibit the abnormal expression of activated or rearranged oncogenes and lead to the growth suppression of leukemic cells in vitro by the induction of apoptosis. In this article, the state of art in antisense research and the feasibility of antisense therapy for leukemia are also discussed.


7. DOCID:22884 SCORE: 0.00310504948044667
DOCNO: 9034844
AUTHOR: H Brink H
AUTHOR: A Deutman A
AUTHOR: L Beex L
AFFILIATION: Institute of Ophthalmology, Bosch Medicentrum, The Netherlands.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie.
COUNTRY: GERMANY
TITLE: Unusual retinal pigment epitheliopathy and choroidopathy in carcinomatosis: a rare case of cancer-associated retinopathy.
PUBDATE: 19970101
BACKGROUND: Cancer-associated retinopathy is a syndrome causing ocular symptoms. It is a rare entity and only a few cases have been reported. METHODS: A 67-year-old woman with small-cell endometrial carcinoma suffering from deterioration of visual acuity is presented. RESULTS: The patient presented with extensive mottled changes of the retinal pigment epithelium, accompanied by diffuse subretinal fluid in the posterior pole and exudative retinal detachments inferior in both eyes. CONCLUSION: This patient suffered from a rare variety of cancer-associated retinopathy.


8. DOCID:21781 SCORE: 0.00298901748892717
DOCNO: 8686054
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: J J Andreasen JJ
AUTHOR: M Krasnik M
AFFILIATION: Thoraxkirurgisk afdeling R, Amtssygehuset i Gentofte.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Treatment of non-small-cell lung cancer and solitary adrenal gland metastasis]
PUBDATE: 19960501
A patient with non-small-cell lung cancer and a solitary adrenal metastasis was treated with right subsegmental pulmonary resection and right adrenalectomy. Four months later an upper right lobectomy was performed because of local recurrence. Forty-one months following the initial operation the patient is doing fine without signs or symptoms of recurrence. Adrenalectomy because of a solitary adrenal metastasis in patients with non-small-cell lung cancer may offer the opportunity of prolonged survival, when a radical thoracotomy can be performed.


9. DOCID:21903 SCORE: 0.00297497469046933
DOCNO: 8149063
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: S S Thomas SS
AUTHOR: R N Matthews RN
AFFILIATION: Manor Hospital, Nuneaton, Warwickshire.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of plastic surgery.
COUNTRY: ENGLAND
TITLE: Squamous cell carcinoma of the pinna: a 6-year study.
PUBDATE: 19940301
Over a 6-year period, 54 sequential lesions of squamous cell carcinoma of the pinna were studied in 44 patients with regard to the side, clinical features and their duration, TNM clinicopathological classification, treatment and follow-up. Treatment delay, types of surgical procedures, anaesthesia and postoperative complications were all analysed. The overall incidence of residual and recurrent cancer was 25.92%. The regional lymph node recurrence was 9.26%, though only 5.56% had clinically persistent cancer. Six patients subsequently died; two of these deaths were due to the cancer.


10. DOCID:22301 SCORE: 0.00296206280888248
DOCNO: 8676132
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: F Fullas F
AUTHOR: D M Brown DM
AUTHOR: M C Wani MC
AUTHOR: M E Wall ME
AUTHOR: T E Chagwedera TE
AUTHOR: N R Farnsworth NR
AUTHOR: J M Pezzuto JM
AUTHOR: A D Kinghorn AD
AFFILIATION: Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: UNITED STATES
TITLE: Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera.
PUBDATE: 19951001
A new polyacetylenic diepoxide compound, gummiferol [1] was isolated from the leaves of Adenia gummifera by KB cytotoxicity-guided fractionation. Compound 1 exhibited significant activity against the KB human cell line and a broad cytotoxic spectrum against other human cancer cell lines. The structure of 1 was established primarily on the basis of its spectral data.


11. DOCID:23663 SCORE: 0.00294023306379175
DOCNO: 7610510
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: G H Mickisch GH
AFFILIATION: Urologische Klinik, Erasmus Universität Rotterdam, Niederlande.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY
TITLE: [Molecular therapeutic control and gene therapy approaches]
PUBDATE: 19950501
The past decade has seen the successful application of genetic techniques to the investigation of the most important phenotypes of cancer cells; for example, the identification of particular molecules on the surface of cancer cells makes it possible to target these antigens and destroy them selectively via immunotoxins. At present, gene therapy is not a new treatment modality in most instances, but rather a new technology facilitating further exploration of preexisting treatment strategies, such as immunotherapy or chemotherapy, owing to the indirect approaches of contemporary clinical application. It can be anticipated that gene transfer technology will have a considerable impact on the way certain urological anticancer strategies are pursued in the future.


12. DOCID:22462 SCORE: 0.00290003581593188
DOCNO: 8678543
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Tomono H
AUTHOR: S Fujioka S
AUTHOR: K Kato K
AFFILIATION: Division of Surgery, Kiryu Kosei General Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of early gastric cancer transformed from adenoma by chemotherapy and radiotherapy]
PUBDATE: 19960601
A 69-year-old male had a gastric adenoma at the greater curvature of the antrum. At the same time, malignant lymphoma of the liver and several bones were disclosed, but these tumors had become remarkably smaller after chemotherapy, radiotherapy and transcatheter hepatic arterial chemoembolization. Five and one half years later, however, the gastric adenoma had developed into gastric cancer that invaded submucosal layer. It is suspected that some chemotherapeutic agents and radiation were associated with malignant transformation of gastric adenoma.


13. DOCID:23650 SCORE: 0.00289173267693763
DOCNO: 8652993
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Contrast Media
QUALIFIER: ultrasonography
QUALIFIER: ultrasonography
QUALIFIER: methods
QUALIFIER: diagnostic use
AUTHOR: A E Elewaut AE
AUTHOR: M Afschrift M
AFFILIATION: Department of Gastroenterology and Ultrasonography, University Hospital Ghent, Belgium.
PUBTYPE: Journal Article
JOURNALTITLE: Bildgebung = Imaging.
COUNTRY: SWITZERLAND
TITLE: Hydrocolonic sonography: a novel screening method for the detection of colon disease?
PUBDATE: 19951201
Hydrocolonic sonography is an easy and harmless technique for the evaluation of the colon wall. In our study, 106 patients were examined by means of hydrocolonic sonography and colonoscopy. The results were compared. Polyps larger than 7 mm were detected, whereas smaller polyps were often missed. Colon cancers were found in 5 patients, and it was possible to stage them. In moderately to severely active forms of inflammatory bowel disease this technique was able to make a differentiation between ulcerative colitis and Crohn's disease. In elderly and very young patients it may well be the primary screening method for evaluating the bowel.


14. DOCID:23865 SCORE: 0.00288385635844455
DOCNO: 7621233
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: genetics
QUALIFIER: pharmacology
QUALIFIER: therapy
QUALIFIER: genetics
QUALIFIER: drug effects
QUALIFIER: genetics
QUALIFIER: biosynthesis
AUTHOR: D C Tang DC
AUTHOR: S A Johnston SA
AUTHOR: D P Carbone DP
AFFILIATION: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8593, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer gene therapy.
COUNTRY: UNITED STATES
TITLE: Butyrate-inducible and tumor-restricted gene expression by adenovirus vectors.
PUBDATE: 19940301
Efficient introduction of biologically active genes into tumor cells in vivo would facilitate cancer gene therapy. In this study, recombinant adenoviruses mediated high-level expression of reporter genes in both human and murine tumor cell lines and freshly resected human solid tumors in vitro. When adenovirus vectors were inoculated intratumorally in a living animal, reporter activity was detected only in the tumor nodule and not in other sites, in contrast to intracardiac injections in which expression was found in several organs. Adenovirus-mediated gene expression was further enhanced by butyrate treatment.