0. DOCID:11702 SCORE: 0.00365036186254935
DOCNO: 6309132
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Terminology
QUALIFIER: classification
QUALIFIER: classification
QUALIFIER: classification
AUTHOR: N C Davis NC
AUTHOR: R C Newland RC
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Terminology and classification of colorectal adenocarcinoma: the Australian clinico-pathological staging system.
PUBDATE: 19830601
A new system--the Australian Clinico-pathological Staging (ACPS) System--is proposed for the reporting of cases of colorectal adenocarcinoma. It utilizes all information available--clinical, operative and pathological--before a stage is allotted. This contrasts with Dukes' classification which is based solely on the pathological examination of the resected specimen. The ACPS has a special category 'D' for incurable cancer--those with a locally advanced irremovable tumour or with distant metastases. This method requires co-operation between clinician and pathologist and the use of precise terminology with strict adherence to definitions. The validity of the system is tested by analysing the survival pattern of 709 patients from Concord Hospital according to the ACPS and Dukes' system.


1. DOCID:11151 SCORE: 0.00363533164907347
DOCNO: 6478393
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: methods
QUALIFIER: drug therapy
AUTHOR: J Mäenpää J
AUTHOR: M Grönroos M
AUTHOR: M Leppänen M
AUTHOR: L Kangas L
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The subrenal capsule assay in mice. Prediction of rat tumor sensitivity to chemotherapy.
PUBDATE: 19841001
The predictive value of the subrenal capsule (SRC) assay for cancer chemotherapy was tested in five rat tumors. Tumor-bearing rats were used as controls. In order to simulate clinical chemotherapy, different dose regimens and drug combinations were used. All five tumors were evaluable in in the SRC assay. Taking into account cytotoxic drugs, 86% compatibility was obtained between the SRC assay and the rat model. Antitumor effect of three antiestrogenic compounds could not be predicted by the SRC assay. It is concluded that the SRC assay can be expected to have predictive value in the assessment of tumor sensitivity to single and combination chemotherapy based on experimental animal models.


2. DOCID:11842 SCORE: 0.00360405692696859
DOCNO: 6322320
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug effects
AUTHOR: J L Borgna JL
AUTHOR: H Rochefort H
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris.
COUNTRY: FRANCE
TITLE: [Effects and mechanism of action of antiestrogens in breast cancer]
PUBDATE: 19840301
Tamoxifen, a non-steroidal antiestrogen, is currently used to treat post-menopausal breast cancer. In estrogen-sensitive breast cancer cell lines, tamoxifen and some of its metabolites display, for the induction of estrogen-regulated proteins, a partial agonist/antagonist activity. They also inhibit totally the proliferation of these cells. Evidence is given, which suggests that the pharmacological properties of these antiestrogens are mediated by the estrogen receptor. These antiestrogens interact with the estrogen receptor but they appear to induce only a partial or altered activation of the receptor. This partial or altered activation and the competition with estrogens for binding to the estrogen receptor could explain the estrogen agonist/antagonist properties of antiestrogens.


3. DOCID:11299 SCORE: 0.00359857719719023
DOCNO: 6306804
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: etiology
QUALIFIER: diagnosis
AUTHOR: A Prier A
AUTHOR: B Augereau B
AUTHOR: D Brugel D
AUTHOR: A C Koeger AC
AUTHOR: J P Camus JP
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris.
COUNTRY: FRANCE
TITLE: [Non-tuberculous abscesses of the psoas. A case of apparently primary abscess of the psoas due to Staphylococcus aureus]
PUBDATE: 19830401
Abscess of the psoas, which is a well recognized complication in tuberculous osteoarticular infections, can also occur in certain regional diseases of the bones or viscera: common germ osteitis, diverticulosis, colic cancer, appendicitis and, above all, Crohn disease. Abscess of the psoas can also present as an apparently primary pyogenic muscular infection. A case is reported of an abscess of the psoas due to Staphylococcus aureus, which occurred spontaneously in an apparently healthy 50-year-old woman, was cured by surgical drainage, and whose course confirmed its primary nature.


4. DOCID:11449 SCORE: 0.00358305878494289
DOCNO: 6394574
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: history
QUALIFIER: history
AUTHOR: R S Griffith RS
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of antimicrobial chemotherapy.
COUNTRY: ENGLAND
TITLE: Vancomycin use--an historical review.
PUBDATE: 19841201
In the early 1950s the increase of antibiotic-resistant strains of Staphylococcus aureus in hospitalized patients with infection stimulated a screening program to develop an effective new agent. A soil sample found in the jungles of Borneo contained a microorganism, Streptomyces orientalis, that produced a substance later called vancomycin. Vancomycin was shown to have antistaphylococcal activity and to be relatively safe when administered to patients. With the resurgence of staphylococcal infections resistant to the newer antistaphylococcal antibiotics, there has been a corresponding increase in the use of vancomycin. Vancomycin is also being used for prophylaxis in patients with reduced renal function undergoing dialysis, for the treatment of patients with antibiotic-induced enterocolitis, and in combination with other antibiotics for 'sterilization' of the intestinal tract in patients with cancer.


5. DOCID:11434 SCORE: 0.00346445403864933
DOCNO: 2412543
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: L E Hughes LE
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: A surgeon's view of oncology.
PUBDATE: 19850401
The past thirty years has seen a profound change in emphasis and direction in the management of cancer. In many countries this has been away from traditional surgical management towards specialists trained primarily in medical oncology or radiotherapy. This trend has occurred despite the fact that surgery is still by far the most effective method of treatment of most common cancers. The effectiveness of sound cancer surgery and the importance of local disease control as an element in improving cure rates and palliation needs to be emphasised so that patients are not denied optimal treatment. The case for surgery can best be developed by encouraging special training and expertise in the field of surgical oncology, as one element in the provision of a surgical service for cancer patients.


6. DOCID:11919 SCORE: 0.00331263882981401
DOCNO: 6351758
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chlorides
DESCRIPTOR: Zinc Compounds
QUALIFIER: surgery
QUALIFIER: administration & dosage
AUTHOR: N A Swanson NA
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Archives of dermatology.
COUNTRY: UNITED STATES
TITLE: Mohs surgery. Technique, indications, applications, and the future.
PUBDATE: 19830901
Each year, it is estimated, more than 500,000 new cases of nonmelanoma skin cancer develop. The majority of these cutaneous neoplasms are treated by various modalities that include excision, electrodesiccation and curettage, cryosurgery, and irradiation, with greater than 90% success. Certain of the remaining primary tumors, as well as recurrent carcinomas, present a demanding therapeutic challenge. For these lesions, Mohs surgery has evolved as the most reliable and cost-effective treatment modality, offering maximal preservation of normal tissue and therefore the lowest functional and cosmetic morbidity. In this review, the history and evolution of Mohs surgery and the technique itself will be briefly outlined. The indications for Mohs surgery, together with methods of handling the postoperative wound and future applications of the technique, will be discussed in detail.


7. DOCID:11767 SCORE: 0.00330648691199407
DOCNO: 6702036
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: E Laor E
AUTHOR: Z Schiffman Z
AUTHOR: R E Reid RE
AUTHOR: B M Tolia BM
AUTHOR: S Z Freed SZ
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Sex-dependent variations in natural history of transitional cell carcinoma of bladder.
PUBDATE: 19840301
The records of 196 patients with transitional cell carcinoma of the bladder diagnosed up to 1975 were analyzed for age, sex, tumor histology, and survival parameters. Analysis of the series as a whole showed it to be comparable to literature controls in the male to female ratio, average age at presentation, and in survival data. Sex stratification combined with parametric analysis showed that females had longer recurrence-free survivals and died less frequently of bladder cancer than their male counterparts. In addition, the incidence of high-grade tumors was lower in females. These facts and the comments that follow point to a probable less aggressive natural history of transitional cell carcinoma of the bladder in females.


8. DOCID:9239 SCORE: 0.00322108055794959
DOCNO: 6365356
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: K W Lam KW
AUTHOR: C Dannaher C
AUTHOR: S Letchford S
AUTHOR: T Eastlund T
AUTHOR: C Y Li CY
AUTHOR: L T Yam LT
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Tartrate-resistant acid phosphatase in serum of cancer patients.
PUBDATE: 19840301
Tartrate-resistant acid phosphatase activity determined by enzyme immunoassay was higher in the serum of cancer patients than that in normal blood donors. The highest activity was found among patients having malignancy metastatic to bone. The classic colorimetric method showed a broad range of values among normal blood donors, and the contrast between normal and cancer patients was less obvious. Most of the cancer patients had normal to low alkaline phosphatase activities.


9. DOCID:10215 SCORE: 0.00321003796586404
DOCNO: 6719163
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymph Node Excision
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: J L Powell JL
AUTHOR: M O Burrell MO
AUTHOR: E W Franklin EW
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Radical hysterectomy and pelvic lymphadenectomy.
PUBDATE: 19840501
In recent years there has been an increasing awareness that radical hysterectomy and pelvic lymphadenectomy can play an important role in the management of early invasive cervical cancer. We present a series of 255 patients who had radical hysterectomy for gynecologic malignancy over a nine-year period. The incidence of ureteral fistulas was 0.8% and of vesical fistulas 1.6%. The operative mortality was 0.78%, which compares favorably with the rates in most larger centers in which radical pelvic operations are common. With proper patient selection and excellent operative technique, survival rates of well over 90%, with minimal complications, can be obtained.


10. DOCID:10264 SCORE: 0.00307542528892646
DOCNO: 3867810
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: R C Bonney RC
AUTHOR: M J Reed MJ
AUTHOR: V H James VH
PUBTYPE: Journal Article
JOURNALTITLE: Journal of steroid biochemistry.
COUNTRY: ENGLAND
TITLE: Kinetic studies of oestradiol 17 beta-hydroxysteroid dehydrogenase in MCF-7 mammary cancer cells.
PUBDATE: 19851201
The kinetic properties of oestradiol 17 beta-dehydrogenase have been studied in the MCF-7 human breast cancer cell line. The activity of the enzyme was found to be linear with respect to time for at least 2 h and with respect to protein concentrations over the range 40-300 micrograms protein per tube. The enzyme was able to utilize both NAD and NADP as cofactors but at higher concentrations NAD was the more effective. The apparent Km was estimated to be 13.4 microM which is approximately two-fold higher than found for breast tumour tissue.


11. DOCID:11612 SCORE: 0.0028938550654748
DOCNO: 6435869
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: analysis
AUTHOR: P A Ganz PA
AUTHOR: M Baras M
AUTHOR: P Y Ma PY
AUTHOR: R M Elashoff RM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Monitoring the therapy of lung cancer with alpha-1-acid glycoprotein.
PUBDATE: 19841101
Alpha-1-Acid glycoprotein is an acute-phase serum protein which is found in increased amounts in patients with a variety of cancers. This paper describes the application of discriminant analysis to the comparison of plasma levels of alpha-1-acid glycoprotein in 95 patients with lung cancer and 84 patients without known cancer. Using this technique, alpha-1-acid glycoprotein measurement yielded a sensitivity of 89% and specificity of 84% in the detection of active lung cancer. In addition, a new method for analysis of serial tumor marker data is presented which demonstrates that normalization of alpha-1-acid glycoprotein levels during antineoplastic therapy correlates with a significantly prolonged relapse-free survival in lung cancer patients.


12. DOCID:10424 SCORE: 0.00289059440367325
DOCNO: 6887904
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: H J de Voogt HJ
AUTHOR: B R Rao BR
PUBTYPE: Journal Article
JOURNALTITLE: Journal of steroid biochemistry.
COUNTRY: ENGLAND
TITLE: Present concept of the relevance of steroid receptors for prostatic cancer.
PUBDATE: 19830701
Suitable assays for nuclear androgen-receptors in human prostatic cancer tissue have been presented. Correlations between NAR-content and response to hormonal therapy are demonstrated. The methods are time consuming and require expensive equipment as well as experience. Individual laboratory standards seem to determine response rates. The earlier methodological difficulties are replaced by a new set of problems for which as yet no single solution is available. As there is a tendency to use aspiration cytology more and more for diagnosis as well as follow-up of prostatic cancer, a cytochemical method would be extremely valuable. Research in that direction should be pursued.


13. DOCID:11077 SCORE: 0.00287456761708245
DOCNO: 3966170
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: physiopathology
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: R Wall R
AUTHOR: P Novotny-Joseph P
AUTHOR: T E Macnamara TE
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Does preamputation pain influence phantom limb pain in cancer patients?
PUBDATE: 19850101
Phantom sensation and phantom limb pain are two recognized sequelae of limb amputation. In most previous surveys, amputations were done for arteriosclerotic or trauma related conditions. We studied 25 patients who had lower extremity amputation for neoplasia. In studying the features of pain before and after amputation, we found phantom limb pain in cancer patients similar in presentation and description to that in noncancer amputees. There appeared to be no correlation between the severity of each episode of phantom pain and the overall effect of the pain on the patient's life. The quality and location of the phantom pain did not resemble the preamputation pain. We recommend a multidisciplinary approach to treatment.


14. DOCID:10915 SCORE: 0.00286595158433882
DOCNO: 7083233
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antineoplastic Combined Chemotherapy Protocols
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: G Cocconi G
AUTHOR: V DeLisi V
AUTHOR: B Di Blasio B
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Randomized comparison of 5-FU alone or combined with mitomycin and cytarabine (MFC) in the treatment of advanced gastric cancer.
PUBDATE: 19820601
In a prospective randomized study, 53 patients with advanced gastric cancer previously untreated by chemotherapy were randomly assigned to treatment with 5-FU alone or combined with mitomycin and cytarabine (MFC). The response rate with MFC was higher (28%) than with 5-FU alone (21%). The difference, however, was not statistically significant. Median response duration was practically identical with 5-FU (16 weeks) and MFC (17 weeks). There was no difference in median survival between the two groups (39 and 43 weeks, respectively).