0. DOCID:19995 SCORE: 0.00431052070540732
DOCNO: 2160117
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: J P Sculier JP
AFFILIATION: Service de Médecine, Clinique H.J. Tagnon, Institut Jules Bordet, Bruxelles, Belgique.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue médicale de Bruxelles.
COUNTRY: BELGIUM
TITLE: [Intensive chemotherapy treatment of small-cell bronchial cancer]
PUBDATE: 19900401
Intensification of chemotherapy is one of the possibilities that we have to improve treatment results in small cell lung cancer. It can be obtained by various ways: increasing the number of active drugs of a combination or the dosage of the agents given, reducing interval between chemotherapy courses or increasing the total duration of therapy. If the addition of a drug to an active combination, the increase of drug dosages or the administration of megadoses of chemotherapy with or without bone marrow transplantation have not improved survival, prolongation of therapy seems more effective, at least in responders. Weekly chemotherapy schedules and hematopoietic growth factors might change today's results.


1. DOCID:18194 SCORE: 0.00424176450124745
DOCNO: 1803291
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Jejunostomy
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: N Morelli N
AUTHOR: R M Lo Casto RM
AUTHOR: M Taviani M
AUTHOR: G V Tommasi GV
AUTHOR: A Akkad Wattar A
AUTHOR: A Verna A
AUTHOR: R Boffano R
AUTHOR: E Cariati E
AFFILIATION: Istituto di Anatomia Chirugica e Corso di Operazioni, Università degli Studi di Genova.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Minerva chirurgica.
COUNTRY: ITALY
TITLE: [Intrahepatic jejunostomy by trans-scission approach in neoplasms of the superior biliary confluent (SBC)]
PUBDATE: 19911201
The Authors consider the trans-scission approach as a quick and safe alternative approach for doing intrahepatic bilio-intestinal anastomoses for the surgical treatment of well confined cancers of hepatic hilus (type I and II of Bismuth e Corlette). This approach should be recommended particularly when the presence of anatomical variations makes the hilar approach hazardous.


2. DOCID:19008 SCORE: 0.0040288481148426
DOCNO: 8247295
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: A Briccoli A
AUTHOR: A Farinetti A
AUTHOR: A G Rizzente AG
AUTHOR: N Guernelli N
AFFILIATION: Università di Modena.
PUBTYPE: Journal Article
JOURNALTITLE: Minerva chirurgica.
COUNTRY: ITALY
TITLE: [Surgery of cancer of the right colon. Analysis of 265 cases]
PUBDATE: 19930801
The analysis of 265 selected cases of right colon cancer treated over a long period of time allows a number of points to be raised. Attention is drawn to the lack of progress made in diagnostic techniques, but this is thought to be due primarily to the vagueness of symptoms and their scarse investigation rather than to limits imposed by instrumental techniques. Moreover, no real benefit would be produced by a more aggressive approach using visceral or lymphatic exeresis. An earlier diagnosis of tumours due to differentiation, slow growth and rare association with adenoma should allow more encouraging results to be achieved.


3. DOCID:19852 SCORE: 0.00390300679073044
DOCNO: 8118413
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: T Y Kondratenko TY
AUTHOR: I V Zacharova IV
AUTHOR: N V Kuzina NV
AUTHOR: E S Severin ES
AUTHOR: Z Ch Kornilova ZCh
AUTHOR: M I Perelman MI
AFFILIATION: Research Center of Molecular Diagnostics and Therapy, Moscow, Russia.
PUBTYPE: Journal Article
JOURNALTITLE: Biochemistry and molecular biology international.
COUNTRY: AUSTRALIA
TITLE: The study of histamine H1- and H2-receptors in human lung cancer.
PUBDATE: 19931101
Data on human lung histamine H1- and H2-receptors in cancer and chronic inflammatory processes are reported. It has been found that the number of histamine H1-receptors significantly increases both in cancer and chronic pneumonia and does not practically change in tuberculosis lung parenchyma. The binding parameters of histamine H2-receptors both in cancer and inflammatory processes were similar to those obtained for the normal tissue. The important role of parenchymal histamine H1-receptors in the neuromodulation of airways in human lung adenocarcinoma is discussed.


4. DOCID:18251 SCORE: 0.00382386688513994
DOCNO: 1525056
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: R C Coombes RC
AFFILIATION: Charing Cross Hospital, London, England.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of steroid biochemistry and molecular biology.
COUNTRY: ENGLAND
TITLE: 4-Hydroxyandrostenedione treatment for postmenopausal patients with breast cancer.
PUBDATE: 19920901
Patients (186) with locally advanced or metastatic breast cancer were treated with the aromatase inhibitor 4-hydroxyandrostenedione given parenterally at 3 different doses. 21% of patients responded to treatment, 93% of objective responders whose oestrogen receptor (ER) status was known had ER positive tumours. The drug was well-tolerated particularly at a dose of 250 mg i.m. every fortnight. At this dose, only 4/96 (4%) patients had to discontinue treatment. We conclude that 4-hydroxyandrostenedione is a well-tolerated form of endocrine treatment for postmenopausal patients with breast cancer.


5. DOCID:23821 SCORE: 0.00380925993382779
DOCNO: 9275681
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Papovaviridae Infections
DESCRIPTOR: Tumor Virus Infections
QUALIFIER: analysis
QUALIFIER: isolation & purification
QUALIFIER: virology
AUTHOR: Q Ding Q
AUTHOR: Y Zhang Y
AUTHOR: S Sun S
AFFILIATION: Huashan Hospital, Shanghai Medical University.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua wai ke za zhi [Chinese journal of surgery].
COUNTRY: CHINA
TITLE: [Role of PCR and dot bolt hybridization in the detection of human papillomavirus of the penile cancer]
PUBDATE: 19960101
Human papillomavirus (HPV), a oncogenicpotential, may be carcinogenic effectors in variety of genital tract malignancies. We examined the association of human papillomavirus type 16 and 18 in 28 penile cancers by the highly sensitive polymerase chain reaction and dot bolt hybridization. Human papillomavirus type 16 was found in 14 of 28 penile cancers (50%), whereas type 18 was identified in 3 of 28 penile cancers (10.6%). Our results suggest humanpapillomavirus type 16 may play a role in the development of this tumor and associate with smoking and ages of patients.


6. DOCID:22686 SCORE: 0.00346539025718881
DOCNO: 7973921
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: therapy
AUTHOR: A Routh A
AUTHOR: T Khansur T
AUTHOR: B T Hickman BT
AUTHOR: D Bass D
AFFILIATION: Department of Radiotherapy, University of Mississippi, Jackson.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Management of brain metastases: past, present, and future.
PUBDATE: 19941201
Brain metastasis is an important cause of morbidity and mortality in cancer patients. Because most of these patients die of systemic disease, the primary therapeutic goal is to improve the quality of life. Conventional therapy for brain metastases is usually whole-brain irradiation. Chemotherapy often results in regression of brain metastases in chemosensitive tumors. We review our institutional experience in the treatment of brain metastasis with both radiation and chemotherapy. In the future, improvement in the management of brain metastases will depend on improved chemotherapy, radiosensitizers, and radiotherapy techniques such as stereotactic radiosurgery.


7. DOCID:18860 SCORE: 0.00344098875780667
DOCNO: 8428350
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prostatectomy
QUALIFIER: therapy
AUTHOR: P H Smith PH
AUTHOR: M K Parmar MK
AFFILIATION: St. James's University Hospital, Leeds, County Yorkshire, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Adjuvant therapy in prostatic cancer.
PUBDATE: 19930201
BACKGROUND. Prostatic cancer is an unusual malignancy because, commonly, it is slowly progressive and occurs at an age where the patient's life expectancy is short as a result of considerable competing mortality rates from other diseases. In addition, the place of radical surgery, i.e., radical prostatectomy is still not defined completely or established uniformly. METHODS. This article attempts to offer comparisons of the initial forms of primary therapy and to determine the way in which adjuvant therapy may be tested and its results assessed. RESULTS AND CONCLUSION. Additional information should come from large-scale randomized clinical trials involving several hundred patients in each treatment arm.


8. DOCID:22710 SCORE: 0.00339719858897166
DOCNO: 8931062
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms
DESCRIPTOR: Quality of Life
AUTHOR: S Donnelly S
AUTHOR: D Walsh D
AFFILIATION: Palliative Care Program, Cleveland Clinic Foundation, Ohio, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Palliative medicine.
COUNTRY: ENGLAND
TITLE: Quality of life assessment in advanced cancer.
PUBDATE: 19961001
Our purpose is to examine how applicable current quality of life instruments are in advanced cancer. Quality of life (QOL) is difficult to define and measure; it is a multidimensional, dynamic and subjective concept. An acceptable QOL instrument for advanced disease should be simple to administer and easy to explain, complete and analyse. In our view, the present instruments used in oncology do not serve the needs of advanced cancer patients. Based on our review, we believe a single question posed on a linear or categorical scale should be used to assess QOL in advanced cancer in preference to other available methods.


9. DOCID:23931 SCORE: 0.00336426928597898
DOCNO: 8877630
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J E Richter JE
AUTHOR: G W Falk GW
PUBTYPE: Editorial
JOURNALTITLE: Journal of clinical gastroenterology.
COUNTRY: UNITED STATES
TITLE: Barrett's esophagus and adenocarcinoma. The need for a consensus conference.
PUBDATE: 19960901
The fear of cancer has evoked calls for intensive surveillance programs in Barrett's esophagus. Two evolving issues are fueling this fire: (a) the rising risk of adenocarcinoma of the esophagus over the past 20 years and (b) the coincidental increase in the recognized prevalence of Barrett's esophagus in the general population. However, these sobering statistics must be carefully weighed against the lack of adverse effects on survival and the cost of an extensive surveillance program for adenocarcinoma in Barrett's esophagus, the latter estimated at between $(300) and $(1,500) million per year. Barrett's esophagus and its associated cancer risk represent a crisis in gastroenterology. A consensus conference of leading basic and clinical scientists is needed in this area.


10. DOCID:21249 SCORE: 0.0033386773043209
DOCNO: 7855452
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Job Description
QUALIFIER: organization & administration
QUALIFIER: organization & administration
AUTHOR: M E Cooley ME
AUTHOR: E M Lin EM
AUTHOR: S W Hunter SW
AFFILIATION: Philadelphia Veterans' Affairs Medical Center, PA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: UNITED STATES
TITLE: The ambulatory oncology nurse's role.
PUBDATE: 19941101
The increasing complexity of cancer care in the ambulatory setting results in the role of the ambulatory oncology nurse being pivotal to ensuring quality health care. Nurses have created a variety of multifaceted roles that include the staff nurse, advanced practice nurse, clinical trials nurse, office nurse, and the head nurse or nurse manager. Common issues encountered by the ambulatory oncology nurse are telephone triage, limitation of time, and transition of care.


11. DOCID:19387 SCORE: 0.00330346069019527
DOCNO: 1413180
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: O H Momsen OH
AUTHOR: H P Graversen HP
AUTHOR: A Kruse A
AFFILIATION: Arhus Kommunehospital, Kirurgisk gastroenterologisk afdeling L.
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Check-ups of colorectal neoplasms--current practice]
PUBDATE: 19920901
In order to investigate the practice for control of patients with colorectal adenomata and cancer, a questionnaire investigation was carried out in 1990-1991 among 53 Danish surgical departments. The investigation revealed great differences in the control programmes offered to these patients as regards the methods, the intensity and duration. In addition, differences were present in the control pattern for adenomata in specialist departments as compared with the remaining departments where there was a tendency to very frequent but, on the other hand, brief control. On the basis of these results, it is considered necessary that a reference programme should be prepared on this subject.


12. DOCID:21982 SCORE: 0.00317478090468393
DOCNO: 9370077
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: antagonists & inhibitors
QUALIFIER: pharmacology
AUTHOR: S Sebti S
AUTHOR: A D Hamilton AD
AFFILIATION: H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9497, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Inhibitors of prenyl transferases.
PUBDATE: 19971101
Because farnesylation of Ras is required for its cancer-causing activity, several classes of farnesyl transferase inhibitors have recently been developed as potential anticancer drugs. During the last 12 months, important advances have been made in this field. In this review, we focus on three topics: targets of farnesyl transferase inhibitors other than Ras, alternative prenylation of K-Ras by the closely related prenyl transferase, geranyl geranyl transferase I, and the effects of geranyl geranyl transferase I inhibitors on cell cycle, apoptosis, and human tumor growth.


13. DOCID:19709 SCORE: 0.00316854170629032
DOCNO: 1851518
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: H Tanaka H
AFFILIATION: First Department of Medicine, Yamaguchi University.
PUBTYPE: Journal Article
JOURNALTITLE: Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology.
COUNTRY: JAPAN
TITLE: [Immunohistochemical studies on epidermal growth factor receptor in hepatocellular carcinoma]
PUBDATE: 19910201
Localization of epidermal growth factor receptor (EGFR) in hepatocellular carcinoma was examined by means of immunohistochemistry. It's localization was observed at plasma membrane of the cancer cells. EGFR was found to be expressed in 7 out of 17 hepatocellular carcinoma. No significant difference was observed between EGFR-positive and EGFR-negative cases in tumor size. AFP, macroscopic and histopathological classification, capsular invasion, and portal invasion. However, in EGFR-positive cases, the number of DNA polymerase-alpha positive cells and recurrence rate were higher than that in EGFR-negative cases. These results suggest that EGFR may play an important role in the development and progression of hepatocellular carcinoma.


14. DOCID:22197 SCORE: 0.0031419590201069
DOCNO: 9183625
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: T Maekawa T
AFFILIATION: Department of Hygiene, Kyoto Prefectural University of Medicine, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Human cell : official journal of Human Cell Research Society.
COUNTRY: JAPAN
TITLE: [Prospects for antisense therapy of human leukemias]
PUBDATE: 19960301
Recent progress in cloning of pathogenic genes and technical advance in the synthesis of antisense oligodeoxynucleotides (AS ODN) analogues have spurred a research effort dedicated to the development of antisense therapy for cancer and viral diseases. We have reported that phosphorothioate AS ODN could effectively inhibit the abnormal expression of activated or rearranged oncogenes and lead to the growth suppression of leukemic cells in vitro by the induction of apoptosis. In this article, the state of art in antisense research and the feasibility of antisense therapy for leukemia are also discussed.