0. DOCID:26484 SCORE: 0.002743044125135
DOCNO: 11063129
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: pathology
QUALIFIER: physiopathology
AUTHOR: M Molinari M
AFFILIATION: European Institute of Oncology, Milan, Italy. mmolinari@ieo.it
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cell proliferation.
COUNTRY: ENGLAND
TITLE: Cell cycle checkpoints and their inactivation in human cancer.
PUBDATE: 20001001
Checkpoints are mechanisms that regulate progression through the cell cycle insuring that each step takes place only once and in the right sequence. Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability. This review will focus on three major areas of cell cycle transition control, with particular attention to the alterations found in human cancer. These areas include the G1/S transition, where most cancer-related defects occur, the G2/M checkpoint and its activation in response to DNA damage, and the spindle checkpoint.

1. DOCID:27997 SCORE: 0.00259343702453295
DOCNO: 9644865
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: pathology
QUALIFIER: radiography
AUTHOR: J Martínez Subías J
AUTHOR: L J Domínguez Ugidos LJ
AUTHOR: A Urpegui García A
AUTHOR: E Sancho Serrano E
AUTHOR: J Royo López J
AUTHOR: J Millán Guevara J
AUTHOR: H Valles Varela H
AFFILIATION: Servicio de ORL, Hospital Clínico Universitario Lozano Blesa, Zaragoza.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Acta otorrinolaringológica española.
COUNTRY: SPAIN
TITLE: [Middle ear carcinoma]
PUBDATE: 19980401
Middle-ear cancer represents 5 to 10% of all ear neoplasms. Risk factors include chronic suppurative pathology of the middle ear and prior irradiation. Most malignant tumors are squamous-cell carcinomas. We report the case of a 51-year-old woman with this process. The ideal treatment is mastoidectomy or pterosectomy followed by radiotherapy. We made a bibliographic review of the clinical manifestations, diagnosis, treatment, and prognosis of middle-ear cancer. Five-year survival rates range from 25 to 50% in patients who undergo surgery and radiotherapy.

2. DOCID:25301 SCORE: 0.0024718142755248
DOCNO: 10862490
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: G A Vakulenko GA
PUBTYPE: Journal Article
JOURNALTITLE: Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny.
COUNTRY: UKRAINE
TITLE: [The treatment of the initial stage of cervical cancer]
PUBDATE: 20000301
The analysis of the author's own experience and of relevant published literature suggest that it is expedient to further elaborate methods for treatment of incipient forms of uterine cervix cancer aimed to preserve the genital organs in women, especially in those at childbearing age. Worthy of mention in this respect is the progress made by the Kiev City Oncological Centre. In choosing a treatment option, it is necessary that etiopathogenic risk factors for development of cancer of the uterine cervix by analyzed and taken account of.

3. DOCID:26412 SCORE: 0.00204567359011998
DOCNO: 10096852
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: H Chávez H
AUTHOR: A Estévez-Braun A
AUTHOR: A G Ravelo AG
AUTHOR: A G González AG
AFFILIATION: Instituto Universitario de Bio-Orgánica "Antonio González", Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez 2, 38206, Tenerife, Canary Islands, Spain.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: UNITED STATES
TITLE: New phenolic and quinone-methide triterpenes from Maytenus amazonica.
PUBDATE: 19990301
The new nortriterpene methylene quinones amazoquinone (1) and (7S, 8S)-7-hydroxy-7,8-dihydro-tingenone (2), and the new norphenolic triterpenes 7,8-dihydro-6-oxo-tingenol (3), 23-nor-6-oxo-tingenol (4), and 23-oxo-iso-tingenone (5) were isolated from Maytenus amazonica. Their structures were elucidated by spectroscopic methods. Compounds 1, 2, 3, and 5 showed low antitumor activity against four cancer cell lines.

4. DOCID:27307 SCORE: 0.00188813510876385
DOCNO: 9875457
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: S H Baek SH
AUTHOR: Y O Kim YO
AUTHOR: J S Kwag JS
AUTHOR: K E Choi KE
AUTHOR: W Y Jung WY
AUTHOR: D S Han DS
AFFILIATION: Department of Chemistry, Wonkwang University, Iksan, Korea.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of pharmacal research.
COUNTRY: KOREA
TITLE: Boron trifluoride etherate on silica-A modified Lewis acid reagent (VII). Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells.
PUBDATE: 19980601
Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their growth inhibitory effects against human oral epitheloid carcinoma cell lines (KB) and NIH 3T3 fibroblasts using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.

5. DOCID:25914 SCORE: 0.00186514198784185
DOCNO: 10576238
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Isoflavones
DESCRIPTOR: Plants
QUALIFIER: prevention & control
QUALIFIER: therapeutic use
QUALIFIER: prevention & control
AUTHOR: L M Chiechi LM
AFFILIATION: Department of Obstetrics and Gynaecology III, University of Bari, Italy. m.chiechi@pangeanet.it
PUBTYPE: Journal Article
JOURNALTITLE: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
COUNTRY: IRELAND
TITLE: Dietary phytoestrogens in the prevention of long-term postmenopausal diseases.
PUBDATE: 19991001
Phytoestrogens (PEs) are natural compounds, with a biological activity like estrogen, which comprise isoflavones, lignans and coumestans. A traditional Asiatic phytoestrogen-rich diet is associated with a lower incidence of breast cancer and postmenopausal illness, and much evidence indicates that PEs prevent bone resorption, increase bone density and reduce cholesterol. The estrogenic effects of phytoestrogens can be useful in preventing postmenopausal osteoporosis and cardiovascular disease.

6. DOCID:24991 SCORE: 0.0018434391476086
DOCNO: 11366935
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
PUBTYPE: Newspaper Article
JOURNALTITLE: TreatmentUpdate.
COUNTRY: CANADA
TITLE: New combination for brain cancer.
PUBDATE: 19990801
People with HIV/AIDS are vulnerable to primary central nervous system lymphoma (PCNSL), a type of brain cancer. Treatment choices are limited, as chemotherapy tends to further weaken the immune system, and radiation does not seem to have a major impact on survival. One promising treatment approach used AZT, Ganciclovir, and IL-2. A five-person clinical trial was conducted using this drug combination, and radiation if necessary. The subjects generally responded well to therapy. However, further research is needed to verify the findings and investigate optimal dosing.

7. DOCID:26594 SCORE: 0.0018341274618164
DOCNO: 10692631
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: R D Penn RD
AUTHOR: J A Paice JA
AFFILIATION: Department of Neurosurgery, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY, USA. rpenn@mssm.edu
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Pain.
COUNTRY: NETHERLANDS
TITLE: Adverse effects associated with the intrathecal administration of ziconotide.
PUBDATE: 20000301
The omega-conopeptide, ziconotide, is an N-type calcium-channel blocker that has been shown to produce antinociception in animals using formalin and hot-plate tests. Initial reports of intrathecal administration of ziconotide in cancer and AIDS patients whose pain was unrelieved with opioids demonstrated analgesic efficacy. Although adverse effects were reported, these appeared to be easily managed through dose reduction or symptomatic treatment. This clinical report describes the experiences of three patients with serious adverse effects associated with intrathecal ziconotide.

8. DOCID:26597 SCORE: 0.0018332864157183
DOCNO: 10422121
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Randomized Controlled Trials
DESCRIPTOR: Research Design
QUALIFIER: therapeutic use
QUALIFIER: prevention & control
QUALIFIER: therapeutic use
AUTHOR: A J Sasco AJ
AFFILIATION: Unité d'Epidémiologie pour la Prévention du Cancer, Centre International de Recherche sur le Cancer, Lyon.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue d'épidémiologie et de santé publique.
COUNTRY: FRANCE
TITLE: [Chemoprevention of breast cancer by tamoxifen: should we still ask this question?]
PUBDATE: 19990601
Pharmacoprevention of cancer is an attractive concept. For breast cancer, several trials were set up some years ago. The largest one was stopped before its planned date of closure and demonstrated an early appearing reduction in breast cancer occurrence; in contrast, the other two trials did not find such a protective effect. The decision is all the more difficult because of tamoxifen side effects, including carcinogenicity. Currently, no definite conclusion can be drawn.

9. DOCID:27203 SCORE: 0.00176730341439115
DOCNO: 9873363
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adaptation, Psychological
QUALIFIER: organization & administration
QUALIFIER: organization & administration
QUALIFIER: psychology
AUTHOR: P J Anderson PJ
AUTHOR: C J Dowell CJ
AUTHOR: G Fairbrother G
AUTHOR: M A Louey MA
AFFILIATION: St. George Hospital and Community Health Services, NSW, Australia.
PUBTYPE: Journal Article
JOURNALTITLE: Urologic nursing : official journal of the American Urological Association Allied.
COUNTRY: UNITED STATES
TITLE: Prostate disease patients: planning services to meet their coping needs.
PUBDATE: 19980901
A committee comprising hospital and community-based urology and oncology nurses and social workers planned, organized, implemented, and evaluated an educational public seminar on prostate cancer (PC). Data relating to satisfaction with the seminar, reasons for attendance, perceived needs for further support/education, and demographics were collected using a feedback questionnaire. Results suggested a need for education and a significant interest in support groups and further educational forums for patients with PC or symptoms and their caregivers.

10. DOCID:26857 SCORE: 0.00173915062772832
DOCNO: 10757338
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
DESCRIPTOR: Vaginal Smears
QUALIFIER: diagnosis
AUTHOR: M H Stoler MH
AFFILIATION: Department of Pathology, University of Virginia Health System, Charlottesville, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
COUNTRY: UNITED STATES
TITLE: Advances in cervical screening technology.
PUBDATE: 20000301
The Pap smear unquestionably is a successful screening test for cervical cancer. However, recent advances in technology have raised questions regarding whether the conventional Pap smear is still the standard of care. This article relates issues of screening and cost-effectiveness to the state of the art in thin layer preparations, cytology automation, human papillomavirus screening, human papillomavirus vaccines, and other cervical screening adjuncts. Perhaps nowhere in medicine is clinical decision making being more strongly influenced by market and other external forces than in cervical cytopathology.

11. DOCID:26070 SCORE: 0.00163553248729925
DOCNO: 10525638
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Infusions, Intra-Arterial
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
AUTHOR: J Görich J
AUTHOR: R Tomczak R
AUTHOR: A Gabelmann A
AUTHOR: C Wisianowski C
AUTHOR: S Krämer S
AFFILIATION: Abteilung für Röntgendiagnostik der Universitätsklinik Ulm.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Der Radiologe.
COUNTRY: GERMANY
TITLE: [Intraarterial chemotherapy in cases of breast cancer]
PUBDATE: 19990901
A general review of the results and technique of intraarterial chemotherapy in cases of breast cancer is given. The remission rate for untreated primary tumors is nearly 100%, for completely treated local relapses approximately 70%. The complication rate is quite low using an intraarterial well-tolerated cytostatic agent such as mitoxantrone. However, thromboembolism of the vertebral artery facing the internal mammary artery may occur. The indication for intraarterial chemotherapy should always be set by an interdisciplinary board.

12. DOCID:27679 SCORE: 0.00163004918411982
DOCNO: 11092173
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: A Natusch A
AUTHOR: S Laitko S
AUTHOR: E Gromnica-Ihle E
AFFILIATION: Rheumaklinik Berlin-Buch. e.gromnica@immanuel.de
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Medizinische Klinik (Munich, Germany : 1983)
COUNTRY: GERMANY
TITLE: [Hypertrophic osteoarthropathy and thrombocytopenia in bronchial carcinoma]
PUBDATE: 20001001
SYMPTOMS: A 40-year-old woman presented with an arthritis of the knees and ankles, digital clubbing and thrombocytopenia. EXAMINATIONS: Blood tests proved an inflammatory reaction. Clinical findings were the above mentioned oligoarthritis and a periostitis of the long extremity bones. Chest X-ray showed a lung tumor. THERAPY: After surgical treatment of the lung cancer both arthritis and thrombocytopenia normalized. CONCLUSION: Hypertrophic osteoarthropathy is characterized by the combination of clubbing, arthropathy and periostitis. This paraneoplasia may be the presenting manifestation of occult malignancy. The diagnosis of hypertrophic osteoarthropathy should cause an intensive search of cancer. Further associated diseases are discussed.

13. DOCID:25057 SCORE: 0.00163000618141013
DOCNO: 11780970
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Signal Transduction
QUALIFIER: metabolism
QUALIFIER: methods
QUALIFIER: metabolism
AUTHOR: R J Simpson RJ
AUTHOR: D S Dorow DS
AFFILIATION: Laboratory, Ludwig Institute for Cancer Research/Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. richard.simpson@ludwig.edu.au
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in biotechnology.
COUNTRY: England
TITLE: Cancer proteomics: from signaling networks to tumor markers.
PUBDATE: 20011001
Along with the great strides that have been made towards understanding cancer, has come a realization of the complexity of molecular events that lead to malignancy. Proteomics-based approaches, which enable the quantitative investigation of both cellular protein expression levels and protein-protein interactions involved in signaling networks, promise to define the molecules controlling the processes involved in cancer.

14. DOCID:26163 SCORE: 0.00162826805763316
DOCNO: 10021794
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: C Martins C
AUTHOR: J A Dores JA
AUTHOR: F R De Carvalho FR
AUTHOR: J C Gonçalves JC
AFFILIATION: Serviço de Dermatovenereologia, Hospital de Santarém.
PUBTYPE: Journal Article
JOURNALTITLE: Acta médica portuguesa.
COUNTRY: PORTUGAL
TITLE: [Squamous cell carcinoma of the face: therapeutic approach]
PUBDATE: 19981101
Cutaneous squamous cell carcinoma is the most common metastatic skin cancer. The importance of early recognition and thorough treatment of premalignant lesions as well as the recognition of risk factors of the neoplasms that are most likely to metastasize must also be emphasized. A retrospective study of 126 patients, treated for primary squamous cell carcinoma of the face, was undertaken over a 7-year period. An attempt is made to define the major therapeutic modalities chosen, taking into consideration the specific anatomic location.