0. DOCID:23352 SCORE: 0.00279657850368443
DOCNO: 7579681
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colectomy
DESCRIPTOR: Laparoscopy
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: M Fodera M
AUTHOR: M J Pello MJ
AUTHOR: U Atabek U
AUTHOR: R K Spence RK
AUTHOR: J B Alexander JB
AUTHOR: R C Camishion RC
AFFILIATION: Department of Surgery, UMDNJ-Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of laparoendoscopic surgery.
COUNTRY: UNITED STATES
TITLE: Trocar site tumor recurrence after laparoscopic-assisted colectomy.
PUBDATE: 19950801
As a variety of procedures become technically feasible with laparoscopic techniques, it becomes increasingly important to appropriately select the patients who will benefit from the laparoscopic approach. We report the case of a patient with Dukes C2 colon cancer treated by laparoscopic-assisted sigmoid colectomy who subsequently developed an abdominal wall recurrence at a trocar site scar. The case raises some concerns about the use of the laparoscopic technique in the surgical management of colon cancer.


1. DOCID:23956 SCORE: 0.00273741426866858
DOCNO: 7658541
AUTHOR: J Baniel J
AUTHOR: R S Foster RS
AUTHOR: L H Einhorn LH
AUTHOR: J P Donohue JP
AFFILIATION: Department of Urology, Indiana University Medical Center, Indianapolis 46202-5250, USA.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Late relapse of clinical stage I testicular cancer.
PUBDATE: 19951001
PURPOSE: The clinical presentation and treatment of late recurrence (2 or more years after initial management) of testis cancer are defined. MATERIALS AND METHODS: A retrospective search was performed to identify patients treated for late relapse at our university from 1979 to 1992 who had initially presented with clinical stage 1 disease. RESULTS: We treated 35 patients with chemotherapy for late relapse. No patient has remained disease-free with chemotherapy alone. Subsequent surgery resulted in 43% of the patients being currently disease-free. CONCLUSIONS: The treatment of late relapse is surgical. Chemotherapy before late relapse for low volume disease does not uniformly prevent late recurrence.


2. DOCID:23714 SCORE: 0.00250435760320092
DOCNO: 9373592
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J D Evans JD
AUTHOR: D G Morton DG
AUTHOR: J P Neoptolemos JP
AFFILIATION: University Department of Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medical journal.
COUNTRY: ENGLAND
TITLE: Chronic pancreatitis and pancreatic carcinoma.
PUBDATE: 19970901
The differential diagnosis between pancreatic cancer and chronic pancreatitis is very important as the management and prognosis of these two diseases is different. In most patients with pancreatic disease, the diagnosis can be established but there is a subgroup of patients in whom it is difficult to differentiate between these conditions because the clinical presentation is often similar and currently available diagnostic tests may be unable to distinguish between an inflammatory or neoplastic pancreatic mass. This paper reviews the aetiology, pathology and clinical features of these diseases and discusses the limitations of conventional diagnostic methods and how newer techniques may be of value in the differential diagnosis.


3. DOCID:22524 SCORE: 0.00224259623589999
DOCNO: 9505220
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: P Fracasso P
AUTHOR: R Caviglia R
AUTHOR: A Grassi A
AUTHOR: R Lapenta R
AUTHOR: V Stigliano V
AUTHOR: D Franco D
AUTHOR: V Casale V
AFFILIATION: Service of Digestive Endoscopy, Istituto Regina Elena, Rome, Italy.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of experimental & clinical cancer research : CR.
COUNTRY: ITALY
TITLE: Turcot syndrome: case report and nosological aspects.
PUBDATE: 19971201
The Turcot syndrome has been defined as the simultaneous presence of multiple polyposis of the colon and a malignant brain tumor. This association is supposed to be genetically transmitted, even though we still do not exactly know whether this occurs in a dominant or recessive way. The case of a 47-year-old man submitted to a right hemicolectomy for cancer and polyposis, following a series of endoscopic polypectomies and, finally, removal of left temporal glioma is here presented.


4. DOCID:23393 SCORE: 0.00194246646083289
DOCNO: 9330407
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: N Murray N
AFFILIATION: University of British Columbia, British Columbia Cancer Agency, Vancouver, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: New drugs for small-cell lung cancer.
PUBDATE: 19970901
Better efficacy of chemotherapy for small-cell lung cancer (SCLC) has not been convincingly demonstrated despite many investigations examining increased drug delivery and enhancement of drug diversity. Improvements in the median- and long-term survival of patients with limited SCLC have been shown, but this change is more closely associated with better integration of chemoradiation than with more effective chemotherapy or radiotherapy components. Recently, a number of new active drugs have been identified for treating patients with SCLC. These drugs include the taxanes, the camptothecins, and gemcitabine. Determining the role of each new agent will require carefully designed and conducted trials like those now in progress.


5. DOCID:21557 SCORE: 0.00182305604040849
DOCNO: 8773506
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: P Lillis P
AUTHOR: I M Thompson IM
AFFILIATION: Department of Radiology, Brooke Army Medical Center, Fort Sam Houston, Texas, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Should asymptomatic progression following definitive local treatment for prostate cancer be treated?
PUBDATE: 19960601
Asymptomatic progression following definitive therapy for prostate cancer can take the form of a detectable prostate-specific antigen (PSA) or local recurrence following radical prostatectomy or a rising PSA or palpable recurrence following radiotherapy. Options for treatment include hormonal therapy, radiotherapy, salvage surgery, and experimental therapies. Although such forms of treatment have known effects on intermediate endpoints, such as reduction of PSA, the overall effect on survival and quality of life is uncertain.


6. DOCID:21960 SCORE: 0.00182210786920574
DOCNO: 7709895
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: P R Cohen PR
AFFILIATION: University of Texas Medical School at Houston, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American family physician.
COUNTRY: UNITED STATES
TITLE: Skin clues to primary and metastatic malignancy.
PUBDATE: 19950401
A new or unusual skin lesion may be the first sign of an internal malignancy, a primary skin cancer or a cutaneous metastasis of carcinoma in another site. Patients with carcinoma that has metastasized to the skin commonly present with lesions in the area overlying the neoplasm, but the morphology, pattern and distribution of cutaneous metastases may vary. Patients with sarcoma, leukemia or lymphoma may also initially present with cutaneous lesions, or lesions may develop later in the course of the disease. Biopsies of suspicious lesions should always be performed.


7. DOCID:23548 SCORE: 0.00182153331925499
DOCNO: 8740564
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: ADP Ribose Transferases
DESCRIPTOR: Virulence Factors
QUALIFIER: therapeutic use
AUTHOR: D Fitzgerald D
AFFILIATION: Laboratory of Molecular Biology, DBS, NCI, Bethesda, MD 20892-4255, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: Why toxins!
PUBDATE: 19960401
Toxins are potent cytotoxic proteins which gain access to the interior of mammalian cells by receptor-mediated endocytosis. However, the trafficking pathways within mammalian cells are complex and toxins must be processed to active forms while avoiding degradation by the lysosomal system. Once delivered to an appropriate intracellular location, the active toxin fragment translocates to the cell cytosol and inhibits protein synthesis. Chimeric toxins are constructed by removing the toxins natural binding domain and replacing it with an antibody or cell-binding ligand that redirects cell killing activity to cancer cells. Gaining an understanding of how toxins manoeuvre within cells is vital for improving the effectiveness of chimeric toxins.


8. DOCID:23481 SCORE: 0.00181942602838027
DOCNO: 9273210
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: C Brzozowski C
AUTHOR: T Krzeski T
AUTHOR: A Borówka A
AFFILIATION: Katedry i Kliniki Urologii Instytutu AM w Warszawie.
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Analysis of clinical symptoms of renal clear cell carcinoma]
PUBDATE: 19961101
An analysis of the clinical symptoms has been carried out in the group of 110 patients who underwent nephrectomy for a clear-cell carcinoma. Total hematuria (47.3% of patients) has been a predominant symptom of the tumour. Pain felt in the back has been noted in 39.1% of patients. Palpable tumour has been noted in 34.5% of patients. Such symptoms have been present simultaneously (Israel's triad) in 12.3% of patients. Tumour has been diagnosed accidentally, mainly with USG, in 37.3% of patients. It has been found that classic clinical symptoms of this cancer are nowadays less frequent than before introducing ultrasound examination.


9. DOCID:23390 SCORE: 0.00181942581278642
DOCNO: 7603429
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
PUBTYPE: Journal Article
JOURNALTITLE: MMWR. Morbidity and mortality weekly report.
COUNTRY: UNITED STATES
TITLE: Pneumonia and influenza death rates--United States, 1979-1994.
PUBDATE: 19950701
The combined cause-of-death category pneumonia and influenza (P&I) (International Classification of Diseases, Ninth Revision, codes 480-487) ranks as the sixth leading cause of death in the United States following heart disease, cancer, stroke, unintentional injuries, and chronic obstructive pulmonary disease. Changes in the epidemiology of Streptococcus pneumoniae and other recognized respiratory pathogens, the increasing occurrence of drug-resistant microorganisms, and the detection of new respiratory pathogens have heightened awareness of the public health importance of severe respiratory infections. To characterize the epidemiology of P&I deaths in the United States, CDC further analyzed underlying and multiple cause-of-death mortality files for 1979-1994. This report summarizes the results of this analysis.


10. DOCID:20551 SCORE: 0.00161772457098404
DOCNO: 7771244
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Scrotum
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: E López Alcina E
AUTHOR: M Rodrigo Aliaga M
AUTHOR: J Morera Martínez J
AUTHOR: S Rivas Rodero S
AUTHOR: A Beamud Gómez A
AUTHOR: J F Jiménez Cruz JF
AFFILIATION: Servicio de Urología, Hospital La Fe, Valencia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Actas urologicas españolas.
COUNTRY: SPAIN
TITLE: [Scrotal verrucous carcinoma]
PUBDATE: 19950201
Cancer of scrotum is of interest, despite its relative infrequency, because of its historical importance (was the first known occupational cancer) and also of its aggressive behavior. We report a rare case of verrucous carcinoma in a 67 years old man, without recrudescence six months after surgical treatment.


11. DOCID:23810 SCORE: 0.001612334133288
DOCNO: 9252098
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H K van Halteren HK
AUTHOR: J M Salemans JM
AUTHOR: H Peters H
AUTHOR: G Vreugdenhil G
AUTHOR: W M Driessen WM
AFFILIATION: Department of Internal Medicine, St Joseph Hospital, Veldhoven, The Netherlands.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of hepatology.
COUNTRY: DENMARK
TITLE: Spontaneous regression of hepatocellular carcinoma.
PUBDATE: 19970701
A 72-year-old Caucasian woman suffered from histologically-proven advanced hepatic cancer, for which she received no treatment. She had been a regular drinker for a long time. Serologic markers for hepatitis B and C were negative. In spite of her poor prognosis, she remained in good clinical condition and at 14 months of follow up the hepatocellular carcinoma could not be visualised any more radiologically. At that time the serum alpha foetoprotein concentration was normal. At present, 28 months after diagnosis, the patient is doing well and her tumour still appears to be in complete spontaneous remission.


12. DOCID:21806 SCORE: 0.0015992092941058
DOCNO: 8705897
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J Hourany J
AUTHOR: R P Byrd RP
AUTHOR: T M Roy TM
AFFILIATION: Division of Pulmonary Medicine, James H. Quillen College of Medicine, Johnson City, TN, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Tennessee medicine : journal of the Tennessee Medical Association.
COUNTRY: UNITED STATES
TITLE: Cardiac tamponade as the initial presentation of bronchioloalveolar cell carcinoma.
PUBDATE: 19960701
Bronchioloalveolar cell carcinoma (BCC) is a relatively uncommon form of bronchogenic cancer with an insidious onset and a variety of radiographic appearances. Although the World Health Organization currently classifies it as a subtype of adenocarcinoma, many investigators view BCC as a distinct tumor with characteristic clinical features. There are still uncertainties regarding its origin, as well as the significance of associated clinical findings such as cardiac tamponade.


13. DOCID:23850 SCORE: 0.00141793385461765
DOCNO: 7550326
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fungal Proteins
DESCRIPTOR: Mutation
QUALIFIER: methods
AUTHOR: N Papadopoulos N
AUTHOR: F S Leach FS
AUTHOR: K W Kinzler KW
AUTHOR: B Vogelstein B
AFFILIATION: Howard Hughes Medical Institute, Baltimore, Maryland, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Nature genetics.
COUNTRY: UNITED STATES
TITLE: Monoallelic mutation analysis (MAMA) for identifying germline mutations.
PUBDATE: 19950901
Dissection of germline mutations in a sensitive and specific manner presents a continuing challenge. In dominantly inherited diseases, mutations occur in only one allele and are often masked by the normal allele. Here we report the development of a sensitive and specific diagnostic strategy based on somatic cell hybridization termed MAMA (monoallelic mutation analysis). We have demonstrated the utility of this strategy in two different hereditary colorectal cancer syndromes, one caused by a defective tumour suppressor gene on chromosome 5 (familial adenomatous polyposis, FAP) and the other caused by a defective mismatch repair gene on chromosome 2 (hereditary non-polyposis colorectal cancer, HNPCC).


14. DOCID:23033 SCORE: 0.00140930285537259
DOCNO: 9009845
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mutation
QUALIFIER: epidemiology
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: A Hartmann A
AUTHOR: H Blaszyk H
AUTHOR: J S Kovach JS
AUTHOR: S S Sommer SS
AFFILIATION: University of Regensberg, Germany. arndt.hartmann@klinik.uni.regensburg.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in genetics : TIG.
COUNTRY: ENGLAND
TITLE: The molecular epidemiology of p53 gene mutations in human breast cancer.
PUBDATE: 19970101
The P53 tumor-suppressor gene is an advantageous tool for analyzing the molecular epidemiology of cancer. We describe the utility of the P53 gene as a 'mutagen test' and a prognostic indicator in breast cancer. Aspects of study design and methodology are discussed. Two major conclusions emerge: (1) there is an extraordinary diversity of mutational patterns among cohorts, hinting that the unique biology of mammary cells results in exposure to high doses of a diversity of ingested lipophilic mutagens; and (2) mutations in the P53 gene predict poor outcome in breast cancer.