0. DOCID:11762 SCORE: 0.00272825821814655
DOCNO: 6734002
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: F C Campbell FC
AUTHOR: D A Morgan DA
AUTHOR: H M Bishop HM
AUTHOR: F M Benton FM
AUTHOR: R W Blamey RW
AUTHOR: C W Elston CW
AUTHOR: R I Nicholson RI
AUTHOR: K Griffiths K
PUBTYPE: Journal Article
JOURNALTITLE: Clinical oncology.
COUNTRY: ENGLAND
TITLE: The management of locally advanced carcinoma of the breast by Nolvadex (tamoxifen): a pilot study.
PUBDATE: 19840601
Fifty-one postmenopausal women with locally advanced breast cancer were treated initially by Nolvadex (Tamoxifen, ICI) alone and followed prospectively between 1974 and 1982. Twenty-three patients (40%) showed an objective response to therapy of whom 17 (75%) remain in remission at median follow-up of 36 months. Patients who failed to respond to Nolvadex therapy were treated by radiotherapy which achieved local control in 64%, with 10 months median duration. Nolvadex therapy conveys a good quality lengthy remission to a sizeable minority of patients. The majority of those who fail to respond are satisfactorily managed by radiotherapy.


1. DOCID:11805 SCORE: 0.00272825558257571
DOCNO: 2998957
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
AUTHOR: J V Hamerlynck JV
AUTHOR: A P Maskens AP
AUTHOR: C Mangioni C
AUTHOR: M E van der Burg ME
AUTHOR: J A Wils JA
AUTHOR: J B Vermorken JB
AUTHOR: N Rotmensz N
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Phase II trial of medroxyprogesterone acetate in advanced ovarian cancer: an EORTC Gynecological Cancer Cooperative Group Study.
PUBDATE: 19851101
Progestin therapy of ovarian carcinoma in the past has been reported to lead to varying response rates. A multicenter phase II study of high-dose MPA was conducted in 53 patients with epithelial ovarian cancer who had received adequate trials of conventional therapy with cytotoxic agents. Forty-one patients were included for response and toxicity evaluations. Only one partial response has been recorded with a duration of 20 weeks. Stabilization of disease was observed in 7 patients. The present investigation shows that MPA given at the present high dose is not effective in patients extensively pretreated with chemotherapy.


2. DOCID:10790 SCORE: 0.00249806167432604
DOCNO: 4079432
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: L H Baker LH
AUTHOR: T D Chin TD
AUTHOR: K V Wagner KV
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Progress in screening for early breast cancer.
PUBDATE: 19851001
Ten years have now passed since the American Cancer Society/National Cancer Institute sponsored Breast Cancer Detection Demonstration Projects (BCDDP) started to evaluate the use of mammography, physical examination, thermography, and breast self-examination in screening women for the presence of unsuspected breast cancer. Criteria have been developed to evaluate population screening as an approach to cancer control and breast cancer screening techniques. Combined physical examination and mammography have been particularly successful in detecting early breast cancer. Although the number of screening programs for breast cancer has increased in the past decade, real progress has been surprisingly slow and the issues in breast cancer screening have proved to be subtle and complex.


3. DOCID:10811 SCORE: 0.00205535277204876
DOCNO: 6469649
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: H D Maillie HD
PUBTYPE: Journal Article
JOURNALTITLE: Health physics.
COUNTRY: UNITED STATES
TITLE: Limited life-table factors for estimating radiation-induced cancers over finite time periods.
PUBDATE: 19840701
A method is presented that allows the estimation of radiation-induced cancer incidence or mortality at varying times post-exposure in irradiated populations of males or females of ages ranging from 10 to 70 yr. Limited life-table factors are given in graphic form for 2 sets of conditions: when the latent period is 2 yr and the plateau 30 yr and when the latent period is 10 yr and the plateau extends to the end of life. Normal incidences for selected forms of cancer are also presented. Examples are given that show how to calculate the radiation excess cancers and to compare this excess with the normal. The implications of these numbers are also discussed.


4. DOCID:9830 SCORE: 0.00204411673991454
DOCNO: 6868243
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radioimmunoassay
DESCRIPTOR: Reagent Kits, Diagnostic
QUALIFIER: analysis
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: T D Moon TD
AUTHOR: R L Vessella RL
AUTHOR: M Eickhoff M
AUTHOR: P H Lange PH
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Acid phosphatase for monitoring prostatic carcinoma. Comparison of radioimmunoassay and enzymatic techniques.
PUBDATE: 19830701
We compared a commercial radioimmunoassay kit with an enzymatic assay for prostatic acid phosphatase in monitoring the progression or remission of disease in 27 patients with prostatic cancer. In 5 of the 18 patients whose disease progressed, and in 4 of the 9 whose disease responded to treatment, the change was reflected better by the radioimmunoassay. In no case was the enzymatic assay better. Radioimmunoassay for prostatic acid phosphatase may be an effective and sensitive way to monitor the course of carcinoma of the prostate.


5. DOCID:11971 SCORE: 0.00199936491566942
DOCNO: 6546490
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: diagnosis
AUTHOR: M J Borowitz MJ
AUTHOR: R B Stein RB
PUBTYPE: Journal Article
JOURNALTITLE: Archives of pathology & laboratory medicine.
COUNTRY: UNITED STATES
TITLE: Diagnostic applications of monoclonal antibodies to human cancer.
PUBDATE: 19840201
Monoclonal antibodies elicited to surface antigens on a wide variety of normal and neoplastic cell types have been used with increasing frequency in the diagnosis and classification of cancer. Their widest application so far has been in the in vitro analysis of leukemia and lymphoma using blood or bone marrow samples or tissue biopsy specimens. Although no true leukemia-specific marker has been found, the complex biologic nature of this group of tumors has been shown by monoclonal antibody studies. More recently, these antibodies were produced against solid tumor-associated antigens. The antibodies have helped to identify the tissue of origin of malignant neoplasms and, in some cases, to monitor the course of disease. Carefully chosen panels of monoclonal antibodies will become valuable additions to the diagnostic pathologist's arsenal.


6. DOCID:11713 SCORE: 0.00199702727843224
DOCNO: 6572208
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Education, Dental
QUALIFIER: pathology
QUALIFIER: methods
AUTHOR: C E Barr CE
AUTHOR: M D Goldberg MD
PUBTYPE: Journal Article
JOURNALTITLE: Journal of dental education.
COUNTRY: UNITED STATES
TITLE: A practicum for oral cancer teaching.
PUBDATE: 19830301
This article describes a hospital-based method for teaching oral cancer to general practice residents, which involves the use of patients for whom the residents are responsible. The residents present prepared cases of patients of the hospital dental department according to a predetermined protocol. These conferences begin with a talk on a subject germane to the cases being presented and include complete documentation of clinical history and laboratory findings, photographs, projection of microscope slides of the lesion, and a thorough discussion of therapy and rehabilitation. The residents have had significant contact with the cancer patients from the time of initial patient complaint to completion of therapy. The practicum is based on thorough case review and builds on didactic information provided in the undergraduate dental school curriculum.


7. DOCID:9924 SCORE: 0.00199190022842537
DOCNO: 6506102
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: blood supply
AUTHOR: L Révész L
AUTHOR: E Siracka E
PUBTYPE: Journal Article
JOURNALTITLE: Strahlentherapie.
COUNTRY: GERMANY, WEST
TITLE: Tumor vascularization, hypoxia, staging of tumors and radiocurability.
PUBDATE: 19841101
Retrospective, morphometric analysis of histological preparations from cervical cancers indicate that the stromal component of the neoplastic tissue is richer in vascular elements in the cases in which the patients have a prolonged survival after radiotherapy. The finding supports earlier observations which indicate a relationship between intercapillary distance and radiocurability of cervical cancers. The routine determination of a vascularity index V, denoting the grade of vascular density in the neoplastic tissue, is suggested as a complementary parameter for the classification of tumours. Access to such an index could promote a more individualized tumor therapy, especially in regard to the control of radioresistant, hypoxic cells.


8. DOCID:11922 SCORE: 0.00184693848170359
DOCNO: 6887517
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secretion
AUTHOR: K Inoue K
AUTHOR: T Morimoto T
AUTHOR: H Tohma H
AUTHOR: K Kubouchi K
AUTHOR: H Ishikawa H
AUTHOR: T Tajima T
AUTHOR: H Yamamoto H
AUTHOR: E Araki E
AUTHOR: T Hirayama T
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Epidemiologic study of breast fluid in Japanese women]
PUBDATE: 19830701
Breast fluid was collected from 805 Japanese women using a negative-pressure breast-pump procedure. All subjects were non-lactating; there were 275 breast cancer patients and 530 healthy women. Women who secreted 20 microliters or more were classified as "secretors" (290/805, 36%); those who secreted less than 20 microliters to as "non-secretors". Breast cancer patients showed a significantly higher incidence of secretion, particularly in the diseased breast, than healthy women. Among secretors, the risk for breast cancer was high in those with earlier menarche, unmarried women, those with a smaller number of pregnancies and children and those with older age at their first delivery.


9. DOCID:11560 SCORE: 0.00161932639773968
DOCNO: 6308307
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: analysis
AUTHOR: T Tominaga T
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Histochemical and biochemical assays of estrogen receptors in breast cancer and significance of endocrine therapy]
PUBDATE: 19830501
Estrogen receptors (ER) in breast cancer patients were determined histologically with estradiol-BSA-FITC and biochemically both by sucrose density gradient and dextran coated charcoal methods. Either 8 S or 4 S ER was found clinically to be related to estrogen dependency. ER-positive cells were in clumps or intermixed with ER-negative cells in cancer tissue, which may be one of the reasons for the fact that surgical ablation of breast cancer patients rarely resulted in complete regression of tumors. High dose administration of Hexestrol of Medroxyprogesterone acetate was occasionally effective for ER-negative human and rat breast cancer, which suggests that there is another endocrinological tumor suppressing mechanism besides the mechanism involving the estrogen-ER system.


10. DOCID:11605 SCORE: 0.00158515665250703
DOCNO: 3966624
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hispanic Americans
DESCRIPTOR: Smoking
AUTHOR: A C Marcus AC
AUTHOR: L A Crane LA
PUBTYPE: Journal Article
JOURNALTITLE: American journal of public health.
COUNTRY: UNITED STATES
TITLE: Smoking behavior among US Latinos: an emerging challenge for public health.
PUBDATE: 19850201
In this paper we review evidence on smoking and lung cancer among Latinos, including findings from several unpublished studies and technical reports. Recent surveys of smoking behavior in California, Texas, and New Mexico indicate a notable sex difference in smoking among Latinos, with Latino males smoking at least as frequently as White males, while Latino females report smoking rates considerably lower than White females. Our analysis of the 1979 and 1980 National Health Interview Surveys corroborates this finding and also indicates that this pattern holds true for subgroups of the Latino population, including country of origin. Taken together, these findings suggest that among Latino males rates of lung cancer and other cigarette-linked diseases may increase in the near future.


11. DOCID:9672 SCORE: 0.00158205451829467
DOCNO: 6701616
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: B Rodu B
AUTHOR: I L Griffin IL
AUTHOR: J P Gockerman JP
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Oral candidiasis in cancer patients.
PUBDATE: 19840301
Oral candidiasis in cancer patients is an infection for which inconsistent diagnostic and therapeutic strategies currently prevail. Recent studies have shown its potential importance in the development of systemic candidiasis. A clinical and cytologic study was undertaken on 52 consecutive cancer patients admitted to our institution. Although the incidence of clinical candidiasis was low (8%), 27% of patients harbored evidence of subclinical colonization by Candida. In addition, a significant correlation was found between candidal colonization and low absolute lymphocyte counts. The significance of these findings in relation to systemic candidiasis and rationale for therapy are discussed.


12. DOCID:9675 SCORE: 0.00149031150235874
DOCNO: 6418307
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diagnostic Tests, Routine
QUALIFIER: prevention & control
QUALIFIER: prevention & control
AUTHOR: R C Lallemand RC
AUTHOR: P A Vakil PA
AUTHOR: P Pearson P
AUTHOR: V Box V
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal (Clinical research ed.)
COUNTRY: ENGLAND
TITLE: Screening for asymptomatic bowel cancer in general practice.
PUBDATE: 19840101
General practitioners screened 4284 asymptomatic people aged over 40 to compare the incidence of large bowel cancer and polyps with a control general practice (4288 patients). Compliance was best in young women (60%), and overall it was 42%. Twenty six patients who had a positive Haemoccult test result (1.5% of those screened) were examined by colonoscopy and 10 had polyps. The incidence of cancers in the two groups was similar but in the control (unscreened patients) practice no polyps were found.


13. DOCID:11192 SCORE: 0.00144216184796128
DOCNO: 4064709
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: S C Cox SC
AUTHOR: S H Norwood SH
AUTHOR: C A Duncan CA
PUBTYPE: Journal Article
JOURNALTITLE: Critical care medicine.
COUNTRY: UNITED STATES
TITLE: Acute respiratory failure: mortality associated with underlying disease.
PUBDATE: 19851201
The hospital and ICU course of 98 patients who required mechanical ventilatory support longer than 72 h was reviewed to determine if mortality rates were influenced by admitting diagnosis. Patients with malignant diagnoses were compared to patients with nonmalignant diagnoses and to those admitted to the ICU after myocardial infarction or cardiorespiratory arrest. Although there was no significant intergroup difference in incidence of multiple organ system failure, age, and length of ICU and hospital stay, there was a much higher incidence of sepsis (p less than .05) and mortality (p less than .01) in the cancer group. Cancer patients and their families should be made aware of the extremely poor prognosis if prolonged acute respiratory failure develops.


14. DOCID:10841 SCORE: 0.00139129911204953
DOCNO: 6897676
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cloning, Molecular
QUALIFIER: genetics
QUALIFIER: metabolism
QUALIFIER: pharmacology
QUALIFIER: drug effects
AUTHOR: P Masiakowski P
AUTHOR: R Breathnach R
AUTHOR: J Bloch J
AUTHOR: F Gannon F
AUTHOR: A Krust A
AUTHOR: P Chambon P
PUBTYPE: Journal Article
JOURNALTITLE: Nucleic acids research.
COUNTRY: ENGLAND
TITLE: Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line.
PUBDATE: 19821201
cDNA clones corresponding to a mRNA whose level is rapidly increased by addition of oestradiol to the culture medium have been isolated by differential screening of a cDNA library from the breast cancer cell line MCF-7, which contains oestrogen receptors. Such clones will be useful in studies of the DNA sequences required for hormonal induction and to determine whether expression of the corresponding gene is in any way related to the cancerous state. We have also obtained a cDNA clone for a messenger whose level is apparently decreased by steroid hormones.