0. DOCID:2022 SCORE: 0.00383676911489625
DOCNO: 12229414
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Diagnosis
DESCRIPTOR: Financial Management
DESCRIPTOR: Government Publications
DESCRIPTOR: Uterine Cervical Neoplasms
PUBTYPE: Journal Article
JOURNALTITLE: Drug research reports.
COUNTRY: United States
TITLE: (Reprint of) National Cancer Act Amendments of 1974. Conference Report.
PUBDATE: 19740701
This is a conference committee report of the House and Senate to amend the Public Health Service Act to improve the national cancer program and to authorize appropriations for such programs. Title 1, Extension of Cancer Program, deals with administrative, budgetary, and personnel matters; programs of routine exfoliative cytology tests; and requirements of peer review of grant applications and contract projects. Title 2, Biomedical Research, establishes a President's Biomedical Research Panel to study and make recommendations concerning the subject, content, organization, and operation of biomedical and behavioral reserach conducted and supported under programs of the National Institutes of Health and the National Institutes of Mental Health. After 15 months, the panel will submit to the President and Congress a comprehensive report of its findings and recomendations. The 7-member panel shall expire after 18 months.


1. DOCID:3739 SCORE: 0.0022052668574883
DOCNO: 922666
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: W P Bradley WP
AUTHOR: A P Blasco AP
AUTHOR: J F Weiss JF
AUTHOR: J C Alexander JC
AUTHOR: N A Silverman NA
AUTHOR: P B Chretien PB
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Correlations among serum protein-bound carbohydrates, serum glycoproteins, lymphocyte reactivity, and tumors burden in cancer patients.
PUBDATE: 19771101
Levels of glycoprotein-associated carbohydrates (neutral hexoses, hexosamine, sialic acid and fucose) were determined in the serum of patients with either local, regional or metastatic cancer, patients clinically cured of cancer, and controls (smokers and nonsmokers). Total protein-bound carbohydrates were compared with levels of 17 normal serum glycoproteins, carcinoembryonic antigen (CEA), and with lymphocyte reactivity to phytohemagglutin (PHA). Tumor burden was directly related to protein-bound carbohydrate levels in patient groups. Levels of bound carbohydrates reflect the sum of all the changes in serum glycoproteins, but primarily changes in the acute-phase proteins (alpha 1-acid glycoprotein, alpha 1-antitrypsin, haptoglobin, ceruloplasmin) found in the alpha-globulin fraction of serum. Increases in protein-bound carbohydrates in tumor-bearers were not related to increases in CEA. Increased levels of the acute-phase proteins occurred in individuals with depressed in vitro lymphocyte reactivity to PHA. A significant positive correlation was found between lymphocyte reactivity and level of alpha 2HS-glycoprotein. The results suggest that serum protein-bound carbohydrates or glycoproteins may be of adjunctive value is assessing tumor burden and immune reactivity in cancer patients.


2. DOCID:3800 SCORE: 0.00205729084159262
DOCNO: 789782
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultraviolet Rays
QUALIFIER: radiation effects
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: B Lambert B
AUTHOR: U Ringborg U
AUTHOR: G Swanbeck G
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of investigative dermatology.
COUNTRY: UNITED STATES
TITLE: Ultraviolet-induced dna repair synthesis in lymphocytes from patients with actinic keratosis.
PUBDATE: 19761101
Actinic keratosis is an epidermal cancer in situ. Extensive exposure to sunlight is considered as a contributing factor to the etiology of this tumor. Ultraviolet (UV) light of solar radiation induces structural damage in DNA, which may give rise to mutations and transformed cells if the damage is not repaired. Repair of UV-induced DNA lesions is an essential property of human cells. The conditions so far reported to have defective DNA repair are all associated with an increased incidence of malignancy. Do patients with actinic keratosis also exhibit a reduced capacity to repair UV-induced DNA lesions? DNA repair synthesis in peripheral leukocytes was studied in 10 patients with actinic keratosis and 10 healthy subjects of corresponding age. After irradiation with various doses of UV light the leukocytes were incubated for 2 hr with [3H]thymidine in the presence of hydroxyurea. A dose-response relationship for the UV-induced DNA repair synthesis was established for each individual. The average repair capacity in the patients with actinic keratosis was about 30% below that of the controls. The difference is statistically significant (p less than 0.02). Reduced DNA repair synthesis may therefore be an important factor in the etiology of actinic keratosis.


3. DOCID:2965 SCORE: 0.00200501881752484
DOCNO: 831494
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymphatic Metastasis
QUALIFIER: classification
AUTHOR: R C Boronow RC
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Stage I cervix cancer and pelvic node metastasis: special reference to the implications of the new and the recently replaced FIGO classifications on Stage Ia.
PUBDATE: 19770101
The current staging system for cervix cancer of the International Federation of Gynecology and Obstetrics (FIGO) has been in use for less than 2 years. It is criticized by many because of a lack of quantitative features. While quantative features are important, the over-all morphology of the histologic pattern--the qualitative features--are those utilized by most pathologists in interpretating the "invasiveness" of a lesion and therefore its biologic potential. The most recent, as well as the previous FIGO Staging System was applied to 108 personal cases with particular reference to lymih node metastasis. By comparing results of the new and older staging system, the validity of the new system is suggested, and the inordinately high rate of node metastasis when using the older system appears to be at least one reason for the relatively high rate of node metastasis reported in earlier series of Stage Ia lesions reported in the literature.


4. DOCID:2324 SCORE: 0.00199899963161427
DOCNO: 852338
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinoma
DESCRIPTOR: Carcinoma, Squamous Cell
DESCRIPTOR: Heart Neoplasms
DESCRIPTOR: Lung Neoplasms
AUTHOR: B L Strauss BL
AUTHOR: M J Matthews MJ
AUTHOR: M H Cohen MH
AUTHOR: R Simon R
AUTHOR: F Tejada F
PUBTYPE: Journal Article
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Cardiac metastases in lung cancer.
PUBDATE: 19770501
Cardiac metastases from bronchogenic carcinoma are not commonly diagnosed prior to death. This study isolates factors associated wtih the development of cardiac involvement. Four hundred eighteen consecutive patients with lung cancer who had autopsies were studied. Twenty-five percent of these patients had cardiac involvement. Factors associated with cardiac metastases were (1) histologic cell type of the tumor, (2) aggressive therapy, (3) extent of disease, and (4) tumor differentiation. The presence of cardiac metatases was not related to the length of survival. Clinical signs of cardiac involvement included an enlarging heart on the chest x-ray film, development of congestive heart failure, or electrocardiographic changes. Suspicion of cardiac metastases in high-risk individuals, prompt diagnostic evaluation, and rapid institution of therapy may improve the outlook for many patients, since reaccumulation of fluid was generally slow.


5. DOCID:3870 SCORE: 0.00197977823834815
DOCNO: 1008360
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: P Mannes P
AUTHOR: R Derriks R
AUTHOR: R Moens R
AUTHOR: C Laurent C
PUBTYPE: Journal Article
JOURNALTITLE: Annales de médecine interne.
COUNTRY: FRANCE
TITLE: [Chemotherapy in primary and metastatic intrathoracic cancer]
PUBDATE: 19760101
Chemotherapy has procured results which are still modest surely valid in the treatment of inoperable primary bronchial cancer: - prolongation of the mean survival time from 3 1/2 months for the nontreated cases to 8 1/2 months for those patients treated with complex combinations; - more than 15% of very good results with return to normal professional activity for 6 to 18 months; - approximately 30% of considerable subjective improvement with a definite sense of "well being"; - considerable reduction in the use of pain-killers. These results amply justify the pursuit of research. 2) The results for the combination hormone-chemotherapy, in the case of thoracic metastases of breast cancer, are definitely better. After leukemia in children, and Hodgking and non-Hodgkin lymphoma, metastases from breast cancer constitute a third group of chemosensitive tumors: - for 64 cases, the percentage of complete or partial remission is 84.3%; - there were 34 complete remissions: mean survival 27 months, at present 11 patients still remain alive: 1 to 16, 1 to 17, 2 to 19, 1 to 23, 31, 35, 38, 43, 68 and 70 months; - 20 partial remissions, mean survival 10 1/2 months, one patient still alive; - 10 failures, mean survival 6 months; - mean duration of complete remission 18 months; - mean duration of partial remission 6 months.


6. DOCID:3581 SCORE: 0.00188977862764375
DOCNO: 180188
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: cytology
AUTHOR: M Pruniéras M
AUTHOR: C Delescluse C
AUTHOR: M Regnier M
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of investigative dermatology.
COUNTRY: UNITED STATES
TITLE: The culture of skin. A review of theories and experimental methods.
PUBDATE: 19760701
Two main criticisms can be leveled against the standard methods of skin culture: they are poorly quantifiable and the cultured cell populations are heterogeneous. A new technique based mainly on enzymatic dissociation allows specific cell types to be extracted from the skin before cultivation. In this way, separate cultures of epidermal keratinocytes and dermal fibroblasts can be obtained from the same piece of skin. These purified systems have been used to study the kinetics of epidermal cell growth and to quantify the effect of various chemically defined substances on the growth and differentiation of keratinocytes. With further refinements in technique, purified populations of melanocytes can be extracted. The co-culture of pigmented melanocytes with albino keratinocytes has been proposed as a model to study pigment donation in vitro. The usual organ culture technique, including the use of large explants of skin immersed in the culture fluid, has been modified to show that adult human skin partially regenerates in vitro and that mitotic activity goes on for months in the regenerated epidermis. The use of nucleic acid hybridization techniques, combined with skin cell cultures from human tumors, opens new avenues of research on human cancer.


7. DOCID:3689 SCORE: 0.00182719074580398
DOCNO: 142934
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hypophysectomy
QUALIFIER: metabolism
AUTHOR: G C Lachelin GC
AUTHOR: S C Yen SC
AUTHOR: J F Alksne JF
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Hormonal changes following hypophysectomy in humans.
PUBDATE: 19770901
Pituitary function was studied before and after surgery in 1 patient who underwent chryohypophysectomy and 5 patients who underwent transsphenoidal excision hypophysectomy for metastatic breast cancer ablation therapy. Changes in serum luteinizing hormone, follicle stimulating hormone, growth hormone, thyrotropin stimulating hormone, pituitary prolactin (PRL), and steroid hormone levels of estrone, estradiol, testosterone, and rostenedione, and dehydroepiandrosterone levels were determined. All of the above were assessed before and from 6 weeks to 10 months after hypophysectomy. Pituitary hormone release in response to sequential stimuli of arginine infusion, thyrotropic releasing factor (TRF), and luteinizing hormone-releaseing factor was analyzed. In 3 patients, hypophysectomy was considered incomplete because of the presence of measurable amounts of circulating pituitary hormones and their release in response to stimuli, although all levels except PRL were markedly reduced. In 3 patients, hypophysectomy was considered nearly complete. Basal PRL levels remained unchanged whether the procedure was considered complete or not. PRL release was absent in response to TRF or arginine stimulation in 4 patients with substantial residual pituitary function. Hypophysectomy was followed by a marked reduction in circulating levels of estrogens and androgens. The assessment of quantitative release of pituitary hormones in response to stimuli is an improved direct measure of residual functioning pituitary tissue.


8. DOCID:1228 SCORE: 0.00179831939255589
DOCNO: 866646
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiotherapy
AUTHOR: A A Mancuso AA
AUTHOR: W N Hanafee WN
AUTHOR: G J Juillard GJ
AUTHOR: J Winter J
AUTHOR: T C Calcaterra TC
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: The role of computed tomography in the management of cancer of the larynx.
PUBDATE: 19770701
Computed tomography (CT) offers a unique method of displaying the anatomy of laryngeal cancer. Asymmetrical contours of the thyroid cartilages have been found as a normal variant. Marked asymmetry may indicate buckling of the cartilage which could contribute to acute airway obstruction following radiation therapy. A low-density, soft-tissue plane medial to the thyroid cartilages may prove valuable in evaluating cartilaginous involvement with tumor. Computed tomography should make a significant contribution to more accurate planning of radiation therapy portals by showing the relationship of lymphatic spread to the primary tumors.


9. DOCID:3421 SCORE: 0.00179807774045097
DOCNO: 612710
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: S A Schepartz SA
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of antibiotics.
COUNTRY: JAPAN
TITLE: Antitumor screening procedures of the National Cancer Institute.
PUBDATE: 19771201
From the time of its inception in 1955, the Drug Development Program of the National Cancer Institute has relied primarily on transplanted rodent tumor systems in vivo for the evaluation and selection of potential antitumor agents. Although greater emphasis has been placed in recent years on rationally designed drugs, the major effort throughout the history of the program has involved the empirical screening of a wide variety of chemical structures and natural products of varying sources. The initial screening spectrum consisted of three mouse tumors, Sarcoma 180, Carcinoma 755 and Leukemia 1210, based on the retrospective analysis presented in the GELLHORN-HIRSCHBERG Report. As a result of further expermental studies and analyses, the screens changed successively to (1) L1210 plus a spectrum of mouse, rat and hamster tumors, (2) L1210 plus the rat tumor, WALKER 256, (3) L1210, plus P388 for natural products and B16 melanoma and LEWIS lung carcinoma for special studies, and finally (4) P388 as a pre-screen followed by a panel of transplanted tumors and xenografts representing the major tumor sites. The rationale underlying each of the successive changes, and results obtained with each approach, will be discussed.


10. DOCID:1098 SCORE: 0.00179569652496304
DOCNO: 190099
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: T J Horvath TJ
AUTHOR: A E Schindler AE
PUBTYPE: Journal Article
JOURNALTITLE: Fortschritte der Medizin.
COUNTRY: GERMANY, WEST
TITLE: [Ovarian metastases in breast carcinoma]
PUBDATE: 19770201
The effect on prognosis of the presence of ovarian metastases was studied in patients oophorectomized in treatment of progressive breast cancer. At laparotomy, 28% (n = 42) were found to have ovarian metastases. This high percentage indicates that cases studied were in a relatively progressed state. In the cases with ovarian metastases, the clinical course of the disease was no different to those histologically free from metastases. It appears therefore that the presence of secondary ovarian metastases at oophorectomy is of no therapeutic or prognostic significance. The time interval between oophorectomy and mastectomy, however, apparently does have a bearing on the progress of the disease.


11. DOCID:1126 SCORE: 0.00172899203712778
DOCNO: 885287
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
AUTHOR: B E Linebaugh BE
AUTHOR: J A Rillema JA
PUBTYPE: Journal Article
JOURNALTITLE: Molecular and cellular endocrinology.
COUNTRY: NETHERLANDS
TITLE: Hydrocortisone enhancement of insulin's action on macromolecular synthesis in MCF-7 cells.
PUBDATE: 19770601
In MCF-7 human breast cancer cells, insulin stimulated the rate of [3H]uridine incorporation into RNA, [3H]thymidine incorporation into DNA, and [3H]leucine incorporation into protein. In addition, hydrocortisone appeared to augment the effect of insulin, by further increasing the rate of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA. A significant increase in the total amount of DNA and protein was present in cultures treated with insulin compared to untreated controls. Hydrocortisone was shown to augment the insulin effect on total protein accumulation and total RNA accumulation in MCF-7 cells.


12. DOCID:2820 SCORE: 0.00170888686987634
DOCNO: 972643
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Iatrogenic Disease
DESCRIPTOR: Research
DESCRIPTOR: Therapeutics
AUTHOR: P V Cardon PV
AUTHOR: F W Dommel FW
AUTHOR: R R Trumble RR
PUBTYPE: Journal Article
JOURNALTITLE: The New England journal of medicine.
COUNTRY: UNITED STATES
TITLE: Injuries to research subjects A survey of investigators.
PUBDATE: 19760901
A task force of the Department of Health, Education, and Welfare conducted a survey aimed at estimating the incidence of research-related injuries, with a view to determining the feasibility of compensating subjects injured during research. The data were obtained by telephone from 331 investigators conducting research on nearly 133,000 human subjects over the past three years. Eighty-five investigators reported at least one injury. Of the 4957 reported injuries, 3926 were classified as trivial, and 974 as temporarily disabling; of 57 injuries resulting in death or permanent disability, one disabling stroke, not clearly related to the research, occurred three days after a non-therapeutic procedure; the rest resulted from treatments expected to benefit the patients directly, usually cancer chemotherapy. The data suggest that the risks of participation in nontherapeutic research may be of no greater than those of everyday life, and in therapeutic research, no greater than those of treatment in other settings.


13. DOCID:2203 SCORE: 0.00165040030399695
DOCNO: 140002
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: blood
QUALIFIER: etiology
QUALIFIER: blood
AUTHOR: P Hill P
AUTHOR: P Chan P
AUTHOR: L Cohen L
AUTHOR: E Wynder E
AUTHOR: K Kuno K
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Diet and endocrine-related cancer.
PUBDATE: 19770401
In women, dietary modification and life style affect the risk of breast cancer and may alter the hormonal status, while in experimental animals diet can alter the incidence of induced mammary tumors. In this study, a high fat diet increased the incidence of DMBA-induced tumors in rats while this increase in incidence was lowered and the effect of a high fat diet obliterated by an anti-prolactin during CB154. Premenopausal Japanese women had a higher estradiol level than their Caucasian counterpart. In Japanese but not Caucasian breast cancer patients, the estradiol decreased. When nurses were transferred from the Western to a vegetarian diet, the menstrual cycle was shortened, while their prolactin and testosterone decreased. Data indicate that dietary factors influence tumor incidence and hormone profile in rat mammary cancer and the hormonal status in women.


14. DOCID:2040 SCORE: 0.0016325647554834
DOCNO: 1086707
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: alpha 1-Antitrypsin Deficiency
QUALIFIER: blood
AUTHOR: C C Harris CC
AUTHOR: M H Cohen MH
AUTHOR: R Connor R
AUTHOR: A Primack A
AUTHOR: G Saccomanno G
AUTHOR: R C Talamo RC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Serum alpha1-antitrypsin in patients with lung cancer or abnormal sputum cytology.
PUBDATE: 19761001
Serum alpha1-antitrypsin Pi types and trypsin inhibitory capacity (TIC) were measured in 72 patients with lung cancer and in 196 patients with abnormal sputum cytology but no clinical evidence of lung cancer to determine if a genetic deficiency of alpha1-antitrypsin (AAT) predisposes to lung cancer. The distributions of Pi types in these two groups of patients and healthy adults are similar. Serum TIC and AAT concentrations are elevated in lung cancer patients. However, patients with abnormal sputum cytology and no clinical lung cancer have normal levels of serum TIC and AAT. A genetic deficiency of AAT probably does not produce a state of increased susceptibility to the carcinogenic effects of respiratory carcinogens such as tobacco smoke.