0. DOCID:2022 SCORE: 0.00383676911489625
DOCNO: 12229414
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Diagnosis
DESCRIPTOR: Financial Management
DESCRIPTOR: Government Publications
DESCRIPTOR: Uterine Cervical Neoplasms
PUBTYPE: Journal Article
JOURNALTITLE: Drug research reports.
COUNTRY: United States
TITLE: (Reprint of) National Cancer Act Amendments of 1974. Conference Report.
PUBDATE: 19740701
This is a conference committee report of the House and Senate to amend the Public Health Service Act to improve the national cancer program and to authorize appropriations for such programs. Title 1, Extension of Cancer Program, deals with administrative, budgetary, and personnel matters; programs of routine exfoliative cytology tests; and requirements of peer review of grant applications and contract projects. Title 2, Biomedical Research, establishes a President's Biomedical Research Panel to study and make recommendations concerning the subject, content, organization, and operation of biomedical and behavioral reserach conducted and supported under programs of the National Institutes of Health and the National Institutes of Mental Health. After 15 months, the panel will submit to the President and Congress a comprehensive report of its findings and recomendations. The 7-member panel shall expire after 18 months.


1. DOCID:6092 SCORE: 0.00374969241550081
DOCNO: 7248438
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Trials
DESCRIPTOR: Education, Graduate
DESCRIPTOR: Statistics
AUTHOR: E A Gehan EA
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: The training of statisticians for cooperative clinical trials: a working statistician's viewpoint.
PUBDATE: 19801201
The methods of training statisticians for clinical trials can take diverse forms: attendance at courses and lectures, personal study, observing and doing, or working as an apprentice. Desirable qualifications for an effective working statistician are: adequate knowledge of biostatistics and the field of application for the clinical trial, an ability to communicate statistical ideas verbally at meetings and in the writing of reports and collaborative research papers, an awareness of potential sources of bias, an understanding of ethical issues, and an ability to set priorities for projects. These issues are discussed in the context of training, and personal comments are made from the viewpoint of a statistician with substantial experience of clinical trials in cancer.


2. DOCID:23352 SCORE: 0.00279657850368443
DOCNO: 7579681
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colectomy
DESCRIPTOR: Laparoscopy
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: M Fodera M
AUTHOR: M J Pello MJ
AUTHOR: U Atabek U
AUTHOR: R K Spence RK
AUTHOR: J B Alexander JB
AUTHOR: R C Camishion RC
AFFILIATION: Department of Surgery, UMDNJ-Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of laparoendoscopic surgery.
COUNTRY: UNITED STATES
TITLE: Trocar site tumor recurrence after laparoscopic-assisted colectomy.
PUBDATE: 19950801
As a variety of procedures become technically feasible with laparoscopic techniques, it becomes increasingly important to appropriately select the patients who will benefit from the laparoscopic approach. We report the case of a patient with Dukes C2 colon cancer treated by laparoscopic-assisted sigmoid colectomy who subsequently developed an abdominal wall recurrence at a trocar site scar. The case raises some concerns about the use of the laparoscopic technique in the surgical management of colon cancer.


3. DOCID:26484 SCORE: 0.002743044125135
DOCNO: 11063129
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: pathology
QUALIFIER: physiopathology
AUTHOR: M Molinari M
AFFILIATION: European Institute of Oncology, Milan, Italy. mmolinari@ieo.it
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cell proliferation.
COUNTRY: ENGLAND
TITLE: Cell cycle checkpoints and their inactivation in human cancer.
PUBDATE: 20001001
Checkpoints are mechanisms that regulate progression through the cell cycle insuring that each step takes place only once and in the right sequence. Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability. This review will focus on three major areas of cell cycle transition control, with particular attention to the alterations found in human cancer. These areas include the G1/S transition, where most cancer-related defects occur, the G2/M checkpoint and its activation in response to DNA damage, and the spindle checkpoint.


4. DOCID:23956 SCORE: 0.00273741426866858
DOCNO: 7658541
AUTHOR: J Baniel J
AUTHOR: R S Foster RS
AUTHOR: L H Einhorn LH
AUTHOR: J P Donohue JP
AFFILIATION: Department of Urology, Indiana University Medical Center, Indianapolis 46202-5250, USA.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Late relapse of clinical stage I testicular cancer.
PUBDATE: 19951001
PURPOSE: The clinical presentation and treatment of late recurrence (2 or more years after initial management) of testis cancer are defined. MATERIALS AND METHODS: A retrospective search was performed to identify patients treated for late relapse at our university from 1979 to 1992 who had initially presented with clinical stage 1 disease. RESULTS: We treated 35 patients with chemotherapy for late relapse. No patient has remained disease-free with chemotherapy alone. Subsequent surgery resulted in 43% of the patients being currently disease-free. CONCLUSIONS: The treatment of late relapse is surgical. Chemotherapy before late relapse for low volume disease does not uniformly prevent late recurrence.


5. DOCID:15022 SCORE: 0.00273709849372928
DOCNO: 2959310
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Workers' Compensation
QUALIFIER: mortality
AUTHOR: M Finkelstein M
AUTHOR: G M Liss GM
AUTHOR: F Krammer F
AUTHOR: R A Kusiak RA
AFFILIATION: Health Studies Service, Ontario Ministry of Labour, Toronto, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of industrial medicine.
COUNTRY: ENGLAND
TITLE: Mortality among workers receiving compensation awards for silicosis in Ontario 1940-85.
PUBDATE: 19870901
The mortality experience of 1190 miners and 289 surface industry workers receiving workers' compensation awards for silicosis in Ontario since 1940 has been studied up to mid-1985. Both groups were found to have a significantly increased mortality from lung cancer (miners' SMR: 230; surface workers' SMR: 302) and stomach cancer (miners' SMR: 188; surface workers' SMR: 366). Adjustment for smoking and country of origin did not explain the excesses observed. The lung cancer findings are consistent with observations from silicosis registries in Europe. Possible explanatory factors are discussed.


6. DOCID:11762 SCORE: 0.00272825821814655
DOCNO: 6734002
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: F C Campbell FC
AUTHOR: D A Morgan DA
AUTHOR: H M Bishop HM
AUTHOR: F M Benton FM
AUTHOR: R W Blamey RW
AUTHOR: C W Elston CW
AUTHOR: R I Nicholson RI
AUTHOR: K Griffiths K
PUBTYPE: Journal Article
JOURNALTITLE: Clinical oncology.
COUNTRY: ENGLAND
TITLE: The management of locally advanced carcinoma of the breast by Nolvadex (tamoxifen): a pilot study.
PUBDATE: 19840601
Fifty-one postmenopausal women with locally advanced breast cancer were treated initially by Nolvadex (Tamoxifen, ICI) alone and followed prospectively between 1974 and 1982. Twenty-three patients (40%) showed an objective response to therapy of whom 17 (75%) remain in remission at median follow-up of 36 months. Patients who failed to respond to Nolvadex therapy were treated by radiotherapy which achieved local control in 64%, with 10 months median duration. Nolvadex therapy conveys a good quality lengthy remission to a sizeable minority of patients. The majority of those who fail to respond are satisfactorily managed by radiotherapy.


7. DOCID:11805 SCORE: 0.00272825558257571
DOCNO: 2998957
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
AUTHOR: J V Hamerlynck JV
AUTHOR: A P Maskens AP
AUTHOR: C Mangioni C
AUTHOR: M E van der Burg ME
AUTHOR: J A Wils JA
AUTHOR: J B Vermorken JB
AUTHOR: N Rotmensz N
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Phase II trial of medroxyprogesterone acetate in advanced ovarian cancer: an EORTC Gynecological Cancer Cooperative Group Study.
PUBDATE: 19851101
Progestin therapy of ovarian carcinoma in the past has been reported to lead to varying response rates. A multicenter phase II study of high-dose MPA was conducted in 53 patients with epithelial ovarian cancer who had received adequate trials of conventional therapy with cytotoxic agents. Forty-one patients were included for response and toxicity evaluations. Only one partial response has been recorded with a duration of 20 weeks. Stabilization of disease was observed in 7 patients. The present investigation shows that MPA given at the present high dose is not effective in patients extensively pretreated with chemotherapy.


8. DOCID:7938 SCORE: 0.00260774173263062
DOCNO: 7284734
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: O J Traynor OJ
AUTHOR: N L Costa NL
AUTHOR: L H Blumgart LH
AUTHOR: C B Wood CB
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: A scanning electron microscopy study of ultrastructural changes in the colonic mucosa of patients with large bowel tumours.
PUBDATE: 19811001
Scanning electron microscopy (SEM) has been used to compare the appearances of the colonic mucosal surface and overlying mucus layer of patients with normal colons, adenomatous polyps and colorectal carcinoma. The normal colonic mucosa had a characteristic orderly arrangement of crypts and was completely covered by an intact mucus layer. Epithelial and cryptal irregularities were seen on the surface of both polyps and carcinomas, and, in addition, the mucus layer was fragmented, leaving areas of the underlying epithelium exposed. These changes were more marked in colorectal cancers than in polyps and were present to a lesser degree in the apparently normal mucosa adjacent to tumours. The findings indicate that SEM can detect minor subtle irregularities on the surface of the colon and so may be useful in detecting pre-neoplastic and early neoplastic changes.


9. DOCID:27997 SCORE: 0.00259343702453295
DOCNO: 9644865
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: pathology
QUALIFIER: radiography
AUTHOR: J Martínez Subías J
AUTHOR: L J Domínguez Ugidos LJ
AUTHOR: A Urpegui García A
AUTHOR: E Sancho Serrano E
AUTHOR: J Royo López J
AUTHOR: J Millán Guevara J
AUTHOR: H Valles Varela H
AFFILIATION: Servicio de ORL, Hospital Clínico Universitario Lozano Blesa, Zaragoza.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Acta otorrinolaringológica española.
COUNTRY: SPAIN
TITLE: [Middle ear carcinoma]
PUBDATE: 19980401
Middle-ear cancer represents 5 to 10% of all ear neoplasms. Risk factors include chronic suppurative pathology of the middle ear and prior irradiation. Most malignant tumors are squamous-cell carcinomas. We report the case of a 51-year-old woman with this process. The ideal treatment is mastoidectomy or pterosectomy followed by radiotherapy. We made a bibliographic review of the clinical manifestations, diagnosis, treatment, and prognosis of middle-ear cancer. Five-year survival rates range from 25 to 50% in patients who undergo surgery and radiotherapy.


10. DOCID:23714 SCORE: 0.00250435760320092
DOCNO: 9373592
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J D Evans JD
AUTHOR: D G Morton DG
AUTHOR: J P Neoptolemos JP
AFFILIATION: University Department of Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medical journal.
COUNTRY: ENGLAND
TITLE: Chronic pancreatitis and pancreatic carcinoma.
PUBDATE: 19970901
The differential diagnosis between pancreatic cancer and chronic pancreatitis is very important as the management and prognosis of these two diseases is different. In most patients with pancreatic disease, the diagnosis can be established but there is a subgroup of patients in whom it is difficult to differentiate between these conditions because the clinical presentation is often similar and currently available diagnostic tests may be unable to distinguish between an inflammatory or neoplastic pancreatic mass. This paper reviews the aetiology, pathology and clinical features of these diseases and discusses the limitations of conventional diagnostic methods and how newer techniques may be of value in the differential diagnosis.


11. DOCID:10790 SCORE: 0.00249806167432604
DOCNO: 4079432
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: L H Baker LH
AUTHOR: T D Chin TD
AUTHOR: K V Wagner KV
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Progress in screening for early breast cancer.
PUBDATE: 19851001
Ten years have now passed since the American Cancer Society/National Cancer Institute sponsored Breast Cancer Detection Demonstration Projects (BCDDP) started to evaluate the use of mammography, physical examination, thermography, and breast self-examination in screening women for the presence of unsuspected breast cancer. Criteria have been developed to evaluate population screening as an approach to cancer control and breast cancer screening techniques. Combined physical examination and mammography have been particularly successful in detecting early breast cancer. Although the number of screening programs for breast cancer has increased in the past decade, real progress has been surprisingly slow and the issues in breast cancer screening have proved to be subtle and complex.


12. DOCID:25301 SCORE: 0.0024718142755248
DOCNO: 10862490
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: G A Vakulenko GA
PUBTYPE: Journal Article
JOURNALTITLE: Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny.
COUNTRY: UKRAINE
TITLE: [The treatment of the initial stage of cervical cancer]
PUBDATE: 20000301
The analysis of the author's own experience and of relevant published literature suggest that it is expedient to further elaborate methods for treatment of incipient forms of uterine cervix cancer aimed to preserve the genital organs in women, especially in those at childbearing age. Worthy of mention in this respect is the progress made by the Kiev City Oncological Centre. In choosing a treatment option, it is necessary that etiopathogenic risk factors for development of cancer of the uterine cervix by analyzed and taken account of.


13. DOCID:29828 SCORE: 0.00239208282495414
DOCNO: 12170569
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: therapy
QUALIFIER: complications
QUALIFIER: methods
QUALIFIER: drug effects
AUTHOR: Donna S Zhukovsky DS
AFFILIATION: Department of Palliative Care and Rehabilitation Medicine, University of Texas, MD Anderson Cancer Center, 1515 Holcombe, Box 8, Houston, TX 77030, USA. dzhukovs@mdanderson.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: United States
TITLE: Fever and sweats in the patient with advanced cancer.
PUBDATE: 20020601
Fever and sweats are common complications of cancer and its treatment. This article reviews potential causes and pathophysiologic mechanisms of fever and sweat. Management recommendations, consisting of primary interventions directed at contributing causes and pathophysiologic mechanisms, and non-specific palliative measures are discussed. Optimal management is contingent on the physician's integration of medical expertise with patient-derived goals of care.


14. DOCID:18182 SCORE: 0.00236257726839165
DOCNO: 1430885
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: methods
QUALIFIER: standards
AUTHOR: C J Baines CJ
AFFILIATION: Department of Preventive Medicine and Biostatistics, University of Toronto.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of gerontology.
COUNTRY: UNITED STATES
TITLE: Physical examination of the breasts in screening for breast cancer.
PUBDATE: 19921101
No currently available evidence from breast cancer screening studies provides strong justification for the implementation of screening in elderly females. Because it is an absence of evidence rather than negative evidence which pertains, it is concluded that if screening is introduced it should include both mammography and clinical examination of the breasts because the two complement one another. As well, stringent quality control procedures are required for both modalities. It is possible that clinical examination of the breasts performed by a nurse-examiner will enhance compliance with screening schedules.