0. DOCID:27348 SCORE: 0.00529479092111998
DOCNO: 11163152
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Oligonucleotide Array Sequence Analysis
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: P L Porter PL
AFFILIATION: Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, and Department of Pathology, University of Washington Medical Center, 1100 Fairview N, Seattle, Washington 98109, USA. pporter@fhcrc.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: England
TITLE: Molecular markers of tumor initiation and progression.
PUBDATE: 20010201
Of the hundreds of genes and proteins reported to be altered in human cancers, only a few are sufficiently central to warrant translation into diagnostic or therapeutic tools. Three recent developments have the potential to alter radically the discovery of molecular markers: the compendium of human genes; the advent of technologies that provide the means to identify simultaneously several known and unknown genes and proteins; and an appreciation of the critical processes involved in tumor initiation and progression.

1. DOCID:27979 SCORE: 0.00371945336633542
DOCNO: 11357148
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: J Peto J
AFFILIATION: Institute of Cancer Research, Sutton, Surrey SM2 5NG, and London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature.
COUNTRY: England
TITLE: Cancer epidemiology in the last century and the next decade.
PUBDATE: 20010501
By the early 1980s, epidemiologists had identified many important causes of cancer. They had also proposed the 'multi-stage' model of cancer, although none of the hypothesized events in human carcinogenesis had then been identified. The remarkable advances in cell and molecular biology over the past two decades have transformed the scope and methods of cancer epidemiology. There have been a few new discoveries based purely on traditional methods, and many long-suspected minor risks have been estimated more precisely. But modern epidemiological studies often depend on genetic, biochemical or viral assays that had not been developed 20 years ago.

2. DOCID:27133 SCORE: 0.00366672228581337
DOCNO: 11383248
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Orchiectomy
DESCRIPTOR: Prostatectomy
QUALIFIER: psychology
QUALIFIER: surgery
AUTHOR: P S Marschke PS
AFFILIATION: Department of Urology, Johns Hopkins School of Medicine, JHOC-4th Floor Urology, 601 N Caroline St, Baltimore, MD 21287-0850, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: United States
TITLE: The role of surgery in the treatment of prostate cancer.
PUBDATE: 20010501
OBJECTIVES: To describe the role of surgery in the treatment of organ-confined prostate cancer and advanced prostate cancer. DATA SOURCES: Journals, textbooks, and personal communication. CONCLUSIONS: Radical prostatectomy plays a possible role in curing those patients with disease confined to the prostate. Bilateral orchiectomy plays a palliative role for patients with advanced disease. IMPLICATIONS FOR NURSING PRACTICE: This article provides nurses with the knowledge needed to teach patients about how the surgery is performed, the associated complications, and the likelihood of cancer control.

3. DOCID:26525 SCORE: 0.00336212470366599
DOCNO: 9840972
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Proportional Hazards Models
QUALIFIER: methods
AUTHOR: S Y Lee SY
AUTHOR: R A Wolfe RA
AFFILIATION: Department of Applied Statistics, Sejong University, Seoul, Korea. leesy@cs.sejong.ac.kr
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: A simple test for independent censoring under the proportional hazards model.
PUBDATE: 19980901
A simple method for testing the assumption of independent censoring is developed using a Cox proportional hazards regression model with a time-dependent covariate. This method involves further follow-up of a subset of lost-to-follow-up censored subjects. An adjusted estimator of the survivor function is obtained for the dependent censoring model under a proportional hazards alternative. The proposed procedure is applied to an example of a clinical trial for lung cancer and a simulation study is given for investigating the power of the proposed test.

4. DOCID:26961 SCORE: 0.00336198254970419
DOCNO: 10235353
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Second Primary
DESCRIPTOR: Pulmonary Artery
DESCRIPTOR: Stents
QUALIFIER: therapy
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: J D Urschel JD
AFFILIATION: Department of Thoracic Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263-0001, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of laparoendoscopic & advanced surgical techniques. Part A.
COUNTRY: UNITED STATES
TITLE: Delayed massive hemoptysis after expandable bronchial stent placement.
PUBDATE: 19990401
Patients with lung cancer often develop airway obstruction that necessitates palliative bronchoscopic interventions. Expandable metal stents are increasingly used for this indication. We report a case of fatal massive hemoptysis that occurred 1 week after uneventful bronchial stent placement. Previous treatment with external-beam radiotherapy, brachytherapy, and photodynamic therapy probably contributed to pulmonary artery-bronchial fistulization in this patient. This complication should be kept in mind when considering expandable airway stent insertion in heavily pretreated lung cancer patients.

5. DOCID:26284 SCORE: 0.00327135035490082
DOCNO: 11445022
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Life
QUALIFIER: diagnosis
QUALIFIER: prevention & control
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: S Samdani S
AUTHOR: E Lachmann E
AUTHOR: W Nagler W
AFFILIATION: Department of Physical Medicine and Rehabilitation, New York Presbyterian Hospital, New York, New York, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of women's health & gender-based medicine.
COUNTRY: United States
TITLE: Unilateral extremity swelling in female patients with cancer.
PUBDATE: 20010501
Unilateral extremity swelling may be secondary to two major causes in female patients with cancer, deep venous thrombosis (DVT) and lymphedema. In women of all ages, DVT is high on the differential diagnosis list for unilateral extremity swelling. However, in women with an underlying malignancy, DVT and lymphedema must both be considered. Appropriate diagnosis and treatment are necessary to improve the quality of life and function of the female patient with cancer.

6. DOCID:27443 SCORE: 0.00317754990602775
DOCNO: 11327501
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diagnosis, Computer-Assisted
DESCRIPTOR: Neural Networks (Computer)
QUALIFIER: classification
QUALIFIER: genetics
AUTHOR: F Azuaje F
AFFILIATION: Artificial Intelligence Group and Centre for Health Informatics, Trinity College, Dublin, Ireland.
PUBTYPE: Journal Article
JOURNALTITLE: IEEE transactions on bio-medical engineering.
COUNTRY: United States
TITLE: A computational neural approach to support the discovery of gene function and classes of cancer.
PUBDATE: 20010301
Advances in molecular classification of tumours may play a central role in cancer treatment. Here, a novel approach to genome expression pattern interpretation is described and applied to the recognition of B-cell malignancies as a test set. Using cDNA microarrays data generated by a previous study, a neural network model known as simplified fuzzy ARTMAP is able to identify normal and diffuse large B-cell lymphoma (DLBCL) patients. Furthermore, it discovers the distinction between patients with molecularly distinct forms of DLBCL without previous knowledge of those subtypes.

7. DOCID:27984 SCORE: 0.00314914074348814
DOCNO: 10839530
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: S Kersten S
AUTHOR: B Desvergne B
AUTHOR: W Wahli W
AFFILIATION: Institut de Biologie Animale, Université de Lausanne, Switzerland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature.
COUNTRY: ENGLAND
TITLE: Roles of PPARs in health and disease.
PUBDATE: 20000501
In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in these diseases. This, together with the fact that PPAR activity can be modulated by drugs such as thiazolidinediones and fibrates, has instigated a huge research effort into PPARs. Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.

8. DOCID:27495 SCORE: 0.00312369572479224
DOCNO: 10556014
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mesentery
QUALIFIER: surgery
QUALIFIER: adverse effects
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: M Pocard M
AUTHOR: J C Vaillant JC
AUTHOR: S Fritsch S
AUTHOR: M Aoudjhane M
AUTHOR: A Najman A
AUTHOR: R Parc R
AFFILIATION: Department of Surgery, Saint-Antoine University Hospital, Paris, France.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
COUNTRY: ENGLAND
TITLE: Possible first report of distant peritoneal metastases from a nodal mesenteric lymphoma after laparoscopic inguinal hernia repair.
PUBDATE: 19991201
Laparoscopic surgery has gained wide acceptance. However, there is still debate as to its role in assessment and staging of gastrointestinal malignancies(1)since it may promote dissemination of cancer cells.(2)We report the first case of a low-grade mesenteric nodal lymphoma for laparoscopic hernia repair, complicated by distant implants both on the peritoneum and wall mesh.

9. DOCID:27527 SCORE: 0.00309303600686064
DOCNO: 11859716
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, BRCA1
DESCRIPTOR: Mutation
QUALIFIER: genetics
AUTHOR: C Lai C
AUTHOR: Z Jiang Z
AUTHOR: S Song S
AFFILIATION: Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: China
TITLE: [Mutation BRCA1 gene in 186 breast cancer patients]
PUBDATE: 20011101
OBJECTIVE: To analysis the mutation of BRCA1 gene in 186 breast cancer patients. METHODS: Polymerase chain reaction-single stranded conformational polymorphism (PCR-SSCP) and sequential were used in this analysis. RESULTS: 13/186 of patients showed mutation which comprised 7% of the total number of patients. In 8 patients, the mutation was observed in the intron splicing region and in 5 patients, the mutation was on the exon. CONCLUSION: Mutation analysis of BRCA1 gene is helpful in the determination of developmental potential, early diagnosis and gene therapy for breast cancer.

10. DOCID:27208 SCORE: 0.00302741904796086
DOCNO: 9798105
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: pathology
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: pathology
AUTHOR: C Camisa C
AUTHOR: F G Hamaty FG
AUTHOR: J D Gay JD
AFFILIATION: Department of Dermatology, Cleveland Clinic Foundation, Ohio 44195, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cutis; cutaneous medicine for the practitioner.
COUNTRY: UNITED STATES
TITLE: Squamous cell carcinoma of the tongue arising in lichen planus: a case report and review of the literature.
PUBDATE: 19981001
Lichen planus is a relatively common inflammatory disorder of unknown cause that affects the skin and mucosal surfaces. The relationship of oral lichen planus to oral squamous cell carcinoma is a matter of concern and debate. We present a case of squamous cell carcinoma of the dorsal surface of the tongue that arose in a previously biopsy-confirmed area of lichen planus. The literature on the development of oral cancer in patients with lichen planus is reviewed.

11. DOCID:26181 SCORE: 0.0030088534834334
DOCNO: 11030041
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fanconi Anemia
AUTHOR: M H Freedman MH
AFFILIATION: University of Toronto, Faculty of Medicine, Hospital for Sick Children, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Baillière's best practice & research. Clinical haematology.
COUNTRY: ENGLAND
TITLE: Diamond-Blackfan anaemia.
PUBDATE: 20000901
Diamond-Blackfan anaemia (DBA) has had an intellectual allure for decades for clinical and experimental haematologists. The syndrome has a haematological phenotype of early-onset red-cell aplasia but is coupled with a baffling array of pleiotropy. There is discordance with modes of inheritance, physical anomalies, erythropoietic response to corticosteroid therapy, spontaneous 'remissions', and evolution to malignant myeloid transformation and to cancer. The recent discovery of two genes associated with DBA is the entry point for explaining the diversity of the phenotype and for understanding the molecular basis of the syndrome.

12. DOCID:26165 SCORE: 0.00300885182976448
DOCNO: 9873556
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: analogs & derivatives
AUTHOR: P Arya P
AUTHOR: N Alibhai N
AUTHOR: H Qin H
AUTHOR: G W Burton GW
AUTHOR: G Batist G
AUTHOR: S X You SX
AUTHOR: M A Alaoui-Jamali MA
AFFILIATION: Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry letters.
COUNTRY: ENGLAND
TITLE: Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells.
PUBDATE: 19980901
Analogs of alpha-tocopherol (vitamin E; compounds 3-9) have been synthesized and tested for their antiproliferative activity using the human breast cancer cell line, MCF7. Compounds 6-9 were synthesized from a common symthom, rac-Trolox (14) and are soluble/miscible at physiological pH. Compounds 4, 8, and 9 were found to have antiproliferative activity at micromolar concentrations.

13. DOCID:24874 SCORE: 0.0029682425942728
DOCNO: 10340036
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: G R Mundy GR
AFFILIATION: Division of Endocrinology and Metabolism, University of Texas Health Science Center at San Antonio, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hospital practice (1995)
COUNTRY: UNITED STATES
TITLE: Bisphosphonates as cancer drugs.
PUBDATE: 19990501
Bone appears to act like fertilizer for many tumors, including myeloma and metastatic breast cancer. The explanation must lie in interactions between tumor cells and the bone-tissue microenvironment. At this level, too, must lie the explanation of how bisphosphonates address not only cancer osteolysis but also the tumor burden. By inhibiting osteoclasts, the drugs may block a cancer-related vicious cycle.

14. DOCID:26710 SCORE: 0.00294183743496858
DOCNO: 9548660
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: K Oomi K
AUTHOR: M Amano M
AFFILIATION: Office of International Cooperation, Minister's Secretariat, Ministry of Health and Welfare, Chiyoda, Tokyo, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pancreas.
COUNTRY: UNITED STATES
TITLE: The epidemiology of pancreatic diseases in Japan.
PUBDATE: 19980401
We reviewed the trends and death rates of pancreatic cancer and pancreatitis in Japan over the past four decades. It is a disturbing fact that the death rate due to pancreatic cancer is rising, parallel to that of lung cancer and colon cancer and that it is affecting primarily the elderly 65 years and older in both sexes. The cause of this increase is partially attributable to improvements in the diagnosis, changes in life-style, and smoking. The death rate due to chronic and acute pancreatitis has remained constant during the past four decades.