0. DOCID:19801 SCORE: 0.00583465533009774
DOCNO: 1561266
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammaplasty
QUALIFIER: radiotherapy
AUTHOR: N Handel N
AUTHOR: B Lewinsky B
AUTHOR: J R Waisman JR
AFFILIATION: Breast Center, Van Nuys, Calif. 91405.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Plastic and reconstructive surgery.
COUNTRY: UNITED STATES
TITLE: Reduction mammaplasty following radiation therapy for breast cancer.
PUBDATE: 19920501
This report describes an unusual case in which reduction mammaplasty was performed following radiation therapy for breast cancer. While healing was significantly prolonged (compared with the nonirradiated contralateral breast), the final result was satisfactory from both the functional and the aesthetic standpoint. Women with prior radiation therapy may be considered candidates for reduction mammaplasty. Patients should be warned of the increased risks of wound complications, the likelihood of delayed healing, and the possibility of pigmentation changes in the grafted nipple-areola complex. We elected to transpose the nipple as a full-thickness graft, but consideration also might be given to use of an inferiorly based pedicle flap.

1. DOCID:17273 SCORE: 0.00346216414357179
DOCNO: 1344668
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: pathogenicity
AUTHOR: J V Solnick JV
AUTHOR: L S Tompkins LS
AFFILIATION: Department of Medicine, Stanford University School of Medicine, California 94305.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Infectious agents and disease.
COUNTRY: UNITED STATES
TITLE: Helicobacter pylori and gastroduodenal disease: pathogenesis and host-parasite interaction.
PUBDATE: 19921201
Helicobacter pylori has been shown to be the cause of chronic active gastritis and the evidence that it is involved in the development of peptic ulcer disease and gastric cancer is compelling. Narrow host range, tissue specificity, and chronic inflammation are hallmarks of infection. The study of virulence determinants has just begun but it seems likely that urease, adhesins, cytotoxins, and mediators of inflammation will prove to be important.

2. DOCID:19018 SCORE: 0.00330100897830613
DOCNO: 8464136
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genetic Counseling
DESCRIPTOR: Human Genome Project
QUALIFIER: genetics
AUTHOR: D L Breo DL
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Altered fates--counseling families with inherited breast cancer.
PUBDATE: 19930401
Breo profiles Barbara Weber, M.D., and Francis Collins, M.D., of the University of Michigan School of Medicine's breast cancer clinic, and their work isolating and identifying genetic markers for the gene that means an 85% lifetime risk of developing breast cancer, as well as a significantly higher risk of ovarian cancer. Their discovery is expected to revolutionize women's health care and to present society with daunting economic, ethical, and counseling issues. [Collins discovered the genes that cause cystic fibrosis, neurofibromatosis, and Huntington's disease. He was named director of the National Center for Human Genome Research at the National Institutes of Health in April 1993].

3. DOCID:17407 SCORE: 0.00323850996723124
DOCNO: 1463995
AUTHOR: F De Waard F
AFFILIATION: Department of Epidemiology, University of Utrecht, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
COUNTRY: ENGLAND
TITLE: Preventive intervention in breast cancer, but when?
PUBDATE: 19921001
After an introductory note on primary preventive intervention of breast cancer during adulthood, the author defends and extends a hypothesis that relates most of the known risk factors for this disease to the development of preneoplastic lesions in the breast. If changes in lifestyle concerning nutritional and/or reproductive risk factors during puberty and adolescence would turn out to be unacceptable socially, an alternative approach might be found in chemoprevention based on cell differentiation.

4. DOCID:17920 SCORE: 0.00300731137535204
DOCNO: 8237741
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinoma, Basal Cell
DESCRIPTOR: Skin Neoplasms
AUTHOR: A S Kuflik AS
AUTHOR: C K Janniger CK
AFFILIATION: North Shore University Hospital, Manhasset, New York.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American family physician.
COUNTRY: UNITED STATES
TITLE: Basal cell carcinoma.
PUBDATE: 19931101
Fair-skinned persons who have had significant exposure to the sun are at greatest risk for basal cell carcinoma. Clinically, basal cell carcinomas include numerous nodular and flat types. The lesions of basal cell carcinoma are usually asymptomatic until enlargement, bleeding or invasion of underlying tissue occurs. Metastasis is rare. A biopsy should be obtained before destructive treatment is carried out. Surgical excision, curettage and electrodesiccation or cryosurgery are acceptable procedures for removal of most lesions. Periodic follow-up is necessary to screen for new or recurrent skin cancer.

5. DOCID:19268 SCORE: 0.00298116076214345
DOCNO: 2381055
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: K Izumiyama K
AUTHOR: Y Imajo Y
AUTHOR: J Hiratsuka J
AUTHOR: S Nishishita S
AUTHOR: Y Furukawa Y
AUTHOR: M Suzuki M
AUTHOR: H Tanaka H
AFFILIATION: Dept. of Radiation Oncology, Kawasaki Medical School.
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Radiotherapy of prostatic cancer]
PUBDATE: 19900801
From 1976 to 1988, 33 patients with a prostatic cancer were treated with radiotherapy at Kawasaki Medical School. The age of these patients ranged from 45 to 82 with the average being 69 years. The actuarial 5 year survival rates for patients in stages B (n = 6), C (n = 12), D1 (n = 5), or D2 (n = 10) were 100%, 65%, 50%, and 40%, respectively. The for those with an adenocarcinoma that was well differentiated (n = 5), moderately differentiated (n = 13), or poorly differentiated (n = 15) was (were?) 100%, 58%, and 41%, respectively.

6. DOCID:18197 SCORE: 0.00288325596438713
DOCNO: 1765687
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: analysis
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: pathology
AUTHOR: M S Amer MS
AUTHOR: H A Sedky HA
AUTHOR: A A Fekry AA
AUTHOR: A A Sabry AA
AFFILIATION: Department of General Medicine, Faculty of Medicine, Ain-Shams University, Abbassia, Cairo.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Egyptian Society of Parasitology.
COUNTRY: EGYPT
TITLE: Study of C-reactive protein in bilharziasis and malignancy as causes of ascites.
PUBDATE: 19911201
C-reactive protein titre was estimated in serum and ascitic fluid in 23 patients, 12 with cancer stomach accompanied by liver metastatases and 11 with bilharzial liver fibrosis. The results showed no statistically significant differences between the titre in serum and ascitic fluid in the group of cancer with mean of serum/ascitic level ratio 1.3, while in bilharzial group there was significant difference with ratio mean 6.3.

7. DOCID:18868 SCORE: 0.00264565767701044
DOCNO: 1386238
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: contraindications
QUALIFIER: chemically induced
QUALIFIER: therapeutic use
AUTHOR: W T Creasman WT
AFFILIATION: Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Recommendations regarding estrogen replacement therapy after treatment of endometrial cancer.
PUBDATE: 19920701
A history of endometrial cancer has long been considered a contraindication to estrogen replacement therapy. Yet women with such a history, like other women when postmenopausal, often suffer vasomotor symptoms that could easily be relieved with estrogen. In fact there is no good evidence that estrogen significantly increases the risk of recurrence after treatment for endometrial cancer. Some studies now suggest that estrogen plus a progestin may actually decrease the risk of cancer recurrence in these patients. The benefits of estrogen in preventing osteoporosis and cardiovascular disease in postmenopausal women is substantial.

8. DOCID:18475 SCORE: 0.00252397996439495
DOCNO: 8322113
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: J C Angulo JC
AUTHOR: J I Lopez JI
AUTHOR: N Flores N
AFFILIATION: Department of Urology, Santo Hospital Civil de Bilbao, Spain.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Minerva urologica e nefrologica = The Italian journal of urology and nephrology.
COUNTRY: ITALY
TITLE: Urologic malignancies and progressive systemic sclerosis.
PUBDATE: 19930301
We present two cases of urologic malignancies, transitional cell carcinoma of the bladder and renal cell carcinoma respectively, closely associated to progressive systemic sclerosis. The relationship between such neoplasms and immune disorders is thereof reviewed. Cancer may develop in a context of diminished immunological surveillance. Conversely, autoimmunity can also be secondary to neoplasia and somehow understood as paraneoplastic. Anyway, the cases here reported could be regarded as unusual associations that may reproduce the still unclear connections between immunity and neoplasia.

9. DOCID:19599 SCORE: 0.00251423417470152
DOCNO: 1744717
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, Emission-Computed, Single-Photon
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
QUALIFIER: diagnostic use
AUTHOR: N Tonami N
AUTHOR: K Yokoyama K
AUTHOR: J Taki J
AUTHOR: K Hisada K
AUTHOR: Y Watanabe Y
AUTHOR: T Takashima T
AUTHOR: A Nonomura A
AFFILIATION: Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
COUNTRY: UNITED STATES
TITLE: Thallium-201 SPECT depicts radiologically occult lung cancer.
PUBDATE: 19911201
A case of radiologically occult lung cancer is presented in which 201TI SPECT of the chest clearly delineated the involved area. A 66-yr-old man underwent chest screening examinations for asymptomatic smokers and presented a positive sputum cytology for lung cancer. Conventional chest x-ray, tomography of computed radiography, and a CT scan failed to locate the lesion in the lung. Thallium-201 SPECT, however, was successful in depicting the area of the involvement.

10. DOCID:18964 SCORE: 0.00243683542596645
DOCNO: 1750402
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: etiology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: L R Boglioli LR
AUTHOR: M L Taff ML
AUTHOR: W U Spitz WU
AUTHOR: R E Gordon RE
AFFILIATION: Wayne County Medical Examiner's Office, Detroit, Michigan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of forensic medicine and pathology : official publication of the National Association of Medical Examiners.
COUNTRY: UNITED STATES
TITLE: Sudden death of an elderly man with multiple malignant neoplasms.
PUBDATE: 19910901
With the lengthening of the human life span, cancer has become an increasingly important medical problem for the aged. It is not uncommon to find multiple primary neoplasms in elderly individuals. We recently investigated the death of an elderly man who had died suddenly and had three incidental malignant neoplasms, including a pleural mesothelioma, first diagnosed at autopsy. The importance of performing a complete medicolegal autopsy for epidemiological and statistical purposes is emphasized.

11. DOCID:18502 SCORE: 0.00242773022872666
DOCNO: 1806030
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Damage
QUALIFIER: pharmacology
AUTHOR: M Kubota M
AFFILIATION: Kyoto University Hospital, Department of Pediatrics, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: Generation of DNA damage by anti-neoplastic agents.
PUBDATE: 19911201
DNA has been one of the major targets of cancer chemotherapy. A variety of anti-neoplastic agents can cause different types of DNA lesions, including base alterations, single- or double-strand DNA breaks, DNA-DNA cross-links and DNA-protein cross-links. The exact processes by which these DNA lesions lead to cell death remain uncertain. However, pivotal roles of intracellular Ca2+ ion mobilization, activation of Ca(2+)-Mg(2+)-dependent endonuclease and induction of several oncogenes have been proposed. Understanding the mechanism of DNA damage and subsequent cell death will be important to improve the efficacy of cancer chemotherapy.

12. DOCID:18018 SCORE: 0.00236171399630358
DOCNO: 2361052
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: C Heredia C
AUTHOR: A Pedro A
AUTHOR: T Ribalta T
AUTHOR: J M Mercader JM
AUTHOR: F Graus F
AFFILIATION: Servicios de Neurología, Hospital Clínic i Provincial, Barcelona.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Neurología (Barcelona, Spain)
COUNTRY: SPAIN
TITLE: [Spinal cord metastasis of carcinoma of the lung: evaluation of magnetic resonance and computed tomography in its diagnosis]
PUBDATE: 19900401
A patient with lung adenocarcinoma had progressive myelopathy. Computed tomography of spinal cord with intravenous contrast and magnetic resonance scan were negative. At autopsy, a spinal cord metastasis was found. In patients with cancer and clinical suspicion of spinal cord metastasis, palliative treatment with radiotherapy is indicated in spite of negative radiological investigations, so as to prevent the progression of myelopathy.

13. DOCID:19835 SCORE: 0.00235221375037692
DOCNO: 2214607
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
AUTHOR: M Schleuning M
AUTHOR: R Munker R
AFFILIATION: Medizinische Klinik III, Universitätsklinikum Grosshadern, München.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Klinische Wochenschrift.
COUNTRY: GERMANY
TITLE: Tumor necrosis factor: an update on basic research and clinical applications.
PUBDATE: 19900901
Tumor necrosis factor is one of the recently cloned cytokines with pleiotropic effects on normal and malignant cells. Our knowledge about the scope of cells producing or responding to this cytokine has enormously expanded. In critically ill patients with acute hepatic failure, acute graft-versus-host disease, or septic shock, circulating tumor necrosis factor can be measured and useful prognostic correlations do exist. Despite promising in vitro results, early clinical trials with tumor necrosis factor for the treatment of cancer have failed thus far to reveal major antineoplastic activity in cancer patients. However, more clinical trials are necessary, since different routes of administration and combinations with other cytokines may lead to favorable results.

14. DOCID:17054 SCORE: 0.00230361561661486
DOCNO: 1583283
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nursing Diagnosis
QUALIFIER: diagnosis
AUTHOR: J Smoller J
AUTHOR: B R Smoller BR
PUBTYPE: Journal Article
JOURNALTITLE: Journal of gerontological nursing.
COUNTRY: UNITED STATES
TITLE: Skin malignancies in the elderly. Diagnosable, treatable, and potentially curable.
PUBDATE: 19920501
Cutaneous malignancies are the most common tumors seen in the elderly population. They are often easily diagnosed while still in an early and potentially curable state. Basal cell carcinoma is the most frequently seen malignant neoplasm, followed by squamous cell carcinoma and malignant melanoma. Correct diagnosis depends on complete physical examination of the skin by health-care personnel who have been trained to recognize these lesions and appropriate referral to dermatologists or other experts in skin cancer.