0. DOCID:3553 SCORE: 0.00210351595839967
DOCNO: 817789
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunoglobulins
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Ameis A
AUTHOR: H S Ko HS
AUTHOR: W Pruzanski W
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: M components-a review of 1242 cases.
PUBDATE: 19760501
Among 1242 patients referred for immunologic investigation 1255 M components were detected in the serum. Of these patients 50.9% had multiple myeloma, 18.1% had nonmyelomatous malignant diseases such as macroglobulinemia, lymphoma, leukemia or cancer, 4.3% had connective tissue diseases, 2.5% had primary generalized amyloidosis (PGA) and the rest had various "benign" conditions. Whereas IgG was the commonest M component in multiple myeloma, connective tissue diseases and the other benign conditions, IgM was the commonest M component in lymphoma and leukemia; Bence Jones proteinemia was most frequently observed in PGA. The ratio of kappa to lambda light chains varied from 1.7:1 in IgG myeloma to 1:9 in IgD myeloma, and was 1:2.1 in PGA. Bence Jones protein was detected in 422 (66%) of 640 urine samples tested, the prevalence ranging from more than 70% in multiple myeloma and PGA to as low as 36% in various benign conditions. It is evident that the class and type of M components and the presence of Bence Jones proteinuria have no definite significance with regard to the diagnosis. Therefore, thorough investigation and follow-up at regular intervals are required when M components are detected.

1. DOCID:2114 SCORE: 0.000866227059661837
DOCNO: 999351
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: P H Sugarbaker PH
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Carcinoembryonic antigen (CEA) assays in obstructive colorectal cancer.
PUBDATE: 19761201
Four of 40 patients with resectable colon or rectal cancer had tumors causing acute large bowel obstruction with colonic dilatation; all 4 patients had preoperative CEA titers above 10 ng/ml with a mean of 28 ng/ml. Thirty-six cancer patients without acute colon obstruction had a mean CEA titer of 4.5 ng/ml; only 6 of 36 patients had circulating CEA titers 10 ng/ml or greater. This suggested that pre-treatment CEA titers in patients with obstructing cancer are unusually high. Multiple CEA assays were performed on two of the 4 patients with colonic obstruction before and after bowel decompressive procedures and prior to their definitive treatment. Relief of obstruction alone produces marked reduction in circulating CEA; this suggested that not only the extent of disease but also the pathophysiological changes associated with obstruction influenced circulating CEA levels.

2. DOCID:2213 SCORE: 0.000865211581410529
DOCNO: 1248904
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: B Armstrong B
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Recent trends in breast-cancer incidence and mortality in relation to changes in possible risk factors.
PUBDATE: 19760201
Breast cancer incidence and mortality in England and Wales and the United States increased between 1950 and 1973, mainly in women aged between 45 and 64 years. These increases appeared to be partly cohort-specific, beginning with cohorts born around 1899, and partly cross-sectional, beginning in the mid-1960s. In both countries, cohort-specific decreases in fertility paralleled the cohort-specific increases in breast cancer rates and may, at least in part, have been responsible for them. Changes in other factors, such as age at menarche and menopause, use of rauwolfia derivatives and oestrogens, consumption of fat and meat, and breast cancer treatment were considered in relation to the cross-sectional increases in breast cancer rates. On the evidence available, it was not certain that any of these could explain the breast cancer increases.

3. DOCID:3708 SCORE: 0.000863850711013577
DOCNO: 1009004
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mitosis
QUALIFIER: physiopathology
AUTHOR: S Gelfant S
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of dermatology.
COUNTRY: ENGLAND
TITLE: The cell cycle in psoriasis: a reappraisal.
PUBDATE: 19761201
The current belief that the clinical manifestations of psoriasis (excessive scaling) are due to a twelve-fold speeding up or shortening of the cell division cycle time of the germinative cells in psoriatic epidermis (from 457 to 37-5 h) is shown to be incorrect. A new concept is introduced--that the germinative layer in human epidermis is composed of not one, but three separate and distinct populations of epidermal cells. First, there are cycling cells which are actively moving through the cell cycle. Then there are two categories of non-cycling cells (blocked in the G1 or the G2 periods of the cell cycle) which are capable of moving into the proliferative pool upon specific stimulation. Thus, increased epidermal cell proliferation in active lesions of psoriasis would be brought about mainly by a recruitment or a relase of the two categories of non-cycling cells. The idea that germinative epidermal cells are primarily non-cycling, leads to the suggestion of focusing attention on non-cycling cells (rather than on cycling cells) for the control and treatment of psoriasis. It might be worthwhile considering treating psoriatic patients during periods of clinical remission--with factors to keep the germinative cells in the non-cycling state--rather than during psoriatic flare up--with cancer chemotherapy drugs.

4. DOCID:1335 SCORE: 0.000863406587734026
DOCNO: 609875
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: V Lemaire V
AUTHOR: J Gueris J
AUTHOR: M Cassou M
AUTHOR: A Ryckewaert A
PUBTYPE: Journal Article
JOURNALTITLE: Revue du rhumatisme et des maladies ostéo-articulaires.
COUNTRY: FRANCE
TITLE: [Radioimmunologic determination of plasma parathormone in hypercalcemia caused by cancer with osseous metastases]
PUBDATE: 19771201
The plasma parathormone was measured by radioimmunological determination in 23 cases of cancer with bone metastases, 8 of mammary origin. In 11 cases the plasma parathormone (iPTH) was less than 4 ng/ml (lower normal limit), as might be expected in view of the hypercalcemia. In 12 cases the iPTH was higher than 4 ng/ml, in 8 of these higher than 8 ng/ml (upper normal limit). These results are suggestive of the role of a substance analogous to parathormone in the genesis of the hypercalcaemia and peritumoral bone resorption of bone metastases of solid tumors.

5. DOCID:2676 SCORE: 0.000556914430527392
DOCNO: 1096824
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Food Microbiology
DESCRIPTOR: Shellfish
QUALIFIER: isolation & purification
AUTHOR: J S Lee JS
AUTHOR: D K Preifer DK
PUBTYPE: Journal Article
JOURNALTITLE: Applied microbiology.
COUNTRY: UNITED STATES
TITLE: Microbiological characteristics of Dungeness crab (Cancer magister).
PUBDATE: 19750701
Aerobic, heterotropic microorganisms of Dungeness crab (Cancer magister) were isolated from raw crab, cooked crab, crab meats obtained during commercial processing, and from retail crab meat samples. Each microbial isolate was then identified to the genus level employing the revised replica plating procedure. Microbial groups most commonly isolated from crab meat were, in the order of predominance, Moraxella, Pseudomonas, Acinetobacter, Arthrobacter, Micrococcus, Flavobacterium-Cytophaga, and Bacillus sp. Proteus, Staphylococcus, yeasts, Vibrio, and Lactobacillus sp. were found less frequetly in some samples. Distribution patterns of microbial flora in crab meat revealed the presence of three classes of microorganisms. Microorganisms that originated from the raw crab and gained predominance by growth during refrigerated storage were Moraxella, Pseudomonas, Acinetobacter, and Flavobacterium-Cytophaga sp. Those that originated from the crab but did not grow in meat were Arthrobacter and Bacillus sp. Micrococcus, Staphylococcus, and Proteus sp. were introduced during processing, but they did not grow in the refrigerated crab meat.

6. DOCID:2929 SCORE: 0.000556856494941906
DOCNO: 1185059
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
AUTHOR: R Parker R
AUTHOR: S Alexander S
AUTHOR: O H Shaheen OH
AUTHOR: P Parkes P
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: ENGLAND
TITLE: On the immunology of head and neck cancer--a prognostic index. Preliminary communication.
PUBDATE: 19750701
A pilot study on the immune response in patients with carcinoma of the head and neck has been made. The clinical behaviour of such neoplasia is reasoned as being partly determined by the immunological response. If prognosis is related to competence of the immune system then this parameter should be assessed. DNCB (di-nitro-chloro-benzene) skin sensitization and serial lymphocyte transformation studies were performed on all patients whose progress was studied for at least two years. On analysing the results of survival, patients could be divided into two groups--DNCB positive and DNCB negative. The negative patients could be further subdivided; those with a lymphocyte stimulation index of over fifteen; and those beneath this level--the former had a much better prognosis than the latter. Also, such cancer patients were shown to have both cellular and serum factors causing depression of lymphocyte transformation. In the light of all findings, a future programme of investigation is proposed.

7. DOCID:124 SCORE: 0.000556632002578305
DOCNO: 921595
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: A A Clairmont AA
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Versatile Karapandzic lip reconstruction.
PUBDATE: 19771101
The Karapandzic reconstruction of lip defects is a versatile, anatomically sound, physiologically and cosmetically acceptable method that should be known to all surgeons who excise lip cancers. Because these myocutaneous advancement flaps have intact nerve and vascular supply, the physiologic functions for speech and managing food are quickly restored, in stark contrast to many other major lip reconstruction techniques.

8. DOCID:877 SCORE: 0.000556561476171104
DOCNO: 615804
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cholangiography
DESCRIPTOR: Endoscopy
QUALIFIER: radiography
AUTHOR: J A Gregg JA
AUTHOR: H F Gramm HF
AUTHOR: M E Clouse ME
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gastrointestinal radiology.
COUNTRY: UNITED STATES
TITLE: Problems in the diagnosis of pancreatic carcinoma by endoscopic retrograde cholangiopancreatography.
PUBDATE: 19770801
Diagnostic problems occurred in five out of 55 patients undergoing endoscopic retrograde cholangiopancreatography who subsequently proved to have carcinoma of the pancreas. In one patient the pancreatic duct was normal, two had non-specific ductal abnormalities, one had pancreas divisum, and one had ductal ectasia. Two patients with non-specific changes on retrograde pancreatography had evidence of tumor on their retrograde cholangiogram. Two patients had ductal obstruction simulating pancreatic cancer, in one due to compression by the thoracic spine, in the other by inflammatory changes.

9. DOCID:988 SCORE: 0.000556314051907659
DOCNO: 1263540
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: R G Vincent RG
AUTHOR: H Takita H
AUTHOR: W W Lane WW
AUTHOR: A C Gutierrez AC
AUTHOR: J W Pickren JW
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of thoracic and cardiovascular surgery.
COUNTRY: UNITED STATES
TITLE: Surgical therapy of lung cancer.
PUBDATE: 19760401
A total of 1,615 patients with a confirmed diagnosis of lung cancer were treated at Roswell Park Memorial Institute between 1963 and 1974. Particular emphasis was given in this review to the 295 patients that underwent surgical resection of their primary lung lesion. Factors such as histology, type of resection, sex, age, staging, and degree of dissemination were considered possible influences on survival. The risks and benefits of intentional reductive or palliative surgery are considered along with the risk related to thoracotomies performed for diagnostic purposes.

10. DOCID:3844 SCORE: 0.000556134026251182
DOCNO: 1275587
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radionuclide Imaging
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: C G Thomas CG
AUTHOR: J A Buckwalter JA
AUTHOR: E V Staab EV
AUTHOR: C Y Kerr CY
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Evaluation of dominant thyroid masses.
PUBDATE: 19760501
Controversy exists concerning the management of solitary thryoid nodules because of conflicting information converning the high clinical incidence of thyroid nodules, the varying incidence of cancer reported in those surgically excised and the infrequency of death from thyroid cancer. During the past several years, a plan for evaluating patients with dominant thyroid masses has evolved. The objective is to avoid unnecessary operations by identifying patients with a high risk of cancer. The criteria which are used are the age and sex of the patient, the duration of the mass, 125I or 99mTc scans, 75Selenomethionine scans, B-mode ultrasonography and the response of the mass to suppressive therapy. This is a report of the findings in 222 patients who have been studied employing this approach. Thirty per cent of the patients were operated upon. Forty per cent had neoplasms (well differentiated cancer--28.8%, adenoma--12.1%), 47.0%--nodular goiter, 6.1% cysts, and 6.1% chronic thyroiditis. The incidence of cancer in the 222 patients was 8.6% and adenoma 3.6%. Patients at greatest risk of having cancer are those with solid nonfunctioning nodules which fail to regress with suppressive therapy. This study indicates that the approach described above is effective in selecting for surgical excision those individuals at greatest risk of having thyroid cancer.

11. DOCID:1990 SCORE: 0.000555880766431004
DOCNO: 912658
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: M A Benarde MA
AUTHOR: W Weiss W
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: A cohort analysis of pancreatic cancer, 1939--1969.
PUBDATE: 19770301
Pancreatic cancer mortality in the United States was examined by cohort analysis for the period of 1939 to 1969. Birth cohorts at 5-year intervals were studied. White males and non-whites of both sexes showed a shift of the cohort mortality rate curves by age toward younger groups as birth cohorts went from 1870--1874 to 1900--1904. This shift disappeared in white males and diminished in non-whites of both sexes between the cohorts of 1890--1894 and 1900--1904. The shift in non-whites was larger than in white males so that although non-whites had lower rates than whites in earlier birth cohorts, their rates exceeded those of whites in the most recent cohort. In the search for environmental cause(s) of pancreatic cancer, exposure characteristics should be compatible with these observations.

12. DOCID:1172 SCORE: 0.000555599907132049
DOCNO: 274943
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: A J Woolcock AJ
AUTHOR: N Berend N
PUBTYPE: Journal Article
JOURNALTITLE: Australian and New Zealand journal of medicine.
COUNTRY: AUSTRALIA
TITLE: The effects of smoking on the lungs.
PUBDATE: 19771201
The literature relating to tobacco smoking has been reviewed and is discussed under a number of headings. The smoking habits of Australians and people of other countries, the constituents of tobacco smoke and the different types of tobacco are discussed. The effects of tobacco smoke on lung defences and and function are outlined and the evidence relating cigarette smoking to lung cancer in Australia, the UK and the USA is reviewed. The relationship between cigarette smoking and diseases which chronic air flow obstruction is outlined. Differences in smoking-related diseases in males and females and the effects of stopping smoking are included in the discussion.

13. DOCID:1461 SCORE: 0.00055549842142227
DOCNO: 1257737
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Family Planning Services
QUALIFIER: diagnosis
AUTHOR: T Hamilton T
AUTHOR: N B Loudon NB
AUTHOR: R J Prescott RJ
AUTHOR: M E Rankin ME
PUBTYPE: Journal Article
JOURNALTITLE: Scottish medical journal.
COUNTRY: SCOTLAND
TITLE: Detection of breast disease in a family planning association clinic.
PUBDATE: 19760101
The incidence and prevalence of disorders of the breast have been assessed in 13,456 women examined annually at a family planning clinic over 5 years. Screening for disorders of the breast was by clinical examination alone and abnormalities were detected in 1 of every 58 women attending the clinic and these were referred for hospital opinion: biopsy was required in 1 in 114. Only 12 cancers of the breast were detected and all of these in women over 35 years. It is suggested that the usual policy of examining the breasts of women taking oral contraceptive preparations should be restricted to those over 40 years.

14. DOCID:2563 SCORE: 0.000555051415084337
DOCNO: 860739
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: F M Muggia FM
AUTHOR: G Chia G
AUTHOR: L J Reed LJ
AUTHOR: S L Romney SL
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Doxorubicin-cyclophosphamide: effective chemotherapy for advanced endometrial adenocarcinoma.
PUBDATE: 19770601
Eight of 11 consecutive patients with metastatic endometrial adenocarcinoma completed more than one course of treatment with a doxorubicin-cyclophosphamide combination. Six of these patients improved, with three showing a complete remission of all disease manifestations and two experiencing an objective partial response (greater than 50 per cent tumor shrinkage). Median duration of all responses was 10 months, with three patients surviving more than one year. Review of patient characteristics suggests that, unlike progestin therapy, this new program is effective in the presence of poorly differentiated tumors and short progression-free intervals. Therefore, chemotherapy should probably supplement progestins in future clinical trials and should certainly be considered when hormone therapy fails in advanced endometrial cancer. Moreover, if the degree of efficacy reported herein is confirmed, it will justify clinical trials that include patients in earlier stages of disease.