0. DOCID:28606 SCORE: 0.000872642773510714
DOCNO: 12801816
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: Christine Théodore C
AFFILIATION: Institut Gustave-Roussy, 94806 Villejuif Cedex.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Cured of testicular cancer]
PUBDATE: 20030401
Nowadays, testicular cancer can be cured in more than 90 % of patients. Most patients we see now as "cured" of testicular cancer were treated either with chemotherapy or with radiotherapy. We detail the complete remission criteria and the follow-up procedure. We describe the long term toxicities of treatments, the risk of second cancer and the carryover of the disease and treatments on long term quality of life, sexuality and fertility.


1. DOCID:31388 SCORE: 0.000561464274014549
DOCNO: 15557797
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, BRCA1
DESCRIPTOR: Genes, BRCA2
DESCRIPTOR: Genetic Predisposition to Disease
DESCRIPTOR: Recombination, Genetic
QUALIFIER: genetics
AUTHOR: Ralph Scully R
AUTHOR: Anyong Xie A
AFFILIATION: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of mammary gland biology and neoplasia.
COUNTRY: United States
TITLE: BRCA1 and BRCA2 in breast cancer predisposition and recombination control.
PUBDATE: 20040701
Hereditary predisposition to breast and ovarian cancer is determined in large part by loss-of-function mutations in one of two genes, BRCA1 and BRCA2 . Early discoveries that the two genes function in the control of homologous recombination and the prevention of genomic instability have been strongly supported by subsequent work. Our aim here is to highlight new advances in the study of BRCA1 and BRCA2 , and to place these advances in the context of existing knowledge.


2. DOCID:26355 SCORE: 0.000561259366333859
DOCNO: 10098366
AUTHOR: L Saita L
AUTHOR: D Polastri D
AUTHOR: F De Conno F
AFFILIATION: Division of Pain Therapy and Palliative Care, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pain and symptom management.
COUNTRY: UNITED STATES
TITLE: Visual disturbances in advanced cancer patients: clinical observations.
PUBDATE: 19990301
Visual disturbances in advanced cancer patients are very rarely signaled, evaluated, or adequately treated. The main causes of sight disturbances are primary eye tumors, ocular metastases, and some paraneoplastic syndromes. Sight alteration can also be associated with asthenia, fatigue, anemia, and hypovitaminosis. These symptoms can be monocular or binocular, and their gravity and evolution can vary. Based on a survey of 156 patients, we estimate the prevalence of visual disturbances to be 12% in advanced cancer patients.


3. DOCID:26304 SCORE: 0.000561259366209126
DOCNO: 11099221
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: pharmacology
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
AUTHOR: N Hosokawa N
AUTHOR: H Naganawa H
AUTHOR: M Hamada M
AUTHOR: H Iinuma H
AUTHOR: T Takeuchi T
AUTHOR: K S Tsuchiya KS
AUTHOR: M Hori M
AFFILIATION: Institute of Microbial Chemistry, Tokyo, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of antibiotics.
COUNTRY: JAPAN
TITLE: New triene-ansamycins, thiazinotrienomycins F and G and a diene-ansamycin, benzoxazomycin.
PUBDATE: 20000901
New triene-ansamycins designated thiazinotrienomycins F (TT-F) and G (TT-G) and a new diene-ansamycin, benzoxazomycin, were isolated from a culture broth of Streptomyces sp. MJ672-m3 and their structures were elucidated by spectroscopic analyses. The Mean Graphs of TT-G suggests that the tumor growth inhibitory activities are almost as strong as TT-B, in respect of GI50 and TGI against several human cancer cell lines.


4. DOCID:26856 SCORE: 0.000561114907663694
DOCNO: 10765601
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: immunology
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: immunology
AUTHOR: W Kedzia W
AUTHOR: A Goździcka-Józefiak A
AUTHOR: H Kedzia H
AUTHOR: M Spaczyński M
AFFILIATION: I Katedry Ginekologii i Połoznictwa AM w Poznaniu.
PUBTYPE: Journal Article
JOURNALTITLE: Ginekologia polska.
COUNTRY: POLAND
TITLE: [Immunohistochemical examination oncogenic c-erb-b2, egf-r proteins and antioncogenic p53 protein in vulvar cancers HPV-16 positive and negative]
PUBDATE: 20000201
In vulvar cancers HPV 16 positive, HPV 16 negative, and vulvar and vaginal precancerous status (VIN, VAIN) immunohistochemical technik onko- and antioncogenic proteins were evaluated. The contrary correlation between HPV 16 presence and overexpression p53 were detected. It suggest the heterogenic etiology of these cancers. There was payed attention to high activity of virus replication and intensive virion production in VAIN. Nontreated vaginal lesion may make difficult to obtain a positive cervical HPV infection treatment.


5. DOCID:24911 SCORE: 0.000559017030932999
DOCNO: 9868550
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: H Lee H
AUTHOR: J Y Choi JY
AUTHOR: S I Lee SI
AUTHOR: S S Hong SS
AUTHOR: J Cho J
AUTHOR: Y H Kim YH
AFFILIATION: College of Pharmacy, Chungbuk National University, Cheongju, Korea.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of pharmacal research.
COUNTRY: KOREA
TITLE: Synthesis and in vitro cytotoxicity of 3- or 4-dialkylaminomethyl-1-azaanthraquinones.
PUBDATE: 19981201
Six 3-dialkylaminomethyl-1-azaanthraquinones and five 4-dialkylaminomethyl-1-azaanthraquinones were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines. The compounds retained much of their cytotoxic activity against the multi-drug-resistant cell line (KB-V-1) as shown by resistance index.


6. DOCID:24098 SCORE: 0.000557911349053753
DOCNO: 11883298
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: W Grzybowski W
AUTHOR: M Powolny M
AUTHOR: P Pietrzak P
AUTHOR: K Szafranko K
AFFILIATION: Oddziału Ginekologiczno-Połozniczego CSK MSWiA w Warszawie.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ginekologia polska.
COUNTRY: Poland
TITLE: [Early diagnosis of gynaecologic and breast cancers]
PUBDATE: 20011201
Gynaecologic malignant neoplasms are significant medical and social problem in Poland. The majority of Polish women suffer from breast, cervix, ovary and endometrial cancer. This paper shows common and new methods in early diagnosis of neoplasmic diseases.


7. DOCID:25679 SCORE: 0.000555750467655045
DOCNO: 10726186
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: F Regueiro F
AUTHOR: A Arnau A
AUTHOR: D Pérez D
AUTHOR: M A Cañizares MA
AUTHOR: P Martínez P
AUTHOR: A Cantó A
AFFILIATION: Servicio de Cirugía Torácica, Hospital General Universitario de Valencia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Archivos de bronconeumología.
COUNTRY: SPAIN
TITLE: [Pneumothorax as the clinical presentation of bronchogenic carcinoma. A report of 3 cases]
PUBDATE: 20000101
The association of pneumothorax and lung cancer is rare and diagnosis is complex in such cases. Clinical suspicion of cancer must be based on radiological findings and the existence of risk factors. We discuss the mechanisms involved in the development of pneumothorax in patients with lung cancer, the clinical significance of the association, and the recommended diagnostic approach and therapeutic guidelines.


8. DOCID:30156 SCORE: 0.000553290524519961
DOCNO: 15806096
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: toxicity
QUALIFIER: etiology
AUTHOR: Alistair J Lax AJ
AFFILIATION: Department of Microbiology, Dental Institute, King's College London, Floor 28 Guy's Tower, Guy's Hospital, London SE1 9RT, UK. alistair.lax@kcl.ac.uk
PUBTYPE: Journal Article
JOURNALTITLE: Nature reviews. Microbiology.
COUNTRY: England
TITLE: Opinion: Bacterial toxins and cancer--a case to answer?
PUBDATE: 20050401
Since the discovery that Helicobacter pylori infection leads to gastric cancer, other chronic bacterial infections have been shown to cause cancer. The bacterial and host molecular mechanisms remain unclear. However, many bacteria that cause persistent infections produce toxins that specifically disrupt cellular signalling to perturb the regulation of cell growth or to induce inflammation. Other bacterial toxins directly damage DNA. Such toxins mimic carcinogens and tumour promoters and might represent a paradigm for bacterially induced carcinogenesis.


9. DOCID:30968 SCORE: 0.000551996775779471
DOCNO: 14605452
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: J Lehmann J
AUTHOR: M Retz M
AUTHOR: M Hack M
AUTHOR: S Siemer S
AUTHOR: M Stöckle M
AFFILIATION: Klinik für Urologie und Kinderurologie, Universität des Saarlandes, Homburg, Deutschland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Onkologie.
COUNTRY: Switzerland
TITLE: [Systemic chemotherapy for transitional cell carcinoma of the urothelium]
PUBDATE: 20031001
Moderate activity of systemic chemotherapy for advanced urothelial cancer has been reported for more than 30 years. Only with the advent of potent combination therapy in the mid eighties of the past century clinically significant response rates as well as prolonged survival has been documented. This review summarizes seven Phase-III trials of systemic chemotherapy for advanced urothelial carcinoma as well as results from adjuvant and neoadjuvant Phase-III trials for muscle-invasive bladder cancer including the most recent reports.


10. DOCID:27671 SCORE: 0.000517137198855093
DOCNO: 11262861
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: immunology
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: S Muthuswamy S
AUTHOR: A S Raste AS
AFFILIATION: Biochemistry Department, Tata Memorial Hospital, Annexe Bld., 6th Floor, Dr E Borges Marg, Parel, Mumbai-400 012.
PUBTYPE: Evaluation Studies
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of medical sciences.
COUNTRY: India
TITLE: Clinical significance of cancer antigen, CA 15.3 in breast cancer.
PUBDATE: 20001001
Breast cancer is the leading type of cancer in women. It is commonly accepted that the earlier the detection of the disease, the better the prognosis. Therefore, the present study was undertaken to evaluate the clinical significance of tumour marker CA 15-3 along with Carcinoembryonic antigen (CEA) in India women population. Tumour marker CA 15-3 concentrations reflected the tumour burden in a better way than CEA. However, the use of CEA as an additional conventional marker improved the Clinical efficiency of the marker CA 15-3.


11. DOCID:30791 SCORE: 0.000249640211425172
DOCNO: 16360471
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
QUALIFIER: methods
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: surgery
AUTHOR: Guilherme C Lima GC
AUTHOR: Sahar Kohanim S
AUTHOR: Soroush Rais-Bahrami S
AUTHOR: Louis R Kavoussi LR
AFFILIATION: James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA. guilolima@terra.com.br
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: United States
TITLE: Laparoscopic retroperitoneal lymph node dissection after prior open retroperitoneal lymphadenectomy and chemotherapy.
PUBDATE: 20051201
Laparoscopic retroperitoneal lymphadenectomy for testicular cancer is a challenging surgical procedure. Several factors can increase the difficulty, including prior chemotherapy or open surgery. We present a case of a laparoscopic "redo" postchemotherapy nodal dissection to treat a residual retroperitoneal mass in a patient with non-seminomatous germ cell tumor. This approach allowed rapid recovery, and at 2.5 years after surgery no evidence of tumor recurrence was seen.


12. DOCID:31340 SCORE: 0.000249640210957148
DOCNO: 16521433
OWNER: NLM
STATUS: In-Process
AUTHOR: Ryszard Zasławski R
AUTHOR: Paweł Surowiak P
AUTHOR: Maciej Zabel M
AFFILIATION: Szpital Wojewódzki w Legnicy, Oddzial Ginekologiczno-Połozniczy.
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: Poland
TITLE: [Classical and novel molecular prognostic factors in ovarian cancers]
PUBDATE: 20051201
Development of molecular biology techniques allows at present for a more rapid and more reliable diagnosis of ovarian cancers. Present paper describes genetic alterations which predispose to development of ovarian cancer and mutations which play principal role in pathogenesis of sporadic cases of the disease. Prognostic significance has also been outlined of expression of cyclooxygenase 2, ligands of P-selectin and inhibitors of complement in cells of ovarian cancer as well as their potential therapeutic significance. A separate chapter has been devoted to the potential and achievements gained using DNA microarray techniques.


13. DOCID:29373 SCORE: 0.000249635836310322
DOCNO: 14520447
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: A Stang A
AUTHOR: C Stegmaier C
AUTHOR: K-H Jöckel KH
AFFILIATION: Epidemiology Unit, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Hufelandstr. 55, 45122 Essen, Germany. andreas.stang@uni-essen.de
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: Nonmelanoma skin cancer in the Federal State of Saarland, Germany, 1995-1999.
PUBDATE: 20031001
We analysed incidence data of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin from the Cancer Registry Saarland, Germany. During 1995-1999, the age-standardised incidence rates (world standard population) of BCC and SCC were 43.7 and 11.2 per 100000 among men and 31.7 and 4.4 per 100000 among women.


14. DOCID:31548 SCORE: 0.000249629067754512
DOCNO: 12925068
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
QUALIFIER: pathology
AUTHOR: R G H Beets-Tan RG
AFFILIATION: Department of Radiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, the Netherlands. rbe@rdia.azm.nl
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.
COUNTRY: England
TITLE: MRI in rectal cancer: the T stage and circumferential resection margin.
PUBDATE: 20030901
Different stages of rectal cancer show differing degrees of risk for local recurrence. Paramount for the selection and differentiated treatment of the different risk groups is a reliable preoperative test that can distinguish between these subgroups. There is recent evidence suggesting that MRI can serve for this purpose, because it accurately predicts the circumferential resection margin. In this article the role of MRI in the preoperative management of rectal cancer patients will be discussed.