0. DOCID:3553 SCORE: 0.00210351595839967
DOCNO: 817789
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunoglobulins
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Ameis A
AUTHOR: H S Ko HS
AUTHOR: W Pruzanski W
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: M components-a review of 1242 cases.
PUBDATE: 19760501
Among 1242 patients referred for immunologic investigation 1255 M components were detected in the serum. Of these patients 50.9% had multiple myeloma, 18.1% had nonmyelomatous malignant diseases such as macroglobulinemia, lymphoma, leukemia or cancer, 4.3% had connective tissue diseases, 2.5% had primary generalized amyloidosis (PGA) and the rest had various "benign" conditions. Whereas IgG was the commonest M component in multiple myeloma, connective tissue diseases and the other benign conditions, IgM was the commonest M component in lymphoma and leukemia; Bence Jones proteinemia was most frequently observed in PGA. The ratio of kappa to lambda light chains varied from 1.7:1 in IgG myeloma to 1:9 in IgD myeloma, and was 1:2.1 in PGA. Bence Jones protein was detected in 422 (66%) of 640 urine samples tested, the prevalence ranging from more than 70% in multiple myeloma and PGA to as low as 36% in various benign conditions. It is evident that the class and type of M components and the presence of Bence Jones proteinuria have no definite significance with regard to the diagnosis. Therefore, thorough investigation and follow-up at regular intervals are required when M components are detected.

1. DOCID:2114 SCORE: 0.000866227059661837
DOCNO: 999351
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: P H Sugarbaker PH
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Carcinoembryonic antigen (CEA) assays in obstructive colorectal cancer.
PUBDATE: 19761201
Four of 40 patients with resectable colon or rectal cancer had tumors causing acute large bowel obstruction with colonic dilatation; all 4 patients had preoperative CEA titers above 10 ng/ml with a mean of 28 ng/ml. Thirty-six cancer patients without acute colon obstruction had a mean CEA titer of 4.5 ng/ml; only 6 of 36 patients had circulating CEA titers 10 ng/ml or greater. This suggested that pre-treatment CEA titers in patients with obstructing cancer are unusually high. Multiple CEA assays were performed on two of the 4 patients with colonic obstruction before and after bowel decompressive procedures and prior to their definitive treatment. Relief of obstruction alone produces marked reduction in circulating CEA; this suggested that not only the extent of disease but also the pathophysiological changes associated with obstruction influenced circulating CEA levels.

2. DOCID:4439 SCORE: 0.000866040698845837
DOCNO: 7031600
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: therapy
AUTHOR: J P Sculier JP
AUTHOR: J Klastersky J
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Hypothermia: a new approach to the treatment of cancer (author's transl)]
PUBDATE: 19811101
Hyperthermia has been known since the last century to be effective against cancer, but it has only developed into a new therapeutic method during the past 20 years. The authors review the theoretical and experimental backgrounds of fever therapy and discuss its local and general applications currently under study, including possible synergistic effects with radiotherapy and/or chemotherapy. Particular attention is paid to systemic hyperthermia.

3. DOCID:2213 SCORE: 0.000865211581410529
DOCNO: 1248904
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: B Armstrong B
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Recent trends in breast-cancer incidence and mortality in relation to changes in possible risk factors.
PUBDATE: 19760201
Breast cancer incidence and mortality in England and Wales and the United States increased between 1950 and 1973, mainly in women aged between 45 and 64 years. These increases appeared to be partly cohort-specific, beginning with cohorts born around 1899, and partly cross-sectional, beginning in the mid-1960s. In both countries, cohort-specific decreases in fertility paralleled the cohort-specific increases in breast cancer rates and may, at least in part, have been responsible for them. Changes in other factors, such as age at menarche and menopause, use of rauwolfia derivatives and oestrogens, consumption of fat and meat, and breast cancer treatment were considered in relation to the cross-sectional increases in breast cancer rates. On the evidence available, it was not certain that any of these could explain the breast cancer increases.

4. DOCID:3708 SCORE: 0.000863850711013577
DOCNO: 1009004
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mitosis
QUALIFIER: physiopathology
AUTHOR: S Gelfant S
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of dermatology.
COUNTRY: ENGLAND
TITLE: The cell cycle in psoriasis: a reappraisal.
PUBDATE: 19761201
The current belief that the clinical manifestations of psoriasis (excessive scaling) are due to a twelve-fold speeding up or shortening of the cell division cycle time of the germinative cells in psoriatic epidermis (from 457 to 37-5 h) is shown to be incorrect. A new concept is introduced--that the germinative layer in human epidermis is composed of not one, but three separate and distinct populations of epidermal cells. First, there are cycling cells which are actively moving through the cell cycle. Then there are two categories of non-cycling cells (blocked in the G1 or the G2 periods of the cell cycle) which are capable of moving into the proliferative pool upon specific stimulation. Thus, increased epidermal cell proliferation in active lesions of psoriasis would be brought about mainly by a recruitment or a relase of the two categories of non-cycling cells. The idea that germinative epidermal cells are primarily non-cycling, leads to the suggestion of focusing attention on non-cycling cells (rather than on cycling cells) for the control and treatment of psoriasis. It might be worthwhile considering treating psoriatic patients during periods of clinical remission--with factors to keep the germinative cells in the non-cycling state--rather than during psoriatic flare up--with cancer chemotherapy drugs.

5. DOCID:1335 SCORE: 0.000863406587734026
DOCNO: 609875
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: V Lemaire V
AUTHOR: J Gueris J
AUTHOR: M Cassou M
AUTHOR: A Ryckewaert A
PUBTYPE: Journal Article
JOURNALTITLE: Revue du rhumatisme et des maladies ostéo-articulaires.
COUNTRY: FRANCE
TITLE: [Radioimmunologic determination of plasma parathormone in hypercalcemia caused by cancer with osseous metastases]
PUBDATE: 19771201
The plasma parathormone was measured by radioimmunological determination in 23 cases of cancer with bone metastases, 8 of mammary origin. In 11 cases the plasma parathormone (iPTH) was less than 4 ng/ml (lower normal limit), as might be expected in view of the hypercalcemia. In 12 cases the iPTH was higher than 4 ng/ml, in 8 of these higher than 8 ng/ml (upper normal limit). These results are suggestive of the role of a substance analogous to parathormone in the genesis of the hypercalcaemia and peritumoral bone resorption of bone metastases of solid tumors.

6. DOCID:5755 SCORE: 0.000841127551683544
DOCNO: 6969375
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonoscopy
QUALIFIER: diagnosis
QUALIFIER: utilization
AUTHOR: W H Isbister WH
PUBTYPE: Journal Article
JOURNALTITLE: The New Zealand medical journal.
COUNTRY: NEW ZEALAND
TITLE: Flexible fibreoptic sigmoidoscopy--an alternative to colonoscopy?
PUBDATE: 19801001
The results of 166 colonoscopic examinations are reported with particular reference to site and nature of the lesion identified. One hundred and fifty-five polyps and 13 colorectal cancers were found, 62 polyps and five cancers being beyond 50 cm from the anal verge. It is suggested that the number of lesions beyond the reach of a flexible fibreoptic sigmoidoscope would be unacceptably high and that there can be no justification for the purchase of such an instrument as an alternative to a full length colonoscope. Whilst the fibreoptic instrument does have advantages as a sigmoidoscope its cost will preclude its widespread use in New Zealand at the present time.

7. DOCID:6038 SCORE: 0.000838802336043531
DOCNO: 646710
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: H R Konrad HR
AUTHOR: R F Canalis RF
AUTHOR: T C Calcaterra TC
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Epidermoid carcinoma of the palate.
PUBDATE: 19780401
A retrospective study was made of 80 cases of epidermoid carcinoma of the palate that were treated at the UCLA Center for the Health Sciences between 1955 and 1977. Tumor size larger than 3 cm, extension to neighboring structures, and contralateral, bilateral, and "fixed" lymph node metastases substantially decreased survival. The presence of ipsilateral nodes and the modality of treatment used (surgery or irradiation) did not appear to affect the outcome. Three-year cure rates for all cases was 40%. Ninety percent of recurrences took place during the first two years after treatment, and additional cancers developed in the upper aerodigestive tract of 20% of the patients.

8. DOCID:6303 SCORE: 0.000829625976638676
DOCNO: 736648
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: T W Buchholtz TW
AUTHOR: C E Welch CE
AUTHOR: R A Malt RA
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Clinical correlates of resectability and survival in gastric carcinoma.
PUBDATE: 19781201
The course of 201 patients with carcinoma of the stomach treated from 1962 through 1966 was followed with 97% determinacy for 10 years. The actual five year survival rate was 11%; the ten year rate was 7%. The mean duration of survival was 5.8 +/- 2.7 (S.D.) months. These results were similar to those reported for the period 1922-1926. Survival was strongly correlated with the surgeon's assessment after exploration. All patients alive after five years had operations thought to be curative, usually partial gastrectomies; the survival rate of this group was 24%. Gastroenterostomy was ineffectual palliation. Better results will require nonsurgical adjuncts, since the correlates of survival are those of minimally invasive cancer.

9. DOCID:6456 SCORE: 0.00080082028983863
DOCNO: 531538
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: H Rostad H
AUTHOR: J R Vale JR
AUTHOR: I Nesthus I
PUBTYPE: Journal Article
JOURNALTITLE: Scandinavian journal of respiratory diseases.
COUNTRY: DENMARK
TITLE: Lung cancer. Symptoms, signs and diagnostic criteria.
PUBDATE: 19790801
A consecutive hospital series of 1 053 patients treated for lung cancer during the period 1962 through 1971 has been studied. Clinical symptoms were present more often in men than in women and in 42% symptoms had been noted more than 6 months prior to the diagnosis. Peripheral tumours gave less symptoms than central ones. Although in 22% of the patients the tumour was discovered on a chest film in the absence of relevant symptoms, 12% only had been detected by regular mass X-ray screening. More than 40% of the peripherally located tumours were clinically silent. Squamous cell and anaplastic small cell cancers were predominantly centrally located (80 and 90%, respectively) against 65% and 74% for adenocarcinomas and undifferentiated large cell tumours.

10. DOCID:7529 SCORE: 0.000559001759309032
DOCNO: 93183
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: P J Selby PJ
AUTHOR: R L Powles RL
AUTHOR: B Janeson B
AUTHOR: H E Kay HE
AUTHOR: J G Watson JG
AUTHOR: R Thornton R
AUTHOR: G Morgenstern G
AUTHOR: H M Clink HM
AUTHOR: T J McElwain TJ
AUTHOR: H G Prentice HG
AUTHOR: R Corringharn R
AUTHOR: M G Ross MG
AUTHOR: A V Hoffbrand AV
AUTHOR: D Brigden D
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Parenteral acyclovir therapy for herpesvirus infections in man.
PUBDATE: 19791201
Acyclovir is a new antiviral agent which is highly active against herpesviruses in vitro and in laboratory animals. Twenty-three cancer patients with cutaneous and/or systemic herpes zoster or herpes simplex infections were treated with parenteral acyclovir. All had received previous specific treatment for their malignant disease and ten had undergone bone-marrow transplantation. The drug seemed to arrest the progress of the infections and was most effective when given early. Although two patients showed transient increases in blood-urea, possibly the result of acyclovir, the drug was remarkably non-toxic in the doses used.

11. DOCID:4845 SCORE: 0.000558829525268081
DOCNO: 255161
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
AUTHOR: A Osaka A
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of microwave power.
COUNTRY: CANADA
TITLE: Use of microwave radiation in surgery and cancer therapy.
PUBDATE: 19780601
In considering the therapy of cancer, the author has been interested in the internal dielectric heating property of microwaves and applied their capacity of rapid protein coagulation to medical treatment. With the purpose of utilizing this phenomenon for the resection of fragile parenchymatous organs, the experiment was conducted on rabbit livers, which were irradiated with microwaves for about 3 min. The effect of this phenomenon on cancer cells was also observed. Malignant tumors induced in rats were exposed to microwave radiation for 2 min.

12. DOCID:7224 SCORE: 0.00055879761447627
DOCNO: 86616
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: blood
QUALIFIER: analysis
AUTHOR: R A Bunning RA
AUTHOR: S L Haworth SL
AUTHOR: E H Cooper EH
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Serum beta-2-microglobulin levels in urological cancer.
PUBDATE: 19790501
Serum beta-2-microglobulin levels were measured in patients with renal, vesical and prostatic cancer. Measurements were made only on samples with a serum creatinine less than or equal to 105 mumol./l. to eliminate the possibility of elevated beta-2-microglobulin being a result of impaired renal function. This criterion eliminated 28 to 50 per cent of the patients with bladder cancer and 73 per cent of those who had undergone nephrectomy for renal carcinoma, which, obviously, limits the value of beta-2-microglobulin measurement for the surveillance in these cancers. Beta-2-microglobulin values in patients with prostatic cancer were seldom increased to more than 3.0 mg./l. In bladder cancer patients with normal serum creatinine the frequency of an elevated serum beta-2-microglobulin increased with the increase in tumor stage.

13. DOCID:7704 SCORE: 0.000558475253812593
DOCNO: 7229433
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiation effects
QUALIFIER: radiation effects
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: I Willis I
AUTHOR: J M Menter JM
AUTHOR: H J Whyte HJ
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of investigative dermatology.
COUNTRY: UNITED STATES
TITLE: The rapid induction of cancers in the hairless mouse utilizing the principle of photoaugmentation.
PUBDATE: 19810501
We report a method for rapidly inducing cancer in the hairless mouse utilizing regimen in which an exposure to highly erythemogenic, but otherwise clinically noninjurious, dose of broad spectrum (290-400 nm) ultraviolet light is increased by 20% every 6th day. Clinical and histological observations reveal the presence of squamous cell cancer after as little as 18 days of irradiation. The rate of cancer induction is enhanced by the 320-400 nm component and this enhancement is shown to be a photoaugmentative effect. The results support the idea that stratum corneum and/or malpighian layer thickening produced in early stages of tumor induction tends to protect against the detrimental effects of UV radiation. Strict monitoring of both the spectral distribution and output of the radiation source is imperative for reproducible rates of tumor induction.

14. DOCID:5918 SCORE: 0.000557241498221573
DOCNO: 7287476
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: J E Altwein JE
PUBTYPE: Journal Article
JOURNALTITLE: Helvetica chirurgica acta.
COUNTRY: SWITZERLAND
TITLE: [Current aspects of hormonal therapy in prostate cancer]
PUBDATE: 19810801
The following endocrine treatment modalities have been used in advanced prostatic carcinoma: 1. orchiectomy plus estrogens; 2. primary orchiectomy with delayed estrogen employment; 3. initial estrogen therapy with delayed orchiectomy; 4. initial cyproterone acetate or medroxyprogesterone acetate; 5. a combination treatment: estramustine phosphate, cyproterone acetate or estrogens plus bromocriptine. The application of phase-III studies permits the subsequent conclusions: Simultaneous orchiectomy is to no advantage (exception: urinary stasis). Cyproterone acetate does neither yield better nor worse results regarding survival than estrogen alone, but has fewer side effects. Estrogens and cyproterone acetate produce a rise of serum prolactin justifying the use of bromocriptine (or lisuride). Estramustine phosphate should be reserved for relapsing prostatic cancer.