0. DOCID:3553 SCORE: 0.00210351595839967
DOCNO: 817789
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunoglobulins
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Ameis A
AUTHOR: H S Ko HS
AUTHOR: W Pruzanski W
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: M components-a review of 1242 cases.
PUBDATE: 19760501
Among 1242 patients referred for immunologic investigation 1255 M components were detected in the serum. Of these patients 50.9% had multiple myeloma, 18.1% had nonmyelomatous malignant diseases such as macroglobulinemia, lymphoma, leukemia or cancer, 4.3% had connective tissue diseases, 2.5% had primary generalized amyloidosis (PGA) and the rest had various "benign" conditions. Whereas IgG was the commonest M component in multiple myeloma, connective tissue diseases and the other benign conditions, IgM was the commonest M component in lymphoma and leukemia; Bence Jones proteinemia was most frequently observed in PGA. The ratio of kappa to lambda light chains varied from 1.7:1 in IgG myeloma to 1:9 in IgD myeloma, and was 1:2.1 in PGA. Bence Jones protein was detected in 422 (66%) of 640 urine samples tested, the prevalence ranging from more than 70% in multiple myeloma and PGA to as low as 36% in various benign conditions. It is evident that the class and type of M components and the presence of Bence Jones proteinuria have no definite significance with regard to the diagnosis. Therefore, thorough investigation and follow-up at regular intervals are required when M components are detected.


1. DOCID:15952 SCORE: 0.000867418362757428
DOCNO: 2707094
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: T Böttger T
AUTHOR: K Sorger K
AUTHOR: T Junginger T
AFFILIATION: Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes Gutenberg-Universität, Mainz.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY, WEST
TITLE: [Progressive papillomatosis of the intra- and extrahepatic bile ducts]
PUBDATE: 19890201
The papillomatosis of the bile duct may occur at any age but more often at the age of 40 and 50 with a slight preference for men. The main symptom is an icterus often combined with right-sided epigastric pain. ERC and PTC allows the preoperative diagnosis on the basis of the typical clinical picture. The papillomatosis of the bile duct has to be considered as a disease with cancer risk. The prognosis in case of incomplete removal is unfavorable because of the continuous growth, the intrahepatic spread and the elevated degenerative tendency. Therefore a complete removal should be considered.


2. DOCID:2114 SCORE: 0.000866227059661837
DOCNO: 999351
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: P H Sugarbaker PH
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Carcinoembryonic antigen (CEA) assays in obstructive colorectal cancer.
PUBDATE: 19761201
Four of 40 patients with resectable colon or rectal cancer had tumors causing acute large bowel obstruction with colonic dilatation; all 4 patients had preoperative CEA titers above 10 ng/ml with a mean of 28 ng/ml. Thirty-six cancer patients without acute colon obstruction had a mean CEA titer of 4.5 ng/ml; only 6 of 36 patients had circulating CEA titers 10 ng/ml or greater. This suggested that pre-treatment CEA titers in patients with obstructing cancer are unusually high. Multiple CEA assays were performed on two of the 4 patients with colonic obstruction before and after bowel decompressive procedures and prior to their definitive treatment. Relief of obstruction alone produces marked reduction in circulating CEA; this suggested that not only the extent of disease but also the pathophysiological changes associated with obstruction influenced circulating CEA levels.


3. DOCID:4439 SCORE: 0.000866040698845837
DOCNO: 7031600
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: therapy
AUTHOR: J P Sculier JP
AUTHOR: J Klastersky J
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Hypothermia: a new approach to the treatment of cancer (author's transl)]
PUBDATE: 19811101
Hyperthermia has been known since the last century to be effective against cancer, but it has only developed into a new therapeutic method during the past 20 years. The authors review the theoretical and experimental backgrounds of fever therapy and discuss its local and general applications currently under study, including possible synergistic effects with radiotherapy and/or chemotherapy. Particular attention is paid to systemic hyperthermia.


4. DOCID:2213 SCORE: 0.000865211581410529
DOCNO: 1248904
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: B Armstrong B
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Recent trends in breast-cancer incidence and mortality in relation to changes in possible risk factors.
PUBDATE: 19760201
Breast cancer incidence and mortality in England and Wales and the United States increased between 1950 and 1973, mainly in women aged between 45 and 64 years. These increases appeared to be partly cohort-specific, beginning with cohorts born around 1899, and partly cross-sectional, beginning in the mid-1960s. In both countries, cohort-specific decreases in fertility paralleled the cohort-specific increases in breast cancer rates and may, at least in part, have been responsible for them. Changes in other factors, such as age at menarche and menopause, use of rauwolfia derivatives and oestrogens, consumption of fat and meat, and breast cancer treatment were considered in relation to the cross-sectional increases in breast cancer rates. On the evidence available, it was not certain that any of these could explain the breast cancer increases.


5. DOCID:8878 SCORE: 0.000864463844949942
DOCNO: 6708220
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: A C Kinn AC
AUTHOR: B Lantz B
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Vitamin B12 deficiency after irradiation for bladder carcinoma.
PUBDATE: 19840501
Vitamin B12 deficiency was found in 10 of 41 patients who underwent radiotherapy before cystectomy with Bricker urinary diversion for carcinoma of the bladder. Of 13 patients given full irradiation because of inoperable bladder cancer 5 had malabsorption of vitamin B12. Serum folic acid was normal in these patients, indicating predominantly ileal irradiation sequelae. Routine evaluation of serum vitamin B12 after radiotherapy is recommended so that appropriate medication can be given, if possible before neurological symptoms appear.


6. DOCID:13075 SCORE: 0.000864081048913627
DOCNO: 3306771
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: economics
QUALIFIER: economics
AUTHOR: R McLelland R
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Low-cost mass screening with mammography as a means of reducing overall mortality from breast cancer.
PUBDATE: 19870901
Screening mammography has made major contributions in the earlier detection of breast cancer. It is the only reliable means of identifying non-palpable cancers, and can detect many "minimal" breast cancers when they appear to be curable. Low-cost, high-quality mass screening mammography is indeed feasible and can be expected to reduce overall mortality from breast cancer. Recognition of the need and desire to provide the service are essential initial motivating factors.


7. DOCID:3708 SCORE: 0.000863850711013577
DOCNO: 1009004
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mitosis
QUALIFIER: physiopathology
AUTHOR: S Gelfant S
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of dermatology.
COUNTRY: ENGLAND
TITLE: The cell cycle in psoriasis: a reappraisal.
PUBDATE: 19761201
The current belief that the clinical manifestations of psoriasis (excessive scaling) are due to a twelve-fold speeding up or shortening of the cell division cycle time of the germinative cells in psoriatic epidermis (from 457 to 37-5 h) is shown to be incorrect. A new concept is introduced--that the germinative layer in human epidermis is composed of not one, but three separate and distinct populations of epidermal cells. First, there are cycling cells which are actively moving through the cell cycle. Then there are two categories of non-cycling cells (blocked in the G1 or the G2 periods of the cell cycle) which are capable of moving into the proliferative pool upon specific stimulation. Thus, increased epidermal cell proliferation in active lesions of psoriasis would be brought about mainly by a recruitment or a relase of the two categories of non-cycling cells. The idea that germinative epidermal cells are primarily non-cycling, leads to the suggestion of focusing attention on non-cycling cells (rather than on cycling cells) for the control and treatment of psoriasis. It might be worthwhile considering treating psoriatic patients during periods of clinical remission--with factors to keep the germinative cells in the non-cycling state--rather than during psoriatic flare up--with cancer chemotherapy drugs.


8. DOCID:1335 SCORE: 0.000863406587734026
DOCNO: 609875
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: V Lemaire V
AUTHOR: J Gueris J
AUTHOR: M Cassou M
AUTHOR: A Ryckewaert A
PUBTYPE: Journal Article
JOURNALTITLE: Revue du rhumatisme et des maladies ostéo-articulaires.
COUNTRY: FRANCE
TITLE: [Radioimmunologic determination of plasma parathormone in hypercalcemia caused by cancer with osseous metastases]
PUBDATE: 19771201
The plasma parathormone was measured by radioimmunological determination in 23 cases of cancer with bone metastases, 8 of mammary origin. In 11 cases the plasma parathormone (iPTH) was less than 4 ng/ml (lower normal limit), as might be expected in view of the hypercalcemia. In 12 cases the iPTH was higher than 4 ng/ml, in 8 of these higher than 8 ng/ml (upper normal limit). These results are suggestive of the role of a substance analogous to parathormone in the genesis of the hypercalcaemia and peritumoral bone resorption of bone metastases of solid tumors.


9. DOCID:5755 SCORE: 0.000841127551683544
DOCNO: 6969375
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonoscopy
QUALIFIER: diagnosis
QUALIFIER: utilization
AUTHOR: W H Isbister WH
PUBTYPE: Journal Article
JOURNALTITLE: The New Zealand medical journal.
COUNTRY: NEW ZEALAND
TITLE: Flexible fibreoptic sigmoidoscopy--an alternative to colonoscopy?
PUBDATE: 19801001
The results of 166 colonoscopic examinations are reported with particular reference to site and nature of the lesion identified. One hundred and fifty-five polyps and 13 colorectal cancers were found, 62 polyps and five cancers being beyond 50 cm from the anal verge. It is suggested that the number of lesions beyond the reach of a flexible fibreoptic sigmoidoscope would be unacceptably high and that there can be no justification for the purchase of such an instrument as an alternative to a full length colonoscope. Whilst the fibreoptic instrument does have advantages as a sigmoidoscope its cost will preclude its widespread use in New Zealand at the present time.


10. DOCID:6038 SCORE: 0.000838802336043531
DOCNO: 646710
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: H R Konrad HR
AUTHOR: R F Canalis RF
AUTHOR: T C Calcaterra TC
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Epidermoid carcinoma of the palate.
PUBDATE: 19780401
A retrospective study was made of 80 cases of epidermoid carcinoma of the palate that were treated at the UCLA Center for the Health Sciences between 1955 and 1977. Tumor size larger than 3 cm, extension to neighboring structures, and contralateral, bilateral, and "fixed" lymph node metastases substantially decreased survival. The presence of ipsilateral nodes and the modality of treatment used (surgery or irradiation) did not appear to affect the outcome. Three-year cure rates for all cases was 40%. Ninety percent of recurrences took place during the first two years after treatment, and additional cancers developed in the upper aerodigestive tract of 20% of the patients.


11. DOCID:6303 SCORE: 0.000829625976638676
DOCNO: 736648
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: T W Buchholtz TW
AUTHOR: C E Welch CE
AUTHOR: R A Malt RA
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Clinical correlates of resectability and survival in gastric carcinoma.
PUBDATE: 19781201
The course of 201 patients with carcinoma of the stomach treated from 1962 through 1966 was followed with 97% determinacy for 10 years. The actual five year survival rate was 11%; the ten year rate was 7%. The mean duration of survival was 5.8 +/- 2.7 (S.D.) months. These results were similar to those reported for the period 1922-1926. Survival was strongly correlated with the surgeon's assessment after exploration. All patients alive after five years had operations thought to be curative, usually partial gastrectomies; the survival rate of this group was 24%. Gastroenterostomy was ineffectual palliation. Better results will require nonsurgical adjuncts, since the correlates of survival are those of minimally invasive cancer.


12. DOCID:6456 SCORE: 0.00080082028983863
DOCNO: 531538
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: H Rostad H
AUTHOR: J R Vale JR
AUTHOR: I Nesthus I
PUBTYPE: Journal Article
JOURNALTITLE: Scandinavian journal of respiratory diseases.
COUNTRY: DENMARK
TITLE: Lung cancer. Symptoms, signs and diagnostic criteria.
PUBDATE: 19790801
A consecutive hospital series of 1 053 patients treated for lung cancer during the period 1962 through 1971 has been studied. Clinical symptoms were present more often in men than in women and in 42% symptoms had been noted more than 6 months prior to the diagnosis. Peripheral tumours gave less symptoms than central ones. Although in 22% of the patients the tumour was discovered on a chest film in the absence of relevant symptoms, 12% only had been detected by regular mass X-ray screening. More than 40% of the peripherally located tumours were clinically silent. Squamous cell and anaplastic small cell cancers were predominantly centrally located (80 and 90%, respectively) against 65% and 74% for adenocarcinomas and undifferentiated large cell tumours.


13. DOCID:15010 SCORE: 0.000789091393109626
DOCNO: 3289821
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: diagnostic use
QUALIFIER: radionuclide imaging
AUTHOR: C Ceccarelli C
AUTHOR: F Pacini F
AUTHOR: F Lippi F
AUTHOR: A Pinchera A
AFFILIATION: Istituto di Metodologia, University of Pisa, Italy.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical nuclear medicine.
COUNTRY: UNITED STATES
TITLE: An unusual case of a false-positive iodine-131 whole body scan in a patient with papillary thyroid cancer.
PUBDATE: 19880301
A false-positive I-131 whole body scan (WBS) for lung uptake in a patient with papillary thyroid cancer, with replacement of his infiltrated esophagus with a left colon graft, is presented. The I-131 image, seen in the upper right lung field, was due to the contaminated colon graft lacking normal peristaltic movements, which was located in the right paramediastinal region. This finding was demonstrated by imaging the upper digestive tract with orally administered Tc-99m DTPA and by a barium x-ray.


14. DOCID:15927 SCORE: 0.000779098539739733
DOCNO: 3731990
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bacterial Physiology
QUALIFIER: microbiology
AUTHOR: G L Simon GL
AUTHOR: S L Gorbach SL
PUBTYPE: Journal Article
JOURNALTITLE: Digestive diseases and sciences.
COUNTRY: UNITED STATES
TITLE: The human intestinal microflora.
PUBDATE: 19860901
The major host defense mechanisms against bacterial overgrowth in the small bowel are the normal propulsive activity of the bowel itself and gastric acid secretion. Microbial interactions are a major factor in regulating the indigenous bacterial flora. Studies of the bacterial enzymes of the gut suggest that changes in diet may lead to marked changes in the colonic flora. Antibiotics affect the composition of the colonic microflora. The microflora also influence the degradation of mucin, the conversion of urobilin to urobilinogen, of cholesterol to coprostanol, and the production of short chain fatty acids. Current interests are focused on the bacterial flora of tropical sprue, the role of bacteria in colorectal cancer, and the involvement of intestinal microflora in the enterohepatic circulation of sex steroid hormones.