0. DOCID:3553 SCORE: 0.00210351595839967
DOCNO: 817789
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunoglobulins
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Ameis A
AUTHOR: H S Ko HS
AUTHOR: W Pruzanski W
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: M components-a review of 1242 cases.
PUBDATE: 19760501
Among 1242 patients referred for immunologic investigation 1255 M components were detected in the serum. Of these patients 50.9% had multiple myeloma, 18.1% had nonmyelomatous malignant diseases such as macroglobulinemia, lymphoma, leukemia or cancer, 4.3% had connective tissue diseases, 2.5% had primary generalized amyloidosis (PGA) and the rest had various "benign" conditions. Whereas IgG was the commonest M component in multiple myeloma, connective tissue diseases and the other benign conditions, IgM was the commonest M component in lymphoma and leukemia; Bence Jones proteinemia was most frequently observed in PGA. The ratio of kappa to lambda light chains varied from 1.7:1 in IgG myeloma to 1:9 in IgD myeloma, and was 1:2.1 in PGA. Bence Jones protein was detected in 422 (66%) of 640 urine samples tested, the prevalence ranging from more than 70% in multiple myeloma and PGA to as low as 36% in various benign conditions. It is evident that the class and type of M components and the presence of Bence Jones proteinuria have no definite significance with regard to the diagnosis. Therefore, thorough investigation and follow-up at regular intervals are required when M components are detected.

1. DOCID:23129 SCORE: 0.00148607969601446
DOCNO: 9137982
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
AUTHOR: G R Mundy GR
AFFILIATION: University of Texas Health Science Center, San Antonio, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et métabolisme.
COUNTRY: GERMANY
TITLE: Malignancy and the skeleton.
PUBDATE: 19970301
Bone is one of the three most common sites of tumor metastasis. Bone metastasis is a catastrophic complication of cancer, since it is not only associated with intractable pain, but also with other morbidity such as hypercalcemia which usually hastens an uncomfortable death. Despite the importance of bone metastasis/hypercalcemia, until recently clinicians have used specific therapies only for the treatment of hypercalcemia but not for bone metastasis. During this presentation, I will review our current understanding of some of the steps involved in the pathophysiology of bone metastasis and its association with hypercalcemia, and how I think these complications of cancer should be treated.

2. DOCID:20319 SCORE: 0.00109098855218961
DOCNO: 8815559
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: A Mottola A
AUTHOR: E Palminteri E
AUTHOR: S Bianchi S
AUTHOR: G Barbagli G
AUTHOR: S Agostini S
AFFILIATION: Dipartimento di Radiologia, Universita degli Studi, Firenze.
PUBTYPE: Journal Article
JOURNALTITLE: Minerva urologica e nefrologica = The Italian journal of urology and nephrology.
COUNTRY: ITALY
TITLE: [Granulomatous prostatitis]
PUBDATE: 19960601
Granulomatous prostatitis is a rare chronic inflammation and its etiology is not well understood. There is difficulty in differential diagnosis with prostatic cancer. But RMN and ultrasound guided biopsy can confirm the diagnosis. The authors report 15 cases and discuss etiological, clinical and diagnostic aspects.

3. DOCID:28606 SCORE: 0.000872642773510714
DOCNO: 12801816
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: Christine Théodore C
AFFILIATION: Institut Gustave-Roussy, 94806 Villejuif Cedex.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Cured of testicular cancer]
PUBDATE: 20030401
Nowadays, testicular cancer can be cured in more than 90 % of patients. Most patients we see now as "cured" of testicular cancer were treated either with chemotherapy or with radiotherapy. We detail the complete remission criteria and the follow-up procedure. We describe the long term toxicities of treatments, the risk of second cancer and the carryover of the disease and treatments on long term quality of life, sexuality and fertility.

4. DOCID:15952 SCORE: 0.000867418362757428
DOCNO: 2707094
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: T Böttger T
AUTHOR: K Sorger K
AUTHOR: T Junginger T
AFFILIATION: Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes Gutenberg-Universität, Mainz.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY, WEST
TITLE: [Progressive papillomatosis of the intra- and extrahepatic bile ducts]
PUBDATE: 19890201
The papillomatosis of the bile duct may occur at any age but more often at the age of 40 and 50 with a slight preference for men. The main symptom is an icterus often combined with right-sided epigastric pain. ERC and PTC allows the preoperative diagnosis on the basis of the typical clinical picture. The papillomatosis of the bile duct has to be considered as a disease with cancer risk. The prognosis in case of incomplete removal is unfavorable because of the continuous growth, the intrahepatic spread and the elevated degenerative tendency. Therefore a complete removal should be considered.

5. DOCID:2114 SCORE: 0.000866227059661837
DOCNO: 999351
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: P H Sugarbaker PH
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Carcinoembryonic antigen (CEA) assays in obstructive colorectal cancer.
PUBDATE: 19761201
Four of 40 patients with resectable colon or rectal cancer had tumors causing acute large bowel obstruction with colonic dilatation; all 4 patients had preoperative CEA titers above 10 ng/ml with a mean of 28 ng/ml. Thirty-six cancer patients without acute colon obstruction had a mean CEA titer of 4.5 ng/ml; only 6 of 36 patients had circulating CEA titers 10 ng/ml or greater. This suggested that pre-treatment CEA titers in patients with obstructing cancer are unusually high. Multiple CEA assays were performed on two of the 4 patients with colonic obstruction before and after bowel decompressive procedures and prior to their definitive treatment. Relief of obstruction alone produces marked reduction in circulating CEA; this suggested that not only the extent of disease but also the pathophysiological changes associated with obstruction influenced circulating CEA levels.

6. DOCID:4439 SCORE: 0.000866040698845837
DOCNO: 7031600
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: therapy
AUTHOR: J P Sculier JP
AUTHOR: J Klastersky J
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Hypothermia: a new approach to the treatment of cancer (author's transl)]
PUBDATE: 19811101
Hyperthermia has been known since the last century to be effective against cancer, but it has only developed into a new therapeutic method during the past 20 years. The authors review the theoretical and experimental backgrounds of fever therapy and discuss its local and general applications currently under study, including possible synergistic effects with radiotherapy and/or chemotherapy. Particular attention is paid to systemic hyperthermia.

7. DOCID:2213 SCORE: 0.000865211581410529
DOCNO: 1248904
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: B Armstrong B
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Recent trends in breast-cancer incidence and mortality in relation to changes in possible risk factors.
PUBDATE: 19760201
Breast cancer incidence and mortality in England and Wales and the United States increased between 1950 and 1973, mainly in women aged between 45 and 64 years. These increases appeared to be partly cohort-specific, beginning with cohorts born around 1899, and partly cross-sectional, beginning in the mid-1960s. In both countries, cohort-specific decreases in fertility paralleled the cohort-specific increases in breast cancer rates and may, at least in part, have been responsible for them. Changes in other factors, such as age at menarche and menopause, use of rauwolfia derivatives and oestrogens, consumption of fat and meat, and breast cancer treatment were considered in relation to the cross-sectional increases in breast cancer rates. On the evidence available, it was not certain that any of these could explain the breast cancer increases.

8. DOCID:22800 SCORE: 0.000865195031413936
DOCNO: 8893871
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: G T Bales GT
AUTHOR: H Kim H
AUTHOR: G D Steinberg GD
AFFILIATION: Department of Surgery, University of Chicago, Pritzker School of Medicine, IL, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Surgical therapy for locally advanced bladder cancer.
PUBDATE: 19961001
Radical cystectomy followed by a urinary diversion or an orthotopic neobladder remains standard treatment for patients with muscle-invasive bladder cancer. The advances in surgical technique and reconstructive options allow many patients to enjoy a high quality of life after surgical extirpation. For those unable or unwilling to undergo a radical cystectomy, several treatment alternatives exist, using aggressive TUR and combinations of chemotherapy and/or radiation. Continued investigations into the biological behavior of this malignancy, as well as the identification of more effective chemotherapeutic agents, will allow more definitive treatment approaches with improved outcomes.

9. DOCID:8878 SCORE: 0.000864463844949942
DOCNO: 6708220
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: A C Kinn AC
AUTHOR: B Lantz B
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Vitamin B12 deficiency after irradiation for bladder carcinoma.
PUBDATE: 19840501
Vitamin B12 deficiency was found in 10 of 41 patients who underwent radiotherapy before cystectomy with Bricker urinary diversion for carcinoma of the bladder. Of 13 patients given full irradiation because of inoperable bladder cancer 5 had malabsorption of vitamin B12. Serum folic acid was normal in these patients, indicating predominantly ileal irradiation sequelae. Routine evaluation of serum vitamin B12 after radiotherapy is recommended so that appropriate medication can be given, if possible before neurological symptoms appear.

10. DOCID:13075 SCORE: 0.000864081048913627
DOCNO: 3306771
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: economics
QUALIFIER: economics
AUTHOR: R McLelland R
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Low-cost mass screening with mammography as a means of reducing overall mortality from breast cancer.
PUBDATE: 19870901
Screening mammography has made major contributions in the earlier detection of breast cancer. It is the only reliable means of identifying non-palpable cancers, and can detect many "minimal" breast cancers when they appear to be curable. Low-cost, high-quality mass screening mammography is indeed feasible and can be expected to reduce overall mortality from breast cancer. Recognition of the need and desire to provide the service are essential initial motivating factors.

11. DOCID:3708 SCORE: 0.000863850711013577
DOCNO: 1009004
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mitosis
QUALIFIER: physiopathology
AUTHOR: S Gelfant S
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of dermatology.
COUNTRY: ENGLAND
TITLE: The cell cycle in psoriasis: a reappraisal.
PUBDATE: 19761201
The current belief that the clinical manifestations of psoriasis (excessive scaling) are due to a twelve-fold speeding up or shortening of the cell division cycle time of the germinative cells in psoriatic epidermis (from 457 to 37-5 h) is shown to be incorrect. A new concept is introduced--that the germinative layer in human epidermis is composed of not one, but three separate and distinct populations of epidermal cells. First, there are cycling cells which are actively moving through the cell cycle. Then there are two categories of non-cycling cells (blocked in the G1 or the G2 periods of the cell cycle) which are capable of moving into the proliferative pool upon specific stimulation. Thus, increased epidermal cell proliferation in active lesions of psoriasis would be brought about mainly by a recruitment or a relase of the two categories of non-cycling cells. The idea that germinative epidermal cells are primarily non-cycling, leads to the suggestion of focusing attention on non-cycling cells (rather than on cycling cells) for the control and treatment of psoriasis. It might be worthwhile considering treating psoriatic patients during periods of clinical remission--with factors to keep the germinative cells in the non-cycling state--rather than during psoriatic flare up--with cancer chemotherapy drugs.

12. DOCID:1335 SCORE: 0.000863406587734026
DOCNO: 609875
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: V Lemaire V
AUTHOR: J Gueris J
AUTHOR: M Cassou M
AUTHOR: A Ryckewaert A
PUBTYPE: Journal Article
JOURNALTITLE: Revue du rhumatisme et des maladies ostéo-articulaires.
COUNTRY: FRANCE
TITLE: [Radioimmunologic determination of plasma parathormone in hypercalcemia caused by cancer with osseous metastases]
PUBDATE: 19771201
The plasma parathormone was measured by radioimmunological determination in 23 cases of cancer with bone metastases, 8 of mammary origin. In 11 cases the plasma parathormone (iPTH) was less than 4 ng/ml (lower normal limit), as might be expected in view of the hypercalcemia. In 12 cases the iPTH was higher than 4 ng/ml, in 8 of these higher than 8 ng/ml (upper normal limit). These results are suggestive of the role of a substance analogous to parathormone in the genesis of the hypercalcaemia and peritumoral bone resorption of bone metastases of solid tumors.

13. DOCID:5755 SCORE: 0.000841127551683544
DOCNO: 6969375
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonoscopy
QUALIFIER: diagnosis
QUALIFIER: utilization
AUTHOR: W H Isbister WH
PUBTYPE: Journal Article
JOURNALTITLE: The New Zealand medical journal.
COUNTRY: NEW ZEALAND
TITLE: Flexible fibreoptic sigmoidoscopy--an alternative to colonoscopy?
PUBDATE: 19801001
The results of 166 colonoscopic examinations are reported with particular reference to site and nature of the lesion identified. One hundred and fifty-five polyps and 13 colorectal cancers were found, 62 polyps and five cancers being beyond 50 cm from the anal verge. It is suggested that the number of lesions beyond the reach of a flexible fibreoptic sigmoidoscope would be unacceptably high and that there can be no justification for the purchase of such an instrument as an alternative to a full length colonoscope. Whilst the fibreoptic instrument does have advantages as a sigmoidoscope its cost will preclude its widespread use in New Zealand at the present time.

14. DOCID:6038 SCORE: 0.000838802336043531
DOCNO: 646710
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: H R Konrad HR
AUTHOR: R F Canalis RF
AUTHOR: T C Calcaterra TC
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Epidermoid carcinoma of the palate.
PUBDATE: 19780401
A retrospective study was made of 80 cases of epidermoid carcinoma of the palate that were treated at the UCLA Center for the Health Sciences between 1955 and 1977. Tumor size larger than 3 cm, extension to neighboring structures, and contralateral, bilateral, and "fixed" lymph node metastases substantially decreased survival. The presence of ipsilateral nodes and the modality of treatment used (surgery or irradiation) did not appear to affect the outcome. Three-year cure rates for all cases was 40%. Ninety percent of recurrences took place during the first two years after treatment, and additional cancers developed in the upper aerodigestive tract of 20% of the patients.