0. DOCID:27310 SCORE: 0.00479014465565183
DOCNO: 9769121
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: embryology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Bonkhoff H
AUTHOR: K Remberger K
AFFILIATION: Institute of Pathology, University of the Saarland, Homburg-Saar, Germany. patfix@med-rz.uni-sb.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Virchows Archiv : an international journal of pathology.
COUNTRY: GERMANY
TITLE: Morphogenetic concepts of normal and abnormal growth in the human prostate.
PUBDATE: 19980901
Benign prostatic hyperplasia (BPH) and prostate cancer are multifactorial disease processes, involving a growing number of biochemical, genetic and epigenetic factors. Their pathogenesis, however, remains poorly understood. The present review examines current morphogenetic concepts of normal and abnormal growth in the human prostate. This includes the role of basal cells in organogenesis and cancerogenesis, the impact of cell-matrix interactions, and the importance of cellular heterogeneity in tumour progression and hormone-insensitive growth. Knowledge of morphogenesis and morphology is required in any scientific approach to BPH and prostate cancer.

1. DOCID:27375 SCORE: 0.00422879480768944
DOCNO: 10518048
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fuzzy Logic
QUALIFIER: diagnosis
QUALIFIER: genetics
QUALIFIER: methods
AUTHOR: C A Pena-Reyes CA
AUTHOR: M Sipper M
AFFILIATION: Logic Systems Laboratory, Swiss Federal Institute of Technology, IN-Ecublens, CH-1015, Lausanne, Switzerland. carlos.pena@di.epfl.ch
PUBTYPE: Journal Article
JOURNALTITLE: Artificial intelligence in medicine.
COUNTRY: NETHERLANDS
TITLE: A fuzzy-genetic approach to breast cancer diagnosis.
PUBDATE: 19991001
The automatic diagnosis of breast cancer is an important, real-world medical problem. In this paper we focus on the Wisconsin breast cancer diagnosis (WBCD) problem, combining two methodologies-fuzzy systems and evolutionary algorithms-so as to automatically produce diagnostic systems. We find that our fuzzy-genetic approach produces systems exhibiting two prime characteristics: first, they attain high classification performance (the best shown to date), with the possibility of attributing a confidence measure to the output diagnosis; second, the resulting systems involve a few simple rules, and are therefore (human-) interpretable.

2. DOCID:27424 SCORE: 0.00358259835283217
DOCNO: 11811208
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Public Opinion
QUALIFIER: etiology
QUALIFIER: history
QUALIFIER: history
AUTHOR: A Mazur A
AUTHOR: S Rothman S
AUTHOR: S R Lichter SR
AFFILIATION: Center for Media and Public Affairs, N.W. Washington, DC 20037, USA. srlichter@cmpa.com
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Social studies of science.
COUNTRY: United States
TITLE: Biases about man-made cancer among researchers.
PUBDATE: 20011001
Can sociological variables significantly predict researchers' positions on a scientific issue? Carcinogenesis offers a good test case because it is not definitively established how important man-made substances are as contributors to human cancer. American cancer researchers divide on this issue, some broadly emphasizing the importance of man-made carcinogens, others consistently minimizing their importance relative to natural carcinogens. We find that cancer researchers who are male, are affiliated with a medical school, and have more publications, are more likely than their colleagues to minimize the importance of man-made carcinogens.

3. DOCID:27282 SCORE: 0.00340055725586374
DOCNO: 10676768
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: S K Parsons SK
AFFILIATION: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in pediatrics.
COUNTRY: UNITED STATES
TITLE: Oncology practice patterns in the use of hematopoietic growth factors.
PUBDATE: 20000201
Recombinant hematopoietic growth factors were introduced into clinical practice a decade ago: erythropoietin in 1989, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in 1991, and interleukin-11 in 1997. The role of these agents in supportive therapy for children with cancer is still under considerable evaluation. This pediatric-based review summarizes current clinical applications, practice guidelines, and practice patterns for hematopoietic growth factors in the supportive care of children with cancer. It also discusses ongoing controversies and unanswered questions.

4. DOCID:26652 SCORE: 0.00316376900039759
DOCNO: 11257397
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: P K Srivastava PK
AUTHOR: R J Amato RJ
AFFILIATION: Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030-1601, USA. srivastava@nso2.uchc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Vaccine.
COUNTRY: England
TITLE: Heat shock proteins: the 'Swiss Army Knife' vaccines against cancers and infectious agents.
PUBDATE: 20010301
The ability of heat shock proteins to: (a) chaperone peptides, including antigenic peptides; (b) interact with antigen presenting cells through a receptor; (c) stimulate antigen presenting cells to secrete inflammatory cytokines; and (d) mediate maturation of dendritic cells, makes them a one-stop shop for the immune system. These properties also permit the utilization of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases.

5. DOCID:26801 SCORE: 0.00294722905785571
DOCNO: 12973411
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: J F Tomera JF
PUBTYPE: Journal Article
JOURNALTITLE: Drugs of today (Barcelona, Spain : 1998)
COUNTRY: Spain
TITLE: Acute tumor lysis syndrome: considerations of cause and prevention.
PUBDATE: 19990201
The need for better chemotherapeutic interventional modalities with adjunctive biotherapy and/or immunotherapy to confront oncologic disease processes will continue into the new millennium. Unfortunately, existing problems encountered as a consequence to chemotherapy centering on acute tumor lysis syndrome (ATLS) will also continue. ATLS results when cytotoxic agents lyse, or lacerate, outer plasma membranes of numerous cancerous cells. Eventually, their contents spill into the bloodstream, indirectly causing kidney damage. This article reviews the induction of ATLS caused by cytotoxic agents and its prevention and/or control. The association of ATLS with the administration of chemotherapeutic agents must be considered when treating various types of cancer.

6. DOCID:25487 SCORE: 0.00292528369562749
DOCNO: 10211987
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
QUALIFIER: metabolism
QUALIFIER: secondary
QUALIFIER: biosynthesis
QUALIFIER: metabolism
QUALIFIER: pathology
QUALIFIER: biosynthesis
AUTHOR: M Tatsumi M
AUTHOR: A Watanabe A
AUTHOR: H Sawada H
AUTHOR: Y Yamada Y
AUTHOR: Y Shino Y
AUTHOR: H Nakano H
AFFILIATION: First Department of Surgery, Nara Medical University, Kashihara, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical & experimental metastasis.
COUNTRY: NETHERLANDS
TITLE: Immunohistochemical expression of the sialyl Lewis x antigen on gastric cancer cells correlates with the presence of liver metastasis.
PUBDATE: 19981101
The expression of the sialyl Lewis x antigen (sLe(x)) on surgical specimens of primary gastric cancer correlates with the degree of differentiation and synchronous and metachronous liver metastasis. Multivariate analysis by means of Quantification theory II revealed that sLe(x) expression was an independent risk factor for liver metastasis from gastric cancer.

7. DOCID:26776 SCORE: 0.00285679609755393
DOCNO: 11366154
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Services Accessibility
DESCRIPTOR: Quality of Health Care
DESCRIPTOR: Specialties, Medical
QUALIFIER: therapy
QUALIFIER: organization & administration
QUALIFIER: economics
AUTHOR: J S James JS
PUBTYPE: Newspaper Article
JOURNALTITLE: AIDS treatment news.
COUNTRY: UNITED STATES
TITLE: New healthcare economics threaten HIV specialization, patient choice, & quality care.
PUBDATE: 19990101
Changes in managed care programs have forced many HIV physicians to spend a significant amount of time on non-HIV cases to support their practices. HIV patients are more negatively impacted than other high-cost patients, such as those with cancer or diabetes, because HIV is treated as part of primary care rather than being recognized as a disease needing a specialist. Health care plans often undercompensate physicians by paying at a lower rate than if HIV was treated as a disease needing specialty care. The managed care situation discourages physicians from gaining HIV expertise.

8. DOCID:25353 SCORE: 0.00273924774083532
DOCNO: 10592271
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Databases, Factual
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: J L Huret JL
AUTHOR: S L Minor SL
AUTHOR: F Dorkeld F
AUTHOR: P Dessen P
AUTHOR: A Bernheim A
AFFILIATION: Genetics, University Hospital, F-86021 Poitiers, France. jlhuret@infobiogen.fr
PUBTYPE: Journal Article
JOURNALTITLE: Nucleic acids research.
COUNTRY: ENGLAND
TITLE: Atlas of genetics and cytogenetics in oncology and haematology, an interactive database.
PUBDATE: 20000101
The 'Atlas of Genetics and Cytogenetics in Oncology and Haematology' (http://www.infobiogen.fr/services/chromcancer ) is a database devoted to chromosome abnormalities in cancer, cancer-prone diseases and genes involved in cancer. Information presented in each page is concise and updated. This database is made for and by: cytogeneticists, molecular biologists, clinicians in oncology and in haematology, and pathologists, who are encouraged to contribute.

9. DOCID:27882 SCORE: 0.00260906954037014
DOCNO: 11743208
AUTHOR: M J Bouchard MJ
AUTHOR: L H Wang LH
AUTHOR: R J Schneider RJ
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: United States
TITLE: Calcium signaling by HBx protein in hepatitis B virus DNA replication.
PUBDATE: 20011201
Hepatitis B virus (HBV) infects more than 300 million people and is a leading cause of liver cancer and disease. The HBV HBx protein is essential for infection; HBx activation of Src is important for HBV DNA replication. In our study, HBx activated cytosolic calcium-dependent proline-rich tyrosine kinase-2 (Pyk2), a Src kinase activator. HBx activation of HBV DNA replication was blocked by inhibiting Pyk2 or calcium signaling mediated by mitochondrial calcium channels, which suggests that HBx targets mitochondrial calcium regulation. Reagents that increased cytosolic calcium substituted for HBx protein in HBV DNA replication. Thus, alteration of cytosolic calcium was a fundamental requirement for HBV replication and was mediated by HBx protein.

10. DOCID:27958 SCORE: 0.00260906835016443
DOCNO: 10920944
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: H Zhi H
AUTHOR: P Mei P
AUTHOR: A Hao A
AFFILIATION: Second Thoracic Surgery Department, Anyang Cancer Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [Esophago-gastric mucosal anastomosis with staples after resection of cancer of the esophagus and gastric cardia]
PUBDATE: 19981101
OBJECTIVE: To delve an effective method to prevent anastomotic leakage and stenosis. METHODS: Staples were used to carry out mucosal anastomosis between the esophagus and stomach. RESULTS: Four hundred thirty four patients were so treated. The morbidity rate was 9.3% and the mortality rate was 1.4%. No leakage or stenosis was found in this series. CONCLUSION: Using staples to perfonm mucosal anastomotis has the advantages of being simple and safe. Besides prevention of leakage and stenosis, sufficient length of resection of the esophagus helps reduce the likelihood of residual stump cancer recurrence.

11. DOCID:25332 SCORE: 0.00253119419823108
DOCNO: 11902575
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: pathology
AUTHOR: N F Mathon NF
AUTHOR: A C Lloyd AC
AFFILIATION: Department of Biochemistry, University College London, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Cell senescence and cancer.
PUBDATE: 20011201
Historically, the senescent state has been associated with, and was named after, the cell-cycle arrest that occurs after cells have undergone an intrinsically defined number of divisions in vitro. More recently, however, it has been shown that extrinsic factors, including those encountered in normal tissue-culture environments, can prematurely induce an indistinguishable senescent phenotype. In this review, we discuss the pathways of cell senescence, the mechanisms involved and the role that these pathways have in regulating the initiation and progression of cancer.

12. DOCID:27818 SCORE: 0.00253068804324988
DOCNO: 10498881
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: M Vooijs M
AUTHOR: A Berns A
AFFILIATION: Division of Molecular Genetics and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncogene.
COUNTRY: ENGLAND
TITLE: Developmental defects and tumor predisposition in Rb mutant mice.
PUBDATE: 19990901
Targeted gene disruption in the mouse germline permits the introduction of gene mutations similar to those found in inherited human diseases. New advances in gene targeting that enable cell type specific gene disruption in mice further increases the utility of mouse models to study genetic defects as found in cancer. Here we review the phenotypes observed in mice carrying germline mutated copies of the retinoblastoma tumor suppressor gene. We will illustrate how methods that permit tissue-specific Rb inactivation in mice provide new and more versatile tools to gain insight into the etiology of sporadic cancer.

13. DOCID:26253 SCORE: 0.00251548149374892
DOCNO: 9702103
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: C von Briel C
AUTHOR: D C Betticher DC
AUTHOR: H B Ris HB
AFFILIATION: Klinik für Radio-Onkologie mit Abteilung für Medizinische Strahlenphysik, Universität Bern, Inselspital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Therapeutische Umschau. Revue thérapeutique.
COUNTRY: SWITZERLAND
TITLE: [Curative radiotherapy in locally advanced non-small-cell bronchial carcinoma (NSCLC)]
PUBDATE: 19980701
Radiation is a standard treatment for patients with locally advanced non-small cell lung cancer. Only 5% of patients are alive after 5 years. Improvement of local control and survival time have been yielded using knowledge in radiobiology and technical innovations, especially three dimensional planning on the basis of CT and MRI. Further improvement could be reached by performing combination of radio- and chemotherapy. However, the best sequence of chemo- and radiotherapy could not be defined yet.

14. DOCID:26472 SCORE: 0.00228684896126729
DOCNO: 11411436
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Oocyte Donation
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: complications
AUTHOR: S M Kavic SM
AUTHOR: M V Sauer MV
AFFILIATION: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Columbia University College of Physicians and Surgeons, Columbia-Presbyterian Medical Center, New York, New York, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of assisted reproduction and genetics.
COUNTRY: United States
TITLE: Oocyte donation treats infertility in survivors of malignancies: ten-year experience.
PUBDATE: 20010301
Women who are survivors of malignancy may achieve pregnancy through oocyte donation. The largest obstacle to successful reproduction in cancer patients relates to iatrogenic damage to the primary reproductive organs associated with their primary oncology treatment. Reactive damage from surgery, radiation, or chemotherapy may render these organs nonfunctional and irreparable. In cases where the ovary is primarily affected, oocyte donation provides a logical alternative for childbearing.