0. DOCID:27310 SCORE: 0.00479014465565183
DOCNO: 9769121
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: embryology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Bonkhoff H
AUTHOR: K Remberger K
AFFILIATION: Institute of Pathology, University of the Saarland, Homburg-Saar, Germany. patfix@med-rz.uni-sb.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Virchows Archiv : an international journal of pathology.
COUNTRY: GERMANY
TITLE: Morphogenetic concepts of normal and abnormal growth in the human prostate.
PUBDATE: 19980901
Benign prostatic hyperplasia (BPH) and prostate cancer are multifactorial disease processes, involving a growing number of biochemical, genetic and epigenetic factors. Their pathogenesis, however, remains poorly understood. The present review examines current morphogenetic concepts of normal and abnormal growth in the human prostate. This includes the role of basal cells in organogenesis and cancerogenesis, the impact of cell-matrix interactions, and the importance of cellular heterogeneity in tumour progression and hormone-insensitive growth. Knowledge of morphogenesis and morphology is required in any scientific approach to BPH and prostate cancer.


1. DOCID:30542 SCORE: 0.0043915758430186
DOCNO: 12575990
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
AUTHOR: Ronen Marmorstein R
AFFILIATION: The Wistar Institute, The Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. marmor@wistar.upenn.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in biochemical sciences.
COUNTRY: England
TITLE: Structure of SET domain proteins: a new twist on histone methylation.
PUBDATE: 20030201
The methylation of lysine residues on histone tails is catalyzed by proteins containing a conserved SET domain. A recent flurry of structures of SET domain proteins has revealed a new protein fold and a scaffold for understanding catalysis and substrate binding by these enzymes. The prospect that histone methylation might form an epigenetic code and the implicated involvement of SET domain proteins in cancer assures that structure-function studies of these enzymes will continue until their detailed mechanism of action is determined.


2. DOCID:27375 SCORE: 0.00422879480768944
DOCNO: 10518048
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fuzzy Logic
QUALIFIER: diagnosis
QUALIFIER: genetics
QUALIFIER: methods
AUTHOR: C A Pena-Reyes CA
AUTHOR: M Sipper M
AFFILIATION: Logic Systems Laboratory, Swiss Federal Institute of Technology, IN-Ecublens, CH-1015, Lausanne, Switzerland. carlos.pena@di.epfl.ch
PUBTYPE: Journal Article
JOURNALTITLE: Artificial intelligence in medicine.
COUNTRY: NETHERLANDS
TITLE: A fuzzy-genetic approach to breast cancer diagnosis.
PUBDATE: 19991001
The automatic diagnosis of breast cancer is an important, real-world medical problem. In this paper we focus on the Wisconsin breast cancer diagnosis (WBCD) problem, combining two methodologies-fuzzy systems and evolutionary algorithms-so as to automatically produce diagnostic systems. We find that our fuzzy-genetic approach produces systems exhibiting two prime characteristics: first, they attain high classification performance (the best shown to date), with the possibility of attributing a confidence measure to the output diagnosis; second, the resulting systems involve a few simple rules, and are therefore (human-) interpretable.


3. DOCID:27424 SCORE: 0.00358259835283217
DOCNO: 11811208
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Public Opinion
QUALIFIER: etiology
QUALIFIER: history
QUALIFIER: history
AUTHOR: A Mazur A
AUTHOR: S Rothman S
AUTHOR: S R Lichter SR
AFFILIATION: Center for Media and Public Affairs, N.W. Washington, DC 20037, USA. srlichter@cmpa.com
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Social studies of science.
COUNTRY: United States
TITLE: Biases about man-made cancer among researchers.
PUBDATE: 20011001
Can sociological variables significantly predict researchers' positions on a scientific issue? Carcinogenesis offers a good test case because it is not definitively established how important man-made substances are as contributors to human cancer. American cancer researchers divide on this issue, some broadly emphasizing the importance of man-made carcinogens, others consistently minimizing their importance relative to natural carcinogens. We find that cancer researchers who are male, are affiliated with a medical school, and have more publications, are more likely than their colleagues to minimize the importance of man-made carcinogens.


4. DOCID:31562 SCORE: 0.00356365729325855
DOCNO: 12607585
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: Asif Rashid A
AFFILIATION: Department of Pathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 85, Houston, TX 77030-4095, USA. arashid@mdanderson.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: United States
TITLE: Cellular and molecular biology of biliary tract cancers.
PUBDATE: 20021001
Cancer of the biliary tract has been associated with point mutations of K-ras and beta-catenin proto-oncogenes; alterations of p53, p16, APC, and DPC4 tumor suppressor genes by a combination of chromosomal deletion, mutation, or methylation; and infrequently microsatellite instability. The frequencies of these alterations vary by location and race of the patient, tumor subsite, histology, and associated disease. Advances in the understanding of the genetics of this disease will help in diagnosing biliary tract cancer, screening at-risk patients, and developing therapies.


5. DOCID:27282 SCORE: 0.00340055725586374
DOCNO: 10676768
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: S K Parsons SK
AFFILIATION: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in pediatrics.
COUNTRY: UNITED STATES
TITLE: Oncology practice patterns in the use of hematopoietic growth factors.
PUBDATE: 20000201
Recombinant hematopoietic growth factors were introduced into clinical practice a decade ago: erythropoietin in 1989, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in 1991, and interleukin-11 in 1997. The role of these agents in supportive therapy for children with cancer is still under considerable evaluation. This pediatric-based review summarizes current clinical applications, practice guidelines, and practice patterns for hematopoietic growth factors in the supportive care of children with cancer. It also discusses ongoing controversies and unanswered questions.


6. DOCID:26652 SCORE: 0.00316376900039759
DOCNO: 11257397
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: P K Srivastava PK
AUTHOR: R J Amato RJ
AFFILIATION: Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030-1601, USA. srivastava@nso2.uchc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Vaccine.
COUNTRY: England
TITLE: Heat shock proteins: the 'Swiss Army Knife' vaccines against cancers and infectious agents.
PUBDATE: 20010301
The ability of heat shock proteins to: (a) chaperone peptides, including antigenic peptides; (b) interact with antigen presenting cells through a receptor; (c) stimulate antigen presenting cells to secrete inflammatory cytokines; and (d) mediate maturation of dendritic cells, makes them a one-stop shop for the immune system. These properties also permit the utilization of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases.


7. DOCID:26801 SCORE: 0.00294722905785571
DOCNO: 12973411
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: J F Tomera JF
PUBTYPE: Journal Article
JOURNALTITLE: Drugs of today (Barcelona, Spain : 1998)
COUNTRY: Spain
TITLE: Acute tumor lysis syndrome: considerations of cause and prevention.
PUBDATE: 19990201
The need for better chemotherapeutic interventional modalities with adjunctive biotherapy and/or immunotherapy to confront oncologic disease processes will continue into the new millennium. Unfortunately, existing problems encountered as a consequence to chemotherapy centering on acute tumor lysis syndrome (ATLS) will also continue. ATLS results when cytotoxic agents lyse, or lacerate, outer plasma membranes of numerous cancerous cells. Eventually, their contents spill into the bloodstream, indirectly causing kidney damage. This article reviews the induction of ATLS caused by cytotoxic agents and its prevention and/or control. The association of ATLS with the administration of chemotherapeutic agents must be considered when treating various types of cancer.


8. DOCID:25487 SCORE: 0.00292528369562749
DOCNO: 10211987
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
QUALIFIER: metabolism
QUALIFIER: secondary
QUALIFIER: biosynthesis
QUALIFIER: metabolism
QUALIFIER: pathology
QUALIFIER: biosynthesis
AUTHOR: M Tatsumi M
AUTHOR: A Watanabe A
AUTHOR: H Sawada H
AUTHOR: Y Yamada Y
AUTHOR: Y Shino Y
AUTHOR: H Nakano H
AFFILIATION: First Department of Surgery, Nara Medical University, Kashihara, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical & experimental metastasis.
COUNTRY: NETHERLANDS
TITLE: Immunohistochemical expression of the sialyl Lewis x antigen on gastric cancer cells correlates with the presence of liver metastasis.
PUBDATE: 19981101
The expression of the sialyl Lewis x antigen (sLe(x)) on surgical specimens of primary gastric cancer correlates with the degree of differentiation and synchronous and metachronous liver metastasis. Multivariate analysis by means of Quantification theory II revealed that sLe(x) expression was an independent risk factor for liver metastasis from gastric cancer.


9. DOCID:26776 SCORE: 0.00285679609755393
DOCNO: 11366154
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Services Accessibility
DESCRIPTOR: Quality of Health Care
DESCRIPTOR: Specialties, Medical
QUALIFIER: therapy
QUALIFIER: organization & administration
QUALIFIER: economics
AUTHOR: J S James JS
PUBTYPE: Newspaper Article
JOURNALTITLE: AIDS treatment news.
COUNTRY: UNITED STATES
TITLE: New healthcare economics threaten HIV specialization, patient choice, & quality care.
PUBDATE: 19990101
Changes in managed care programs have forced many HIV physicians to spend a significant amount of time on non-HIV cases to support their practices. HIV patients are more negatively impacted than other high-cost patients, such as those with cancer or diabetes, because HIV is treated as part of primary care rather than being recognized as a disease needing a specialist. Health care plans often undercompensate physicians by paying at a lower rate than if HIV was treated as a disease needing specialty care. The managed care situation discourages physicians from gaining HIV expertise.


10. DOCID:25353 SCORE: 0.00273924774083532
DOCNO: 10592271
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Databases, Factual
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: J L Huret JL
AUTHOR: S L Minor SL
AUTHOR: F Dorkeld F
AUTHOR: P Dessen P
AUTHOR: A Bernheim A
AFFILIATION: Genetics, University Hospital, F-86021 Poitiers, France. jlhuret@infobiogen.fr
PUBTYPE: Journal Article
JOURNALTITLE: Nucleic acids research.
COUNTRY: ENGLAND
TITLE: Atlas of genetics and cytogenetics in oncology and haematology, an interactive database.
PUBDATE: 20000101
The 'Atlas of Genetics and Cytogenetics in Oncology and Haematology' (http://www.infobiogen.fr/services/chromcancer ) is a database devoted to chromosome abnormalities in cancer, cancer-prone diseases and genes involved in cancer. Information presented in each page is concise and updated. This database is made for and by: cytogeneticists, molecular biologists, clinicians in oncology and in haematology, and pathologists, who are encouraged to contribute.


11. DOCID:31129 SCORE: 0.00266899879059138
DOCNO: 15510898
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: Zbigniew Wolski Z
AUTHOR: Tomasz Drewa T
AUTHOR: Dorota Olszewska-SÅ‚onina D
AUTHOR: Olivier Cussenot O
AFFILIATION: Klinika Urologii AM w Bydgoszczy.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: Poland
TITLE: [Hereditary prostate cancer]
PUBDATE: 20040601
About 10% of the prostate cancer cases were recognized as familial or hereditary. Till now gene/genes responsible for hereditary prostate cancer are not identified. Hereditary prostate cancer case concerning 3 brothers in family of 6 siblings from first marriage and a grandson from second marriage was presented. Two brothers were treated radical prostatectomy because of confined disease. The third brother with spreading disease died after androgen blockade management. We did not find any linkage between chosen markers of PCaP region (Predisposing for Prostate Cancer) and prostate cancer occurrence in this family.


12. DOCID:31091 SCORE: 0.00266898481264378
DOCNO: 12957621
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: physiopathology
QUALIFIER: methods
AUTHOR: Morton S Kahlenberg MS
AUTHOR: John M Sullivan JM
AUTHOR: Diana Dickson Witmer DD
AUTHOR: Nicholas J Petrelli NJ
AFFILIATION: Division of Surgical Oncology, Department of Surgery, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. kahlenberg@uthscsa.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology.
COUNTRY: Netherlands
TITLE: Molecular prognostics in colorectal cancer.
PUBDATE: 20031101
Conventional staging of colorectal cancer does not account for the marked variability in outcome that exists within each stage. Certain populations of patients with early recurrence, resistance to chemotherapy and decreased survival cannot be predicted utilizing common histopathologic criteria. As the molecular mechanisms underlying colorectal carcinogenesis are elucidated, putative molecular prognostic factors are identified. A comprehensive review of various molecular markers and their roles as prognostic factors in colorectal cancer is presented.


13. DOCID:27882 SCORE: 0.00260906954037014
DOCNO: 11743208
AUTHOR: M J Bouchard MJ
AUTHOR: L H Wang LH
AUTHOR: R J Schneider RJ
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: United States
TITLE: Calcium signaling by HBx protein in hepatitis B virus DNA replication.
PUBDATE: 20011201
Hepatitis B virus (HBV) infects more than 300 million people and is a leading cause of liver cancer and disease. The HBV HBx protein is essential for infection; HBx activation of Src is important for HBV DNA replication. In our study, HBx activated cytosolic calcium-dependent proline-rich tyrosine kinase-2 (Pyk2), a Src kinase activator. HBx activation of HBV DNA replication was blocked by inhibiting Pyk2 or calcium signaling mediated by mitochondrial calcium channels, which suggests that HBx targets mitochondrial calcium regulation. Reagents that increased cytosolic calcium substituted for HBx protein in HBV DNA replication. Thus, alteration of cytosolic calcium was a fundamental requirement for HBV replication and was mediated by HBx protein.


14. DOCID:27958 SCORE: 0.00260906835016443
DOCNO: 10920944
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: H Zhi H
AUTHOR: P Mei P
AUTHOR: A Hao A
AFFILIATION: Second Thoracic Surgery Department, Anyang Cancer Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [Esophago-gastric mucosal anastomosis with staples after resection of cancer of the esophagus and gastric cardia]
PUBDATE: 19981101
OBJECTIVE: To delve an effective method to prevent anastomotic leakage and stenosis. METHODS: Staples were used to carry out mucosal anastomosis between the esophagus and stomach. RESULTS: Four hundred thirty four patients were so treated. The morbidity rate was 9.3% and the mortality rate was 1.4%. No leakage or stenosis was found in this series. CONCLUSION: Using staples to perfonm mucosal anastomotis has the advantages of being simple and safe. Besides prevention of leakage and stenosis, sufficient length of resection of the esophagus helps reduce the likelihood of residual stump cancer recurrence.