0. DOCID:22943 SCORE: 0.00462240271417162
DOCNO: 8178132
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nuclear Reactors
QUALIFIER: mortality
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: V F Hohryakov VF
AUTHOR: S A Romanov SA
AFFILIATION: Public Health Ministry of the Russian Federation, Biophysics Institute Branch N1, Chelyabinsk-65.
PUBTYPE: Journal Article
JOURNALTITLE: The Science of the total environment.
COUNTRY: NETHERLANDS
TITLE: Lung cancer in radiochemical industry workers.
PUBDATE: 19940301
The frequency of lung cancer was investigated among 2346 workers in the radiochemical plant 'Mayak' who were exposed to radiation, both externally and internally from incorporation of plutonium. The results from the follow-up were analysed in terms of a linear relative risk model, accounting for the protracted exposures. On the basis of the observed data, it is deduced that the life-span incidence of radiation-induced lung cancer is several times larger than the value 0.0085 Sv-1 that is recommended in ICRP Publication 60 for the risk to this organ.

1. DOCID:22938 SCORE: 0.00459941037978569
DOCNO: 8059474
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: prevention & control
AUTHOR: H S Hansen HS
AFFILIATION: Onkologisk afdeling, Rigshospitalet, København.
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Medullary thyroid cancer--screening]
PUBDATE: 19940601
It is possible to screen for medullary thyroid cancer (MTC) with biochemical tests, imaging and genetic testing in families with multiple endocrine neoplasia type 2. The recommendation is based on a consensus statement made by the Members of the European Community concerted action for MTC. The prognostic characteristics are based on 117 patients with MTC diagnosed in Denmark between 1970-1991. Twenty percent of all MTC patients were members of families with two or more thyroid cancer patients. More than half of all MTC patients had neck lymph node involvement at the time of diagnosis. The frequency of neck lymph node involvement was however only 20% amongst those with familiar MTC.

2. DOCID:18747 SCORE: 0.00429492230526342
DOCNO: 2224844
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Differentiation
QUALIFIER: physiopathology
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: Y S Cho-Chung YS
AFFILIATION: Cellular Biochemistry Section, National Cancer Institute, NIH, Bethesda, Maryland 20892.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy.
PUBDATE: 19901101
Two isoforms of the regulatory subunits of cyclic AMP (cAMP)-dependent protein kinase that bind cAMP are inversely expressed during ontogeny and cell differentiation. These cAMP-binding receptor proteins in harmony may regulate the growth of normal cells and their differentiation into nondividing states. Cancer cells can also be made to differentiate and stop growing when the functional balance of these cAMP receptor proteins is restored by treatment with site-selective cAMP analogues or by the use of an antisense oligodeoxynucleotide, suggesting new approaches to cancer treatment.

3. DOCID:18699 SCORE: 0.00393254545843047
DOCNO: 1998233
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: A K Jakobsen AK
AUTHOR: K Bertelsen K
AUTHOR: B Andreasson B
AUTHOR: P Bichel P
AUTHOR: J J Christensen JJ
AUTHOR: I S Christophersen IS
AUTHOR: S A Engelholm SA
AUTHOR: H Havsteen H
AUTHOR: M Hjelm-Hansen M
AUTHOR: F Jensen F
AFFILIATION: Onkologisk afdeling, Arhus Kommunehospital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Treatment of cervix cancer in Denmark]
PUBDATE: 19910101
The current status of cervical cancer treatment in Denmark is discussed. Diagnostic aspects and problems of classification are presented briefly supplemented with a comment on new prognostic parameters based on a semiquantitative score system and flow cytometry. Surgery is the treatment of election for the early stages whereas radiotherapy is the treatment of choice in advanced stages. Chemotherapy should only be employed in the framework of clinical trials. It is concluded that centralised treatment should be maintained.

4. DOCID:17343 SCORE: 0.00377379783205755
DOCNO: 1813556
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ciliary Body
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: T K Wilcox TK
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Optometric Association.
COUNTRY: UNITED STATES
TITLE: Case report: ciliary body melanoma with extrascleral extension.
PUBDATE: 19910701
Uveal melanoma is an uncommon cancer that is most often diagnosed in the sixth decade and is somewhat more common in males. Early detection and treatment of melanoma is important as metastasis can be fatal. A case of ciliary body melanoma that was detected in an asymptomatic patient because of extrascleral extension is presented. Signs and symptoms that may lead to the diagnosis of uveal melanoma are presented, as well as lesions that may simulate extrascleral extension of melanoma.

5. DOCID:18643 SCORE: 0.00374693499265719
DOCNO: 1608657
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: physiology
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: A Sarasin A
AUTHOR: C Robert-Knebelmann C
AUTHOR: A Stary A
AFFILIATION: Laboratoire de Génétique Moléculaire, Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pathologie-biologie.
COUNTRY: FRANCE
TITLE: [DNA repair and related diseases]
PUBDATE: 19920201
DNA-repair is a complex enzymatic process which enables all living cells to withstand the deleterious and mutagenic effects of most genotoxic agents. Defective DNA-repair is caused by mutations involving genes which encode the enzymes responsible for recognition and excision of DNA lesions. Some of these genes have been identified in humans. Several severe human diseases are caused by defective DNA repair affecting the entire genome (e.g. xeroderma pigmentosum and trichotiodystrophy) or only actively transcribed genes (Cockayne's syndrome). Some of these conditions are associated with extremely high rate of cancer.

6. DOCID:23205 SCORE: 0.00368862706161586
DOCNO: 9410650
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nursing Process
QUALIFIER: nursing
QUALIFIER: methods
AUTHOR: D K Mayer DK
AUTHOR: C Struthers C
AUTHOR: G Fisher G
AFFILIATION: Cancer Pain Control Program, Princess Margaret Hospital, Toronto, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinical journal of oncology nursing.
COUNTRY: UNITED STATES
TITLE: Bone metastases: Part II--Nursing management.
PUBDATE: 19970401
Nurses play a crucial role in identifying bone metastases and managing clinical sequelae, such as pain. Understanding the metastatic process is necessary for delivering effective nursing care. Part I of this article described the pathophysiology and assessment. Part II will provide an overview of the nursing management of the sequelae of bone metastases, including pain, pathologic fractures, spinal cord compression, hypercalcemia, and anemia. Risk factor identification can lead to prevention and early detection of these clinically significant problems. Clinical management of bone metastases will contribute to the nurse's ability to improve the quality of life of patients with cancer.

7. DOCID:21046 SCORE: 0.00363715541601181
DOCNO: 7545107
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Balloon Dilatation
DESCRIPTOR: Palliative Care
DESCRIPTOR: Stents
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: I Raijman I
AUTHOR: M Siemens M
AUTHOR: N Marcon N
AFFILIATION: Division of Gastroenterology, Wellesley Hospital, University of Toronto, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Endoscopy.
COUNTRY: GERMANY
TITLE: Use of an expandable Ultraflex stent in the treatment of malignant rectal stricture.
PUBDATE: 19950301
Obstructive colorectal cancer is usually an indication for surgical intervention. For patients with metastatic disease, medical contraindications, or those who refuse surgery, palliation by nonoperative means is necessary. The advent of expandable metallic stents may allow for speedy palliation. We have treated one patient with unresectable colon cancer with a new selfexpanding endoprosthesis made of nitinol (Ultraflex, Microvasive, Watertown, MA, U.S.A.).

8. DOCID:23652 SCORE: 0.00349464862728244
DOCNO: 8555151
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: diagnosis
QUALIFIER: complications
AUTHOR: A J Dickenson AJ
AUTHOR: W J Currie WJ
AUTHOR: B S Avery BS
AFFILIATION: Department of Maxillofacial Surgery, Middlesbrough General Hospital, Cleveland.
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of oral & maxillofacial surgery.
COUNTRY: SCOTLAND
TITLE: Screening for syphilis in patients with carcinoma of the tongue.
PUBDATE: 19951001
The oral signs of syphilis have been comprehensively described and can be identified at each stage of the infection. Despite the historical recognition that inadequately treated or untreated syphilitic leukoplakia may undergo malignant transformation, many surgical units no longer routinely screen patients presenting with malignant or premalignant lesions. In this study, five of the 63 patients (8%) who presented with neoplasms of the tongue reacted to syphilis antibodies. These results indicate that syphilis is still prevalent in this group of patients and suggest that serological investigations may be warranted in the initial assessment of all patients with oral cancer.

9. DOCID:23435 SCORE: 0.00345679124795605
DOCNO: 8599720
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: P S Smitt PS
AUTHOR: J B Posner JB
AFFILIATION: Dr Daniel den Hoed Kliniek, Department of Neuro-Oncology, Rotterdam, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Baillière's clinical neurology.
COUNTRY: ENGLAND
TITLE: Paraneoplastic peripheral neuropathy.
PUBDATE: 19951101
Paraneoplastic peripheral neuropathies are not common. They are out-numbered by the far more common peripheral neuropathies that occur either as a direct result of the cancer (metastases) or its treatment (usually chemotherapy). Nevertheless, paraneoplastic peripheral neuropathies are important because they may be the first sign of an otherwise occult cancer and/or because they may substantially disable the patient even when the cancer itself is asymptomatic. Paraneoplastic disorders are sometimes marked by the presence of autoantibodies that react with proteins both in the underlying cancer and in the nervous system. Their discovery may lead to an early diagnosis and potential cure of the underlying cancer.

10. DOCID:19866 SCORE: 0.00345671714859467
DOCNO: 8471552
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: E Tomiak E
AUTHOR: M Piccart M
AFFILIATION: Institut Jules Bordet, Brussels, Belgium.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO.
COUNTRY: NETHERLANDS
TITLE: Routine follow-up of patients after primary therapy for early breast cancer: changing concepts and challenges for the future.
PUBDATE: 19930301
In an era of increasing financial constraints, physicians are being forced to critically re-evaluate various clinical practices that have not been shown to be cost-effective or associated with definitive patient benefit. Routine follow-up programs following primary therapy for early-stage breast cancer vary widely from centre to centre, and although the subject of numerous retrospective analyses, they have not been prospectively evaluated to date. This review paper presents arguments for changing the emphasis of follow-up visits and stresses the need for prospective clinical and cost-benefit evaluations of current follow-up practices.

11. DOCID:22675 SCORE: 0.00325006436667366
DOCNO: 8306267
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnostic use
QUALIFIER: diagnostic use
QUALIFIER: radionuclide imaging
QUALIFIER: diagnostic use
AUTHOR: S M Larson SM
AUTHOR: C R Divgi CR
AUTHOR: A M Scott AM
AFFILIATION: Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Overview of clinical radioimmunodetection of human tumors.
PUBDATE: 19940201
The role of radioimmunodetection in the detection of cancer has been established through the development of high affinity immunoconjugates and recent improvements in radiochemistry. Advances in imaging techniques, particularly single-photon emission computed tomography and image registration, also have dramatically improved the sensitivity and accuracy of tumor detection. Molecular engineering of immune constructs provides promise of enhanced tumor localization properties and reduced immunogenicity, allowing repeated studies to be performed. The role of radioimmunodetection in the evaluation of cancer patients will increase in importance in the future.

12. DOCID:22814 SCORE: 0.00323732236521453
DOCNO: 7480254
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radiation Oncology
QUALIFIER: radiotherapy
AUTHOR: N Janjan N
AUTHOR: M Miller M
AUTHOR: M A Schusterman MA
AFFILIATION: Department of Radiotherapy, University of Texas M.D. Anderson Cancer Center, Houston, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Plastic and reconstructive surgery.
COUNTRY: UNITED STATES
TITLE: Therapeutic principles and options in radiation oncology.
PUBDATE: 19951101
Radiation therapy is used increasingly as a definitive or adjunctive treatment for cancer. Definitive irradiation allows functional preservation of structures critical to function. Adjunctive irradiation following surgical resection of the primary lesion treats regional lymph nodes and/or sites of primary extension at high risk for microscopic involvement. Specialized techniques can be applied to deliver higher total doses of irradiation and minimize late normal tissue effects to adjacent normal tissues. Local-regional tumor control combined with functional preservation represents the specific goals of radiation therapy applied alone or in conjunction with surgical resection.

13. DOCID:22735 SCORE: 0.00309993655820474
DOCNO: 7640935
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Frontal Lobe
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: R Jyothirmayi R
AUTHOR: J Edison J
AUTHOR: P P Nayar PP
AUTHOR: M K Nair MK
AUTHOR: B Rajan B
AFFILIATION: Department of Radiotherapy and Clinical Oncology, Regional Cancer Centre, Trivandrum, India.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of radiology.
COUNTRY: ENGLAND
TITLE: Case report: brain metastases from papillary carcinoma thyroid.
PUBDATE: 19950701
Papillary carcinoma, the commonest thyroid malignancy, has a good prognosis and low incidence of distant metastases. Brain metastasis is extremely rare with a frequency of 0.1-5% in reported series. The clinical details of two cases of histologically proven brain metastases from papillary thyroid cancer treated in our centre are presented. In one patient, the lesion was in the cerebellar hemisphere, and in the other, the frontal lobe. Also presented is a review of the literature of this unusual clinical presentation.

14. DOCID:21450 SCORE: 0.00309802703127164
DOCNO: 8632969
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: diagnosis
AUTHOR: E Randrup E
AUTHOR: N Baum N
AFFILIATION: Tulane University School of Medicine, New Orleans, La, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Prostate-specific antigen testing for prostate cancer. Practical interpretation of values.
PUBDATE: 19960201
The mere mention of prostate cancer strikes fear in the hearts of men. Fortunately, prostate-specific antigen (PSA) is now a recognized tumor marker that can indicate but not exclude the presence of this potentially fatal disease. In this article, Drs Randrup and Baum explain the nature of PSA and the practical application of serum PSA determination. Also discussed are three PSA-based strategies for early diagnosis and guidelines for interpreting PSA values in the primary care setting.