0. DOCID:7140 SCORE: 0.00580707759131625
DOCNO: 6947013
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R W Correll RW
AUTHOR: W B Wescott WB
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Dental Association (1939)
COUNTRY: UNITED STATES
TITLE: Asymptomatic nonulcerated swelling of the mandible.
PUBDATE: 19811201
This case emphasizes that radiographic changes, although not diagnostic, can be characteristic and highly suggestive of a disease process especially a benign or malignant tumor. Radiographic changes that suggested the possibility of a malignant process in this case included ill-defined margins of the lesion; bone production within the lesion, especially interdentally at the alveolar crest; widening of the periodontal ligament space around tooth roots within the lesions; and perpendicular bony striae extending outward from the surface of the bone (sun-ray effect). THese changes are not specific for a malignant process: however, when coupled with the clinical history, the probability of malignancy is high. Failure of recognition is considered the greatest problem in malignancy of the oral cavity. Clinicians should consider every abnormal condition as suspicious unless there are valid reasons for ruling out cancer.


1. DOCID:3607 SCORE: 0.00559399727805165
DOCNO: 65207
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
DESCRIPTOR: Immunologic Techniques
DESCRIPTOR: Leukocyte Adherence Inhibition Test
QUALIFIER: immunology
AUTHOR: T Fujisawa T
AUTHOR: S R Waldman SR
AUTHOR: R H Yonemoto RH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Leukocyte adherence inhibition by soluble tumor antigens in breast cancer patients.
PUBDATE: 19770201
The authors modified and refined the Leukocyte Adherence Inhibition Assay (LAI) first described by Halliday, et al. in 1972 by standardizing the protein concentration of tumor-associated antigens (TAA) and by utilizing paired normal tissue extracts as controls to eliminate interference of HL-A histocompatibility antigens and organ-associated antigens. When dose response studies were performed, a progressively larger percentage of patients reacted to the LAI test with increasing concentration of tumor extracts, but the optimal concentration was found to be 200 mug/ml, where 42 out of 66 (63%) leukocytes from 54 breast cancer patients reacted to the breast cancer extracts. At this dose range, only three out of 39 (7%) normal donors and four out of 30 (13%) patients with other types of cancer were positive. When breast cancer patients were tested against TAA of colon cancer and malignant melanoma, one of 24 (4%) and two of 24 (8%), respectively, were positive. Although a higher response rate (72%) was noted in Stage II disease, this was not statistically different from Stage I and Stage III disease. Likewise, no difference was noted in LAI at varying phases following the mastectomy.


2. DOCID:7883 SCORE: 0.00476128509248607
DOCNO: 6943367
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: S Tokudome S
AUTHOR: S Kono S
AUTHOR: M Ikeda M
AUTHOR: M Kuratsune M
AUTHOR: S Kumamaru S
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Cancer and other causes of death among leprosy patients.
PUBDATE: 19810801
A follow-up study was done on the mortality from 1956 to 1975 among 2,383 Japanese patients with leprosy who were admitted to a leprosarium in Japan. The leprosy was classified into two types: lepromatous and tuberculoid. Irrespective of the type of leprosy or the sex of leprosy patient, mortalities were increased from tuberculosis, pneumonia and bronchitis, nephritis and nephrosis, and from total causes. The suicide rate was high among female patients. Deaths from total malignant neoplasms were higher than expected among patients with lepromatous leprosy for both sexes (49 observed vs. 44.02 expected), whereas they were lower than expected among patients with tuberculoid leprosy (35 observed vs. 36.83 expected); however, the differences were not statistically significant. Mortalities from cancers of the cervix and the esophagus among females with lepromatous leprosy were significantly higher. The risk of lymphoreticular cancers was not increased.


3. DOCID:3532 SCORE: 0.00444730426389348
DOCNO: 60156
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W R Vogler WR
AUTHOR: D S Miller DS
AUTHOR: J W Keller JW
PUBTYPE: Journal Article
JOURNALTITLE: Blood.
COUNTRY: UNITED STATES
TITLE: 5-Azacytidine (NSC 102816): a new drug for the treatment of myeloblastic leukemia.
PUBDATE: 19760901
The pyrimidine analog, 5-azacytidine (NSC 102816), was administered by continuous intravenous infusion in Ringer's lactate in increasing doses to sets of patients with metastatic cancer to establish a dose sufficient to produce mild toxicity. Twenty-one patients (23 trials) were treated with doses of 50-200 mg/sq/m/day for 5 days every 2-4 wk. Nausea and vomiting were moderate and easily preventable. Doses of 100-200 mg/sq/m for 5 days every 14 days produced granulocytopenia, usually after two courses. Less toxicity was observed when courses were given every 21-28 days. Forty-five patients with previously treated and refractory acute myeloblastic leukemia were treated. The majority received doses of 150 mg/sq m for 5 days every 2 wk. Eleven (24%) complete remissions and four partial remissions were observed. The number of courses to achieve remission averaged three and required an average of 59 days. Nine patients with blastic crisis of chronic myeloblastic leukemia and four with refractory acute lymphoblastic leukemia failed to respond. 5-Azacytidine administered by continuous infusion is well tolerated and is an active compound in acute myeloblastic leukemia.


4. DOCID:6721 SCORE: 0.00419957080382445
DOCNO: 7351010
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: A U Buzdar AU
AUTHOR: S S Legha SS
AUTHOR: M A Luna MA
AUTHOR: C K Tashima CK
AUTHOR: G N Hortobagyi GN
AUTHOR: G R Blumenschein GR
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Pulmonary toxicity of mitomycin.
PUBDATE: 19800101
Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progressing to interstitial pulmonary fibrosis. Corticosteroid therapy resulted in complete resolution of pneumonia in one patient. Respiratory symptoms improved in 3 patients following discontinuation of the drug. Two patients with extensive bilateral pneumonitis, who were not treated with steroids, died of respiratory failure. Mitomycin-induced lung toxicity appears to be reversible with the discontinuation of drug and the administration of corticosteroids. Lung biopsy is necessary in order to rule out other diagnoses.


5. DOCID:3937 SCORE: 0.00419710421845162
DOCNO: 1278659
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vaginal Smears
QUALIFIER: diagnosis
AUTHOR: W Furch W
AUTHOR: H Cramer H
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [Results of cytologic examinations of the cervix in women under the age of thirty (author's transl)]
PUBDATE: 19760501
154 suspicious and positive findings for carcinoma in women between the ages of 18 and 30 were reported. Included here were 7 cases of invasive carcinoma, 57 cases of epithelial carcinoma, 8 cases of advanced dysplasia and 17 cases of dysplasia in beginning and intermediate stages. The findings from two gynecologic practices in which the physicians annually conducted a cytologic examination of the cervix on every woman, regardless of age, were studied in particular. In both of these practices, 64 of the 89 preliminary stages of carcinoma and carcinoma itself in this age group were discovered in this way. The total material came from 26 contributors. The participation on the part of the young women in both gynecologic practices was unexpectedly high (33% of all those patients receiving preventive examinations). The established practice of conducting cytologic cancer tests on the cervix uteri only after the age of 30 can no longer be justified. One possible causal factor for the increased morbidity and the earlier occurrence of the disease is the coincidence between genital infections and the increased occurrence of neoplasia of the cervix due to earlier onset of sexual activity. It is imperative that women be informed of the increased risks and that they be given the opportunity of a cervical cancer test even before the age of thirty.


6. DOCID:2743 SCORE: 0.00386929131445411
DOCNO: 832225
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: J N Ingle JN
AUTHOR: D C Tormey DC
AUTHOR: J M Bull JM
AUTHOR: R M Simon RM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Bone marrow involvement in breast cancer: effect on response and tolerance to combination chemotherapy.
PUBDATE: 19770101
Forty-three patients with metastatic breast cancer who had not received prior chemotherapy were divided into two groups on the basis of whether or not a bone marrow examination revealed tumor. Both groups were treated with combination chemotherapy regimens and were analyzed with regard to response and toxicity parameters. The positive marrow group had a response rate similar to that of the negative marrow group (67% vs 71%), and a slightly shorter median time to progressive disease (240 vs 258 days) and median duration of remission (213 vs 243 days). The positive marrow group had higher requirements for hematologic support and tended to have more infectious complications. The data suggest that metastatic breast cancer patients with a bone marrow examination revealing tumor, although requiring more supportive care, may be treated as effectively with combination chemotherapy as those patients in whom the marrow examination does not reveal tumor.


7. DOCID:7351 SCORE: 0.00376558648858626
DOCNO: 6970069
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: drug therapy
AUTHOR: V T DeVita VT
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The consequences of the chemotherapy of Hodgkin's disease: The 10th David A. Karnofsky Memorial Lecture.
PUBDATE: 19810101
The most important consequence of using chemotherapy for Hodgkin's disease is its cure. Results of the MOPP program, developed at the National Cancer Institute in 1964, indicate that the majority of the 80% of patients who attain complete remission, who are at risk for ten years, have remained disease-free. The presence of symptoms and the histologic subtype, nodular sclerosis, has had important negative influences on prognosis. Review of three long-term adverse consequences of chemotherapy revealed sterility to be the most significant effect of drug treatment in this young population. Adverse effects of the immunosuppressive drugs in MOPP proved to be minimal. The carcinogenic effect of MOPP when used alone was surprisingly small, but increased significantly when combined with irradiation. National mortality from Hodgkin's disease has decreased abruptly since the introduction of effective chemotherapy for Hodgkin's disease in 1970.


8. DOCID:3027 SCORE: 0.00375373009380599
DOCNO: 920870
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: diagnosis
QUALIFIER: pathology
QUALIFIER: diagnosis
AUTHOR: W H Wolinska WH
AUTHOR: M R Melamed MR
AUTHOR: P F Schellhammer PF
AUTHOR: W F Whitmore WF
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of surgical pathology.
COUNTRY: UNITED STATES
TITLE: Urethral cytology following cystectomy for bladder carcinoma.
PUBDATE: 19770901
There is a high probability of urethral carcinoma in patients who have had cystectomy for carcinoma of the urinary bladder, and their survival is poor when the disease is sufficiently advanced to be symptomatic or tumor is visible endoscopically. This study was undertaken to evaluate urethral cytology as a means of detecting and diagnosing in situ and invasive carcinoma of the urethral remnant following cystectomy. A total of 109 cytology specimens were examined from 65 patients who had cystectomy for bladder cancer. "Positive" or "suspicious" cytologic diagnoses of cancer were made on 28 patients; 24 had urethrectomy and 11 proved to have invasive carcinoma, 10 had carcinoma in situ and three had atypia or metaplastic changes in the urethra. One of 37 patients with "negative" cytologic diagnoses was found to have a low-grade carcinoma. It is suggested that all patients who undergo cystectomy without urethrectomy be followed with urethral cytological examination at regular intervals for an indefinite period.


9. DOCID:2709 SCORE: 0.00373673682978026
DOCNO: 865201
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: K Dahm K
AUTHOR: A Knipper A
AUTHOR: H Mitschke H
PUBTYPE: Journal Article
JOURNALTITLE: Langenbecks Archiv für Chirurgie.
COUNTRY: GERMANY, WEST
TITLE: [Malignant degeneration of experimental ulcerative colitis of the rat following s.c. injection of 1,2-dimethylhydrazine (author's transl)]
PUBDATE: 19770401
Animal experiments were performed to answer the question whether ulcerative colitis is predisposed to malignant degeneration. Male Wistar rats were given aqueous solutions of degraded Carrageenan (4%; w/v). After induction of ulcerative colitis, 1,2-Dimethylhydrazine (DMH; 132 mg/kg body weight) was applicated during a period of 7 weeks. 17 of 18 rats developed multiple adenocarcinomas in the distal colon 15 weeks after the last injection of DMH. The Carrageenan induced colitis was localized predominantly in the distal part of the large bowel. Only 3 rats of a control group of 18 animals exposed to DMH only showed carcinomas of the colon. The difference is proven significant (P less than 0.01). Carrageenan for itself caused no malignancy. The results of the experiments demonstrate that, during ulcerative colitis, the colon of the rat is more susceptible to induction of cancer than the intact one.


10. DOCID:2017 SCORE: 0.00371496584235737
DOCNO: 1155427
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Air Pollution
QUALIFIER: epidemiology
AUTHOR: B E Henderson BE
AUTHOR: R J Gordon RJ
AUTHOR: H Menck H
AUTHOR: J Soohoo J
AUTHOR: S P Martin SP
AUTHOR: M C Pike MC
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Lung cancer and air pollution in southcentral Los Angeles County.
PUBDATE: 19750601
An increased rate of lung cancer has been consistently observed from 1968-1972 among males in southcentral Los Angeles. This excess risk occurs across several social classes and occupational categories. No differential excess of oral cavity, pancreatic, laryngeal and bladder cancer was observed in the same area, lessening the possibility that regional variations in smoking habits accounted for the excess lung cancer. Air sampling has indicated an excess of certain polynuclear aromatic hydrocarbons (PAH) in southcentral Los Angeles. There was a correlation between the geographic distribution of lung cancer cases and the general location of industries which have emitted these PAH. A case-controlled study of smoking, occupational and residential history in the southcentral area is underway.


11. DOCID:3557 SCORE: 0.00368591797619372
DOCNO: 1175145
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: R Izbicki R
AUTHOR: B T Weyhing BT
AUTHOR: L Baker L
AUTHOR: E M Caoili EM
AUTHOR: V K Vaitkevicius VK
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Pleural effusion in cancer patients. A prospective randomized study of pleural drainage with the addition of radioactive phsophorous to the pleural space vs. pleural drainage alone.
PUBDATE: 19751001
Sixty-seven patients with disseminated cancer were randomly allocated to treatment with continuous closed chest drainage removing all fluid for 72 hours (PD) or pleural drainage for 72 hours with the instillation into the pleural space of radioactive colloidal chromic phosphate (PD + 32P). Forty-nine patients had breast carcinoma, and the remaining 18 patients had other cancers. Four of 49 patients with breast cancer and 13 of 18 with other cancer were dead in 8 weeks from the onset of effusion. In the group of patients with breast cancer PD + 32P controlled the effusion in 12 of 22 (54%) and PD alone in 15 of 30 episodes (50%). In the nonbreast group of patients PD + 32P controlled the effusion in five of six evaluable episodes (83%), and PD alone was successful in two of nine (22%). In 33% of breast cancer patients and 25% of the nonbreast-cancer patients, systemic chemotherapy produced objective remissions. Pleural effusion did not recur in any of these patients.


12. DOCID:2589 SCORE: 0.00355632311922187
DOCNO: 332575
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pancreatic Ducts
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: J A Gregg JA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gastroenterology.
COUNTRY: UNITED STATES
TITLE: Detection of bacterial infection of the pancreatic ducts in patients with pancreatitis and pancreatic cancer during endoscopic cannulation of the pancreatic duct.
PUBDATE: 19771101
Bacterial infections of the pancreas and bacteremia may occur during episodes of pancreatitis. Detection of bacterial infections of the pancreas in the past has required laparotomy. The present study was undertaken to determine whether bacterial infection of the pancreas occurred during nonsuppurative pancreatitis. During endoscopic cannulation of the main pancreatic duct, secretin was administered intravenously and pancreatic juice aspirated from within the duct was cultured. Bacterial infections were detected in 11 of 35 patients with pancreatitis and 3 of 5 with pancreatic cancer. The pancreatic juice was sterile in 25 controls. Cultures from the common bile duct in 9 controls were also sterile whereas 4 of 6 with pancreatitis showed infected bile. The infecting organisms were principally gram-negative and the infections were usually polymicrobial. Antibiotics, where used, successfully eradicated the infecting organisms but did not appear to affect the patient's clinical course.


13. DOCID:7669 SCORE: 0.00350228641533894
DOCNO: 6154909
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: enzymology
QUALIFIER: analysis
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: analysis
AUTHOR: S Di Blasi S
AUTHOR: M Cuffaro M
AUTHOR: S Rizzo S
AUTHOR: M Belvedere M
AUTHOR: G Genova G
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Alkaline phosphatase isoenzymes and alpha-1-fetoprotein in hepatic neoplasms]
PUBDATE: 19800401
A study was made of possible relations between the placental alkaline phosphatase-isoenzyme (PAP), alpha 1-fetoprotein and liver neoplasia. Ninety-six with various liver diseases were examined, including 10 with primary and 16 with metastatic carcinoma. It was found that both PAP and AFP may be present in a certain percentage of subjects in this pathology. PAP (observed in 30% of cases of primary carcinoma and 43.6% of metastatic forms, as opposed to only 5.6% in cirrhotics) proved much more specific than AFP, which was present in both types of cancer (albeit at much lower concentrations) and also in acute, active chronic and persistent hepatitis, and in cirrhosis of the liver. The theories presented in the relevant literature are discussed in an attempt to explain the "reawakening" of both PAP and AFP, especially in liver neoplasias.


14. DOCID:3362 SCORE: 0.00347653386442093
DOCNO: 1093678
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: analysis
AUTHOR: J P Harris JP
AUTHOR: M H Caleb MH
AUTHOR: M A South MA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Secretory component in human mammary carcinoma.
PUBDATE: 19750701
Since secretory component is thought to be a normal glandular epithelial cell product, surgical specimens from patients with mammary carcinoma, an epithelial cancer, were studied with antisera to human free secretory component by indirect immunofluorescence microscopy. Normal breast tissue (10 cases) showed fluorescent epithelial cells confined to normal ducts. This was in marked contrast to ubvasive mammary carcinoma (20 cases), which showed intense staining of tumor cells and stromal cells in addition to the normal ductular epithelium. Metastases in axillary lymph nodes (2 cases) showed intense fluorescence for secretory component, whereas axillary nodes without metastases from 2 patients with breast cancer showed no fluorescence. In both normal and tumor tissue, antiimmunoglobulin A stained only ducts and subepithelial plasma cells, thus establishing that the secretory component in tumor cells was not part of an intact secretory immunoglobulin A molecule. This finding was not restricted to mammary carcinoma, since preliminary studies of colon, lung, and bladder carcinoma also demonstrated tumor cells with cytoplasmic fluorescence for secretory component. In contrast, the tumor cells in 2 cases of sarcoma, a nonepithelial cancer, did not exhibit fluorescence for secretory component.