0. DOCID:7140 SCORE: 0.00580707759131625
DOCNO: 6947013
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R W Correll RW
AUTHOR: W B Wescott WB
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Dental Association (1939)
COUNTRY: UNITED STATES
TITLE: Asymptomatic nonulcerated swelling of the mandible.
PUBDATE: 19811201
This case emphasizes that radiographic changes, although not diagnostic, can be characteristic and highly suggestive of a disease process especially a benign or malignant tumor. Radiographic changes that suggested the possibility of a malignant process in this case included ill-defined margins of the lesion; bone production within the lesion, especially interdentally at the alveolar crest; widening of the periodontal ligament space around tooth roots within the lesions; and perpendicular bony striae extending outward from the surface of the bone (sun-ray effect). THese changes are not specific for a malignant process: however, when coupled with the clinical history, the probability of malignancy is high. Failure of recognition is considered the greatest problem in malignancy of the oral cavity. Clinicians should consider every abnormal condition as suspicious unless there are valid reasons for ruling out cancer.

1. DOCID:3607 SCORE: 0.00559399727805165
DOCNO: 65207
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
DESCRIPTOR: Immunologic Techniques
DESCRIPTOR: Leukocyte Adherence Inhibition Test
QUALIFIER: immunology
AUTHOR: T Fujisawa T
AUTHOR: S R Waldman SR
AUTHOR: R H Yonemoto RH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Leukocyte adherence inhibition by soluble tumor antigens in breast cancer patients.
PUBDATE: 19770201
The authors modified and refined the Leukocyte Adherence Inhibition Assay (LAI) first described by Halliday, et al. in 1972 by standardizing the protein concentration of tumor-associated antigens (TAA) and by utilizing paired normal tissue extracts as controls to eliminate interference of HL-A histocompatibility antigens and organ-associated antigens. When dose response studies were performed, a progressively larger percentage of patients reacted to the LAI test with increasing concentration of tumor extracts, but the optimal concentration was found to be 200 mug/ml, where 42 out of 66 (63%) leukocytes from 54 breast cancer patients reacted to the breast cancer extracts. At this dose range, only three out of 39 (7%) normal donors and four out of 30 (13%) patients with other types of cancer were positive. When breast cancer patients were tested against TAA of colon cancer and malignant melanoma, one of 24 (4%) and two of 24 (8%), respectively, were positive. Although a higher response rate (72%) was noted in Stage II disease, this was not statistically different from Stage I and Stage III disease. Likewise, no difference was noted in LAI at varying phases following the mastectomy.

2. DOCID:7883 SCORE: 0.00476128509248607
DOCNO: 6943367
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: S Tokudome S
AUTHOR: S Kono S
AUTHOR: M Ikeda M
AUTHOR: M Kuratsune M
AUTHOR: S Kumamaru S
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Cancer and other causes of death among leprosy patients.
PUBDATE: 19810801
A follow-up study was done on the mortality from 1956 to 1975 among 2,383 Japanese patients with leprosy who were admitted to a leprosarium in Japan. The leprosy was classified into two types: lepromatous and tuberculoid. Irrespective of the type of leprosy or the sex of leprosy patient, mortalities were increased from tuberculosis, pneumonia and bronchitis, nephritis and nephrosis, and from total causes. The suicide rate was high among female patients. Deaths from total malignant neoplasms were higher than expected among patients with lepromatous leprosy for both sexes (49 observed vs. 44.02 expected), whereas they were lower than expected among patients with tuberculoid leprosy (35 observed vs. 36.83 expected); however, the differences were not statistically significant. Mortalities from cancers of the cervix and the esophagus among females with lepromatous leprosy were significantly higher. The risk of lymphoreticular cancers was not increased.

3. DOCID:9722 SCORE: 0.00446824675563077
DOCNO: 6709743
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: psychology
AUTHOR: L A Stevens LA
AUTHOR: M H McGrath MH
AUTHOR: R G Druss RG
AUTHOR: S J Kister SJ
AUTHOR: F E Gump FE
AUTHOR: K A Forde KA
PUBTYPE: Journal Article
JOURNALTITLE: Plastic and reconstructive surgery.
COUNTRY: UNITED STATES
TITLE: The psychological impact of immediate breast reconstruction for women with early breast cancer.
PUBDATE: 19840401
Twenty-five patients were evaluated, 13 who had immediate breast reconstruction and 12 who had delayed breast reconstruction for early breast cancer. Data were elicited about the psychological impact of the cancer, the mastectomy, and the reconstruction. Our results support the conclusion that immediate breast reconstruction is accompanied by a lower incidence of psychological morbidity postoperatively, and we recommend that immediate breast reconstruction be offered as an alternative to women with early breast cancer.

4. DOCID:3532 SCORE: 0.00444730426389348
DOCNO: 60156
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W R Vogler WR
AUTHOR: D S Miller DS
AUTHOR: J W Keller JW
PUBTYPE: Journal Article
JOURNALTITLE: Blood.
COUNTRY: UNITED STATES
TITLE: 5-Azacytidine (NSC 102816): a new drug for the treatment of myeloblastic leukemia.
PUBDATE: 19760901
The pyrimidine analog, 5-azacytidine (NSC 102816), was administered by continuous intravenous infusion in Ringer's lactate in increasing doses to sets of patients with metastatic cancer to establish a dose sufficient to produce mild toxicity. Twenty-one patients (23 trials) were treated with doses of 50-200 mg/sq/m/day for 5 days every 2-4 wk. Nausea and vomiting were moderate and easily preventable. Doses of 100-200 mg/sq/m for 5 days every 14 days produced granulocytopenia, usually after two courses. Less toxicity was observed when courses were given every 21-28 days. Forty-five patients with previously treated and refractory acute myeloblastic leukemia were treated. The majority received doses of 150 mg/sq m for 5 days every 2 wk. Eleven (24%) complete remissions and four partial remissions were observed. The number of courses to achieve remission averaged three and required an average of 59 days. Nine patients with blastic crisis of chronic myeloblastic leukemia and four with refractory acute lymphoblastic leukemia failed to respond. 5-Azacytidine administered by continuous infusion is well tolerated and is an active compound in acute myeloblastic leukemia.

5. DOCID:14684 SCORE: 0.00440792661380785
DOCNO: 2746756
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
DESCRIPTOR: Chromosomes, Human, Pair 11
DESCRIPTOR: Chromosomes, Human, Pair 9
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: R Lundgren R
AUTHOR: P Elfving P
AUTHOR: S Heim S
AUTHOR: U Kristoffersson U
AUTHOR: N Mandahl N
AUTHOR: F Mitelman F
AFFILIATION: Department of Clinical Genetics, University Hospital, Lund, Sweden.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: A squamous cell bladder carcinoma with karyotypic abnormalities reminiscent of transitional cell carcinoma.
PUBDATE: 19890801
A squamous cell carcinoma was investigated cytogenetically by means of chromosome banding. The karyotype was complex with many structural and numerical changes, including -9 and del(11p), aberrations that also have been noted in transitional cell carcinoma. Thus, cytogenetic studies may be an important complement to the histological classification of bladder tumors, and may even contribute to our understanding of the etiology and pathogenesis of the 2 main types of bladder cancer.

6. DOCID:11785 SCORE: 0.00421369741099242
DOCNO: 6340203
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: H MacMahon H
AUTHOR: J V Courtney JV
AUTHOR: A G Little AG
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Diagnostic methods in lung cancer.
PUBDATE: 19830301
We feel that the guidelines described here reflect the state of the art at the time of writing (April 1982). The role of CT scanning is likely to evolve further and nuclear magnetic resonance (NMR) will probably play a significant role in the future. Experience, expertise, and equipment will vary from one hospital to another and thus rigid rules cannot reasonably be applied for the workup of suspected lung cancer. Ideally the diagnostic approach to an individual patient will be highly tailored, not only in regard to the nature of the pulmonary lesion, but also to his or her overall medical and social situation. We have found that a policy of early consultation between clinician and imaging specialist most readily facilitates effective use of available diagnostic resources.

7. DOCID:6721 SCORE: 0.00419957080382445
DOCNO: 7351010
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: A U Buzdar AU
AUTHOR: S S Legha SS
AUTHOR: M A Luna MA
AUTHOR: C K Tashima CK
AUTHOR: G N Hortobagyi GN
AUTHOR: G R Blumenschein GR
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Pulmonary toxicity of mitomycin.
PUBDATE: 19800101
Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progressing to interstitial pulmonary fibrosis. Corticosteroid therapy resulted in complete resolution of pneumonia in one patient. Respiratory symptoms improved in 3 patients following discontinuation of the drug. Two patients with extensive bilateral pneumonitis, who were not treated with steroids, died of respiratory failure. Mitomycin-induced lung toxicity appears to be reversible with the discontinuation of drug and the administration of corticosteroids. Lung biopsy is necessary in order to rule out other diagnoses.

8. DOCID:3937 SCORE: 0.00419710421845162
DOCNO: 1278659
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vaginal Smears
QUALIFIER: diagnosis
AUTHOR: W Furch W
AUTHOR: H Cramer H
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [Results of cytologic examinations of the cervix in women under the age of thirty (author's transl)]
PUBDATE: 19760501
154 suspicious and positive findings for carcinoma in women between the ages of 18 and 30 were reported. Included here were 7 cases of invasive carcinoma, 57 cases of epithelial carcinoma, 8 cases of advanced dysplasia and 17 cases of dysplasia in beginning and intermediate stages. The findings from two gynecologic practices in which the physicians annually conducted a cytologic examination of the cervix on every woman, regardless of age, were studied in particular. In both of these practices, 64 of the 89 preliminary stages of carcinoma and carcinoma itself in this age group were discovered in this way. The total material came from 26 contributors. The participation on the part of the young women in both gynecologic practices was unexpectedly high (33% of all those patients receiving preventive examinations). The established practice of conducting cytologic cancer tests on the cervix uteri only after the age of 30 can no longer be justified. One possible causal factor for the increased morbidity and the earlier occurrence of the disease is the coincidence between genital infections and the increased occurrence of neoplasia of the cervix due to earlier onset of sexual activity. It is imperative that women be informed of the increased risks and that they be given the opportunity of a cervical cancer test even before the age of thirty.

9. DOCID:15394 SCORE: 0.00408867425289454
DOCNO: 2694155
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: prevention & control
AUTHOR: W F Malone WF
AUTHOR: G J Kelloff GJ
AUTHOR: C Boone C
AUTHOR: D W Nixon DW
AFFILIATION: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland 20852-4200.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Preventive medicine.
COUNTRY: UNITED STATES
TITLE: Chemoprevention and modern cancer prevention.
PUBDATE: 19890901
Chemoprevention is a new area of research emphasis in cancer control. The rationale is based on the accumulation of laboratory and epidemiological data indicating that various agents may halt or reverse cancer progression in animals and may reduce risks in humans. For planning purposes, research leads are submitted to a strategic system of staging with defined criteria and decision points. A research lead that enters an intervention stage must evolve through a series of phases of testing and evaluation. Human intervention clinical trials have begun to test the hypothesis that certain agents can lower cancer incidence.

10. DOCID:11705 SCORE: 0.00402282201692395
DOCNO: 6407408
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: F Alcobendas F
AUTHOR: A Milla A
AUTHOR: J Estape J
AUTHOR: J Curto J
AUTHOR: C Pera C
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Mitomycin C as an adjuvant in resected gastric cancer.
PUBDATE: 19830701
As a result of their previous experience with mitomycin C at high discontinuous doses in advanced gastric cancer, the authors studied its role as an adjuvant for locally advanced cases after surgical complete resection. Results from 70 evaluable patients are presented. Patients were allocated randomly to receive mitomycin C, 20 mg/m2 I.V. direct once every 6 weeks, four courses, or a placebo. After a follow-up period of 250 weeks, seven patients of treatment arm and 23 controls have already relapsed (p less than 0.001). Toxicity was moderate and controllable by symptomatic measures. The authors consider this investigation a positive contribution in the field of adjuvant therapy of gastric cancer.

11. DOCID:11631 SCORE: 0.00402278791245427
DOCNO: 6887659
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Suzuki A
AUTHOR: T Takahashi T
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: Histogenesis of the gallbladder carcinoma induced by methylcholanthrene beeswax pellets in hamsters.
PUBDATE: 19830101
Gallbladder carcinoma was induced in hamsters by inserting methylcholanthrene beeswax pellets into the gallbladder lumen. The histogenesis and mode of development of the cancer was studied. The mode of development was classified into four; the infiltrative, the polypoid, the para-adenoma, and the mixed type. Twenty-one gallbladder carcinoma included six of the infiltrative type, seven of the polypoid type, three of the para-adenoma type (each case was accompanied by the infiltrative type), and eight of the mixed type (containing three of the infiltrative plus the para-adenoma type, and five of the infiltrative plus the polypoid type). Concerning histogenesis, the infiltrative type developed as de novo cancer. The polypoid and the para-adenoma type developed from adenomatous hyperplasia or adenoma.

12. DOCID:2743 SCORE: 0.00386929131445411
DOCNO: 832225
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: J N Ingle JN
AUTHOR: D C Tormey DC
AUTHOR: J M Bull JM
AUTHOR: R M Simon RM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Bone marrow involvement in breast cancer: effect on response and tolerance to combination chemotherapy.
PUBDATE: 19770101
Forty-three patients with metastatic breast cancer who had not received prior chemotherapy were divided into two groups on the basis of whether or not a bone marrow examination revealed tumor. Both groups were treated with combination chemotherapy regimens and were analyzed with regard to response and toxicity parameters. The positive marrow group had a response rate similar to that of the negative marrow group (67% vs 71%), and a slightly shorter median time to progressive disease (240 vs 258 days) and median duration of remission (213 vs 243 days). The positive marrow group had higher requirements for hematologic support and tended to have more infectious complications. The data suggest that metastatic breast cancer patients with a bone marrow examination revealing tumor, although requiring more supportive care, may be treated as effectively with combination chemotherapy as those patients in whom the marrow examination does not reveal tumor.

13. DOCID:7351 SCORE: 0.00376558648858626
DOCNO: 6970069
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: drug therapy
AUTHOR: V T DeVita VT
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The consequences of the chemotherapy of Hodgkin's disease: The 10th David A. Karnofsky Memorial Lecture.
PUBDATE: 19810101
The most important consequence of using chemotherapy for Hodgkin's disease is its cure. Results of the MOPP program, developed at the National Cancer Institute in 1964, indicate that the majority of the 80% of patients who attain complete remission, who are at risk for ten years, have remained disease-free. The presence of symptoms and the histologic subtype, nodular sclerosis, has had important negative influences on prognosis. Review of three long-term adverse consequences of chemotherapy revealed sterility to be the most significant effect of drug treatment in this young population. Adverse effects of the immunosuppressive drugs in MOPP proved to be minimal. The carcinogenic effect of MOPP when used alone was surprisingly small, but increased significantly when combined with irradiation. National mortality from Hodgkin's disease has decreased abruptly since the introduction of effective chemotherapy for Hodgkin's disease in 1970.

14. DOCID:3027 SCORE: 0.00375373009380599
DOCNO: 920870
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: diagnosis
QUALIFIER: pathology
QUALIFIER: diagnosis
AUTHOR: W H Wolinska WH
AUTHOR: M R Melamed MR
AUTHOR: P F Schellhammer PF
AUTHOR: W F Whitmore WF
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of surgical pathology.
COUNTRY: UNITED STATES
TITLE: Urethral cytology following cystectomy for bladder carcinoma.
PUBDATE: 19770901
There is a high probability of urethral carcinoma in patients who have had cystectomy for carcinoma of the urinary bladder, and their survival is poor when the disease is sufficiently advanced to be symptomatic or tumor is visible endoscopically. This study was undertaken to evaluate urethral cytology as a means of detecting and diagnosing in situ and invasive carcinoma of the urethral remnant following cystectomy. A total of 109 cytology specimens were examined from 65 patients who had cystectomy for bladder cancer. "Positive" or "suspicious" cytologic diagnoses of cancer were made on 28 patients; 24 had urethrectomy and 11 proved to have invasive carcinoma, 10 had carcinoma in situ and three had atypia or metaplastic changes in the urethra. One of 37 patients with "negative" cytologic diagnoses was found to have a low-grade carcinoma. It is suggested that all patients who undergo cystectomy without urethrectomy be followed with urethral cytological examination at regular intervals for an indefinite period.