0. DOCID:7140 SCORE: 0.00580707759131625
DOCNO: 6947013
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R W Correll RW
AUTHOR: W B Wescott WB
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Dental Association (1939)
COUNTRY: UNITED STATES
TITLE: Asymptomatic nonulcerated swelling of the mandible.
PUBDATE: 19811201
This case emphasizes that radiographic changes, although not diagnostic, can be characteristic and highly suggestive of a disease process especially a benign or malignant tumor. Radiographic changes that suggested the possibility of a malignant process in this case included ill-defined margins of the lesion; bone production within the lesion, especially interdentally at the alveolar crest; widening of the periodontal ligament space around tooth roots within the lesions; and perpendicular bony striae extending outward from the surface of the bone (sun-ray effect). THese changes are not specific for a malignant process: however, when coupled with the clinical history, the probability of malignancy is high. Failure of recognition is considered the greatest problem in malignancy of the oral cavity. Clinicians should consider every abnormal condition as suspicious unless there are valid reasons for ruling out cancer.


1. DOCID:3607 SCORE: 0.00559399727805165
DOCNO: 65207
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
DESCRIPTOR: Immunologic Techniques
DESCRIPTOR: Leukocyte Adherence Inhibition Test
QUALIFIER: immunology
AUTHOR: T Fujisawa T
AUTHOR: S R Waldman SR
AUTHOR: R H Yonemoto RH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Leukocyte adherence inhibition by soluble tumor antigens in breast cancer patients.
PUBDATE: 19770201
The authors modified and refined the Leukocyte Adherence Inhibition Assay (LAI) first described by Halliday, et al. in 1972 by standardizing the protein concentration of tumor-associated antigens (TAA) and by utilizing paired normal tissue extracts as controls to eliminate interference of HL-A histocompatibility antigens and organ-associated antigens. When dose response studies were performed, a progressively larger percentage of patients reacted to the LAI test with increasing concentration of tumor extracts, but the optimal concentration was found to be 200 mug/ml, where 42 out of 66 (63%) leukocytes from 54 breast cancer patients reacted to the breast cancer extracts. At this dose range, only three out of 39 (7%) normal donors and four out of 30 (13%) patients with other types of cancer were positive. When breast cancer patients were tested against TAA of colon cancer and malignant melanoma, one of 24 (4%) and two of 24 (8%), respectively, were positive. Although a higher response rate (72%) was noted in Stage II disease, this was not statistically different from Stage I and Stage III disease. Likewise, no difference was noted in LAI at varying phases following the mastectomy.


2. DOCID:27310 SCORE: 0.00479014465565183
DOCNO: 9769121
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: embryology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Bonkhoff H
AUTHOR: K Remberger K
AFFILIATION: Institute of Pathology, University of the Saarland, Homburg-Saar, Germany. patfix@med-rz.uni-sb.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Virchows Archiv : an international journal of pathology.
COUNTRY: GERMANY
TITLE: Morphogenetic concepts of normal and abnormal growth in the human prostate.
PUBDATE: 19980901
Benign prostatic hyperplasia (BPH) and prostate cancer are multifactorial disease processes, involving a growing number of biochemical, genetic and epigenetic factors. Their pathogenesis, however, remains poorly understood. The present review examines current morphogenetic concepts of normal and abnormal growth in the human prostate. This includes the role of basal cells in organogenesis and cancerogenesis, the impact of cell-matrix interactions, and the importance of cellular heterogeneity in tumour progression and hormone-insensitive growth. Knowledge of morphogenesis and morphology is required in any scientific approach to BPH and prostate cancer.


3. DOCID:7883 SCORE: 0.00476128509248607
DOCNO: 6943367
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: S Tokudome S
AUTHOR: S Kono S
AUTHOR: M Ikeda M
AUTHOR: M Kuratsune M
AUTHOR: S Kumamaru S
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Cancer and other causes of death among leprosy patients.
PUBDATE: 19810801
A follow-up study was done on the mortality from 1956 to 1975 among 2,383 Japanese patients with leprosy who were admitted to a leprosarium in Japan. The leprosy was classified into two types: lepromatous and tuberculoid. Irrespective of the type of leprosy or the sex of leprosy patient, mortalities were increased from tuberculosis, pneumonia and bronchitis, nephritis and nephrosis, and from total causes. The suicide rate was high among female patients. Deaths from total malignant neoplasms were higher than expected among patients with lepromatous leprosy for both sexes (49 observed vs. 44.02 expected), whereas they were lower than expected among patients with tuberculoid leprosy (35 observed vs. 36.83 expected); however, the differences were not statistically significant. Mortalities from cancers of the cervix and the esophagus among females with lepromatous leprosy were significantly higher. The risk of lymphoreticular cancers was not increased.


4. DOCID:22943 SCORE: 0.00462240271417162
DOCNO: 8178132
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nuclear Reactors
QUALIFIER: mortality
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: V F Hohryakov VF
AUTHOR: S A Romanov SA
AFFILIATION: Public Health Ministry of the Russian Federation, Biophysics Institute Branch N1, Chelyabinsk-65.
PUBTYPE: Journal Article
JOURNALTITLE: The Science of the total environment.
COUNTRY: NETHERLANDS
TITLE: Lung cancer in radiochemical industry workers.
PUBDATE: 19940301
The frequency of lung cancer was investigated among 2346 workers in the radiochemical plant 'Mayak' who were exposed to radiation, both externally and internally from incorporation of plutonium. The results from the follow-up were analysed in terms of a linear relative risk model, accounting for the protracted exposures. On the basis of the observed data, it is deduced that the life-span incidence of radiation-induced lung cancer is several times larger than the value 0.0085 Sv-1 that is recommended in ICRP Publication 60 for the risk to this organ.


5. DOCID:22938 SCORE: 0.00459941037978569
DOCNO: 8059474
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: prevention & control
AUTHOR: H S Hansen HS
AFFILIATION: Onkologisk afdeling, Rigshospitalet, KĂžbenhavn.
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Medullary thyroid cancer--screening]
PUBDATE: 19940601
It is possible to screen for medullary thyroid cancer (MTC) with biochemical tests, imaging and genetic testing in families with multiple endocrine neoplasia type 2. The recommendation is based on a consensus statement made by the Members of the European Community concerted action for MTC. The prognostic characteristics are based on 117 patients with MTC diagnosed in Denmark between 1970-1991. Twenty percent of all MTC patients were members of families with two or more thyroid cancer patients. More than half of all MTC patients had neck lymph node involvement at the time of diagnosis. The frequency of neck lymph node involvement was however only 20% amongst those with familiar MTC.


6. DOCID:9722 SCORE: 0.00446824675563077
DOCNO: 6709743
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: psychology
AUTHOR: L A Stevens LA
AUTHOR: M H McGrath MH
AUTHOR: R G Druss RG
AUTHOR: S J Kister SJ
AUTHOR: F E Gump FE
AUTHOR: K A Forde KA
PUBTYPE: Journal Article
JOURNALTITLE: Plastic and reconstructive surgery.
COUNTRY: UNITED STATES
TITLE: The psychological impact of immediate breast reconstruction for women with early breast cancer.
PUBDATE: 19840401
Twenty-five patients were evaluated, 13 who had immediate breast reconstruction and 12 who had delayed breast reconstruction for early breast cancer. Data were elicited about the psychological impact of the cancer, the mastectomy, and the reconstruction. Our results support the conclusion that immediate breast reconstruction is accompanied by a lower incidence of psychological morbidity postoperatively, and we recommend that immediate breast reconstruction be offered as an alternative to women with early breast cancer.


7. DOCID:3532 SCORE: 0.00444730426389348
DOCNO: 60156
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W R Vogler WR
AUTHOR: D S Miller DS
AUTHOR: J W Keller JW
PUBTYPE: Journal Article
JOURNALTITLE: Blood.
COUNTRY: UNITED STATES
TITLE: 5-Azacytidine (NSC 102816): a new drug for the treatment of myeloblastic leukemia.
PUBDATE: 19760901
The pyrimidine analog, 5-azacytidine (NSC 102816), was administered by continuous intravenous infusion in Ringer's lactate in increasing doses to sets of patients with metastatic cancer to establish a dose sufficient to produce mild toxicity. Twenty-one patients (23 trials) were treated with doses of 50-200 mg/sq/m/day for 5 days every 2-4 wk. Nausea and vomiting were moderate and easily preventable. Doses of 100-200 mg/sq/m for 5 days every 14 days produced granulocytopenia, usually after two courses. Less toxicity was observed when courses were given every 21-28 days. Forty-five patients with previously treated and refractory acute myeloblastic leukemia were treated. The majority received doses of 150 mg/sq m for 5 days every 2 wk. Eleven (24%) complete remissions and four partial remissions were observed. The number of courses to achieve remission averaged three and required an average of 59 days. Nine patients with blastic crisis of chronic myeloblastic leukemia and four with refractory acute lymphoblastic leukemia failed to respond. 5-Azacytidine administered by continuous infusion is well tolerated and is an active compound in acute myeloblastic leukemia.


8. DOCID:14684 SCORE: 0.00440792661380785
DOCNO: 2746756
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
DESCRIPTOR: Chromosomes, Human, Pair 11
DESCRIPTOR: Chromosomes, Human, Pair 9
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: R Lundgren R
AUTHOR: P Elfving P
AUTHOR: S Heim S
AUTHOR: U Kristoffersson U
AUTHOR: N Mandahl N
AUTHOR: F Mitelman F
AFFILIATION: Department of Clinical Genetics, University Hospital, Lund, Sweden.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: A squamous cell bladder carcinoma with karyotypic abnormalities reminiscent of transitional cell carcinoma.
PUBDATE: 19890801
A squamous cell carcinoma was investigated cytogenetically by means of chromosome banding. The karyotype was complex with many structural and numerical changes, including -9 and del(11p), aberrations that also have been noted in transitional cell carcinoma. Thus, cytogenetic studies may be an important complement to the histological classification of bladder tumors, and may even contribute to our understanding of the etiology and pathogenesis of the 2 main types of bladder cancer.


9. DOCID:30542 SCORE: 0.0043915758430186
DOCNO: 12575990
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
AUTHOR: Ronen Marmorstein R
AFFILIATION: The Wistar Institute, The Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. marmor@wistar.upenn.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in biochemical sciences.
COUNTRY: England
TITLE: Structure of SET domain proteins: a new twist on histone methylation.
PUBDATE: 20030201
The methylation of lysine residues on histone tails is catalyzed by proteins containing a conserved SET domain. A recent flurry of structures of SET domain proteins has revealed a new protein fold and a scaffold for understanding catalysis and substrate binding by these enzymes. The prospect that histone methylation might form an epigenetic code and the implicated involvement of SET domain proteins in cancer assures that structure-function studies of these enzymes will continue until their detailed mechanism of action is determined.


10. DOCID:18747 SCORE: 0.00429492230526342
DOCNO: 2224844
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Differentiation
QUALIFIER: physiopathology
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: Y S Cho-Chung YS
AFFILIATION: Cellular Biochemistry Section, National Cancer Institute, NIH, Bethesda, Maryland 20892.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy.
PUBDATE: 19901101
Two isoforms of the regulatory subunits of cyclic AMP (cAMP)-dependent protein kinase that bind cAMP are inversely expressed during ontogeny and cell differentiation. These cAMP-binding receptor proteins in harmony may regulate the growth of normal cells and their differentiation into nondividing states. Cancer cells can also be made to differentiate and stop growing when the functional balance of these cAMP receptor proteins is restored by treatment with site-selective cAMP analogues or by the use of an antisense oligodeoxynucleotide, suggesting new approaches to cancer treatment.


11. DOCID:27375 SCORE: 0.00422879480768944
DOCNO: 10518048
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fuzzy Logic
QUALIFIER: diagnosis
QUALIFIER: genetics
QUALIFIER: methods
AUTHOR: C A Pena-Reyes CA
AUTHOR: M Sipper M
AFFILIATION: Logic Systems Laboratory, Swiss Federal Institute of Technology, IN-Ecublens, CH-1015, Lausanne, Switzerland. carlos.pena@di.epfl.ch
PUBTYPE: Journal Article
JOURNALTITLE: Artificial intelligence in medicine.
COUNTRY: NETHERLANDS
TITLE: A fuzzy-genetic approach to breast cancer diagnosis.
PUBDATE: 19991001
The automatic diagnosis of breast cancer is an important, real-world medical problem. In this paper we focus on the Wisconsin breast cancer diagnosis (WBCD) problem, combining two methodologies-fuzzy systems and evolutionary algorithms-so as to automatically produce diagnostic systems. We find that our fuzzy-genetic approach produces systems exhibiting two prime characteristics: first, they attain high classification performance (the best shown to date), with the possibility of attributing a confidence measure to the output diagnosis; second, the resulting systems involve a few simple rules, and are therefore (human-) interpretable.


12. DOCID:11785 SCORE: 0.00421369741099242
DOCNO: 6340203
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: H MacMahon H
AUTHOR: J V Courtney JV
AUTHOR: A G Little AG
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Diagnostic methods in lung cancer.
PUBDATE: 19830301
We feel that the guidelines described here reflect the state of the art at the time of writing (April 1982). The role of CT scanning is likely to evolve further and nuclear magnetic resonance (NMR) will probably play a significant role in the future. Experience, expertise, and equipment will vary from one hospital to another and thus rigid rules cannot reasonably be applied for the workup of suspected lung cancer. Ideally the diagnostic approach to an individual patient will be highly tailored, not only in regard to the nature of the pulmonary lesion, but also to his or her overall medical and social situation. We have found that a policy of early consultation between clinician and imaging specialist most readily facilitates effective use of available diagnostic resources.


13. DOCID:6721 SCORE: 0.00419957080382445
DOCNO: 7351010
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: A U Buzdar AU
AUTHOR: S S Legha SS
AUTHOR: M A Luna MA
AUTHOR: C K Tashima CK
AUTHOR: G N Hortobagyi GN
AUTHOR: G R Blumenschein GR
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Pulmonary toxicity of mitomycin.
PUBDATE: 19800101
Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progressing to interstitial pulmonary fibrosis. Corticosteroid therapy resulted in complete resolution of pneumonia in one patient. Respiratory symptoms improved in 3 patients following discontinuation of the drug. Two patients with extensive bilateral pneumonitis, who were not treated with steroids, died of respiratory failure. Mitomycin-induced lung toxicity appears to be reversible with the discontinuation of drug and the administration of corticosteroids. Lung biopsy is necessary in order to rule out other diagnoses.


14. DOCID:3937 SCORE: 0.00419710421845162
DOCNO: 1278659
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vaginal Smears
QUALIFIER: diagnosis
AUTHOR: W Furch W
AUTHOR: H Cramer H
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [Results of cytologic examinations of the cervix in women under the age of thirty (author's transl)]
PUBDATE: 19760501
154 suspicious and positive findings for carcinoma in women between the ages of 18 and 30 were reported. Included here were 7 cases of invasive carcinoma, 57 cases of epithelial carcinoma, 8 cases of advanced dysplasia and 17 cases of dysplasia in beginning and intermediate stages. The findings from two gynecologic practices in which the physicians annually conducted a cytologic examination of the cervix on every woman, regardless of age, were studied in particular. In both of these practices, 64 of the 89 preliminary stages of carcinoma and carcinoma itself in this age group were discovered in this way. The total material came from 26 contributors. The participation on the part of the young women in both gynecologic practices was unexpectedly high (33% of all those patients receiving preventive examinations). The established practice of conducting cytologic cancer tests on the cervix uteri only after the age of 30 can no longer be justified. One possible causal factor for the increased morbidity and the earlier occurrence of the disease is the coincidence between genital infections and the increased occurrence of neoplasia of the cervix due to earlier onset of sexual activity. It is imperative that women be informed of the increased risks and that they be given the opportunity of a cervical cancer test even before the age of thirty.