0. DOCID:27072 SCORE: 0.00348078098618004
DOCNO: 10524806
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: K Kelly K
AUTHOR: N Mikhaeel-Kamel N
AFFILIATION: Lung Cancer Program and the Division of Medical Oncology, The University of Colorado Cancer Center, Denver, USA. karen.kelly@UCHSC.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of thoracic imaging.
COUNTRY: UNITED STATES
TITLE: Medical treatment of lung cancer.
PUBDATE: 19991001
Lung cancer is the leading cause of cancer deaths for both men and women in the United States. Most patients present with late stages of disease, rendering them incurable. Despite this dismal outcome, there is optimism; modern treatment for lung cancer has been shown to increase survival, improve quality of life, and be cost effective. This article reviews the current treatment strategies for non-small cell lung cancer and small cell lung cancer as well as discusses future treatments, including the exciting biologic agents that are in clinical trials.


1. DOCID:27200 SCORE: 0.00346532480790057
DOCNO: 9930353
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: A J Wight AJ
AUTHOR: G R Ogden GR
AFFILIATION: Unit of Oral Medicine and Oral Surgery, Dundee Dental Hospital and School, University of Dundee, U.K.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oral oncology.
COUNTRY: ENGLAND
TITLE: Possible mechanisms by which alcohol may influence the development of oral cancer--a review.
PUBDATE: 19981101
Although pure ethanol has never been shown to be carcinogenic in laboratory experiments, alcoholic beverages are now recognised as being important aetiological factors in the development of oral cancer. Despite this, the exact mechanism by which alcohol may exert an influence upon the oral mucosa has received less attention. An overview of the association of alcohol and oral cancer, both in combination with tobacco and without, is provided and consideration given to some of the pathways by which alcohol exerts its effect upon the oral mucosa.


2. DOCID:27363 SCORE: 0.0034278635004598
DOCNO: 10844946
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adenocarcinoma
DESCRIPTOR: Carcinoma, Squamous Cell
DESCRIPTOR: Esophageal Neoplasms
DESCRIPTOR: Primary Health Care
AUTHOR: J R Fox JR
AUTHOR: S K Kuwada SK
AFFILIATION: Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Today's approach to esophageal cancer. What is the role of the primary care physician?
PUBDATE: 20000501
Esophageal cancer is a devastating disease. Patients are most likely to first present to a primary care physician, who should immediately undertake an initial diagnostic and staging evaluation. The approach then should become multidisciplinary, involving surgical and medical oncologists, radiation oncologists, and gastroenterologists. Optimal therapy of esophageal cancer continues to evolve. While multimodality therapy remains controversial, studies are ongoing to determine the best approaches to improve survival. Further studies to define the role of surveillance endoscopy in certain high-risk patients are warranted.


3. DOCID:26733 SCORE: 0.00342215975487986
DOCNO: 11435021
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ovarian Hyperstimulation Syndrome
QUALIFIER: drug therapy
QUALIFIER: agonists
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: C Turan C
AUTHOR: O Unal O
AUTHOR: R Dansuk R
AUTHOR: K Guzelmeric K
AUTHOR: B Cengizoglu B
AUTHOR: E Esim E
AFFILIATION: Department of Obstetrics and Gynecology, Kartal Research Hospital, Petrol-is Mah. Batman Sok. No. 11, D 14, Toprakyol-Kartal, 81410, Istanbul, Turkey.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of obstetrics, gynecology, and reproductive biology.
COUNTRY: Ireland
TITLE: Successful management of an ovarian enlargement resembling ovarian hyperstimulation in a premenopausal breast cancer patient receiving tamoxifen with cotreatment of GnRH-agonist.
PUBDATE: 20010701
Tamoxifen use in breast cancer patients may cause ovarian cysts. This report presents a case of complex cyst resembling ovarian hyperstimulation in a premenopausal breast cancer patient receiving tamoxifen which resolved by administering monthly depot GnRH-agonist (GnRH-a) without abandoning the tamoxifen treatment.


4. DOCID:27805 SCORE: 0.00335951720979578
DOCNO: 10919157
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: N Matsubara N
AUTHOR: H Isozaki H
AUTHOR: N Tanaka N
AFFILIATION: First Department of Surgery, Okayama University Medical School, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon Geka Gakkai zasshi.
COUNTRY: JAPAN
TITLE: [Genetic analysis for colorectal cancer: what can we learn from microsatellite research?]
PUBDATE: 20000601
Recent advances in molecular biology have unveiled the mechanisms of carcinogenesis, especially colorectal carcinogenesis. A large body of evidence supports the idea that accumulated genetic changes due to inherited as well as environmental factors underlie colorectal cancer development. Recently, several reports have suggested that aberrant methylation of the CpG island may also play an important role in colorectal carcinogenesis. This genetic information is not yet sufficient but some useful genetic information can be applied clinically. This paper presents the results of intensive study of microsatellite instability in colorectal cancers and some clinically applicable discoveries. Future problems are also discussed.


5. DOCID:25540 SCORE: 0.00304405877903864
DOCNO: 10418050
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Paraneoplastic Syndromes
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: B Mennecier B
AUTHOR: L Moreau L
AUTHOR: B Goichot B
AUTHOR: G Pauli G
AUTHOR: E Quoix E
AFFILIATION: Pavillon Laënnec, Hôpital Civil, Strasbourg.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue de pneumologie clinique.
COUNTRY: FRANCE
TITLE: [Paraneoplastic Cushing's syndrome and small cell bronchial carcinoma]
PUBDATE: 19990401
Approximately 30% of small-cell bronchogenic cancers are associated with hypersecretion of ACTH. However, in most cases, there is no clinical expression. When a paraneoplastic Cushing syndrome occurs, it is an independent factor of poor prognosis. Management is extremely complex. Treatment must be based on high dose inhibitors prior to chemotherapy. Opportunistic infections, often fungal infections, are the main complications, even outside periods of aplasia, and cause significantly earlier mortality.


6. DOCID:26687 SCORE: 0.00292659593121345
DOCNO: 10211543
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Delivery Systems
QUALIFIER: administration & dosage
QUALIFIER: methods
QUALIFIER: drug therapy
AUTHOR: B N Singh BN
AUTHOR: C Dwivedi C
AFFILIATION: Department of Industrial Pharmacy, College of Allied Health Professions, Saint Johns University, Jamaica, NY 11429, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: Antitumor drug delivery by tissue electroporation.
PUBDATE: 19990201
Tissue electroporation has been explored to enhance the local delivery of chemotherapueutic agents to solid tumors. The technique, known as electrochemotherapy (ECT), uses high-voltage pulses to deliver drugs across cancerous tissues. ECT has been demonstrated to be an effective treatment for cutaneous malignancies. Recent studies also indicate that the applications of ECT can be extended from the treatment of cutaneous cancers to the treatment of tumors of vital organs such as brain, liver, lungs and others. This review also discusses electrogene antitumor therapy.


7. DOCID:26216 SCORE: 0.00290525808634263
DOCNO: 11004802
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mycobacterium bovis
AUTHOR: T Yamada T
AFFILIATION: Nagasaki University, Japan.
PUBTYPE: Lectures
JOURNALTITLE: Kekkaku : [Tuberculosis].
COUNTRY: JAPAN
TITLE: [Study on recombinant BCG]
PUBDATE: 20000801
The progress of study on recombinant BCG was stated briefly. And then our studies on recombinant BCG were mentioned. Recombinant BCG secreting alpha antigen-fused merozoite surface protein 1 (MSP 1) was prepared and tested for its ability to control infections of Plasmodium yoelii. Result turned out it controlled the infection better than recombinant MSP 1 mixed with Freund incomplete adjuvant did. Recombinant BCG secreting excess amounts of antigen 85 complex A controlled infection of Mycobacterium leprae. Addition of recombinant BCG secreting alpha antigen-fused IL-2 to peritoneal exudate cells induced IFN-gamma resulting in killing bladder cancer cells more efficiently than parental BCG did.


8. DOCID:26934 SCORE: 0.00271412566074952
DOCNO: 11002316
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Spectroscopy
PUBTYPE: Bibliography
JOURNALTITLE: NMR in biomedicine.
COUNTRY: ENGLAND
TITLE: Current awareness in NMR in biomedicine.
PUBDATE: 20001001
In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of NMR in biomedicine. Each bibliography is divided into 9 sections: 1 Books, Reviews ' Symposia; 2 General; 3 Technology; 4 Brain and Nerves; 5 Neuropathology; 6 Cancer; 7 Cardiac, Vascular and Respiratory Systems; 8 Liver, Kidney and Other Organs; 9 Muscle and Orthopaedic. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.


9. DOCID:27422 SCORE: 0.00264855412569924
DOCNO: 11852397
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: R Lamy R
AUTHOR: T Conroy T
AUTHOR: L Brunaud L
AUTHOR: L Bresler L
AFFILIATION: Département d'Oncologie Médicale, Centre Alexis-Vautrin, France.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gastroentérologie clinique et biologique.
COUNTRY: France
TITLE: [Tamoxifen for metastatic pancreatic adenocarcinoma: a complete response]
PUBDATE: 20011001
Pancreatic adenocarcinoma tissue contains estrogen receptors and some pilot studies have suggested that tamoxifen could increase the survival of patients with unresectable pancreatic cancer. However data of comparative studies are conflicting. We report the case of a woman who presented with unresectable pancreatic head carcinoma with hepatic metastasis. The patient refused chemotherapy and was treated with tamoxifen 30 mg/day. A complete clinical remission of 50 months was observed. A further large-scale study may be required to assess the usefulness of tamoxifen in the second-line treatment of advanced pancreatic carcinoma.


10. DOCID:25074 SCORE: 0.00257672565458513
DOCNO: 10912492
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: secondary
QUALIFIER: diagnosis
QUALIFIER: surgery
QUALIFIER: diagnosis
AUTHOR: M G Dube MG
AUTHOR: J H Scholefield JH
AFFILIATION: Section of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of gastroenterology & hepatology.
COUNTRY: ENGLAND
TITLE: A 'palliative' resection which became potentially curative.
PUBDATE: 20000601
We report a very unusual case of a woman with rectal cancer, who, at operation, appeared to have peritoneal metastases. An anterior resection was carried out, and subsequent histology showed the rectal tumour to be a well-differentiated Dukes' B adenocarcinoma, which had been completely excised. The apparent 'metastases' were found to be schistosomal granulomas and there was also a schistosomal granuloma within the tumour.


11. DOCID:26529 SCORE: 0.00254004182522185
DOCNO: 9781904
AUTHOR: M Li M
AUTHOR: J A Squire JA
AUTHOR: R Weksberg R
AFFILIATION: Department of Pediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of medical genetics.
COUNTRY: UNITED STATES
TITLE: Molecular genetics of Wiedemann-Beckwith syndrome.
PUBDATE: 19981001
Wiedemann-Beckwith syndrome (WBS) is a heterogeneous overgrowth syndrome associated with malformations and an elevated risk of developing embryonal tumors. WBS is a multigenic disorder caused by dysregulation of imprinted growth regulatory genes within the 11p15 region. Elucidation of the genetic cause of WBS will provide important insights into the molecular and epigenetic changes associated with loss of normal growth control and cancer in this syndrome. Currently available protocols for diagnostic testing, patient monitoring and genetic counselling will evolve as our understanding of the molecular basis of WBS progresses.


12. DOCID:27395 SCORE: 0.00243626630053055
DOCNO: 9873104
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: W M Mendenhall WM
AFFILIATION: Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in radiation oncology.
COUNTRY: UNITED STATES
TITLE: T3-4 squamous cell carcinoma of the larynx treated with radiation therapy alone.
PUBDATE: 19981001
This article reviews the results of radiation therapy alone for T3-4 squamous cell carcinoma of the larynx. Local control after radiation therapy is approximately 65% for patients with T3 glottic and supraglottic carcinoma. The likelihood of local control is inversely related to tumor volume and, for those with glottic cancers, is adversely influenced by cartilage sclerosis on pretreatment computed tomography of the larynx. Local control after radiotherapy is approximately 60% for T4 glottic cancers and 50% for T4 supraglottic carcinomas. The probability of severe complications is related to primary site and T-stage.


13. DOCID:25260 SCORE: 0.00234580647891366
DOCNO: 11366993
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: pathology
QUALIFIER: adverse effects
AUTHOR: J S James JS
PUBTYPE: Newspaper Article
JOURNALTITLE: AIDS treatment news.
COUNTRY: UNITED STATES
TITLE: Poppers: large cancer increase and immune suppression in animal tests.
PUBDATE: 19990401
A study on mice injected with cancer cells and then exposed to isobutyl nitrite (poppers) revealed that inhalant-treated mice developed tumors more readily and rapidly than control mice. The control mice were also injected with cancer cells, but only breathed air. Related studies found that poppers suppress certain immune functions involved in killing tumor cells. These studies suggest that further research of persons with HIV/AIDS who use poppers is needed to determine if they are at a high risk for developing malignancies.


14. DOCID:26517 SCORE: 0.00232237887830695
DOCNO: 10566234
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: L Malina L
AUTHOR: H Michalíková H
AUTHOR: L Hussarová L
AFFILIATION: Dermatovenerologická klinika 3, LF UK, Praha.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Casopís lékar̆ů c̆eských.
COUNTRY: CZECH REPUBLIC
TITLE: [Porphyria cutanea tarda after antineoplastic drugs]
PUBDATE: 19990801
Chronic hepatic porphyria is in some cases a paraneoplasia, in others part of the neoplastic disease. Sometimes it is, on the other hand manifested during antineoplastic treatment. Its development may be associated with this therapy. The presented case-history describes a female patient with breast cancer treated with antineoplastic agents, who developed a sporadic form of late cutaneous porphyria with a classical clinical and laboratory picture. The authors contemplate on the possible porphyrinogenic effect of antineoplastic agents, in particular cyclophosphamide and tamoxifen, which in the latter preparation was not described so far.