0. DOCID:19584 SCORE: 0.00582941961402019
DOCNO: 1555196
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sister Chromatid Exchange
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: L Lukovic L
AUTHOR: J Milasin J
AFFILIATION: Institute of Biology and Human Genetics, University of Belgrade School of Medicine and Dentistry, Yugoslavia.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Sister chromatid exchanges in patients with carcinoma in situ of cervix uteri.
PUBDATE: 19920301
Sister chromatid exchange (SCE) was analyzed in lymphocytes of 21 patients with carcinoma in situ of cervix uteri and 19 control subjects. The mean SCE frequencies were 8.92 +/- 0.31 (n = 417) and 6.94 +/- 0.23, (n = 375) per metaphase in patients and controls, respectively. The increase of SCE levels in cancer patients was highly significant in respect to controls (p less than 0.001). Together with data of other authors in patients with precancerous and cancerous lesions of the cervix, our results suggest that there is no correlation between SCE rate and severity of cancerous lesions.


1. DOCID:19260 SCORE: 0.00388820941834377
DOCNO: 2258086
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pregnancy Complications, Neoplastic
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M Shaves M
AUTHOR: R R Kamps RR
AUTHOR: L R Laufman LR
AUTHOR: C D Runowicz CD
AFFILIATION: Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10461.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: A successful term pregnancy following the systemic and intraperitoneal administration of cisplatin chemotherapy.
PUBDATE: 19901201
The advent of successful chemotherapy has improved the prognosis and long-term disease-free survival for many patients with a variety of malignancies. Preservation of reproductive function in female patients is now possible with conservative surgery in certain selected malignancies. Successful pregnancies following chemotherapy or ovarian cancer have been reported. This is the first reported case of a term pregnancy following the systemic and intraperitoneal administration of cisplatin chemotherapy in the treatment of ovarian cancer.


2. DOCID:18725 SCORE: 0.00293083048306512
DOCNO: 1585237
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
QUALIFIER: genetics
QUALIFIER: pathology
QUALIFIER: genetics
AUTHOR: F Solé F
AUTHOR: S Woessner S
AUTHOR: A Pérez A
AUTHOR: L Florensa L
AUTHOR: C Besses C
AUTHOR: J Sans Sabrafén J
AFFILIATION: Departamento de Hematología y Oncología, Hospital Central L'Aliança, Barcelona.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Sangre.
COUNTRY: SPAIN
TITLE: [Description of 2 patients with cytogenetically abnormal clones]
PUBDATE: 19920201
We present two patients with two cytogenetically unrelated clones. A patient was diagnosed of refractory anaemia and showed an abnormal clone with trisomy 8 and other clone with 5q-; the other patient, diagnosed as chronic lymphocytic leukaemia showed a clone with an inversion of chromosome 2, inv(2) (p23q12) and the other clone with a 47,XX,+5,t(16;17)(p13;q11),+2ac karyotype. The discussion is focused on the presence of unrelated clones in relation to the monoclonal origin of cancer.


3. DOCID:18812 SCORE: 0.00292472686986987
DOCNO: 1929452
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Infusion Pumps, Implantable
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: pathology
AUTHOR: M Hoshino M
AUTHOR: Y Koyama Y
AUTHOR: N Satou N
AUTHOR: R Abe R
AFFILIATION: Dept. of Surgery 2, Fukushima Medical College, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Hepatic arterial infusion of farmorubicin (FARM) and 5-fluorouracil (5-FU) in a patient with massive hepatic metastasis from gastric cancer]
PUBDATE: 19911001
A patient with massive hepatic metastasis from gastric cancer was treated with hepatic arterial injection of FARM and 5-FU one month after total gastrectomy. Response rate was 88% at 3 months after arterial infusion therapy. Severe side effects were not seen during treatment. It is suggested that the hepatic arterial infusion of combined FARM and 5-FU is a useful method for treatment of hepatic metastasis of gastric cancer.


4. DOCID:17697 SCORE: 0.00277921064186207
DOCNO: 8508382
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: B D Collier BD
AFFILIATION: Department of Radiology, Medical College of Wisconsin, Milwaukee 53226.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: New radiographic techniques for colorectal cancer.
PUBDATE: 19930601
Before surgical staging and resection, patients with primary colorectal cancer undergo a thorough diagnostic evaluation. The initial imaging study to identify a primary site of disease often is endoscopy, which frequently is supplemented with a double contrast barium enema. Once the presence of colorectal cancer has been established, new radiographic imaging techniques, including computed tomography (CT), magnetic resonance imaging (MRI), and special ultrasound (US) may be used. Clinical questions addressed by these special imaging techniques include detection of liver and lymph metastases and clarification of local extent of disease.


5. DOCID:17056 SCORE: 0.00258179077253204
DOCNO: 1567293
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: analysis
AUTHOR: W Manzar W
AUTHOR: M R Raghavan MR
AUTHOR: A R Aroor AR
AUTHOR: K R Keshavamurthy KR
AFFILIATION: Department of Oral Medicine, Oral Diagnosis and Radiology, College of Dental Surgery, Kasturba Medical College, India.
PUBTYPE: Journal Article
JOURNALTITLE: Australian dental journal.
COUNTRY: AUSTRALIA
TITLE: Evaluation of serum beta 2-microglobulin in oral cancer.
PUBDATE: 19920201
Beta 2-microglobulin (beta 2-m) low molecular mass protein was measured in serum of normal subjects and in patients with oral cancer. There was a significant increase in beta 2-m levels in oral cancer patients. The possible role of beta 2-m as a biochemical parameter and its significance in oral cancer is discussed.


6. DOCID:19203 SCORE: 0.00247336582913379
DOCNO: 8479624
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Monoclonal
AUTHOR: K Mogensen K
AFFILIATION: Department of Veterans Affairs Medical Center, Buffalo, NY 14215.
PUBTYPE: Journal Article
JOURNALTITLE: Military medicine.
COUNTRY: UNITED STATES
TITLE: 1992 Federal Nursing Service Award recipient. An introduction to monoclonal antibody concepts for the oncology nurse.
PUBDATE: 19930401
Over the past 16 years, there has been an explosion of knowledge in the field of monoclonal antibody technology. There is an enormous potential for the use of monoclonal antibodies in the diagnosis and treatment of malignancies, and many clinical trials are under way. This paper serves as an introduction to monoclonal antibody concepts for the oncology nurse. Antibody/antigen principles, production of monoclonal antibodies, common side effects of use, and nursing implications are discussed. Results of a recent clinical trial and a patient case study are used to illustrate the application of radiolabeled monoclonal antibodies as a cancer diagnostic technique.


7. DOCID:18930 SCORE: 0.00245169135205487
DOCNO: 8239672
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Stem Cell Transplantation
QUALIFIER: methods
AUTHOR: M Harada M
AFFILIATION: First Dept. of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Autologous blood stem cell transplantation]
PUBDATE: 19931101
Autologous blood stem cell transplantation (ABSCT) has been increasingly used, as the third generation of hemopoietic stem cell transplantation next to allogeneic and autologous bone marrow transplantation (allo-BMT and ABMT), in the treatment of malignant diseases. As to the principle of treatment, ABSCT is identical to ABSCT. However, ABSCT has some advantages over ABMT as follows: 1) a rapid engraftment, 2) no requirement of general anesthesia for harvesting hemopoietic stem cells, and 3) possibility of less contamination of tumor cells. Accordingly, ABSCT will take place of ABMT in the strategy of cancer treatment and improved results will be expected.


8. DOCID:17829 SCORE: 0.00238712824352618
DOCNO: 1935721
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Collagen
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: M J Glasgold MJ
AUTHOR: A I Glasgold AI
AUTHOR: F H Silver FH
AFFILIATION: Manhattan Eye, Ear & Throat Hospital, New York.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ear, nose, & throat journal.
COUNTRY: UNITED STATES
TITLE: The use of Collagen Matrix to enhance closure of facial defects.
PUBDATE: 19910801
Facial defects created by removal of various types of skin cancer are usually closed primarily. There are some areas of the face where primary closure produces less than optimal results. We have utilized a non-reactive collagen sponge (Collagen Matrix) to enhance closure by secondary intention following removal of skin cancers. This presentation describes the properties of Collagen Matrix as well as the technique we utilized for closure of facial defects following tumor removal.


9. DOCID:19598 SCORE: 0.00228832924235589
DOCNO: 1748847
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Computer Terminals
QUALIFIER: organization & administration
QUALIFIER: instrumentation
QUALIFIER: instrumentation
AUTHOR: J W London JW
AUTHOR: D E Morton DE
AUTHOR: D Polekoff D
AUTHOR: J Reber J
AFFILIATION: Fox Chase Cancer Center, Philadelphia, PA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of medical systems.
COUNTRY: UNITED STATES
TITLE: The use of X-terminals as clinical workstations.
PUBDATE: 19910201
The Medical Computer Facility at the Fox Chase Cancer Center has installed X-terminals in patient examination rooms and at nursing stations for clinical data access by physicians and nurses. The X-terminals are connected to UNIX operating system RISC processors via Ethernet. The RISC processors communicate with databases on a minicomputer cluster. Simultaneous presentation of textual (e.g., pathology and radiology reports) and graphical (e.g., clinical laboratory results) clinical data is provided under X-Windows. CT and MRI images can also be displayed in windows. Our experiences implementing X-terminal clinical workstations in a production environment will be discussed.


10. DOCID:19328 SCORE: 0.00221270703389414
DOCNO: 2072171
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: K Yuki K
AUTHOR: Y Kodama Y
AUTHOR: J Onda J
AUTHOR: K Emoto K
AUTHOR: T Morimoto T
AUTHOR: T Uozumi T
AFFILIATION: Department of Neurosurgery, Kure National Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of neurosurgery.
COUNTRY: UNITED STATES
TITLE: Coronary vasospasm following subarachnoid hemorrhage as a cause of stunned myocardium. Case report.
PUBDATE: 19910801
A patient with subarachnoid hemorrhage was found to have electrocardiographic abnormalities resembling an acute myocardial infarction as well as left ventriculographic findings of cardiac dysfunction. These cardiac abnormalities resolved following surgical clipping of the aneurysm and the patient recovered well from the operation. She died 2 months later from cancer and a postmortem examination at that time revealed no evidence of myocardial necrosis. In this report, the authors discuss coronary vasospasm and reversible postischemic "stunned myocardium," a condition that has not been considered previously in relation to subarachnoid hemorrhage.


11. DOCID:18454 SCORE: 0.00218271348491224
DOCNO: 2330610
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: drug therapy
QUALIFIER: chemically induced
AUTHOR: G Zampa G
AUTHOR: A Andriani A
AUTHOR: A Beni A
AUTHOR: N Patino N
AUTHOR: P Rinaldi P
AFFILIATION: Divisione di Medicina, Ospedale S. Giacomo, Roma, Italy.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Acute non lymphoid leukemia following CMF treatment as adjuvant therapy in positive node breast cancer. Case report.
PUBDATE: 19900401
The CMF regimen as an adjuvant therapy for breast cancer with axillary node involvement has become "standard therapy" at least for some subsets of patients (according to the Second Consensus Development Conference on Adjuvant Chemotherapy for Breast Cancer). The acute toxicity of such a regimen is usually mild and well tolerated; the late toxicity is mainly represented by amenorrhea. Here a case of acute non-lymphoid-leukemia (ANLL) after six CMF cycles is reported.


12. DOCID:19879 SCORE: 0.00216633865401792
DOCNO: 1445777
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: complications
AUTHOR: J L Shuster JL
AUTHOR: T A Stern TA
AUTHOR: D B Greenberg DB
AFFILIATION: Division of Medical/Surgical Psychiatry, University of Alabama, Birmingham.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Pros and cons of fluoxetine for the depressed cancer patient.
PUBDATE: 19921101
When major depression develops in patients with cancer, specific antidepressant treatment should be initiated. Fluoxetine (Prozac) is one of several effective treatments for depression; it is currently the most frequently prescribed antidepressant in the United States. Unfortunately, the information from studies and reports regarding the use of fluoxetine in patients with cancer is limited. This article reviews the properties, drug interactions, and side-effect profiles of fluoxetine and the other antidepressants most relevant to the care of cancer patients. Also discussed are strategies for the prudent prescription of fluoxetine, the tricyclic antidepressants, and the psychostimulants in depressed cancer patients.


13. DOCID:19095 SCORE: 0.00210151299178501
DOCNO: 8262160
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: physiopathology
QUALIFIER: physiopathology
QUALIFIER: physiology
AUTHOR: A Frankel A
AUTHOR: J Viallet J
AFFILIATION: Department of Medicine, Montreal General Hospital, PQ, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: Experimental cell research.
COUNTRY: UNITED STATES
TITLE: Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells.
PUBDATE: 19931201
Homologous desensitization of responses to bombesin in small cell lung cancer cells can be mimicked by protein kinase C-activating phorbol esters. We show that phorbol ester-induced desensitization can be blocked by prior treatment with the protein kinase C inhibitor staurosporine or prolonged pretreatment with phorbol esters. However, under these conditions, homologous desensitization to bombesin persists. These data indicate that phorbol ester-induced desensitization is distinguishable from bombesin-induced homologous desensitization. Protein kinase C is not a dominant component in the homologous desensitization to bombesin in small cell lung cancer cells.


14. DOCID:18478 SCORE: 0.00206469161164558
DOCNO: 8468270
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mutagenesis
QUALIFIER: therapy
AUTHOR: K T Kelsey KT
AUTHOR: M Caggana-Aviles M
AUTHOR: P Mauch P
AUTHOR: C N Coleman CN
AUTHOR: L N Shulman LN
AUTHOR: H L Liber HL
AFFILIATION: Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts.
PUBTYPE: Journal Article
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: ENGLAND
TITLE: Mutagenesis after therapy for Hodgkin's disease.
PUBDATE: 19930401
Therapy for Hodgkin's disease has been associated with a significant increase in risk for second cancers. To begin an investigation of the association of therapy-induced genetic damage with this risk, somatic mutations at the hypoxanthine phosphoribosyltransferase locus were measured in lymphocytes from patients previously treated for Hodgkin's disease. The results demonstrate that a subset of patients have persistently elevated mutation frequencies, perhaps suggesting that these individuals are among those at significant risk of second cancer development.