0. DOCID:30756 SCORE: 0.00380403703723908
DOCNO: 12527493
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: David Johnson D
AUTHOR: Christopher M Pyke CM
AUTHOR: Deborah L Norris DL
AUTHOR: Graham F Adkins GF
AFFILIATION: Department of Surgery, University of Queensland, Mater Adult Hospital, South Brisbane, Queensland, Australia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Asian journal of surgery / Asian Surgical Association.
COUNTRY: China
TITLE: Atypical ductal hyperplasia of the breast in young women: two case reports.
PUBDATE: 20030101
Atypical ductal hyperplasia of the breast is a benign proliferative condition that is associated with an increased risk of development of breast cancer in either the ipsilateral or contralateral breast. Following diagnosis at biopsy, respective management options range from observation to chemoprophylaxis to prophylactic surgery. We present two cases in young women, facing prolonged follow-up, one managed with observation only, and the other managed with ipsilateral mastectomy and reconstruction.

1. DOCID:27072 SCORE: 0.00348078098618004
DOCNO: 10524806
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: K Kelly K
AUTHOR: N Mikhaeel-Kamel N
AFFILIATION: Lung Cancer Program and the Division of Medical Oncology, The University of Colorado Cancer Center, Denver, USA. karen.kelly@UCHSC.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of thoracic imaging.
COUNTRY: UNITED STATES
TITLE: Medical treatment of lung cancer.
PUBDATE: 19991001
Lung cancer is the leading cause of cancer deaths for both men and women in the United States. Most patients present with late stages of disease, rendering them incurable. Despite this dismal outcome, there is optimism; modern treatment for lung cancer has been shown to increase survival, improve quality of life, and be cost effective. This article reviews the current treatment strategies for non-small cell lung cancer and small cell lung cancer as well as discusses future treatments, including the exciting biologic agents that are in clinical trials.

2. DOCID:27200 SCORE: 0.00346532480790057
DOCNO: 9930353
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: A J Wight AJ
AUTHOR: G R Ogden GR
AFFILIATION: Unit of Oral Medicine and Oral Surgery, Dundee Dental Hospital and School, University of Dundee, U.K.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oral oncology.
COUNTRY: ENGLAND
TITLE: Possible mechanisms by which alcohol may influence the development of oral cancer--a review.
PUBDATE: 19981101
Although pure ethanol has never been shown to be carcinogenic in laboratory experiments, alcoholic beverages are now recognised as being important aetiological factors in the development of oral cancer. Despite this, the exact mechanism by which alcohol may exert an influence upon the oral mucosa has received less attention. An overview of the association of alcohol and oral cancer, both in combination with tobacco and without, is provided and consideration given to some of the pathways by which alcohol exerts its effect upon the oral mucosa.

3. DOCID:31482 SCORE: 0.00345454243761578
DOCNO: 16286900
OWNER: NLM
STATUS: In-Process
AUTHOR: Joachim Andrassy J
AUTHOR: Christian Graeb C
AUTHOR: Markus Rentsch M
AUTHOR: Karl-Waller Jauch KW
AUTHOR: Markus Guba M
AFFILIATION: Department of Surgery, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Transplantation.
COUNTRY: United States
TITLE: mTOR inhibition and its effect on cancer in transplantation.
PUBDATE: 20050901
A considerable amount of data indicates that transplanted patients are at increased risk for de novo and recurrent cancer. Treatment of this population is difficult. It remains unclear if the immunosuppressive therapy should be continued, tapered or even stopped or if immunosuppressive drugs with antiproliferative properties have beneficial effects in this situation. In various models, mTOR-inhibitors were shown to have immunosuppressive and anti-tumor effects. Here, we have reviewed the current literature trying to clarify if mTOR-inhibition brings advantages for the transplanted patients suffering from tumors.

4. DOCID:27363 SCORE: 0.0034278635004598
DOCNO: 10844946
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adenocarcinoma
DESCRIPTOR: Carcinoma, Squamous Cell
DESCRIPTOR: Esophageal Neoplasms
DESCRIPTOR: Primary Health Care
AUTHOR: J R Fox JR
AUTHOR: S K Kuwada SK
AFFILIATION: Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Today's approach to esophageal cancer. What is the role of the primary care physician?
PUBDATE: 20000501
Esophageal cancer is a devastating disease. Patients are most likely to first present to a primary care physician, who should immediately undertake an initial diagnostic and staging evaluation. The approach then should become multidisciplinary, involving surgical and medical oncologists, radiation oncologists, and gastroenterologists. Optimal therapy of esophageal cancer continues to evolve. While multimodality therapy remains controversial, studies are ongoing to determine the best approaches to improve survival. Further studies to define the role of surveillance endoscopy in certain high-risk patients are warranted.

5. DOCID:26733 SCORE: 0.00342215975487986
DOCNO: 11435021
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ovarian Hyperstimulation Syndrome
QUALIFIER: drug therapy
QUALIFIER: agonists
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: C Turan C
AUTHOR: O Unal O
AUTHOR: R Dansuk R
AUTHOR: K Guzelmeric K
AUTHOR: B Cengizoglu B
AUTHOR: E Esim E
AFFILIATION: Department of Obstetrics and Gynecology, Kartal Research Hospital, Petrol-is Mah. Batman Sok. No. 11, D 14, Toprakyol-Kartal, 81410, Istanbul, Turkey.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of obstetrics, gynecology, and reproductive biology.
COUNTRY: Ireland
TITLE: Successful management of an ovarian enlargement resembling ovarian hyperstimulation in a premenopausal breast cancer patient receiving tamoxifen with cotreatment of GnRH-agonist.
PUBDATE: 20010701
Tamoxifen use in breast cancer patients may cause ovarian cysts. This report presents a case of complex cyst resembling ovarian hyperstimulation in a premenopausal breast cancer patient receiving tamoxifen which resolved by administering monthly depot GnRH-agonist (GnRH-a) without abandoning the tamoxifen treatment.

6. DOCID:27805 SCORE: 0.00335951720979578
DOCNO: 10919157
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: N Matsubara N
AUTHOR: H Isozaki H
AUTHOR: N Tanaka N
AFFILIATION: First Department of Surgery, Okayama University Medical School, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon Geka Gakkai zasshi.
COUNTRY: JAPAN
TITLE: [Genetic analysis for colorectal cancer: what can we learn from microsatellite research?]
PUBDATE: 20000601
Recent advances in molecular biology have unveiled the mechanisms of carcinogenesis, especially colorectal carcinogenesis. A large body of evidence supports the idea that accumulated genetic changes due to inherited as well as environmental factors underlie colorectal cancer development. Recently, several reports have suggested that aberrant methylation of the CpG island may also play an important role in colorectal carcinogenesis. This genetic information is not yet sufficient but some useful genetic information can be applied clinically. This paper presents the results of intensive study of microsatellite instability in colorectal cancers and some clinically applicable discoveries. Future problems are also discussed.

7. DOCID:31853 SCORE: 0.00315307048161048
DOCNO: 16341982
OWNER: NLM
STATUS: In-Process
AUTHOR: G R Blackledge GR
AFFILIATION: AstraZeneca Pharmaceuticals, Macclesfield, UK. George.Blackledge@astrazeneca.com
PUBTYPE: Journal Article
JOURNALTITLE: Zentralblatt für Gynäkologie.
COUNTRY: Germany
TITLE: Developing an oncology portfolio of anticancer drugs: the experience of one pharmaceutical company.
PUBDATE: 20051201
For a company or institute that wishes to develop new anti-cancer agents, it is necessary to establish a portfolio of agents to reduce the risk of failure. Success rates for developing new agents are low and therefore different biological effect areas should be explored to ensure that at least one agent targeting cancer or a specific histological sub-type of cancer is effectively developed. This paper describes how one pharmaceutical company has developed a range of different agents with the ultimate aim of developing as many of these as is technically feasible into useful new medicines for the treatment of cancer.

8. DOCID:31356 SCORE: 0.00315306167702119
DOCNO: 16296738
OWNER: NLM
STATUS: In-Process
AUTHOR: Rafael Mañon R
AUTHOR: Minesh Mehta M
AFFILIATION: University of Wisconsin, Department of Radiotherapy, K4/B100, 600 Highland Avenue, Madison, WI 53792, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert opinion on drug delivery.
COUNTRY: England
TITLE: Strategies for enhanced radiation delivery in patients with lung cancer.
PUBDATE: 20050101
Since the 1970s primary management for regionally advanced non-small cell lung cancer has shifted from radiotherapy alone to sequential chemoradiation to concurrent chemoradiation. The increase in survival with these approaches has been small; an approximately 3-4 month per decade increase in median survival. Future avenues to improve on these outcomes could involve: i)dose-intense radiotherapy; ii) better target delineation; and iii) combining molecularly targeted agents with optimised radiation therapy. However, to accomplish this, techniques to control tumour motion and decrease toxicity must be developed.

9. DOCID:25540 SCORE: 0.00304405877903864
DOCNO: 10418050
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Paraneoplastic Syndromes
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: B Mennecier B
AUTHOR: L Moreau L
AUTHOR: B Goichot B
AUTHOR: G Pauli G
AUTHOR: E Quoix E
AFFILIATION: Pavillon Laënnec, Hôpital Civil, Strasbourg.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue de pneumologie clinique.
COUNTRY: FRANCE
TITLE: [Paraneoplastic Cushing's syndrome and small cell bronchial carcinoma]
PUBDATE: 19990401
Approximately 30% of small-cell bronchogenic cancers are associated with hypersecretion of ACTH. However, in most cases, there is no clinical expression. When a paraneoplastic Cushing syndrome occurs, it is an independent factor of poor prognosis. Management is extremely complex. Treatment must be based on high dose inhibitors prior to chemotherapy. Opportunistic infections, often fungal infections, are the main complications, even outside periods of aplasia, and cause significantly earlier mortality.

10. DOCID:26687 SCORE: 0.00292659593121345
DOCNO: 10211543
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Delivery Systems
QUALIFIER: administration & dosage
QUALIFIER: methods
QUALIFIER: drug therapy
AUTHOR: B N Singh BN
AUTHOR: C Dwivedi C
AFFILIATION: Department of Industrial Pharmacy, College of Allied Health Professions, Saint Johns University, Jamaica, NY 11429, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: Antitumor drug delivery by tissue electroporation.
PUBDATE: 19990201
Tissue electroporation has been explored to enhance the local delivery of chemotherapueutic agents to solid tumors. The technique, known as electrochemotherapy (ECT), uses high-voltage pulses to deliver drugs across cancerous tissues. ECT has been demonstrated to be an effective treatment for cutaneous malignancies. Recent studies also indicate that the applications of ECT can be extended from the treatment of cutaneous cancers to the treatment of tumors of vital organs such as brain, liver, lungs and others. This review also discusses electrogene antitumor therapy.

11. DOCID:31741 SCORE: 0.00291956195311317
DOCNO: 16122510
OWNER: NLM
STATUS: In-Process
AUTHOR: Natalie D Shaw ND
AUTHOR: Eddie L Hoover EL
AFFILIATION: Division of Thoracic Surgery, VA Western New York Healthcare System, State University of New York, Buffalo, New York, USA.
PUBTYPE: Journal Article
JOURNALTITLE: The Annals of thoracic surgery.
COUNTRY: Netherlands
TITLE: Postoperative pleural effusion in bronchioloalveolar cancer.
PUBDATE: 20050901
Bronchioloalveolar carcinoma occasionally presents with bronchorrhea and can appear on roentgenogram as cavitary lesions similar to a lung abscess. We present a case of multifocal, cavitary bronchioloalveolar cancer, which was originally treated unsuccessfully as lung abscesses. At surgery, two cavities were identified without evidence of tumor or chronic infection and were left open. The postoperative course was complicated by 5 weeks of massive chest tube drainage, which was finally controlled with radiation and time. This report chronicles our difficulty with diagnosis and management and suggests recommendations for future providers.

12. DOCID:26216 SCORE: 0.00290525808634263
DOCNO: 11004802
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mycobacterium bovis
AUTHOR: T Yamada T
AFFILIATION: Nagasaki University, Japan.
PUBTYPE: Lectures
JOURNALTITLE: Kekkaku : [Tuberculosis].
COUNTRY: JAPAN
TITLE: [Study on recombinant BCG]
PUBDATE: 20000801
The progress of study on recombinant BCG was stated briefly. And then our studies on recombinant BCG were mentioned. Recombinant BCG secreting alpha antigen-fused merozoite surface protein 1 (MSP 1) was prepared and tested for its ability to control infections of Plasmodium yoelii. Result turned out it controlled the infection better than recombinant MSP 1 mixed with Freund incomplete adjuvant did. Recombinant BCG secreting excess amounts of antigen 85 complex A controlled infection of Mycobacterium leprae. Addition of recombinant BCG secreting alpha antigen-fused IL-2 to peritoneal exudate cells induced IFN-gamma resulting in killing bladder cancer cells more efficiently than parental BCG did.

13. DOCID:31004 SCORE: 0.00285274381067926
DOCNO: 11897559
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: Yasuhiro Matsumura Y
AUTHOR: Honnavara N Ananthaswamy HN
AFFILIATION: Department of Immunology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 178, Houston, TX, 77030, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Frontiers in bioscience : a journal and virtual library.
COUNTRY: United States
TITLE: Molecular mechanisms of photocarcinogenesis.
PUBDATE: 20020401
Photocarcinogenesis represents the accumulation of genetic changes as well as immune system modulation, which ultimately lead to the development of skin cancers. The recent advances in molecular and cellular biology have clarified the mechanisms of photocarcinogenesis, including the formation of DNA photoproducts, DNA repair, mutation of proto-oncogenes and tumor suppressor genes, and UV-induced immunosuppression. The understanding and further investigation of photocarcinogenesis is critical to the development of effective prevention and intervention strategies for human skin cancer.

14. DOCID:26934 SCORE: 0.00271412566074952
DOCNO: 11002316
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Spectroscopy
PUBTYPE: Bibliography
JOURNALTITLE: NMR in biomedicine.
COUNTRY: ENGLAND
TITLE: Current awareness in NMR in biomedicine.
PUBDATE: 20001001
In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of NMR in biomedicine. Each bibliography is divided into 9 sections: 1 Books, Reviews ' Symposia; 2 General; 3 Technology; 4 Brain and Nerves; 5 Neuropathology; 6 Cancer; 7 Cardiac, Vascular and Respiratory Systems; 8 Liver, Kidney and Other Organs; 9 Muscle and Orthopaedic. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.