0. DOCID:19584 SCORE: 0.00582941961402019
DOCNO: 1555196
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sister Chromatid Exchange
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: L Lukovic L
AUTHOR: J Milasin J
AFFILIATION: Institute of Biology and Human Genetics, University of Belgrade School of Medicine and Dentistry, Yugoslavia.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Sister chromatid exchanges in patients with carcinoma in situ of cervix uteri.
PUBDATE: 19920301
Sister chromatid exchange (SCE) was analyzed in lymphocytes of 21 patients with carcinoma in situ of cervix uteri and 19 control subjects. The mean SCE frequencies were 8.92 +/- 0.31 (n = 417) and 6.94 +/- 0.23, (n = 375) per metaphase in patients and controls, respectively. The increase of SCE levels in cancer patients was highly significant in respect to controls (p less than 0.001). Together with data of other authors in patients with precancerous and cancerous lesions of the cervix, our results suggest that there is no correlation between SCE rate and severity of cancerous lesions.


1. DOCID:19260 SCORE: 0.00388820941834377
DOCNO: 2258086
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pregnancy Complications, Neoplastic
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M Shaves M
AUTHOR: R R Kamps RR
AUTHOR: L R Laufman LR
AUTHOR: C D Runowicz CD
AFFILIATION: Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10461.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: A successful term pregnancy following the systemic and intraperitoneal administration of cisplatin chemotherapy.
PUBDATE: 19901201
The advent of successful chemotherapy has improved the prognosis and long-term disease-free survival for many patients with a variety of malignancies. Preservation of reproductive function in female patients is now possible with conservative surgery in certain selected malignancies. Successful pregnancies following chemotherapy or ovarian cancer have been reported. This is the first reported case of a term pregnancy following the systemic and intraperitoneal administration of cisplatin chemotherapy in the treatment of ovarian cancer.


2. DOCID:30756 SCORE: 0.00380403703723908
DOCNO: 12527493
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: David Johnson D
AUTHOR: Christopher M Pyke CM
AUTHOR: Deborah L Norris DL
AUTHOR: Graham F Adkins GF
AFFILIATION: Department of Surgery, University of Queensland, Mater Adult Hospital, South Brisbane, Queensland, Australia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Asian journal of surgery / Asian Surgical Association.
COUNTRY: China
TITLE: Atypical ductal hyperplasia of the breast in young women: two case reports.
PUBDATE: 20030101
Atypical ductal hyperplasia of the breast is a benign proliferative condition that is associated with an increased risk of development of breast cancer in either the ipsilateral or contralateral breast. Following diagnosis at biopsy, respective management options range from observation to chemoprophylaxis to prophylactic surgery. We present two cases in young women, facing prolonged follow-up, one managed with observation only, and the other managed with ipsilateral mastectomy and reconstruction.


3. DOCID:23103 SCORE: 0.00353139372821189
DOCNO: 8912548
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: drug therapy
QUALIFIER: blood
AUTHOR: G J Rustin GJ
AUTHOR: T G Quinnell TG
AUTHOR: J Johnson J
AUTHOR: H Clarke H
AUTHOR: A E Nelstrop AE
AUTHOR: W Bollag W
AFFILIATION: Department of Medical Oncology, Mount Vernon Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, Middlesex, UK.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Trial of isotretinoin and calcitriol monitored by CA 125 in patients with ovarian cancer.
PUBDATE: 19961101
Twenty-two asymptomatic women with rising CA 125 levels after chemotherapy for ovarian cancer were entered into a trial of isotretinoin combined with calcitriol. Tumours were evaluated according to precise criteria based on serial CA 125 levels and by comparing regression slopes of CA 125 before and during therapy. There was no evidence based on CA 125 of any responses or significant change in tumour growth rate.


4. DOCID:23097 SCORE: 0.00353137973944471
DOCNO: 8051769
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prostatectomy
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: H B Heidenberg HB
AUTHOR: J W Moul JW
AUTHOR: F K Mostofi FK
AUTHOR: D G McLeod DG
AFFILIATION: Urology Service, Walter Reed Army Medical Center, Bethesda, Maryland.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Clinically detected carcinoma of the prostate treated by radical prostatectomy in a 29-year-old man.
PUBDATE: 19940901
Prostate cancer is rare in young adults and when clinically detected it has been invariably locally or distantly advanced, undifferentiated and exhibiting aggressive behavior. To our knowledge no previous report documents clinically detected and localized disease amenable to curative surgery in a young adult. We report on a 29-year-old man with clinically detected, moderately differentiated adenocarcinoma of the prostate who was treated by nerve sparing radical retropubic prostatectomy. The patient was disease-free and morbidity-free 30 months after treatment.


5. DOCID:27072 SCORE: 0.00348078098618004
DOCNO: 10524806
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: K Kelly K
AUTHOR: N Mikhaeel-Kamel N
AFFILIATION: Lung Cancer Program and the Division of Medical Oncology, The University of Colorado Cancer Center, Denver, USA. karen.kelly@UCHSC.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of thoracic imaging.
COUNTRY: UNITED STATES
TITLE: Medical treatment of lung cancer.
PUBDATE: 19991001
Lung cancer is the leading cause of cancer deaths for both men and women in the United States. Most patients present with late stages of disease, rendering them incurable. Despite this dismal outcome, there is optimism; modern treatment for lung cancer has been shown to increase survival, improve quality of life, and be cost effective. This article reviews the current treatment strategies for non-small cell lung cancer and small cell lung cancer as well as discusses future treatments, including the exciting biologic agents that are in clinical trials.


6. DOCID:27200 SCORE: 0.00346532480790057
DOCNO: 9930353
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: A J Wight AJ
AUTHOR: G R Ogden GR
AFFILIATION: Unit of Oral Medicine and Oral Surgery, Dundee Dental Hospital and School, University of Dundee, U.K.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oral oncology.
COUNTRY: ENGLAND
TITLE: Possible mechanisms by which alcohol may influence the development of oral cancer--a review.
PUBDATE: 19981101
Although pure ethanol has never been shown to be carcinogenic in laboratory experiments, alcoholic beverages are now recognised as being important aetiological factors in the development of oral cancer. Despite this, the exact mechanism by which alcohol may exert an influence upon the oral mucosa has received less attention. An overview of the association of alcohol and oral cancer, both in combination with tobacco and without, is provided and consideration given to some of the pathways by which alcohol exerts its effect upon the oral mucosa.


7. DOCID:31482 SCORE: 0.00345454243761578
DOCNO: 16286900
OWNER: NLM
STATUS: In-Process
AUTHOR: Joachim Andrassy J
AUTHOR: Christian Graeb C
AUTHOR: Markus Rentsch M
AUTHOR: Karl-Waller Jauch KW
AUTHOR: Markus Guba M
AFFILIATION: Department of Surgery, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Transplantation.
COUNTRY: United States
TITLE: mTOR inhibition and its effect on cancer in transplantation.
PUBDATE: 20050901
A considerable amount of data indicates that transplanted patients are at increased risk for de novo and recurrent cancer. Treatment of this population is difficult. It remains unclear if the immunosuppressive therapy should be continued, tapered or even stopped or if immunosuppressive drugs with antiproliferative properties have beneficial effects in this situation. In various models, mTOR-inhibitors were shown to have immunosuppressive and anti-tumor effects. Here, we have reviewed the current literature trying to clarify if mTOR-inhibition brings advantages for the transplanted patients suffering from tumors.


8. DOCID:27363 SCORE: 0.0034278635004598
DOCNO: 10844946
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adenocarcinoma
DESCRIPTOR: Carcinoma, Squamous Cell
DESCRIPTOR: Esophageal Neoplasms
DESCRIPTOR: Primary Health Care
AUTHOR: J R Fox JR
AUTHOR: S K Kuwada SK
AFFILIATION: Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Today's approach to esophageal cancer. What is the role of the primary care physician?
PUBDATE: 20000501
Esophageal cancer is a devastating disease. Patients are most likely to first present to a primary care physician, who should immediately undertake an initial diagnostic and staging evaluation. The approach then should become multidisciplinary, involving surgical and medical oncologists, radiation oncologists, and gastroenterologists. Optimal therapy of esophageal cancer continues to evolve. While multimodality therapy remains controversial, studies are ongoing to determine the best approaches to improve survival. Further studies to define the role of surveillance endoscopy in certain high-risk patients are warranted.


9. DOCID:26733 SCORE: 0.00342215975487986
DOCNO: 11435021
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ovarian Hyperstimulation Syndrome
QUALIFIER: drug therapy
QUALIFIER: agonists
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: C Turan C
AUTHOR: O Unal O
AUTHOR: R Dansuk R
AUTHOR: K Guzelmeric K
AUTHOR: B Cengizoglu B
AUTHOR: E Esim E
AFFILIATION: Department of Obstetrics and Gynecology, Kartal Research Hospital, Petrol-is Mah. Batman Sok. No. 11, D 14, Toprakyol-Kartal, 81410, Istanbul, Turkey.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of obstetrics, gynecology, and reproductive biology.
COUNTRY: Ireland
TITLE: Successful management of an ovarian enlargement resembling ovarian hyperstimulation in a premenopausal breast cancer patient receiving tamoxifen with cotreatment of GnRH-agonist.
PUBDATE: 20010701
Tamoxifen use in breast cancer patients may cause ovarian cysts. This report presents a case of complex cyst resembling ovarian hyperstimulation in a premenopausal breast cancer patient receiving tamoxifen which resolved by administering monthly depot GnRH-agonist (GnRH-a) without abandoning the tamoxifen treatment.


10. DOCID:23004 SCORE: 0.00338622062082413
DOCNO: 7609971
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cholecystectomy, Laparoscopic
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J Sándor J
AUTHOR: M Ihász M
AUTHOR: T Fazekas T
AUTHOR: J Regöly-Mérei J
AUTHOR: J Bátorfi J
AFFILIATION: III. sz. Sebészeti Klinika, Semmelweis Orvostudományi Egyetem, Budapest.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Orvosi hetilap.
COUNTRY: HUNGARY
TITLE: [Laparoscopic cholecystectomy and cancer of the gallbladder]
PUBDATE: 19950701
Performing a series of 960 laparoscopic cholecystectomies we have removed 3 unsuspected gallbladder cancers. In one case we have observed the development of trocar site abdominal wall metastasis twice. After resection and reresection of the metastases the patient is symptom-free in the 14th month. During laparoscopic cholecystectomy if there is a suspicion of gallbladder cancer we have to manipulate with special care to avoid rupture of the gallbladder. In doubtful cases frozen section is mandatory. If the malignant process extends over the serosal layer--conversion and radical-extended operation is recommended.


11. DOCID:27805 SCORE: 0.00335951720979578
DOCNO: 10919157
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: N Matsubara N
AUTHOR: H Isozaki H
AUTHOR: N Tanaka N
AFFILIATION: First Department of Surgery, Okayama University Medical School, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon Geka Gakkai zasshi.
COUNTRY: JAPAN
TITLE: [Genetic analysis for colorectal cancer: what can we learn from microsatellite research?]
PUBDATE: 20000601
Recent advances in molecular biology have unveiled the mechanisms of carcinogenesis, especially colorectal carcinogenesis. A large body of evidence supports the idea that accumulated genetic changes due to inherited as well as environmental factors underlie colorectal cancer development. Recently, several reports have suggested that aberrant methylation of the CpG island may also play an important role in colorectal carcinogenesis. This genetic information is not yet sufficient but some useful genetic information can be applied clinically. This paper presents the results of intensive study of microsatellite instability in colorectal cancers and some clinically applicable discoveries. Future problems are also discussed.


12. DOCID:31853 SCORE: 0.00315307048161048
DOCNO: 16341982
OWNER: NLM
STATUS: In-Process
AUTHOR: G R Blackledge GR
AFFILIATION: AstraZeneca Pharmaceuticals, Macclesfield, UK. George.Blackledge@astrazeneca.com
PUBTYPE: Journal Article
JOURNALTITLE: Zentralblatt für Gynäkologie.
COUNTRY: Germany
TITLE: Developing an oncology portfolio of anticancer drugs: the experience of one pharmaceutical company.
PUBDATE: 20051201
For a company or institute that wishes to develop new anti-cancer agents, it is necessary to establish a portfolio of agents to reduce the risk of failure. Success rates for developing new agents are low and therefore different biological effect areas should be explored to ensure that at least one agent targeting cancer or a specific histological sub-type of cancer is effectively developed. This paper describes how one pharmaceutical company has developed a range of different agents with the ultimate aim of developing as many of these as is technically feasible into useful new medicines for the treatment of cancer.


13. DOCID:31356 SCORE: 0.00315306167702119
DOCNO: 16296738
OWNER: NLM
STATUS: In-Process
AUTHOR: Rafael Mañon R
AUTHOR: Minesh Mehta M
AFFILIATION: University of Wisconsin, Department of Radiotherapy, K4/B100, 600 Highland Avenue, Madison, WI 53792, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert opinion on drug delivery.
COUNTRY: England
TITLE: Strategies for enhanced radiation delivery in patients with lung cancer.
PUBDATE: 20050101
Since the 1970s primary management for regionally advanced non-small cell lung cancer has shifted from radiotherapy alone to sequential chemoradiation to concurrent chemoradiation. The increase in survival with these approaches has been small; an approximately 3-4 month per decade increase in median survival. Future avenues to improve on these outcomes could involve: i)dose-intense radiotherapy; ii) better target delineation; and iii) combining molecularly targeted agents with optimised radiation therapy. However, to accomplish this, techniques to control tumour motion and decrease toxicity must be developed.


14. DOCID:22807 SCORE: 0.00305553953124535
DOCNO: 8691599
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, Tumor Suppressor
DESCRIPTOR: Oncogenes
QUALIFIER: analysis
AUTHOR: H Kondo H
AUTHOR: A Nobuoka A
AFFILIATION: Division of G1 oncology, National Cancer Center Hospital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Clinical application of oncogene and antioncogene as a tumor marker]
PUBDATE: 19960601
Since it is generally accepted that neoplasm is developed by accumulation of abnormalities in oncogenes and antioncogenes, these genetic analysis would be useful as new tumor markers. The present clinical applications of genetic analysis of oncogenes are as follows, 1) diagnosis of neoplasm (early detection, differential diagnosis for borderline lesion), 2) speculation of the prognosis of a cancer patient and prediction of chemosensitivity and, 3) establishment of high risk group of cancer. In regard to clinical practice, a medical doctor take care of scientific interpretation of genetic examinations as well as ethical problems.