0. DOCID:19584 SCORE: 0.00582941961402019
DOCNO: 1555196
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sister Chromatid Exchange
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: L Lukovic L
AUTHOR: J Milasin J
AFFILIATION: Institute of Biology and Human Genetics, University of Belgrade School of Medicine and Dentistry, Yugoslavia.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Sister chromatid exchanges in patients with carcinoma in situ of cervix uteri.
PUBDATE: 19920301
Sister chromatid exchange (SCE) was analyzed in lymphocytes of 21 patients with carcinoma in situ of cervix uteri and 19 control subjects. The mean SCE frequencies were 8.92 +/- 0.31 (n = 417) and 6.94 +/- 0.23, (n = 375) per metaphase in patients and controls, respectively. The increase of SCE levels in cancer patients was highly significant in respect to controls (p less than 0.001). Together with data of other authors in patients with precancerous and cancerous lesions of the cervix, our results suggest that there is no correlation between SCE rate and severity of cancerous lesions.


1. DOCID:3980 SCORE: 0.00496883008030261
DOCNO: 1107828
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: drug effects
AUTHOR: T Rossman T
AUTHOR: M S Meyn MS
AUTHOR: W Troll W
PUBTYPE: Journal Article
JOURNALTITLE: Mutation research.
COUNTRY: NETHERLANDS
TITLE: Effects of sodium arsenite on the survival of UV-irradiated Escherichia coli: inhibition of a recA-dependent function.
PUBDATE: 19751101
Epidemiological studies and clinical observation suggesting potential hazards of arsenic compounds in increasing the incidence of cancer have been in complete contradiction with experimental findings in animals. Because of the predominance of skin cancers in the epidemiological reports, we decided to investigate the possibility that arsenic compounds might interfere with DNA repair. Using Escherichia coli as a test system, we show that this is indeed the case. Sodium arsenite, at concentrations of 0.1 mM and higher, decreases the survival of ultraviolet-irradiated E. coli WP2, a strain which possesses the full complement of repair genes. The effect of the arsenite increases with increasing ultraviolet dose. Similar results were obtained with the excision repair deficient strains WWP2 (uvrA) and WP6 (polA). Sodium arsenite had no effect on the survival of a recA mutant, WP10. Survival of ultraviolet-irradiated WP5 (exrA) was enhanced by sodium ardenite, the effect being greatest at low ultraviolet doses. It is postulated that arsenite inhibits a recA-dependent step in DNA repair. To account for the increased survival of the exrA mutant, we suggest that in the absence of the exr+ gene, the arsenite-sensitive recA-dependent function is deleterious. The ability of arsenite to inhibit DNA repair may account for the clinical and epidemiological reports linking arsenicals with an increased incidence of cancer.


2. DOCID:11849 SCORE: 0.00447762467239293
DOCNO: 6416244
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: economics
AUTHOR: R B Black RB
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Considerations of cost and effectiveness in the choice of mastectomy.
PUBDATE: 19831001
Operable breast cancer may be managed equally well by a number of different regimens of mastectomy and/or radiotherapy. This paper examines the financial and morbidity costs, together with the node sampling efficacy, of three commonly employed techniques: simple mastectomy; total mastectomy with node biopsy or limited node excision; and modified radical mastectomy. Adjuvant radiotherapy (and/or chemotherapy) can only be applied rationally if node sampling is effective. Simple mastectomy cannot achieve this. Total mastectomy, providing that a node sample is obtained, is effective, and is probably the cheapest option. Total axillary clearance runs the risk of increased morbidity (and financial cost), while not necessarily guaranteeing more effective node sampling. Much of the cost and morbidity of mastectomy may be reduced by a limited but rational radiation policy.


3. DOCID:3617 SCORE: 0.00398032709227016
DOCNO: 1122765
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Smoking
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: O Auerbach O
AUTHOR: L Garfinkel L
AUTHOR: V R Parks VR
PUBTYPE: Journal Article
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Histologic type of lung cancer in relation to smoking habits, year of diagnosis and sites of metastases.
PUBDATE: 19750401
A study was made of histologic type of lung cancer in relation to smoking habit, year of diagnosis, age and sites of metastasis. It comprised 662 autopsies of men during the period from 1955 to 1972. As classified by the WHO system, 35.2 percent were epidermoid carcinoma, 24.6 percent were small cell carcinoma, 25.2 percent were adenocarcinoma and 14.2 percent were large cell undifferentiated carcinoma. The six non-smokers of the series were all found to be in class 3, adenocarcinoma. No clearcut and consistent relationships were observed. Although there was a steady decrease in the incidence of small cell carcinoma during this time period, this observation did not prove to be statistically significant. Small cell carcinomas increased with amount of smoking but not for all age groups. Adenocarcinomas decreased with advancing age but not in all smoking groups. Metastases were found in 96.3 percent of the cases and the sites most frequently involved were regional lymph nodes, liver, brain, distant lymph nodes, adrenals and bone. Small cell carcinomas showed the greatest percentage of involvement for those major sites and for the same sites, epidermoid carcinoma showed the lowest percentage.


4. DOCID:19260 SCORE: 0.00388820941834377
DOCNO: 2258086
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pregnancy Complications, Neoplastic
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M Shaves M
AUTHOR: R R Kamps RR
AUTHOR: L R Laufman LR
AUTHOR: C D Runowicz CD
AFFILIATION: Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10461.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: A successful term pregnancy following the systemic and intraperitoneal administration of cisplatin chemotherapy.
PUBDATE: 19901201
The advent of successful chemotherapy has improved the prognosis and long-term disease-free survival for many patients with a variety of malignancies. Preservation of reproductive function in female patients is now possible with conservative surgery in certain selected malignancies. Successful pregnancies following chemotherapy or ovarian cancer have been reported. This is the first reported case of a term pregnancy following the systemic and intraperitoneal administration of cisplatin chemotherapy in the treatment of ovarian cancer.


5. DOCID:30756 SCORE: 0.00380403703723908
DOCNO: 12527493
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: David Johnson D
AUTHOR: Christopher M Pyke CM
AUTHOR: Deborah L Norris DL
AUTHOR: Graham F Adkins GF
AFFILIATION: Department of Surgery, University of Queensland, Mater Adult Hospital, South Brisbane, Queensland, Australia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Asian journal of surgery / Asian Surgical Association.
COUNTRY: China
TITLE: Atypical ductal hyperplasia of the breast in young women: two case reports.
PUBDATE: 20030101
Atypical ductal hyperplasia of the breast is a benign proliferative condition that is associated with an increased risk of development of breast cancer in either the ipsilateral or contralateral breast. Following diagnosis at biopsy, respective management options range from observation to chemoprophylaxis to prophylactic surgery. We present two cases in young women, facing prolonged follow-up, one managed with observation only, and the other managed with ipsilateral mastectomy and reconstruction.


6. DOCID:6982 SCORE: 0.00367132393208309
DOCNO: 6791024
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: therapy
AUTHOR: K M Foley KM
PUBTYPE: Journal Article
JOURNALTITLE: NIDA research monograph.
COUNTRY: UNITED STATES
TITLE: Current issues in the management of cancer pain: Memorial Sloan-Kettering Cancer Center.
PUBDATE: 19810501
Recent attention to the management of cancer pain in the mass media (TV, books, newspapers) and the medical press provides ample evidence to suggest that many cancer patients are not receiving appropriate therapy for their pain. Since cancer therapy is often not curative, only palliative, specific attention to the management of pain in such patients is essential. However, the management of cancer pain requires a specific approach and expertise. Narcotic analgesics are the mainstay of therapy in the management of such patients, yet physicians lack sufficient knowledge of narcotic pharmacology to use these drugs appropriately. Recent controversy has arisen in 3 specific aspects of narcotic drug therapy: 1) the choice of a narcotic drug and its method of administration; 2) the development of tolerance, and 3) the risk of substance abuse, drug dependence, and addiction.


7. DOCID:10755 SCORE: 0.00354778783076975
DOCNO: 6632212
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: I Takanami I
AUTHOR: T Utsunomiya T
AUTHOR: H Onishi H
AUTHOR: H Shinohara H
AUTHOR: T Besso T
AUTHOR: T Kondo T
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Costus root oil test in cancer patients; correlation with tumor stage]
PUBDATE: 19830901
Delayed hypersensitivity skin responses to costus root oil were measured in patients with colon, stomach, breast and lung cancer and in healthy controls. Cancer patients were staged according to tumor spread. Differences were demonstrated between cancer patients and controls. Patients with localized cancer showed no impairment, but diminished responses did occur in patients with advanced or metastatic cancer. There were no significant differences among any cancer groups with lymph node involvement. In the late cancer stage, costus root oil sensitivity was lost to a greater extent in patients with gastric cancer than in those with colon cancer.


8. DOCID:23103 SCORE: 0.00353139372821189
DOCNO: 8912548
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: drug therapy
QUALIFIER: blood
AUTHOR: G J Rustin GJ
AUTHOR: T G Quinnell TG
AUTHOR: J Johnson J
AUTHOR: H Clarke H
AUTHOR: A E Nelstrop AE
AUTHOR: W Bollag W
AFFILIATION: Department of Medical Oncology, Mount Vernon Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, Middlesex, UK.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Trial of isotretinoin and calcitriol monitored by CA 125 in patients with ovarian cancer.
PUBDATE: 19961101
Twenty-two asymptomatic women with rising CA 125 levels after chemotherapy for ovarian cancer were entered into a trial of isotretinoin combined with calcitriol. Tumours were evaluated according to precise criteria based on serial CA 125 levels and by comparing regression slopes of CA 125 before and during therapy. There was no evidence based on CA 125 of any responses or significant change in tumour growth rate.


9. DOCID:23097 SCORE: 0.00353137973944471
DOCNO: 8051769
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prostatectomy
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: H B Heidenberg HB
AUTHOR: J W Moul JW
AUTHOR: F K Mostofi FK
AUTHOR: D G McLeod DG
AFFILIATION: Urology Service, Walter Reed Army Medical Center, Bethesda, Maryland.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Clinically detected carcinoma of the prostate treated by radical prostatectomy in a 29-year-old man.
PUBDATE: 19940901
Prostate cancer is rare in young adults and when clinically detected it has been invariably locally or distantly advanced, undifferentiated and exhibiting aggressive behavior. To our knowledge no previous report documents clinically detected and localized disease amenable to curative surgery in a young adult. We report on a 29-year-old man with clinically detected, moderately differentiated adenocarcinoma of the prostate who was treated by nerve sparing radical retropubic prostatectomy. The patient was disease-free and morbidity-free 30 months after treatment.


10. DOCID:3983 SCORE: 0.00351789750163376
DOCNO: 602778
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: I Dahl I
AUTHOR: L Angervall L
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica et microbiologica Scandinavica. Section A, Pathology.
COUNTRY: DENMARK
TITLE: Pseudosarcomatous lesions of the soft tissues reported as sarcoma during a 6-year period (1958-1963).
PUBDATE: 19771101
Pseudosarcomatous lesion of the soft tissues is a term used in the present study for various soft tissue lesions and tumours easily clinically or histologically, or both, misinterpreted as sarcoma. Eighty-one cases, that is to say 10 per cent of all tumours classified and reported to the Swedish Cancer Registry as malignant soft tissue tumours during the 6-year period studied (1958-1963), were reclassified as pseudosarcomatous lesions of the soft tissues. Forty-seven cases were classified as pseudoarcomatous proliferative lesions of the soft tissue with or without bone formation; 38 cases of nodular fasciitis, 1 of proliferative fasciitis and 8 of proliferative myositis. In 3 of these cases there were mixed forms of proliferative fasciitis and proliferative myositis with areas compatible with the diagnosis of nodular fasciitis evident in all cases. Twenty-two cases of atypical fibroxanthomas of the skin were next in frequency, followed by 7 ancient neurilemmomas, 2 spindle cell lipomas, 1 pseudomalignant osseous tumour of the soft tissues, 1 pigmented villonodular synovitis and 1 juvenile xanthogranuloma. An attempt is made to explain the reasons for these erroneous diagnoses of sarcoma and it is stressed that for these lesions the conventional histological criteria for malignancy are not valid. The awareness and knowledge of the existence of these particular entities are therefore considered mandatory for an accurate diagnosis.


11. DOCID:7899 SCORE: 0.00349878543478216
DOCNO: 7193368
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: J E Altwein JE
AUTHOR: G H Jacobi GH
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Hormone therapy of prostatic cancer (author's transl)]
PUBDATE: 19801101
64% of all patients with newly diagnosed prostatic carcinoma present with metastases. Hormone application with or without orchiectomy appears to be the adequate form of primary treatment. The most common therapeutic modality is estrogen administration, which has, however distinct disadvantages: The patient is protected up to 5 years only, there is a 27% cardiovascular mortality, it induces a prolactin surge, and is immunosuppressive. Phase III-studies of the EORTC and VACURG have demonstrated that medroxyprogesterone acetate and cyproterone acetate parallel the effectiveness of estrogens. In a phase II-trial adjunctive bromocriptine was found to be necessary to suppress estrogen or antiandrogen induced hyperprolactinemia. The following concept is derived: In disseminated untreated prostatic cancer estrogens or antiandrogens in combination with bromocriptine or high dose injectable gestagens are effective means of primary treatment. Distinct clinical parameters determine the "hormone of first choice". Orchiectomy is reserved for patients with ureteral compression or progressing disease.


12. DOCID:27072 SCORE: 0.00348078098618004
DOCNO: 10524806
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: K Kelly K
AUTHOR: N Mikhaeel-Kamel N
AFFILIATION: Lung Cancer Program and the Division of Medical Oncology, The University of Colorado Cancer Center, Denver, USA. karen.kelly@UCHSC.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of thoracic imaging.
COUNTRY: UNITED STATES
TITLE: Medical treatment of lung cancer.
PUBDATE: 19991001
Lung cancer is the leading cause of cancer deaths for both men and women in the United States. Most patients present with late stages of disease, rendering them incurable. Despite this dismal outcome, there is optimism; modern treatment for lung cancer has been shown to increase survival, improve quality of life, and be cost effective. This article reviews the current treatment strategies for non-small cell lung cancer and small cell lung cancer as well as discusses future treatments, including the exciting biologic agents that are in clinical trials.


13. DOCID:5911 SCORE: 0.00346754370199041
DOCNO: 98229
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: B C Ghosh BC
AUTHOR: L Ghosh L
AUTHOR: B L Newson BL
AUTHOR: T K Das Gupta TK
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Histochemical and ultrastructural study of lactic dehydrogenase in chemically induced lung cancer.
PUBDATE: 19780901
Light and electron microscopy studies of lactic dehydrogenase activity were carried out in embryonic, neonatal, and adult mouse lungs and in lungs undergoing chemically induced carcinogenesis. Embryonic mouse lungs were collected on the 6th, 12th, and 18th days of gestation; 1-day-old lungs were used for the neonatal model. These were compared with adult normal mouse lung and lungs of the animals treated with 4-nitroquinoline 1-oxide at a monthly interval until cancer developed. Enzymatic activity was seen in the embryonic, precancerous, and malignant lung tissues and was found diffusely in the cytoplasm of the epithelial cells.


14. DOCID:27200 SCORE: 0.00346532480790057
DOCNO: 9930353
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: A J Wight AJ
AUTHOR: G R Ogden GR
AFFILIATION: Unit of Oral Medicine and Oral Surgery, Dundee Dental Hospital and School, University of Dundee, U.K.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oral oncology.
COUNTRY: ENGLAND
TITLE: Possible mechanisms by which alcohol may influence the development of oral cancer--a review.
PUBDATE: 19981101
Although pure ethanol has never been shown to be carcinogenic in laboratory experiments, alcoholic beverages are now recognised as being important aetiological factors in the development of oral cancer. Despite this, the exact mechanism by which alcohol may exert an influence upon the oral mucosa has received less attention. An overview of the association of alcohol and oral cancer, both in combination with tobacco and without, is provided and consideration given to some of the pathways by which alcohol exerts its effect upon the oral mucosa.