0. DOCID:16551 SCORE: 0.00323988422524013
DOCNO: 1958849
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: J A Wils JA
AFFILIATION: Department of Internal Medicine, Laurentius Hospital, Roermond, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: Chemotherapy in pancreatic cancer: a rational pursuit?
PUBDATE: 19910201
A review on the chemotherapy in advanced pancreatic cancer is presented. Pancreatic cancer is an extremely chemotherapy resistant tumor and results of cytostatic drug treatment so far are unsatisfactory. For patients with locally advanced disease the combination of chemo- and radiotherapy may palliate some patients. To date no standard treatment is available and patients should be entered in clinical protocols assessing new treatment options.

1. DOCID:19551 SCORE: 0.00274175534269548
DOCNO: 7691376
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Stents
QUALIFIER: complications
QUALIFIER: surgery
AUTHOR: P L Mitchell PL
AUTHOR: V J Harvey VJ
AUTHOR: M R Lane MR
AUTHOR: B D Evans BD
AUTHOR: P I Thompson PI
AUTHOR: I Hamilton I
AFFILIATION: Department of Medical Oncology, Auckland Hospital, New Zealand.
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Palliation of biliary obstruction in patients with advanced breast cancer using endoscopic stents.
PUBDATE: 19930901
Endoscopic insertion of a biliary endoprosthesis was successful in eight patients with extrahepatic biliary obstruction caused by breast cancer metastases. The serum bilirubin level was significantly reduced in seven patients and in four this was accompanied by marked symptomatic improvement. Endoprostheses required replacement after a median of 8 (range 3-127) weeks. Two patients responding to systemic anticancer therapy survived 27 and 43 months. Endoscopically placed stents offer effective palliation of extrahepatic biliary obstruction caused by metastatic breast cancer and long-term survival may be possible.

2. DOCID:17405 SCORE: 0.00273514061651874
DOCNO: 1493433
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R Weide R
AUTHOR: C Görg C
AUTHOR: K H Pflüger KH
AUTHOR: A Ramaswamy A
AUTHOR: A Steinmetz A
AUTHOR: S Falk S
AUTHOR: W B Schwerk WB
AFFILIATION: Department of Internal Medicine, Philipps University, Marburg, Germany.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Leukemia & lymphoma.
COUNTRY: SWITZERLAND
TITLE: Concomitant primary low grade non-Hodgkin's lymphoma of the spleen and breast carcinoma.
PUBDATE: 19920701
A case is described of a 71 year old woman with scirrhous breast cancer and multiple hypoechogenic lesions in the spleen. The patient was treated successfully by mastectomy and splenectomy. Morphologic examination of the spleen showed a primary, centroblastic-centrocytic, low grade non-Hodgkin's lymphoma. Eight months after splenectomy the patient still remains in complete remission.

3. DOCID:19973 SCORE: 0.00223535261794064
DOCNO: 1831702
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: methods
AUTHOR: Z Chen Z
AFFILIATION: Institute of Oncology, Beijing.
PUBTYPE: Journal Article
JOURNALTITLE: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
COUNTRY: CHINA
TITLE: [The development of DELFIA with novel tumor monoclonal antibodies E-11 and G-4]
PUBDATE: 19910201
Monoclonal antibodies E-11 and G-4 were purified by Sepharose 4B column chromatography and labelled with europium as tracer. The solid-phase antibodies were prepared by attaching pure E-11 and G-4 to polysterene strips. The supernatant of 8611 cell culture or perchloric acid extracts from ovarian cancer tissues provided standard antigens. The solid-phase sandwich-type DELFIAs for monoclonal antibodies E-11 and G-4 were thus established, and the resulting standard curves were extremely steep. The ratio of CPS in high-concentration tubes to CPS in the zero tube exceeded 300:1, indicating the very high sensitivity and accuracy of this method.

4. DOCID:19872 SCORE: 0.00218582899453816
DOCNO: 1286158
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: antagonists & inhibitors
AUTHOR: P Workman P
AUTHOR: V G Brunton VG
AUTHOR: D J Robins DJ
AFFILIATION: CRC Department of Medical Oncology, University of Glasgow, Bearsden, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: Tyrosine kinase inhibitors.
PUBDATE: 19921201
Tyrosine kinases are associated with the cytoplasmic domains of growth factor receptors as well as oncoproteins and many have the potential to cause transformation if mutated or hyperexpressed. Tyrosine kinases therefore represent an excellent target for the development of cancer drugs. A large number of inhibitors have now been identified and many show promising cytostatic activity, particularly using in vitro models. Some in vivo activity has been reported. Progress with various structural classes is reviewed. It is not clear whether specific or broad spectrum tyrosine kinase inhibitors should be developed as potential anticancer drugs. It does seem likely, however, that tyrosine inhibitors will enter clinical trial in cancer patients.

5. DOCID:17293 SCORE: 0.00197295344678097
DOCNO: 1787682
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: V P Vagner VP
AUTHOR: E G Voĭtkevich EG
AUTHOR: G I Zakora GI
AUTHOR: E D Chirvina ED
PUBTYPE: Journal Article
JOURNALTITLE: Klinicheskaia meditsina.
COUNTRY: USSR
TITLE: [Effectiveness of immunomodulators in multimodal treatment of patients with lung cancer]
PUBDATE: 19911201
The analysis of clinical and immunologic findings indicate that retinol and decaris influence functional activity of immune cells at stage II of lung cancer irrespective of histological structure. In stage III, retinol induced changes in proportion of lymphocyte subpopulations, more evident in glandular cancer. Both immunomodulators lowered the number of purulent complications after surgical interventions. It is only retinol that influenced metastatic dissemination in lung cancer stage II-III.

6. DOCID:16288 SCORE: 0.00197210863005027
DOCNO: 1846777
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: D M Hoffman DM
AUTHOR: B Brigham B
AFFILIATION: Department of Medical Oncology, Prince of Wales Hospital, Sydney, NSW, Australia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The use of ketoconazole in ectopic adrenocorticotropic hormone syndrome.
PUBDATE: 19910301
The authors report a patient with ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) resulting from small cell lung cancer. Treatment with ketoconazole (KCZ) resulted in significant suppression of serum cortisol levels. The authors confirmed KCZ to be a useful adjunct in the treatment of Cushing's syndrome.

7. DOCID:17745 SCORE: 0.00189414253607539
DOCNO: 8223007
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: H Z Qui HZ
AFFILIATION: Peking Union Medical College Hospital, Beijing.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua wai ke za zhi [Chinese journal of surgery].
COUNTRY: CHINA
TITLE: [Posterior transsphincteric approach for the surgery of the rectum]
PUBDATE: 19930201
The posterior transsphincteric approach was used in the surgery of the rectum for 18 patients. They included 7 patients with rectal cancer, 7 villous adenoma malignant change 4, 1 carcinoid, and 3 benign stenosis, parasitic granulation and rectocele. The method of the operation and its main poits were described in detail; the indications of the operation were discussed. The anastomosis was influenced by the length, blood supply and cleaning of the proximal colon. Anastomotic leakage and pelvic infection were the main surgical complications.

8. DOCID:17296 SCORE: 0.0018890370647437
DOCNO: 1949155
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hemiterpenes
DESCRIPTOR: Pentanes
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: A M Spiegel AM
AUTHOR: P S Backlund PS
AUTHOR: J E Butrynski JE
AUTHOR: T L Jones TL
AUTHOR: W F Simonds WF
AFFILIATION: Molecular Pathophysiology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in biochemical sciences.
COUNTRY: ENGLAND
TITLE: The G protein connection: molecular basis of membrane association.
PUBDATE: 19910901
Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

9. DOCID:17313 SCORE: 0.00183324074762353
DOCNO: 2194908
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: S A Proper SA
AUTHOR: P T Rose PT
AUTHOR: N A Fenske NA
AFFILIATION: Division of Dermatology, University of South Florida, Tampa.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Geriatrics.
COUNTRY: UNITED STATES
TITLE: Non-melanomatous skin cancer in the elderly: diagnosis and management.
PUBDATE: 19900701
Non-melanomatous skin cancers, particularly basal cell and squamous cell carcinomas, are frequently observed in elderly persons and are primarily the result of the chronic, cumulative effects of exposure to sunlight (ultraviolet light radiation). Characteristics of both types of neoplasm and diagnosis and management of non-melanomatous skin cancer are reviewed. Treatment based on multiple factors, including patient age, overall health status, histologic pattern, and cosmetic considerations, is described.

10. DOCID:18018 SCORE: 0.00173233940154136
DOCNO: 2361052
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: C Heredia C
AUTHOR: A Pedro A
AUTHOR: T Ribalta T
AUTHOR: J M Mercader JM
AUTHOR: F Graus F
AFFILIATION: Servicios de Neurología, Hospital Clínic i Provincial, Barcelona.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Neurología (Barcelona, Spain)
COUNTRY: SPAIN
TITLE: [Spinal cord metastasis of carcinoma of the lung: evaluation of magnetic resonance and computed tomography in its diagnosis]
PUBDATE: 19900401
A patient with lung adenocarcinoma had progressive myelopathy. Computed tomography of spinal cord with intravenous contrast and magnetic resonance scan were negative. At autopsy, a spinal cord metastasis was found. In patients with cancer and clinical suspicion of spinal cord metastasis, palliative treatment with radiotherapy is indicated in spite of negative radiological investigations, so as to prevent the progression of myelopathy.

11. DOCID:19944 SCORE: 0.00172840743779266
DOCNO: 8339238
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: diagnosis
QUALIFIER: mortality
AUTHOR: D B Kopans DB
AFFILIATION: Department of Radiology, Massachusetts General Hospital, Boston 02114.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Breast cancer detection in an institution. Is mammography detrimental?
PUBDATE: 19930801
The poor results of the National Breast Screening Study of Canada regarding the screening of women aged 40-49 have been interpreted to suggest that mammography might be detrimental. Our comparison of women who had mammography and had their cancers detected by mammography with women who did not have mammography and had palpable cancers suggest that this is not the case. There is no detrimental effect; rather, the use of mammography results in an improvement in survival. The poor results of the National Breast Screening Study likely are due to the unbalanced allocation of women with advanced cancers to the screened group, the poor quality of the mammography in the trial, and an insufficient sample size.

12. DOCID:19922 SCORE: 0.00172318297405374
DOCNO: 2143669
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: therapy
AUTHOR: R L Theriault RL
AFFILIATION: Department of Medical Oncology, MD Anderson Cancer Center, Houston, Texas 77030.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Management of hypercalcemia in breast cancer.
PUBDATE: 19900201
Hypercalcemia is a common metabolic problem in patients with metastatic breast cancer. Osteolytic bone destruction with release of calcium into circulation and humoral factors can lead to hypercalcemia. Clinical manifestations may be so mild as to be overlooked or include severe nervous system, gastrointestinal and renovascular complications. Treatment with saline infusions to replenish intravascular volume and restore renal function provides the basis for other therapeutic interventions. A variety of pharmacologic approaches include intravenous fluids, diuretics, steroids, calcitonin, bisphosphonates, and plicamycin. Investigation of new agents, particularly bisphosphonates and gallium, continues. The optimal treatment of hypercalcemia in breast cancer patients has not been defined, though control of metastatic disease obviously is of utmost importance.

13. DOCID:16936 SCORE: 0.00167731977704803
DOCNO: 1638494
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: S A Husain SA
AUTHOR: S Balasubramanian S
AUTHOR: R Bamezai R
AFFILIATION: Department of Human Biology and Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Sister chromatid exchange frequency in breast cancer cases.
PUBDATE: 19920701
Sister chromatid exchange (SCE) were studied in 22 patients with breast cancer (i.e., four stage II; 12 stage III, six stage IV) and 10 normal healthy females as age-matched controls. The data obtained in these cases followed a Poisson distribution. An apparent increase in the average rate of SCE/cell was observed with the advancing stage of breast cancer.

14. DOCID:18792 SCORE: 0.0015980557343417
DOCNO: 1506167
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cause of Death
DESCRIPTOR: Life Expectancy
DESCRIPTOR: Mortality
AUTHOR: G Rennert G
AFFILIATION: Department of Community Medicine and Epidemiology, Lady Davis Carmel Hospital, Haifa, Israel.
PUBTYPE: Journal Article
JOURNALTITLE: Israel journal of medical sciences.
COUNTRY: ISRAEL
TITLE: Premature mortality, Israel 1986.
PUBDATE: 19920701
Mortality statistics serve as the most common tool for health policy planning. However, this method suffers from several shortcomings. The mortality patterns in Israel in 1986 are presented in this article using the measure of years of potential life lost (YPLL), which better expresses premature mortality and the burden of diseases on society. Ischemic heart disease, cancer, and accidents of all types are responsible equally for most premature deaths in males in Israel, whereas cancer is the leading cause of premature mortality in women in Israel. Planning future health policy should rely more heavily on measures such as YPLL.