0. DOCID:2485 SCORE: 0.00366003329436751
DOCNO: 67887
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
DESCRIPTOR: Mutagens
QUALIFIER: adverse effects
QUALIFIER: drug effects
QUALIFIER: drug effects
AUTHOR: W F Benedict WF
AUTHOR: A Banerjee A
AUTHOR: A Gardner A
AUTHOR: P A Jones PA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Induction of morphological transformation in mouse C3H/10T1/2 clone 8 cells and chromosomal damage in hamster A(T1)C1-3 cells by cancer chemotherapeutic agents.
PUBDATE: 19770701
Various cancer chemotherapeutic agents including alkylating agents, antimetabolites, and antibiotics or natural products were studied for their ability to produce morphological transformation in the C3H/10T1/2 clone 8 mouse cell line and chromosomal damage in the A(T1)C1-3 hamster cell line following a 24-hr exposure of each agent at different concentrations. Those drugs that were known to be carcinogenic in vivo also produced morphological transformation and chromosomal damage, whereas those agents that have not been shown to be carcinogenic in vivo produced neither transformation nor chromosomal lesions. The concentrations used for these studies were in general similar to those actually reached in the plasma of patients treated with these same drugs for malignant, as well as certain nonmalignant, conditions.

1. DOCID:2248 SCORE: 0.00325287793221342
DOCNO: 1192373
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: W D DeWys WD
AUTHOR: K Walters K
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Abnormalities of taste sensation in cancer patients.
PUBDATE: 19751101
In fifty patients with cancer, subjective and objective correlates of anorexia of malignancy were studied. Decreased taste was reported by 25 patients, and an aversion for meat was reported by 16 patients. The decreased taste symptom correlated with an elevated taste threshold for sweet (sucrose), and the symptom of meat aversion correlated with a lowered taste threshold for bitter (urea). The likelihood of having a taste abnormality increased with increasing extent of disease, but not with histologic type of neoplasm. Patients with an abnormality of taste had an increased incidence of weight loss compared with patients with normal taste, even though many in the latter group had other causes of weight loss. These observations suggest that an abnormality of taste may be one determinant of the anorexia of malignancy. Better understanding of the anorexia in the cancer patient may contribute to the care of the patient.

2. DOCID:1912 SCORE: 0.00307503910389699
DOCNO: 868056
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: H L Duthie HL
PUBTYPE: Journal Article
JOURNALTITLE: World journal of surgery.
COUNTRY: MEXICO
TITLE: Surgery for gastric ulcer.
PUBDATE: 19770101
Despite the initial healing achieved by medical treatment with carbenoxolone, surgery is frequently needed in the management of gastric ulcer. We have studied 150 patients over the past 10 years in an attempt to define the place of conservative surgery compared with the standard partial gastrectomy of the Billroth I type. Functional results have not been significantly different and the individual surgeon's choice will depend on his philosophy with regard to the risk of cancer in the postoperative stomach, and his technical expertise with the newer kinds of vagotomy. To my mind it is perfectly justifiable to use highly selective vagotomy with excision of the ulcer to treat gastric ulcer alone, especially if the patient is one in whom postgastrectomy symptoms could be disabling. Further follow-up is needed to decide whether it should replace partial gastrectomy as the standard procedure.

3. DOCID:3699 SCORE: 0.00299863777992834
DOCNO: 1234637
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: metabolism
QUALIFIER: enzymology
AUTHOR: W H Fishman WH
AUTHOR: N R Inglis NR
AUTHOR: J Vaitukaitis J
AUTHOR: L L Stolbach LL
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: National Cancer Institute monograph.
COUNTRY: UNITED STATES
TITLE: Regan isoenzyme and human chorionic gonadotropin in ovarian cancer.
PUBDATE: 19751001
Among 833 cancer patients whose sera were investigated for Regan isoenzyme and among 1,319 cancer patients from a different population whose sera were assayed for human chorionic gonadotropin (HCG), those patients with neoplasms of the testis or ovary showed the highest frequency of both placental proteins. Among another 22 patients with ovarian cancer, for whom both placental proteins were measured, 59% showed Regan isoenzyme and 68% showed HCG in ascitic fluids, whereas the figures were 65% and 30%, respectively, for sera. In 55% of both fluids and sera, there was a positive correlation of Regan isoenzyme with HCG (positive or negative). Almost invariably, the ascitic fluid was richer in Regan isoenzyme and HCG than the serum when both were collected on the same day. Progressively increasing levels of each placental protein generally correlated with the spread of the disease, though there were instances when only one was expressed. Evidence indicated the existence of two forms of alkaline phosphatase in ovarian cancer, Regan and non-Regan; the latter was assumed to be of fetal origin. Ultrastructural studies of one ovarian cancer revealed a morphologic entity, i.e., mitochondria enveloped by inverted tubules of endoplasmic reticulum.

4. DOCID:3500 SCORE: 0.00290484844220858
DOCNO: 1111936
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: F Ghavimi F
AUTHOR: P R Exelby PR
AUTHOR: G J D'Angio GJ
AUTHOR: W Cham W
AUTHOR: P H Lieberman PH
AUTHOR: C Tan C
AUTHOR: V Miké V
AUTHOR: M L Murphy ML
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Multidisciplinary treatment of embryonal rhabdomyosarcoma in children.
PUBDATE: 19750301
Twenty-nine children under 15 years of age with embryonal rhabdomyosarcoma were treated according to a multidisciplinary protocol (T-2). The protocol consisted of surgical removal of the tumor if possible, followed by chemotherapy, and also with radiation therapy in patients with gross or microscopic residual disease. Radiation therapy was given in the 4500-7000 rads range. The chemotherapy consisted of cycles of sequential administration of dactinomycin, Adriamycin, vincristine, and cyclophosphamide, with obligatory periods of rest. The drug therapy was continued for 2 years. Following surgery, clinicopathologic staging of the disease revealed 10 patients with no residual disease (I-A), 5 with microscopic residual disease (I-B), 5 with unresectable tumors (II), 6 with unresectable tumors plus regional lymph node involvement (III), and 3 with disseminated tumors (IV). Twenty-four (82%) of the patients (20 Stages I-II, 4 Stage III) are alive with no evidence of disease for 4 plus to 42 plus months. These results are superior to those achieved between 1960-1970 among 108 children treated at Memorial Sloan-Kettering Cancer Center.

5. DOCID:478 SCORE: 0.00272978464869365
DOCNO: 1192406
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diet
QUALIFIER: etiology
AUTHOR: E L Wynder EL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: The epidemiology of large bowel cancer.
PUBDATE: 19751101
Results from epidemiogical studies have provided clues as to etiological factors involved in the development of large bowel cancer. Overnutrition, especially in terms of dietary fat consumed, appears to be a key etiological variable affecting the rate of colon cancer. Epidemiologists can provide the leads for chemists and bacteriologists to pursue in population groups and for experimentalists to test in laboratory animals. Coordination of and cooperation between many disciplines is necessary in order to contribute to the prevention of this man-made disease.

6. DOCID:2590 SCORE: 0.00242904964804234
DOCNO: 302737
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: W H Wolberg WH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Binding of colonic tissue membrane to mononuclear peripheral blood leukocytes.
PUBDATE: 19771001
Colonic tissue membrane binding to peripheral blood mononuclear leukocytes was quantitated by 125I labeling of membrane fragments and by determining the acquisition of membrane-specific enzyme activity and radioactivity in mononuclear cells after contact with the tissue membrane fragments. Mononuclear cells bound equal amounts of normal and tumor tissue membrane fragments. Mononuclear cells capable of binding homologous but not autologous colonic tissue membranes were recovered from the peripheral blood of colon cancer-bearing patients. Mononuclear cells capable of binding autologous colonic tissue membranes appeared in the peripheral blood of patients after curative but not palliative tumor resection. Tumor membrane enzymes, including alkaline phosphatase, were introduced to mononuclear cells by bound tissue fragments. The activity of alkaline phosphatase present in the bound membrane fragments was inhibited by the immunorestorative drug, levamisole. Cellular debris liberated from tumors may play an important role in overcoming the host's defenses by binding to mononuclear cells, saturating antigen-binding sites, and introducing exogenous enzymes.

7. DOCID:2821 SCORE: 0.00216097058839269
DOCNO: 949681
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
AUTHOR: J B Caderao JB
AUTHOR: D H Hussey DH
AUTHOR: G H Fletcher GH
AUTHOR: V A Sampiere VA
AUTHOR: D E Johnson DE
AUTHOR: J T Wharton JT
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Fast neutron radiotherapy for locally advanced pelvic cancer.
PUBDATE: 19760601
Between March 1973 and May 1975, 82 patients with locally advanced pelvic tumors were treated with 50 MeVdleads to Be neutrons. Seventy-nine have been included for analysis. The clinical material included 51 patients with gynecologic cancers, 15 with colorectal adenocarcinomas, and 13 with prostatic adenocarcinomas. Three treatment approaches have been used: 1) neutrons only--160 rad mu gamma twice weekly, 2) neutron boost following 25 MV photon irradiation--160 rad mu gamma twice weekly, and 3) mixed beam--photons (200 rads) three times weekly and neutrons (65 rad mu gamma) twice weekly. The preliminary results with the mixed beam are superior to those obtained with neutrons only or a neutron boost. However, the cancer and have been treated to slightly higher equivalent doses than those treated with neutrons only. The superior results with the mixed beam may be related to a better volume distribution and/or five-times weekly fractionation.

8. DOCID:2646 SCORE: 0.00215755508224599
DOCNO: 1170935
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aorta
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: S E Chism SE
AUTHOR: R C Park RC
AUTHOR: H M Keys HM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Prospects for para-aortic irradiation in treatment of cancer of the cervix.
PUBDATE: 19750601
The incidence of para-aortic node metastasis in cancer of the cervix ranges from 5%to 50% in clinical Stages i-iv. Extended field irradiation is being administered more frequently because of high incidence of extrapelvic disease. The cancer of the cervix material at Walter Reed General Hospital has been analyzed as to site and time of failure to determine who might have benefited from extended field irradiation. Of patients who fail, the majority will have uncontrolled pelvic disease regardless of other involvement. Diagnostic procedures including staging laparotomy are unable to predict pelvic failure or the presence of occult distant disease in lung and bone.The maximum number of patients who could benefit from pari-aortic irradiation is lessthan 3% of a total series. It is concluded that the salvage of patients with para-aortic metastasis will be small, but for those few long-term survivors, the benefit will be great.

9. DOCID:2822 SCORE: 0.0021304677683442
DOCNO: 1254157
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: A Pfleiderer A
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [The problems of prophylactic chemotherapy, the second-look operation and the maintenance of the remission in the treatment of ovarian cancer (author's transl)]
PUBDATE: 19760201
The results of the treatment of 1022 ovarian cancers were reviewed and the problems of prophylactic chemotherapy, a second look operation and the maintenance of the remission were studied. In ovarian cancers of stage 1 and stage 2, a post-operative prophylactic chemotherapy is useful only in cases with tumor cells in the secretions of the pouch of Douglas or in the ascites and in cases where a sensitivity to the chemotherapy can be assumed. In about 50% of primarily inoperable stage 3 ovarian cancers, the random treatment with cyclophosphamide (Endoxan) results in a clinical remission. A significant five year cure rate can only be obtained if the uterus and the adnexa are removed. Radical operation during the remission appears to be very important for survival of the patient. For the maintenance of the remission continuous chemotherapy for at least 2 years following treatment by operation and radiotherapy is necessary.

10. DOCID:809 SCORE: 0.00211237853376472
DOCNO: 1264151
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: N S Weiss NS
AUTHOR: D R Szekely DR
AUTHOR: D F Austin DF
PUBTYPE: Journal Article
JOURNALTITLE: The New England journal of medicine.
COUNTRY: UNITED STATES
TITLE: Increasing incidence of endometrial cancer in the United States.
PUBDATE: 19760601
Data from eight areas in the United States served by population-based cancer reporting systems indicate that, after many years of relative stability, incidence rates of endometrial cancer have risen sharply in the 1970's. In some areas the amount of the increase has exceeded 10 per cent per year. The incidence among middle-aged women has changed most (by 40 to 150 per cent between 1969 and 1973, depending on the area), but rates have increased in younger women and the elderly as well.

11. DOCID:3566 SCORE: 0.00206421887050645
DOCNO: 941626
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: H König H
AUTHOR: P Hermanek P
AUTHOR: W Rösch W
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta hepato-gastroenterologica.
COUNTRY: GERMANY, WEST
TITLE: Clinical conference: Unusual course of chronic colitis.
PUBDATE: 19760601
Case presentation of a 35-year-old patient with a history of chronic colitis of 16 years duration. Crohn's disease in this patient involved the entire colon without skip lesions and without terminal ileitis. The course was complicated by recurrent erythema nodosum and wandering arthritis as well as sclerosing cholangitis and multifocal adenocarcinoma of the large bowel. Sclerosing cholangitis is a rare condition in Crohn's disease (1,8) whereas pericholangitis in liver biopsy specimen was diagnosed in prospective studies in 8 (7) to 30 (2) per cent. The same is true for carcinomas complicating granulomatous enterocolitis. In a recent review 36 cases of small bowel cancer (4) and 20 cases of colon cancer (5) were reported. Weedon et al. (9) calculated the risk of developing carcinoma to be 20 times greater in Crohn's enterocolitis than in a control population. Using life-table methods the 10-year probability of remaining cancer free was 99.7 per cent, the 20-year probability 97.2 per cent. In our patient the long-lasting history of Crohn's colitis with several minor complications and the multiplicity of colonic carcinomas speak in favor of a causal relationship between the chronic inflammation and the development of malignancy.

12. DOCID:1097 SCORE: 0.00193038541844088
DOCNO: 848662
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: standards
AUTHOR: L Kalisher L
AUTHOR: D Schaffer D
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Indications and guidelines for mammographic examinations.
PUBDATE: 19770301
The value of mammography in evaluating the asymptomatic patient has been clearly demonstrated by the HIP program, as well as the National Cancer Institute's breast demonstration projects. A one-third reduction in mortality from breast cancer in mammographically screened women has been substantiated. Nonetheless, questions concerning the long-term effects of repeated radiation exposure associated with mammography have been raised, and for this reason judicious selection of women is urged. In general, women who are asymptomatic or at high risk for breast carcinoma should be evaluated with a planned regimen. Mammographic guidelines and recommendations for attaining the greatest benefit at the lowest possible risk are suggested.

13. DOCID:571 SCORE: 0.00191288297521216
DOCNO: 989474
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: A Singer A
AUTHOR: B L Reid BL
PUBTYPE: Journal Article
JOURNALTITLE: Comprehensive therapy.
COUNTRY: UNITED STATES
TITLE: Causes of cervical carcinoma: new ideas.
PUBDATE: 19760901
There are many features of cervical cancer that distinguish it from other common human cancers. It is extraordinarily sensitive to environmental variation, thus coming under early notice by the epidemiologists. Its accessibility and the introduction of aids to visualization, such as the colposcope, have enabled us to combine the methods of epidemiology and molecular biology in studying disease. This combination may well untangle one of the more serious conceptual problems in contemporary biology - the real nature of the carcinogenic process and all this in man himself.

14. DOCID:1220 SCORE: 0.00190726878099377
DOCNO: 1237519
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
AUTHOR: F J Primus FJ
AUTHOR: R H Wang RH
AUTHOR: R M Sharkey RM
AUTHOR: D M Goldenberg DM
PUBTYPE: Journal Article
JOURNALTITLE: Journal of immunological methods.
COUNTRY: NETHERLANDS
TITLE: Detection of carcinoembryonic antigen in tissue sections by immunoperoxidase.
PUBDATE: 19750901
A triple-bridge, indirect, immunoperoxidase method for detecting and localizing carcinoembryonic antigen (CEA) in tissue sections is described. By this technique, a cell-surface localization of CEA in colonic carcinoma and ovarian mucinous cystadenocarcinoma cells could be visualized. In the case of the colonic cancer, both the tumor from the descending colon and a metastasis to the skin gave positive peroxidase reactions for CEA. This immunocytochemical method for demonstrating the presence of CEA functioned in both frozen, ethanol-fixed and formalin-fixed, paraffin-embedded tissues, thus making it applicable for use with tissue sections conventionally prepared for light microscopy.