0. DOCID:25859 SCORE: 0.00388420247229774
DOCNO: 12113028
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
QUALIFIER: drug therapy
QUALIFIER: methods
QUALIFIER: classification
QUALIFIER: drug therapy
QUALIFIER: methods
AUTHOR: M J Edelman MJ
AFFILIATION: University of Maryland, Greenebaum Cancer Center, Baltimore, Maryland, USA. medelman@umm.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert review of anticancer therapy.
COUNTRY: England
TITLE: Neoadjuvant chemotherapy in early-stage non-small cell lung cancer.
PUBDATE: 20010801
Of the patients that undergo complete resection of early-stage non-small cell lung cancer (NSCLC), 30-60% will die. Postoperative adjuvant chemotherapy has yet to demonstrate an unequivocal benefit and there are significant difficulties in administering postoperative chemotherapy to patients with the significant comorbidities found in NSCLC. Currently, several trials are evaluating the role of preoperative chemotherapy in stage I and II NSCLC. This paper reviews the rationale for this approach and potential future developments.


1. DOCID:25851 SCORE: 0.00388420233620071
DOCNO: 9555428
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Home Care Services
QUALIFIER: methods
QUALIFIER: nursing
QUALIFIER: methods
AUTHOR: R Van Gerpen R
PUBTYPE: Journal Article
JOURNALTITLE: ONS news / Oncology Nursing Society.
COUNTRY: UNITED STATES
TITLE: Homecare nurses face unique challenges in caring for patients with cancer.
PUBDATE: 19980201
Oncology care is going home. The changes in health care that have occurred during the past decade have significantly impacted the growth of home care. Factors that have contributed to this growth include prospective payments for hospital services to Medicare patients leading to a decreased length of stay, advances in the development of equipment for providing high-tech treatments in the home, changes in reimbursement from fee-for-service to managed care and capitation, an aging population, and improved survival rates for patients with chronic illnesses, including cancer.


2. DOCID:27875 SCORE: 0.00382758928799462
DOCNO: 9752329
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: immunology
QUALIFIER: physiology
AUTHOR: A Berger A
AUTHOR: B Piqueras B
AUTHOR: F Pages F
AUTHOR: E Tartour E
AUTHOR: P H Cugnenc PH
AUTHOR: W H Fridman WH
AFFILIATION: Service de chirurgie générale, digestive et oncologique, Hôpital Laennec, Paris.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: FRANCE
TITLE: [Fas, fas ligand, immune tolerance, and cancer: implications in cancer of the colon]
PUBDATE: 19980201
Fas and Fas ligand (FasL) are implicated in programmed cell death or apoptosis. In the immunological field, they are particularly important in auto-immunity, graft rejection and anti-tumoral response. Fas ligand expression on thymocytes, activated T lymphocytes, and in sites of immune privilege, suggests the importance of Fas/FasL interactions in negative control of the immune response. The recent description of FasL expression by tumoral cells, represents a new mechanism of immune escape for different cancer, and has been well studied in colon adenocarcinoma.


3. DOCID:27800 SCORE: 0.003827588820948
DOCNO: 10967793
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aromatase Inhibitors
DESCRIPTOR: Oncologic Nursing
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: A O Cloutier AO
AFFILIATION: Shering Oncology Biotech, Kenilworth, NJ, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: UNITED STATES
TITLE: Advanced breast cancer: recent developments in hormonal therapy.
PUBDATE: 20000801
OBJECTIVES: To review recent developments in hormonal therapy for metastatic breast cancer. DATA SOURCES: Published books and articles. CONCLUSIONS: Newer hormonal agents are offering women alternatives for sequential therapy of metastatic disease that provide benefit with less risk. IMPLICATIONS FOR NURSING PRACTICE: A thorough understanding of the relationship between hormonal influences and breast cancer will assist nurses to better appreciate the variety of agents now available and their specific indications, outcomes, and effects. Common side effects include weight gain, hot flashes, nausea, and skin and vaginal changes. Nursing efforts focus on the areas of body image disturbance, side effect management, and fostering healthy relationships.


4. DOCID:25868 SCORE: 0.00306369715937712
DOCNO: 11787295
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: standards
QUALIFIER: methods
QUALIFIER: standards
AUTHOR: A Yoshizawa A
AUTHOR: Y Gyouda Y
AUTHOR: T Ishiguro T
AUTHOR: S Yoshida S
AUTHOR: T Yoshizawa T
AUTHOR: I Narita I
AUTHOR: M Tsuruta M
AUTHOR: Y Fukumoto Y
AFFILIATION: Dept. of Home Care, Kaname-cho Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: Japan
TITLE: [Indication of home oxygen therapy for terminal cancer patients--comparison with present standards--as the result from investigation of our patients and questionnaire survey to home care doctors]
PUBDATE: 20011201
As the result of the observation of our patients and a questionnaire answered by home care doctors, we think it is necessary to establish new standards for home oxygen therapy, based on the characteristics of terminal cancer patients and to put great emphasis on the QOL of patients.


5. DOCID:27163 SCORE: 0.00292115875936772
DOCNO: 10884619
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bifidobacterium
DESCRIPTOR: Lactobacillus
QUALIFIER: prevention & control
QUALIFIER: therapeutic use
AUTHOR: K Hirayama K
AUTHOR: J Rafter J
AFFILIATION: Department of Medical Nutrition, Karolinska Institute, NOVUM, S-141 86, Huddinge, Sweden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Microbes and infection / Institut Pasteur.
COUNTRY: FRANCE
TITLE: The role of probiotic bacteria in cancer prevention.
PUBDATE: 20000501
Colorectal cancer is one of the most important causes of cancer morbidity and mortality in western countries [1]. A myriad of healthful effects have been attributed to the probiotic lactic acid bacteria; perhaps the most controversial remains that of anticancer activity. There is no direct experimental evidence for cancer suppression in humans as a result of consumption of lactic cultures in fermented or unfermented dairy products. However, there is a wealth of indirect evidence, based largely on laboratory studies, in the literature and this will be summarised in the present paper.


6. DOCID:26706 SCORE: 0.00286790081896959
DOCNO: 9676499
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sick Role
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: psychology
QUALIFIER: statistics & numerical data
AUTHOR: R A Schneider RA
AFFILIATION: Buena Vista University, Storm Lake, IA 50588, USA. bschneid@pionet.net
PUBTYPE: Journal Article
JOURNALTITLE: Psychological reports.
COUNTRY: UNITED STATES
TITLE: Concurrent validity of the Beck Depression Inventory and the multidimensional fatigue inventory-20 in assessing fatigue among cancer patients.
PUBDATE: 19980601
Cancer patients experience both fatigue and depression while undergoing treatment for their disease. A number of authors have conceptualized such depression among this populations as secondary to fatigue. This study of 54 patients was done to test the concurrent validity of two inventories. Scores on the five subscales of the 20-item Multidimensional Fatigue Inventory were correlated with those on the 21-item Beck Depression Inventory. Moderate correlations are reported and the potential usefulness of the Multidimensional Fatigue Inventory is discussed.


7. DOCID:25275 SCORE: 0.00252695227001758
DOCNO: 10619518
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoadjuvant Therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: J S Friedberg JS
AFFILIATION: Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA. josephf@mail.med.upenn.edu
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Clinical presentation of stage IIIA (N2) non-small cell lung cancer: role of multimodality therapy.
PUBDATE: 19991201
Neoadjuvant chemotherapy before surgical resection of locally advanced non-small cell lung cancer (NSCLC) has been shown to improve survival compared with surgery alone in several randomized clinical trials. A case report is presented describing the use of paclitaxel and carboplatin in a multimodality regimen for a patient with stage IIIA N2 NSCLC. Studies are ongoing to determine the optimal type and timing of chemotherapy.


8. DOCID:25219 SCORE: 0.00252695226376516
DOCNO: 9739758
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Repressor Proteins
DESCRIPTOR: Trans-Activation (Genetics)
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: L Rapp L
AUTHOR: J J Chen JJ
AFFILIATION: Department of Dermatology, New England Medical Center, Boston, MA, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: NETHERLANDS
TITLE: The papillomavirus E6 proteins.
PUBDATE: 19980801
Specific types of human papillomaviruses (HPV) are strongly associated with the development of cervical cancer. The E6 gene from cancer-related HPVs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. Cancer-related HPVs E6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. Several additional cellular E6-binding proteins have recently been identified and implicated in playing roles in p53-independent functions of E6.


9. DOCID:24807 SCORE: 0.00238686048923705
DOCNO: 9818899
AUTHOR: D M Wingerchuk DM
AUTHOR: J H Noseworthy JH
AUTHOR: D W Kimmel DW
AFFILIATION: Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Neurology.
COUNTRY: UNITED STATES
TITLE: Paraneoplastic encephalomyelitis and seminoma: importance of testicular ultrasonography.
PUBDATE: 19981101
We report two patients with paraneoplastic limbic and brainstem encephalitis associated with occult nonmetastatic testicular seminoma. In each patient, the neoplasm was detectable only by testicular ultrasonography. Male patients with this syndrome in whom lung cancer is not found should undergo testicular ultrasonography as part of the search for an extrapulmonary neoplasm. A normal clinical testicular examination is insufficient to exclude an occult seminoma.


10. DOCID:25324 SCORE: 0.00230112052742586
DOCNO: 9617329
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: pathology
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: secondary
AUTHOR: Y Hata Y
AUTHOR: S Morita S
AUTHOR: Y Noda Y
AUTHOR: R Kawasaki R
AUTHOR: Y Morita Y
AUTHOR: T Awatani T
AUTHOR: T Horimi T
AFFILIATION: Dept. of Radiology, Kochi Municipal Central Hospital.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [The evaluation of weekly hepatic arterial infusion of high-dose 5-FU for liver metastases from colorectal cancer]
PUBDATE: 19980501
A study was conducted on weekly infusion of high-dose 5-FU through the hepatic artery for liver metastases from colorectal cancer. In the evaluation of 38 cases, no CR and 16 PR were to control the extrahepatic metastases is a subject for forthcoming study.


11. DOCID:27817 SCORE: 0.00227346751793788
DOCNO: 10516378
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: P W Pisters PW
AUTHOR: R E Pollock RE
AFFILIATION: Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4095, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in radiation oncology.
COUNTRY: UNITED STATES
TITLE: Staging and prognostic factors in soft tissue sarcoma.
PUBDATE: 19991001
Significant advances have been made in the understanding of clinicopathologic prognostic factors for soft tissue sarcoma over the past decade. Foremost among these advances is an improved ability to recognize the subset of patients at high risk for recurrent disease based on clinicopathologic data available at the time of initial presentation. Progress has also helped to elucidate specific molecular factors that have independent prognostic significance. This review outlines the updated American Joint Committee on Cancer staging system for soft tissue sarcoma and summarizes the available data on traditional clinicopathologic and molecular prognostic factors.


12. DOCID:27970 SCORE: 0.00223093035476859
DOCNO: 10740628
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: H Ueoka H
AFFILIATION: Department of Internal Medicine II, Okayama University Medical School, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Treatment of unresectable non-small-cell lung cancer]
PUBDATE: 20000301
Current progress in the treatment of unresectable non-small-cell lung cancer (NSCLC) is reviewed. Several new agents including vinorelbine, paclitaxel, docetaxel, gemcitabine, and irinotecan have been shown to have distinct activity for NSCLC. Combinations of a new agent with cisplatin or carboplatin were highly active for advanced NSCLC, and randomized trials are in progress to establish the standard chemotherapy regimen for advanced NSCLC. The effectiveness of concurrent chemoradiotherapy has been established in Japan, while that of induction chemotherapy has yet to be confirmed. Induction chemoradiotherapy may be useful and randomized trials comparing chemotherapy alone with chemoradiotherapy as an induction therapy are needed.


13. DOCID:27922 SCORE: 0.00223092787388856
DOCNO: 10853145
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mastectomy
QUALIFIER: radiotherapy
AUTHOR: A Recht A
AFFILIATION: Department of Radiation Oncology, Harvard Medical School, Boston, MA 02215, USA. arecht@caregroup.harvard.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Locally advanced breast cancer and postmastectomy radiotherapy.
PUBDATE: 20000701
Most patients with locally advanced breast cancer should be treated with a combination of chemotherapy, mastectomy (with immediate reconstruction if the patient so desires), and radiotherapy. Nonetheless, it seems reasonable to offer breast-conserving treatment to selected individuals who respond well to neoadjuvant therapy. Postmastectomy radiotherapy clearly reduces the risk of local-regional and distant failure for patients with earlier-stage invasive breast cancer with involved axillary lymph nodes. Certain subgroups of patients, however, may have such low local-regional failure rates that patients will not routinely find the benefits of radiotherapy sufficient to undergo such treatment. Further investigation of this issue is needed.


14. DOCID:27039 SCORE: 0.00221290925126381
DOCNO: 11122823
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: pharmacology
QUALIFIER: immunology
QUALIFIER: prevention & control
QUALIFIER: immunology
QUALIFIER: prevention & control
AUTHOR: J Weber J
AFFILIATION: University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Suite 3447, Los Angeles, CA 90089, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current oncology reports.
COUNTRY: United States
TITLE: Melanoma peptide vaccines: from preclinical background to clinical trials.
PUBDATE: 20000101
The discovery that immune T-cells recognize intracellularly processed peptides associated with major histocompatibility locus molecules has revolutionized the cancer vaccine field by providing new reagents for the generation of immune responses against cancer. The cloning of tumor antigen genes has proceeded most rapidly in melanoma because of the ease with which melanoma-specific T-cells can be propagated in vitro. The cloning and identification of tumor regression antigens and data from the initial clinical trials with peptides vaccines derived from those antigens are presented here.