0. DOCID:15506 SCORE: 0.00441659659740152
DOCNO: 3185198
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mathematical Computing
QUALIFIER: statistics & numerical data
QUALIFIER: statistics & numerical data
AUTHOR: A Iu Iakovlev AIu
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Biomathematical approaches to the problems of radiation biology and medicine]
PUBDATE: 19881101
A vast experience in the introduction of modern mathematical methods into research activities of the Central Research Roentgenoradiology Institute was accumulated in the Department of Biomathematics. The Information-retrieval System for Storage and Analysis of Data on the Activities of X-ray Service in the USSR, a package of applied programs for statistical analysis of radiation therapy effectiveness, a controlled data base on 6 cancer sites, 2 systems for simulation of radiation effects on heterogeneous cell systems were worked out. Some priority results in the fields of mathematical biology and statistical analysis of incomplete selective data were obtained. The Department is heading the work on the problem "Mathematics and computer technology in radiobiology and radiation biophysics".


1. DOCID:15579 SCORE: 0.00410469012867606
DOCNO: 2695654
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: G Dugue G
AUTHOR: G Bock G
AUTHOR: L Molho L
AUTHOR: J W Cordice JW
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the National Medical Association.
COUNTRY: UNITED STATES
TITLE: Breast cancer in the young.
PUBDATE: 19891101
Breast cancer in the young is rare. Some cases can be treated with modest surgical intervention and prognosis is good. We present a report of a 17-year-old black girl with adenocarcinoma of the breast. In our case, the disease pursued a devastatingly rapid course in spite of treatment and the patient died within 6 months of diagnosis. The literature relating to clinical experience with various types of breast carcinoma seen in pre- and postpubertal patients is also reviewed. We conclude that this case, and certain other cases cited, demonstrates the need for a high index of suspicion and earlier and more aggressive intervention in young patients with axillary breast masses.


2. DOCID:14945 SCORE: 0.00230115264610243
DOCNO: 3593337
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: L G Baggetto LG
AUTHOR: A L Lehninger AL
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Isolated tumoral pyruvate dehydrogenase can synthesize acetoin which inhibits pyruvate oxidation as well as other aldehydes.
PUBDATE: 19870501
Oxidation of 1 mM pyruvate by Ehrlich and AS30-D tumor mitochondria is inhibited by acetoin, an unusual and important metabolite of pyruvate utilization by cancer cells, by acetaldehyde, methylglyoxal and excess pyruvate. The respiratory inhibition is reversed by other substrates added to pyruvate and also by 0.5 mM ATP. Kinetic properties of pyruvate dehydrogenase complex isolated from these tumor mitochondria have been studied. This complex appears to be able to synthesize acetoin from acetaldehyde plus pyruvate and is competitively inhibited by acetoin. The role of a new regulatory pattern for tumoral pyruvate dehydrogenase is presented.


3. DOCID:12878 SCORE: 0.00210966436938629
DOCNO: 2657851
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: R F Thoeni RF
AFFILIATION: CT/Gastrointestinal Section, University of California, San Francisco.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: CT evaluation of carcinomas of the colon and rectum.
PUBDATE: 19890701
Computed tomography (CT) has proved to be a powerful tool in the detection and staging of carcinomas of the colon and rectum. It is unsurpassed in the detection of recurrent colon cancer and is particularly useful in patients who have undergone abdominal-perineal resections for rectal neoplasms. The current applications of CT in colon cancer are contrasted with barium studies, endoscopy, and magnetic resonance imaging.


4. DOCID:15091 SCORE: 0.00202810896808167
DOCNO: 3167811
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Kamma H
AUTHOR: K Fujii K
AUTHOR: T Ogata T
AFFILIATION: Department of Pathology, University of Tsukuba, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Lymphocytic infiltration in juvenile thyroid carcinoma.
PUBDATE: 19881101
In this study, the significance of lymphocytic infiltration in juvenile thyroid carcinoma is clarified. We examined nine patients younger than 20 years of age. Histopathologically, there was good correlation between lymphocytic infiltration and the development and spread of carcinoma. It is believed that lymphocytic infiltration around the tumor is an immunologic reaction induced by antigens from the carcinoma itself, and also that the reaction may progress according to tumor development. Immunocytochemically, we determined what type of inflammatory cells infiltrated the thyroid and demonstrated HLA-DR expression in the cancer cells. These findings are similar to autoimmune thyroiditis in which antibody-dependent cellular cytotoxicity (ADCC) works as a main immunomechanism.


5. DOCID:14968 SCORE: 0.0019441624059837
DOCNO: 3729499
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prostatic Neoplasms
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: N Miyaji N
AUTHOR: M Nakajo M
AUTHOR: K Ueki K
AUTHOR: H Kobayashi H
AUTHOR: S Onohara S
AUTHOR: S Shinohara S
AUTHOR: K Niimura K
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of metastatic brain tumor from prostatic cancer showing remarkable shrinkage following CDDP administration]
PUBDATE: 19860701
A patient with brain metastases from prostatic cancer received chemotherapy using CDDP alone. A dose of 80 mg of CDDP was administered twice intravenously, followed by intra-arterial injections of 70 mg and 50 mg for the primary lesion over the course of three months. The main brain tumor showed a 70% decrease in size when estimated by CT, along with improvement of clinical symptoms related to the brain metastases. Intravenous injection of CDDP may thus have potential therapeutic value against metastatic brain tumors.


6. DOCID:14980 SCORE: 0.00194416240581217
DOCNO: 2876282
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Biological
QUALIFIER: therapy
AUTHOR: A P Forrest AP
AUTHOR: P A Levack PA
AUTHOR: U Chetty U
AUTHOR: R A Hawkins RA
AUTHOR: W R Miller WR
AUTHOR: J F Smyth JF
AUTHOR: T J Anderson TJ
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: A human tumour model.
PUBDATE: 19861001
An approach to the management of patients with large (greater than 4 cm) operable breast cancers is described. The conventional sequence of mastectomy followed by systemic therapy is reversed, allowing accurate measurements of response to individual forms of endocrine therapy or chemotherapy. Such a method not only permits individual selection of appropriate systemic therapy, but also allows clinical response to be related to histological and biochemical tumour parameters. A response was observed in eleven of twenty-three patients to endocrine treatment and in twelve of thirteen to combination chemotherapy. In five of the latter the response was histologically complete.


7. DOCID:15832 SCORE: 0.00188275096870351
DOCNO: 3469458
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: W J Blot WJ
AUTHOR: S S Devesa SS
AUTHOR: J F Fraumeni JF
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Declining breast cancer mortality among young American women.
PUBDATE: 19870301
Changes in age-specific breast cancer mortality rates among white females in the United States during 1950-80 were shown to be correlated with changes in patterns of childbearing in early adulthood. However, for the most recent 5-year period among women below age 40 years, small declines in breast cancer mortality were observed in the late 1970's, despite a predicted increase following delays in childbearing that began in the 1960's and despite evidence of a rising incidence of the cancer. Although correlation analyses have inherent limitations, the findings raise the possibility that recent changes in the detection and management of breast cancer have contributed to a lowered mortality from this cancer among young American women.


8. DOCID:12549 SCORE: 0.00162428827637571
DOCNO: 2432682
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
AUTHOR: K M Müller KM
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Thoracic and cardiovascular surgeon.
COUNTRY: GERMANY, WEST
TITLE: Pulmonary metastases. Pathological anatomy.
PUBDATE: 19861101
In 88 operative specimens topography, size and histopathological findings of lung metastases were analyzed. The stages of formation of metastases as the phase of invasion, embolization and implantation were differentiated by postmortem angiographies investigating the neo-vascularization of the metastases by 20 to 60 micron vessels. Analyses of metastases by morphological quantification of tumor regression after cytostatic therapy and immune histochemical examinations of lung metastases in unknown primary cancer have gained clinical importance.


9. DOCID:13235 SCORE: 0.00162089498622853
DOCNO: 3368675
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Registries
DESCRIPTOR: Statistics
QUALIFIER: methods
AUTHOR: G M Tallis GM
AUTHOR: P Leppard P
AUTHOR: T J O'Neill TJ
AFFILIATION: Department of Statistics, University of Adelaide, South Australia.
PUBTYPE: Journal Article
JOURNALTITLE: Statistics in medicine.
COUNTRY: ENGLAND
TITLE: The analysis of survival data from a central cancer registry with passive follow-up.
PUBDATE: 19880401
We present analyses for survival data obtained from a central cancer registry with passive follow-up. This method of data collection has the potential to produce unknown random losses which would affect estimates of survival. We show that non-parametrically estimated conditional distributions remove any effect of these unknown losses and that a compound mixture model estimates their magnitude. Lung cancer data are used to illustrate the procedures.


10. DOCID:15239 SCORE: 0.00157451499434836
DOCNO: 2417690
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: drug therapy
AUTHOR: G W van Imhoff GW
AUTHOR: D T Sleijfer DT
AUTHOR: M H Breuning MH
AUTHOR: G J Anders GJ
AUTHOR: N H Mulder NH
AUTHOR: M R Halie MR
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Acute nonlymphocytic leukemia 5 years after treatment with cisplatin, vinblastine, and bleomycin for disseminated testicular cancer.
PUBDATE: 19860301
The combination of cisplatin, vinblastine, and bleomycin (PVB) was used to treat a 25-year-old man for disseminated testicular germ cell cancer, leading to a complete remission. Acute nonlymphocytic leukemia (ANLL), resistant to chemotherapy, developed 5 years later. The secondary nature of this ANLL was corroborated by the detection of nonrandom chromosomal aberrations in bone marrow cells of chromosomes, 7, 5, and 3. This is one of the first reports of possible leukemogenic activity of PVB treatment when applied without additional irradiation or alkylating agents.


11. DOCID:15163 SCORE: 0.00157451139031873
DOCNO: 2559271
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Duodenoscopes
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: P Stömmer P
AUTHOR: J Kraus J
AUTHOR: E C Foerster EC
AUTHOR: W Domschke W
AFFILIATION: Pathologisches Institut, Universität Erlangen.
PUBTYPE: Journal Article
JOURNALTITLE: Leber, Magen, Darm.
COUNTRY: GERMANY, WEST
TITLE: [Endoscopy and biopsy of the pancreatic duct--a new method of pancreas diagnosis]
PUBDATE: 19891201
Newly developed endoscopes make it possible to inspect the major papilla, the pancreatic and choledochal ducts without previous papillotomy. First results of this new method in surgical specimens and patients are presented. Ductal dilatations, and irregularities as well as secretion plugs and calcifications are characteristic phenomenons of chronic pancreatitis; the diagnosis of a malignant pancreatic tumour can be made by observing an irregular compression of the pancreatic duct and the infiltration of its wall. Perhaps by this method precursors of ductal pancreatic cancer will be recognized. We assume that ERCP will be supported by this method.


12. DOCID:14152 SCORE: 0.00137235934407962
DOCNO: 3408862
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ambulatory Care
DESCRIPTOR: Urography
QUALIFIER: radiography
QUALIFIER: etiology
AUTHOR: M W Jones MW
AUTHOR: R Cox R
AUTHOR: K I Davies KI
AUTHOR: M B Rose MB
AFFILIATION: Department of Urology, Morriston Hospital, Swansea.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: The value of the pre-clinic intravenous urogram in the earlier diagnosis of the cause of haematuria.
PUBDATE: 19880701
The early treatment of patients with bladder cancer reduces mortality. By arranging a pre-clinic intravenous urogram we reduced the time from receipt of the General Practitioner's referral letter to making a diagnosis from 85 to 67 days and saved on clinic time and resources. A further reduction to 52 days was made by not using any out-patient time at all. Significant saving of time and resources is possible without any disadvantage to the patient.


13. DOCID:14256 SCORE: 0.00131091166255975
DOCNO: 3947128
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R B Kinney RB
AUTHOR: C S Burton CS
AUTHOR: R T Vollmer RT
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of dermatology.
COUNTRY: UNITED STATES
TITLE: Necrotizing sialometaplasia: a sheep in wolf's clothing. Healing as a diagnostic test.
PUBDATE: 19860201
Necrotizing sialometaplasia is a benign self-limited intraoral lesion that is easily confused both clinically and histologically with squamous cell carcinoma. It presents as a painless ulceration, frequently on the hard palate, that histologically shows necrosis, inflammation, squamous metaplasia, and granulation tissue. It is thought to be due to infarction of minor salivary glands and heals spontaneously in six to 12 weeks. A brief period of observation for evidence of healing can be an important diagnostic clue in distinguishing this entity from cancer, thus saving the patient unnecessary surgery or radiation therapy.


14. DOCID:12143 SCORE: 0.00108642229541133
DOCNO: 2708926
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vocal Cords
QUALIFIER: radiotherapy
AUTHOR: G Ayers G
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Medical Association of Georgia.
COUNTRY: UNITED STATES
TITLE: Treatment of early stage vocal cord carcinoma.
PUBDATE: 19890301
The cure rates for early stage vocal cord cancer are excellent with primary radiotherapy. Voice quality remains as good or becomes better than prior to treatment. For the local failures that do occur, surgical salvage will yield ultimate cure rates of about 95% for T1 and 90% for T2 tumors.