0. DOCID:3773 SCORE: 0.00427809812227008
DOCNO: 1104491
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunologic Techniques
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A E Powell AE
AUTHOR: A M Sloss AM
AUTHOR: R N Smith RN
AUTHOR: J T Makley JT
AUTHOR: C A Hubay CA
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Specific responsiveness of leukocytes to soluble extracts of human tumors.
PUBDATE: 19751201
The leukocyte adherence inhibition (LAI) method was studied with respect to its specificity in detecting responses to extracts of tumor tissues or normal lymphocytes. Responses of cells from normal persons were within 10% of each other whether incubation was carried out with culture medium alone or with any of the extracts. The same was true of cells from 78 cancer patients unless the cells were incubated with extracts of the same histologic type as their own. In the latter case, statistically significant responses occurred in 95% of the 110 analyses done. Negative responses were given by cells from 14 patients tentatively diagnosed as having breast carcinoma but whose lesions later proved benign. There was one positive response inconsistent with the diagnosis. Of 29 normal individuals known to have been exposed to tumors or tumor extracts, 11 responded positively and specifically to the relevant tumor extract. Cells from 12 of 30 multiparous female breast-cancer patients responded to extracts of pooled normal lymphocytes. The results establish that the LAI analysis is an extremely specific means of detecting systemic responses to malignant diseases. In addition, analyses have proven positive in 95% of the cases studied.


1. DOCID:3145 SCORE: 0.00217915054639121
DOCNO: 412099
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
AUTHOR: W T Hughes WT
AUTHOR: S Kuhn S
AUTHOR: S Chaudhary S
AUTHOR: S Feldman S
AUTHOR: M Verzosa M
AUTHOR: R J Aur RJ
AUTHOR: C Pratt C
AUTHOR: S L George SL
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: The New England journal of medicine.
COUNTRY: UNITED STATES
TITLE: Successful chemoprophylaxis for Pneumocystis carinii pneumonitis.
PUBDATE: 19771201
In a randomized, double-blind, placebocontrolled study to evaluate the efficacy of trimethoprim-sulfamethoxazole for the prevention of Pneumocystis carinii pneumonia, we studied 160 patients with cancer who were at high risk for this pneumonia over a two-year period. Seventeen of the 80 patients receiving a placebo acquired P. carinii pneumonitis, whereas none of the 80 given 150 mg of trimethoprim and 750 mg of sulfamethoxazole per square meter per day had the infection P less than 0.01). Bacterial sepsis, pneumonia other than that caused by P. carinii, acute otitis media, upper-respiratory-tract infections, sinusitis and cellulitis occurred less frequently in recipients of the drug than in the placebo group (P less than 0.01 in each case). Oral candidiasis was the only adverse effect ecountered from trimethoprim-sulfamethoxazole administration. The study shows the combination to be highly effective in the prevention of P. carinii pneumonitis.


2. DOCID:3224 SCORE: 0.0018784253715109
DOCNO: 1247963
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: epidemiology
AUTHOR: P Strax P
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Results of mass screening for breast cancer in 50,000 examinations.
PUBDATE: 19760101
Detection of earlier breast cancer, especially in its preclinical stage, offers the only method available today for reducing mortality from this disease. The Health Insurance Plan study, conducted since 1963 under contract with the National Institutes of Health, has achieved a one-third reduction in death rate in a study group compared to a matched control which has persisted in 7 years of follow-up. The Guttman Institute, founded in 1968 to develop practical methods for large scale screening, is operating a tandem approach using interview, clinical examination, improved mammography, and thermography for greatest yield. Emphasis is placed on motivation to accept the examination, teaching and encouragement of breast self-examination, and emphasis on periodic reexaminations. At the present time, almost 300 women receive this complete examination per day at the Institute's fixed facility. Periodic examinations leads to marked increase in number of cancers detected free of axillary nodal involvement. The tandem approach emphasizes substantial percentage of cancers detected on only one modality, two-thirds of which are without nodal involvement. Breast self-examination is necessary to detect "interval" cancers in more localized stage.


3. DOCID:3243 SCORE: 0.0016272094422622
DOCNO: 178610
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Angiogenesis Inducing Agents
DESCRIPTOR: Growth Substances
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: P Phillips P
AUTHOR: J K Steward JK
AUTHOR: S Kumar S
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Tumour angiogenesis factor (TAF) in human and animal tumours.
PUBDATE: 19760501
Extracts were made from Walker 256 carcinoma, spontaneous rat mammary adenocarcinoma, Wilms' tumour, human neuroblastoma and human haemangioma. Chromatography of the extracts on Sephadex G-100 yielded four fractions, A, B, C and D. Injection of fractions B and C resulted in the growth of new capillaries in the subcutaneous fascia or rats. Controls, e.g. similar extracts of rat liver or human kidney, did not induce neovascularisation. The endothelium of newly-formed blood vessels contained many mitotic figures. A limitation of this method is that it is qualitative only. In order to develop a quantitative in vitro assay for a tumour angiogenesis factor (TAF), short-term primary cultures were initiated from adult rat brain white matter, as cells from such cultures were shown to be vascular in origin. Addition of fractions containing TAF (B and C) which were active in vivo failed to stimulate thymidine uptake by the cells. The possible reasons for this failure and the therapeutic potential of TAF in cancer control are discussed.


4. DOCID:2283 SCORE: 0.00161461890832121
DOCNO: 173459
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: urine
QUALIFIER: urine
AUTHOR: D P Rose DP
AUTHOR: W E Fahl WE
AUTHOR: L Liskowski L
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The urinary excretion of corticosteroid sulfates by cancer patients.
PUBDATE: 19751201
Urinary excretions of free cortisol and corticosteroid sulfates were determined in 31 female controls, 77 breast cancer patients, 14 cases of colonic cancer, and 7 patients with bronchial carcinoma. Elevated corticosteroid sulfate excretion was present in 38% of patients with locally recurrent breast cancer and 30% of those with distant metastases, but in only 13% of the "early" breast cancer cases. A similar abnormality was seen in colonic cancer. Urinary free cortisol was usually normal. ACTH stimulation in a normal subject produced marked increases of both urinary free cortisol and corticosteroid sulfates. It is concluded that elevated corticosteroid sulfate excretion in cancer patients arises from an increased cortisol production rate combined with increased sulfurylation of the steroid. In bronchial carcinoma patients, changes similar to those occurring in the ACTH-treated normal subject may have resulted from ectopic ACTH production in the tumor.


5. DOCID:3964 SCORE: 0.0015905450535216
DOCNO: 1277167
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: H M Jensen HM
AUTHOR: S R Wellings SR
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Preneoplastic lesions of the human mammary gland transplanted into the nude athymic mouse.
PUBDATE: 19760701
Morphologically normal lobules and atypical lobules postulated precancerous to ductal carcinoma were transplanted to test their biological behavior. Supravital staining disclosed the 1 to 4-mm microorgans. "Cleared" mammary fat pads of nude mice were optimal transplantation sites. Of the total of 217 transplants from 19 cancer-associated and 13 non-cancer-associated breast, 151 survived after 2 to 27 weeks. Of 61 surviving normal-appearing lobules from cancer-associated breasts transplanted without prior in vitro maintenance, 20 (30%) dedifferentiated, and of 48 surviving lobules from noncancerous breasts, 11 (20%) dedifferentiated. Fifteen of 28 histologically normal-appearing lobules (60%) obtained from cancer-associated breasts after age 50 dedifferentiated. Thirty of 36 atypical lobules isolated from the breast tissue were obtained from cancer-associated breasts and the 5 of those that dedifferentiated came from cancer-associated breasts. Twenty of 22 (90%) dedifferentiating transplants from cancer-associated breasts showed a vascularization response, whereas 3 of 7 (43%) from noncancer-associated breasts did so. If dedifferentiation in this experimental setting is indicative of a precancerous potential, the data on normal-appearing lobules obtained from cancer-associated breasts from women over age 50 suggest that these lobules carry the greatest precancerous potential. Such lobules probably belong to a type persisting after menopause and they may be hormonally autonomous. Such lobules might undergo further atypia in vivo and, eventually, cancerous transformation.


6. DOCID:3216 SCORE: 0.00135243390068741
DOCNO: 868853
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: A Nomura A
AUTHOR: G W Comstock GW
AUTHOR: J A Tonascia JA
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Epidemiologic characteristics of benign breast disease.
PUBDATE: 19770601
To see if the risk factors associated with fibroadenoma and cystic disease were similar to those reported for breast cancer, a retrospective study of benign breast tumor in a general population was conducted in Washington County, Maryland. The study population consisted of 320 white women 20 to 49 years of age who had had benign breast disease and 320 age-matched controls. More cystic disease cases than controls had the following characteristics, which had been reported to have been associated with breast cancer in other studies: higher socioeconomic status; fewer pregnancies; and a lack of association with lactation patterns. Nulliparity, late natural menopause and a maternal history of breast cancer were also more common among cystic cases than controls, although these differences could have occurred by chance. Cystic disease cases and controls did not differ with respect to other factors associated with breast cancer, such as early age at menarche, late age at first pregnancy, and negative history of artificial menopause. In contrast to cystic breast disease, fibroadenoma was not associated with most of the risk factors of breast cancer.


7. DOCID:3892 SCORE: 0.00131734684262124
DOCNO: 192433
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: R G Vincent RG
AUTHOR: J W Pickren JW
AUTHOR: W W Lane WW
AUTHOR: I Bross I
AUTHOR: H Takita H
AUTHOR: L Houten L
AUTHOR: A C Gutierrez AC
AUTHOR: T Rzepka T
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The changing histopathology of lung cancer: a review of 1682 cases.
PUBDATE: 19770401
We have reviewed the histopathology of lung cancer patients seen over the past 13 years at RPMI. Assessment of this data indicates that adenocarcinoma is becoming progressively more prevalent as related to the other forms of lung cancer. Factors which in part may account for this increased prevalence are: 1) changes in criteria for reading histopathology of lung cancer, particularly since 1967; 2) the increased incidence of lung cancer among the female population who have a propensity for adenocarcinoma; and 3) occupational and environmental factors. In 1974 adenocarcinoma for the first time became the most prevalent type of lung cancer at RPMI. Whatever the reason, if our data are truly representative of a national trend, adenocarcinoma will soon become the most prevalent type of lung cancer in the United States. This fact may result in an increasing death rate since the present 18-month survival rate for adenocarcinoma is substantially less than for squamous cell carcinoma, which has in the past been the prevalent form of the disease. As the smoking habits of women more closely approximate those of men, we expect that the incidence and mortality of lung cancer will prove to be quite similar in both sexes.


8. DOCID:485 SCORE: 0.0012970838639673
DOCNO: 64701
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: M Wass M
AUTHOR: G A Rawlins GA
AUTHOR: C R Pentycross CR
AUTHOR: K D Bagshawe KD
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Response of lymphocytes from cancer patients to human chorionic gonadotrophin.
PUBDATE: 19770101
Positive responses to human chroionic gonadotrophin (H.C.G.) were observed in the macrophage electrophoretic mobility test when lymphocytes from 34/44 patients with various types of cancer and from 7/21 patients with non-malignant disease were tested. Lymphocytes from some pregnant women also responded but those from parous women who were not pregnant did not respond. Positive responses were also obtained with H.C.G. sub-units but not with luteinising hormone.


9. DOCID:3238 SCORE: 0.00127568562158367
DOCNO: 844735
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: blood supply
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: F Gottesfeld F
AUTHOR: G Zickel G
AUTHOR: D D Bass DD
AUTHOR: B Weintraub B
AUTHOR: B Czernobilsky B
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Harefuah.
COUNTRY: ISRAEL
TITLE: [Ischemic colitis in a woman on contraceptive pills]
PUBDATE: 19770101
This is the first published report in Israel of ischemic colitis in a woman using the contraceptive pill; 20 such cases have been reported in other parts of the world. The patient was a 46 year old married woman with 3 children; she had been in good health except for obesity and chronic hypertension. Her medications included an oral contraceptive for a period of 3 years, and methyldopa for treatment of her hypertension. She presented with abdominal pain and diarrhea of 5 weeks duration. She underwent surgical reanastamosis of the bowel and was doing well at follow-up 1 year after surgery. The presence of ischemic colitis was definitively diagnosed by histological examination; the differential diagnosis included cancer, ulcerative colitis, Crohn's disease, and infectious disease. The authors note that although there is possible association between taking oral contraceptives and the appearance of ischemic colitis, there is not yet any statistical evidence for such a relationship. Similar cases have been reported among young women who were not using oral contraceptives.


10. DOCID:1775 SCORE: 0.00125881844252017
DOCNO: 167699
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Biological
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: W I Onuigbo WI
PUBTYPE: Journal Article
JOURNALTITLE: Archives of pathology.
COUNTRY: UNITED STATES
TITLE: Human model for studying seed-soil factors in blood-borne metastasis.
PUBDATE: 19750601
The relationship between tumor "seed" and tissue "soil" in blood-borne metastasis is poorly understood. Therefore, an explanatory human model is proposed. It is based on the hypothesis that the spread of lung cancer cells to the adrenal vein provides in man not only a variable attribute, lung cancer seed, but also a constant attribute, adrenal venous soil, as in a scientific experiment. Out of 100 cases of lung cancer, four histologic types proved their invasive potentiality in 45 subjects by colonizing the adrenal parenchyma proper and yet differed appreciably in their ability to grow in the adrenal venous blood. Hence, in all probability, the systematic study of venous blood will help in the discovery of the potentialities and limitations of human blood in tumor metastasis.


11. DOCID:1608 SCORE: 0.00111793257274982
DOCNO: 319706
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Metastasis
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: drug effects
AUTHOR: J Katz J
AUTHOR: A B Levin AB
PUBTYPE: Journal Article
JOURNALTITLE: Anesthesiology.
COUNTRY: UNITED STATES
TITLE: Treatment of diffuse metastatic cancer pain by instillation of alcohol into the sella turcica.
PUBDATE: 19770201
The technique of "chemical hypophysectomy" was modified for the management of pain due to metastatic cancer. Using stereotaxic control, a needle is introduced via the nose into the sella turcica. Absolute alcohol is then injected into the pituitary. Of 13 patients who had severe uncontrollable pain, 11 obtained marked symptomatic relief. The longest follow-up period to date is seven months, with results persisting. Sequelae are those associated with destruction of the pituitary gland, the most significant being diabetes insipidus. Several cerebrospinal fluid leaks prompted us routinely to instill alpha-ethyl cyanoacrylate to seal the sella floor. Three patients had slight extraocular nerve palsies. There was no death related to the procedure.


12. DOCID:311 SCORE: 0.00111208325787526
DOCNO: 860700
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: N S Mann NS
AUTHOR: A J Sachdev AJ
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of gastroenterology.
COUNTRY: UNITED STATES
TITLE: Carcinoma of the esophagus and hypercalcemia.
PUBDATE: 19770201
Hypercalcemia was found in 19 (28%) of 67 patients with cancer of the esophagus. There was no evidence of bone metastases in 14 (20%) of the patients with hypercalcemia. The location of the lesion (upper, middle or lower esophagus) appears to have no bearing on the clinical features in this condition and the association of hypercalcemia with esophageal malignancy, even in the absence of bone metastases, should be recognized.


13. DOCID:1905 SCORE: 0.00110394792651256
DOCNO: 1118078
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: P Rossotto P
AUTHOR: G F Azzena GF
AUTHOR: F Consiglio F
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Interposition of the jejunal loop in the surgical treatment of gastroduodenal ulcer, postprandial syndromes and gastric cancer]
PUBDATE: 19750101
50 cases of interposition of jejunal loop (32 for gastric cancer and 18 for ulcerous pathology) carried out over the last 3 years are reported. From a technical point of view and as an alternative to degastroenteroanastomosis, interposition of the loop is preferred in partial oral end-to-end on the stomach. In neoplastic lesions, Mouchet-Camey type reconstruction was adopted as a routine measure. After describing the complications of the operation and analyzing the causes, the long-term results are evaluated using absorption curves with 131-I labelled oleic acid. The excellent weight increase in the inflammatory forms, and the lack of reflow and dumping in patients subjected to total gastrectomy for cancer, confirm the value of the technique.


14. DOCID:2949 SCORE: 0.00107340049614716
DOCNO: 820422
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: S S Legha SS
AUTHOR: M Slavik M
AUTHOR: S K Carter SK
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Hexamethylmelamine. An evaluation of its role in the therapy of cancer.
PUBDATE: 19760701
Hexamethylmelamine (HMM) has been undergoing clinical trials for about a decade under the sponsorship of the National Cancer Institute. It has been tested in Phase II and III cooperative group studies and has a wide spectrum of activity in solid tumors. Its activity is most marked in ovarian cancer, lymphomas, and carcinoma of the cervix; the drug is also active in bronchogenic carcinoma and carcinoma of the breast. Considerable clinical evidence suggests a lack of cross-resistance between HMM and alkylating agents. the currently popular dose is 300 mg/m2/day p.o. for indefinite periods if tolerated. The dose-limiting toxicity is neurologic, but gastrointestinal side effects and a moderate degree of myelosuppression are also observed. Combination chemotherapy using HMM is underway in ovarian and lung cancer. Futher exploration of its activity as a single agent in tumors such as those of the bladder, prostate, and uterus, and in combination chemotherapy in lymphomas, and mammary, cervical, and pulmonary tumors is warranted.