0. DOCID:25859 SCORE: 0.00388420247229774
DOCNO: 12113028
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
QUALIFIER: drug therapy
QUALIFIER: methods
QUALIFIER: classification
QUALIFIER: drug therapy
QUALIFIER: methods
AUTHOR: M J Edelman MJ
AFFILIATION: University of Maryland, Greenebaum Cancer Center, Baltimore, Maryland, USA. medelman@umm.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert review of anticancer therapy.
COUNTRY: England
TITLE: Neoadjuvant chemotherapy in early-stage non-small cell lung cancer.
PUBDATE: 20010801
Of the patients that undergo complete resection of early-stage non-small cell lung cancer (NSCLC), 30-60% will die. Postoperative adjuvant chemotherapy has yet to demonstrate an unequivocal benefit and there are significant difficulties in administering postoperative chemotherapy to patients with the significant comorbidities found in NSCLC. Currently, several trials are evaluating the role of preoperative chemotherapy in stage I and II NSCLC. This paper reviews the rationale for this approach and potential future developments.
1. DOCID:25851 SCORE: 0.00388420233620071
DOCNO: 9555428
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Home Care Services
QUALIFIER: methods
QUALIFIER: nursing
QUALIFIER: methods
AUTHOR: R Van Gerpen R
PUBTYPE: Journal Article
JOURNALTITLE: ONS news / Oncology Nursing Society.
COUNTRY: UNITED STATES
TITLE: Homecare nurses face unique challenges in caring for patients with cancer.
PUBDATE: 19980201
Oncology care is going home. The changes in health care that have occurred during the past decade have significantly impacted the growth of home care. Factors that have contributed to this growth include prospective payments for hospital services to Medicare patients leading to a decreased length of stay, advances in the development of equipment for providing high-tech treatments in the home, changes in reimbursement from fee-for-service to managed care and capitation, an aging population, and improved survival rates for patients with chronic illnesses, including cancer.
2. DOCID:27875 SCORE: 0.00382758928799462
DOCNO: 9752329
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: immunology
QUALIFIER: physiology
AUTHOR: A Berger A
AUTHOR: B Piqueras B
AUTHOR: F Pages F
AUTHOR: E Tartour E
AUTHOR: P H Cugnenc PH
AUTHOR: W H Fridman WH
AFFILIATION: Service de chirurgie générale, digestive et oncologique, Hôpital Laennec, Paris.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: FRANCE
TITLE: [Fas, fas ligand, immune tolerance, and cancer: implications in cancer of the colon]
PUBDATE: 19980201
Fas and Fas ligand (FasL) are implicated in programmed cell death or apoptosis. In the immunological field, they are particularly important in auto-immunity, graft rejection and anti-tumoral response. Fas ligand expression on thymocytes, activated T lymphocytes, and in sites of immune privilege, suggests the importance of Fas/FasL interactions in negative control of the immune response. The recent description of FasL expression by tumoral cells, represents a new mechanism of immune escape for different cancer, and has been well studied in colon adenocarcinoma.
3. DOCID:27800 SCORE: 0.003827588820948
DOCNO: 10967793
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aromatase Inhibitors
DESCRIPTOR: Oncologic Nursing
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: A O Cloutier AO
AFFILIATION: Shering Oncology Biotech, Kenilworth, NJ, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: UNITED STATES
TITLE: Advanced breast cancer: recent developments in hormonal therapy.
PUBDATE: 20000801
OBJECTIVES: To review recent developments in hormonal therapy for metastatic breast cancer. DATA SOURCES: Published books and articles. CONCLUSIONS: Newer hormonal agents are offering women alternatives for sequential therapy of metastatic disease that provide benefit with less risk. IMPLICATIONS FOR NURSING PRACTICE: A thorough understanding of the relationship between hormonal influences and breast cancer will assist nurses to better appreciate the variety of agents now available and their specific indications, outcomes, and effects. Common side effects include weight gain, hot flashes, nausea, and skin and vaginal changes. Nursing efforts focus on the areas of body image disturbance, side effect management, and fostering healthy relationships.
4. DOCID:25868 SCORE: 0.00306369715937712
DOCNO: 11787295
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: standards
QUALIFIER: methods
QUALIFIER: standards
AUTHOR: A Yoshizawa A
AUTHOR: Y Gyouda Y
AUTHOR: T Ishiguro T
AUTHOR: S Yoshida S
AUTHOR: T Yoshizawa T
AUTHOR: I Narita I
AUTHOR: M Tsuruta M
AUTHOR: Y Fukumoto Y
AFFILIATION: Dept. of Home Care, Kaname-cho Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: Japan
TITLE: [Indication of home oxygen therapy for terminal cancer patients--comparison with present standards--as the result from investigation of our patients and questionnaire survey to home care doctors]
PUBDATE: 20011201
As the result of the observation of our patients and a questionnaire answered by home care doctors, we think it is necessary to establish new standards for home oxygen therapy, based on the characteristics of terminal cancer patients and to put great emphasis on the QOL of patients.
5. DOCID:27163 SCORE: 0.00292115875936772
DOCNO: 10884619
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bifidobacterium
DESCRIPTOR: Lactobacillus
QUALIFIER: prevention & control
QUALIFIER: therapeutic use
AUTHOR: K Hirayama K
AUTHOR: J Rafter J
AFFILIATION: Department of Medical Nutrition, Karolinska Institute, NOVUM, S-141 86, Huddinge, Sweden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Microbes and infection / Institut Pasteur.
COUNTRY: FRANCE
TITLE: The role of probiotic bacteria in cancer prevention.
PUBDATE: 20000501
Colorectal cancer is one of the most important causes of cancer morbidity and mortality in western countries [1]. A myriad of healthful effects have been attributed to the probiotic lactic acid bacteria; perhaps the most controversial remains that of anticancer activity. There is no direct experimental evidence for cancer suppression in humans as a result of consumption of lactic cultures in fermented or unfermented dairy products. However, there is a wealth of indirect evidence, based largely on laboratory studies, in the literature and this will be summarised in the present paper.
6. DOCID:26706 SCORE: 0.00286790081896959
DOCNO: 9676499
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sick Role
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: psychology
QUALIFIER: statistics & numerical data
AUTHOR: R A Schneider RA
AFFILIATION: Buena Vista University, Storm Lake, IA 50588, USA. bschneid@pionet.net
PUBTYPE: Journal Article
JOURNALTITLE: Psychological reports.
COUNTRY: UNITED STATES
TITLE: Concurrent validity of the Beck Depression Inventory and the multidimensional fatigue inventory-20 in assessing fatigue among cancer patients.
PUBDATE: 19980601
Cancer patients experience both fatigue and depression while undergoing treatment for their disease. A number of authors have conceptualized such depression among this populations as secondary to fatigue. This study of 54 patients was done to test the concurrent validity of two inventories. Scores on the five subscales of the 20-item Multidimensional Fatigue Inventory were correlated with those on the 21-item Beck Depression Inventory. Moderate correlations are reported and the potential usefulness of the Multidimensional Fatigue Inventory is discussed.
7. DOCID:30247 SCORE: 0.00256592957518748
DOCNO: 16139958
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: physiopathology
QUALIFIER: physiology
AUTHOR: Ze-Jun Liu ZJ
AUTHOR: Xin Lu X
AUTHOR: Shan Zhong S
AFFILIATION: Laboratory of International Cooperation, Southwest Hospital, Third Military Medical University, Chongqing 400038, PRC. a65424208@cta.cq.cn
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: Netherlands
TITLE: ASPP--Apoptotic specific regulator of p53.
PUBDATE: 20050901
The p53 protein is one of the best-known tumor suppressors. The recently identified ASPP family (apoptosis-stimulating protein of p53) can interfere with the working of p53. Three members of ASPP family are proved to be apoptotic specific regulators of p53. The discovery of ASPP family may answer such questions as "how cells choose to die". Understanding the ASPP status in human cancer will allow us to develop better strategies to treat cancer.
8. DOCID:25275 SCORE: 0.00252695227001758
DOCNO: 10619518
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoadjuvant Therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: J S Friedberg JS
AFFILIATION: Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA. josephf@mail.med.upenn.edu
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Clinical presentation of stage IIIA (N2) non-small cell lung cancer: role of multimodality therapy.
PUBDATE: 19991201
Neoadjuvant chemotherapy before surgical resection of locally advanced non-small cell lung cancer (NSCLC) has been shown to improve survival compared with surgery alone in several randomized clinical trials. A case report is presented describing the use of paclitaxel and carboplatin in a multimodality regimen for a patient with stage IIIA N2 NSCLC. Studies are ongoing to determine the optimal type and timing of chemotherapy.
9. DOCID:25219 SCORE: 0.00252695226376516
DOCNO: 9739758
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Repressor Proteins
DESCRIPTOR: Trans-Activation (Genetics)
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: L Rapp L
AUTHOR: J J Chen JJ
AFFILIATION: Department of Dermatology, New England Medical Center, Boston, MA, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: NETHERLANDS
TITLE: The papillomavirus E6 proteins.
PUBDATE: 19980801
Specific types of human papillomaviruses (HPV) are strongly associated with the development of cervical cancer. The E6 gene from cancer-related HPVs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. Cancer-related HPVs E6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. Several additional cellular E6-binding proteins have recently been identified and implicated in playing roles in p53-independent functions of E6.
10. DOCID:29442 SCORE: 0.00248915953012363
DOCNO: 12635085
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: Maureen F Zakowski MF
AFFILIATION: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: United States
TITLE: Pathology of small cell carcinoma of the lung.
PUBDATE: 20030201
Small cell carcinoma of the lung is one of the major subtypes of primary lung cancer. It is a highly aggressive lethal neuroendocrine carcinoma. It is closely related to other neuroendocrine carcinomas of the lung, including carcinoid, atypical carcinoid, and large cell neuroendocrine carcinoma. This article discusses the classification of small cell carcinoma of the lung, identifies its cytologic and histologic characteristics, and places it in context with the other neuroendocrine carcinomas of the lung.
11. DOCID:29456 SCORE: 0.00248915951017022
DOCNO: 16425560
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: physiopathology
QUALIFIER: radiation effects
QUALIFIER: etiology
QUALIFIER: physiopathology
QUALIFIER: radiotherapy
QUALIFIER: etiology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: radiation effects
QUALIFIER: adverse effects
AUTHOR: Wai Yip Stephen Lau WY
AUTHOR: Chun Kuen Chow CK
AFFILIATION: Division of Otorhinolaryngology, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Annals of otology, rhinology, and laryngology.
COUNTRY: United States
TITLE: Radiation-induced petrous internal carotid artery aneurysm.
PUBDATE: 20051201
Iatrogenic internal carotid artery aneurysm is a rare complication of irradiation. There are few reported cases in the literature. A case of radiation-induced petrous internal carotid artery aneurysm in a patient with nasopharyngeal cancer treated with radiotherapy is reported. The approach to managing such an aneurysm is discussed.
12. DOCID:29853 SCORE: 0.00243890358567412
DOCNO: 16355210
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Peter Carmeliet P
AFFILIATION: Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology (VIB), B-3000 Leuven, Belgium. peter.carmeliet@med.kuleuven.be.
PUBTYPE: Journal Article
JOURNALTITLE: Nature.
COUNTRY: England
TITLE: Angiogenesis in life, disease and medicine.
PUBDATE: 20051201
The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.
13. DOCID:30583 SCORE: 0.00243888742240874
DOCNO: 16308096
OWNER: NLM
STATUS: In-Data-Review
QUALIFIER: pathology
QUALIFIER: trends
QUALIFIER: pathology
QUALIFIER: surgery
AUTHOR: William Chesnut Dooley WC
AFFILIATION: Oklahoma University Breast Institute, Cade Cancer Center, Oklahoma City, OK 73104, USA. william-dooley@ouhsc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinics in laboratory medicine.
COUNTRY: United States
TITLE: The future prospect: ductoscopy-directed brushing and biopsy.
PUBDATE: 20051201
The intraductal approach to breast cancer and premalignant lesions has now developed to yield substantial cytologic samples of exfoliated cells. Standard cytology is still inadequate in sensitivity and specificity to accurately interpret the majority of samples. As techniques evolve using ductoscopic biopsy and molecular marker panels to increase accuracy of cytologic interpretation, these tools will be able to unravel the breast carcinogenesis pathways. They will also offer considerable benefit in screening for premalignant changes and developing effective chemoprevention strategies.
14. DOCID:30585 SCORE: 0.00243888698147658
DOCNO: 16408163
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Jerome E Tanner JE
AFFILIATION: TanTec Biosystems Inc., 11 Des Arbres, Dollard-Des-Ormeaux, Montreal, Quebec, Canada, H9G 3C2, jetanner@tantecbiosystems.com.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer metastasis reviews.
COUNTRY: Netherlands
TITLE: Designing antibodies for oncology.
PUBDATE: 20051201
The past five years have witnessed the emergence of monoclonal antibodies as important therapeutics for cancer treatment. Lower toxicity for antibodies versus small molecules, the potential for increased efficacy by conjugation to radioisotopes and cellular toxins, or the ability to exploit immune cell functions have led to clinical performances on par or superior to conventional drug therapies. This review outlines the various immunoglobulin design strategies currently available, techniques used to reduce Ig antigenicity and toxicity, and points to consider during the manufacture of antibodies for use in clinical oncology.