0. DOCID:15506 SCORE: 0.00441659659740152
DOCNO: 3185198
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mathematical Computing
QUALIFIER: statistics & numerical data
QUALIFIER: statistics & numerical data
AUTHOR: A Iu Iakovlev AIu
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Biomathematical approaches to the problems of radiation biology and medicine]
PUBDATE: 19881101
A vast experience in the introduction of modern mathematical methods into research activities of the Central Research Roentgenoradiology Institute was accumulated in the Department of Biomathematics. The Information-retrieval System for Storage and Analysis of Data on the Activities of X-ray Service in the USSR, a package of applied programs for statistical analysis of radiation therapy effectiveness, a controlled data base on 6 cancer sites, 2 systems for simulation of radiation effects on heterogeneous cell systems were worked out. Some priority results in the fields of mathematical biology and statistical analysis of incomplete selective data were obtained. The Department is heading the work on the problem "Mathematics and computer technology in radiobiology and radiation biophysics".

1. DOCID:15579 SCORE: 0.00410469012867606
DOCNO: 2695654
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: G Dugue G
AUTHOR: G Bock G
AUTHOR: L Molho L
AUTHOR: J W Cordice JW
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the National Medical Association.
COUNTRY: UNITED STATES
TITLE: Breast cancer in the young.
PUBDATE: 19891101
Breast cancer in the young is rare. Some cases can be treated with modest surgical intervention and prognosis is good. We present a report of a 17-year-old black girl with adenocarcinoma of the breast. In our case, the disease pursued a devastatingly rapid course in spite of treatment and the patient died within 6 months of diagnosis. The literature relating to clinical experience with various types of breast carcinoma seen in pre- and postpubertal patients is also reviewed. We conclude that this case, and certain other cases cited, demonstrates the need for a high index of suspicion and earlier and more aggressive intervention in young patients with axillary breast masses.

2. DOCID:8474 SCORE: 0.00252011064353541
DOCNO: 7184463
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Plasma Exchange
QUALIFIER: therapy
QUALIFIER: secondary
AUTHOR: T Kamano T
AUTHOR: H Kishino H
AUTHOR: K Mizukami K
AUTHOR: N Azuma N
AUTHOR: J Tamura J
AUTHOR: T Kidokoro T
AUTHOR: S Yuasa S
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Plasma exchange therapy in colonic cancer with hepatic metastasis]
PUBDATE: 19820901
The plasma exchange using Carcino embryonic Antigen (CEA) value as an index was performed for 3 colonic cancer patients with liver metastasis. A remarkable regression of hepatomegaly in two cases with rectal cancer was obtained and a significant decrease of CEA was observed in all patients.

3. DOCID:14945 SCORE: 0.00230115264610243
DOCNO: 3593337
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: L G Baggetto LG
AUTHOR: A L Lehninger AL
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Isolated tumoral pyruvate dehydrogenase can synthesize acetoin which inhibits pyruvate oxidation as well as other aldehydes.
PUBDATE: 19870501
Oxidation of 1 mM pyruvate by Ehrlich and AS30-D tumor mitochondria is inhibited by acetoin, an unusual and important metabolite of pyruvate utilization by cancer cells, by acetaldehyde, methylglyoxal and excess pyruvate. The respiratory inhibition is reversed by other substrates added to pyruvate and also by 0.5 mM ATP. Kinetic properties of pyruvate dehydrogenase complex isolated from these tumor mitochondria have been studied. This complex appears to be able to synthesize acetoin from acetaldehyde plus pyruvate and is competitively inhibited by acetoin. The role of a new regulatory pattern for tumoral pyruvate dehydrogenase is presented.

4. DOCID:11681 SCORE: 0.00211009588155456
DOCNO: 6748244
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Coitus
DESCRIPTOR: Urination
QUALIFIER: surgery
QUALIFIER: physiopathology
AUTHOR: S Kodaira S
AUTHOR: T Teramoto T
AUTHOR: J Kuromizu J
AUTHOR: M Ikoma M
AUTHOR: O Abe O
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Radical operation for rectal cancer to preserve anorectal, urinary and sexual function]
PUBDATE: 19840501
Recently, preservation of physiological functions have become to be considered in the operative treatment for rectal cancer. Dysfunction caused following radical operation for rectal cancer is divided into two parts as follows, (1) disturbance or loss of anorectal function due to sacrifice of the anus in abdomino-perineal resection and decrease function as fecal reservoir following anal sphincter preserving resection of the rectum. (2) anorectal, urinary and sexual dysfunction following surgical injury to the autonomic nerves by pelvic lymph nodes dissection. Our conceptions of the indication for sphincter preserving operation and for wide dissection of pelvic lymph nodes which cause severe dysfunction of urinary and sexual functions postoperatively were discussed.

5. DOCID:12878 SCORE: 0.00210966436938629
DOCNO: 2657851
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: R F Thoeni RF
AFFILIATION: CT/Gastrointestinal Section, University of California, San Francisco.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: CT evaluation of carcinomas of the colon and rectum.
PUBDATE: 19890701
Computed tomography (CT) has proved to be a powerful tool in the detection and staging of carcinomas of the colon and rectum. It is unsurpassed in the detection of recurrent colon cancer and is particularly useful in patients who have undergone abdominal-perineal resections for rectal neoplasms. The current applications of CT in colon cancer are contrasted with barium studies, endoscopy, and magnetic resonance imaging.

6. DOCID:15091 SCORE: 0.00202810896808167
DOCNO: 3167811
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Kamma H
AUTHOR: K Fujii K
AUTHOR: T Ogata T
AFFILIATION: Department of Pathology, University of Tsukuba, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Lymphocytic infiltration in juvenile thyroid carcinoma.
PUBDATE: 19881101
In this study, the significance of lymphocytic infiltration in juvenile thyroid carcinoma is clarified. We examined nine patients younger than 20 years of age. Histopathologically, there was good correlation between lymphocytic infiltration and the development and spread of carcinoma. It is believed that lymphocytic infiltration around the tumor is an immunologic reaction induced by antigens from the carcinoma itself, and also that the reaction may progress according to tumor development. Immunocytochemically, we determined what type of inflammatory cells infiltrated the thyroid and demonstrated HLA-DR expression in the cancer cells. These findings are similar to autoimmune thyroiditis in which antibody-dependent cellular cytotoxicity (ADCC) works as a main immunomechanism.

7. DOCID:14968 SCORE: 0.0019441624059837
DOCNO: 3729499
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prostatic Neoplasms
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: N Miyaji N
AUTHOR: M Nakajo M
AUTHOR: K Ueki K
AUTHOR: H Kobayashi H
AUTHOR: S Onohara S
AUTHOR: S Shinohara S
AUTHOR: K Niimura K
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of metastatic brain tumor from prostatic cancer showing remarkable shrinkage following CDDP administration]
PUBDATE: 19860701
A patient with brain metastases from prostatic cancer received chemotherapy using CDDP alone. A dose of 80 mg of CDDP was administered twice intravenously, followed by intra-arterial injections of 70 mg and 50 mg for the primary lesion over the course of three months. The main brain tumor showed a 70% decrease in size when estimated by CT, along with improvement of clinical symptoms related to the brain metastases. Intravenous injection of CDDP may thus have potential therapeutic value against metastatic brain tumors.

8. DOCID:14980 SCORE: 0.00194416240581217
DOCNO: 2876282
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Biological
QUALIFIER: therapy
AUTHOR: A P Forrest AP
AUTHOR: P A Levack PA
AUTHOR: U Chetty U
AUTHOR: R A Hawkins RA
AUTHOR: W R Miller WR
AUTHOR: J F Smyth JF
AUTHOR: T J Anderson TJ
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: A human tumour model.
PUBDATE: 19861001
An approach to the management of patients with large (greater than 4 cm) operable breast cancers is described. The conventional sequence of mastectomy followed by systemic therapy is reversed, allowing accurate measurements of response to individual forms of endocrine therapy or chemotherapy. Such a method not only permits individual selection of appropriate systemic therapy, but also allows clinical response to be related to histological and biochemical tumour parameters. A response was observed in eleven of twenty-three patients to endocrine treatment and in twelve of thirteen to combination chemotherapy. In five of the latter the response was histologically complete.

9. DOCID:9168 SCORE: 0.00193360941158773
DOCNO: 7163527
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Castration
QUALIFIER: secondary
QUALIFIER: therapy
AUTHOR: A Severini A
AUTHOR: J D Tesoro Tess JD
AUTHOR: S Oriana S
PUBTYPE: Journal Article
JOURNALTITLE: La Radiologia medica.
COUNTRY: ITALY
TITLE: [Effect of ovariectomy on bone metastases of breast cancer: analysis of radiographic pictures]
PUBDATE: 19821101
The radiograms of the skeleton of 41 patients with advanced breast cancer treated with bilateral ovariectomy were reviewed. The modifications in the secondary localizations and/or their appearance after castration were compared with the findings of the clinical examination. Appearance and progression of osteolytic lesions, corresponded to a clinical progression of the disease. Osteoblastic evolution of osteolytic lesions and the appearance of osteoblastic lesions in bones undamaged before ovariectomy were signs of a favorable response to therapy.

10. DOCID:15832 SCORE: 0.00188275096870351
DOCNO: 3469458
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: W J Blot WJ
AUTHOR: S S Devesa SS
AUTHOR: J F Fraumeni JF
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Declining breast cancer mortality among young American women.
PUBDATE: 19870301
Changes in age-specific breast cancer mortality rates among white females in the United States during 1950-80 were shown to be correlated with changes in patterns of childbearing in early adulthood. However, for the most recent 5-year period among women below age 40 years, small declines in breast cancer mortality were observed in the late 1970's, despite a predicted increase following delays in childbearing that began in the 1960's and despite evidence of a rising incidence of the cancer. Although correlation analyses have inherent limitations, the findings raise the possibility that recent changes in the detection and management of breast cancer have contributed to a lowered mortality from this cancer among young American women.

11. DOCID:10290 SCORE: 0.00185955379577195
DOCNO: 6727045
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nuclear Warfare
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: T Jubashi T
AUTHOR: T Matsuo T
AUTHOR: I Shimokawa I
AUTHOR: M Wago M
AUTHOR: T Ikeda T
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Epidemiological studies on thyroid cancer in Nagasaki City]
PUBDATE: 19840501
We studied 89 cases of thyroid cancer registered at the Nagasaki Tumor Registry during the period from 1973--1977. The incidence of thyroid cancer tended to be higher in persons exposed to the atomic bomb, especially women, than in the nonexposed population. Compared with nonexposed individuals, the relative risk for thyroid cancer was increased in distally as well as proximally exposed persons, but not in early entrants to the bombed city. In 83 histologically examined patients, papillary carcinomas were highly predominant, they were more prevalent in the exposed than in the nonexposed population.

12. DOCID:9364 SCORE: 0.00181050725279585
DOCNO: 6708302
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pelvis
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Sakamoto A
AUTHOR: T Kitagawa T
AUTHOR: H Sugano H
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Cervical adenocarcinoma: histologic staging and pelvic lymph node metastasis]
PUBDATE: 19840201
The relationship between histologic staging of cervical adenocarcinoma and pelvic lymph node metastasis was analyzed in 138 patients who had undergone hysterectomy. In AIS, the cervical glands were replaced by cancer. When glandular or solid cancer budding into the stroma was identified in AIS, it was designated Stage Ia adenocarcinoma. Pelvic lymph node metastases were found in cases with Stage Ib-III adenocarcinoma, but not in Stage Ia adenocarcinoma. This suggests that Stage Ia adenocarcinoma might be treated the same as AIS.

13. DOCID:10997 SCORE: 0.00169809216069839
DOCNO: 4061371
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: G A Omura GA
AUTHOR: J Hubbard J
AUTHOR: K Hatch K
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: Chemotherapy of cervix cancer with doxorubicin and cisplatin. A phase I pilot study of the Gynecologic Oncology Group.
PUBDATE: 19851001
Twelve women with previously irradiated advanced pelvic cancer were treated with doxorubicin and cisplatin to determine a maximum tolerable dose. Response was not an objective of this phase I study, but one partial response was seen in four cases of cervix cancer with measurable lesions. Hematologic toxicity was frequent and severe at the starting doses (doxorubicin 30 mg/M2 and cisplatin 100 mg/M2 every 3 weeks), but was acceptable when cisplatin was used at 75 mg/M2. Further evaluation of this combination in squamous carcinoma of the cervix is not recommended.

14. DOCID:12549 SCORE: 0.00162428827637571
DOCNO: 2432682
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
AUTHOR: K M Müller KM
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Thoracic and cardiovascular surgeon.
COUNTRY: GERMANY, WEST
TITLE: Pulmonary metastases. Pathological anatomy.
PUBDATE: 19861101
In 88 operative specimens topography, size and histopathological findings of lung metastases were analyzed. The stages of formation of metastases as the phase of invasion, embolization and implantation were differentiated by postmortem angiographies investigating the neo-vascularization of the metastases by 20 to 60 micron vessels. Analyses of metastases by morphological quantification of tumor regression after cytostatic therapy and immune histochemical examinations of lung metastases in unknown primary cancer have gained clinical importance.