0. DOCID:15506 SCORE: 0.00441659659740152
DOCNO: 3185198
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mathematical Computing
QUALIFIER: statistics & numerical data
QUALIFIER: statistics & numerical data
AUTHOR: A Iu Iakovlev AIu
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Biomathematical approaches to the problems of radiation biology and medicine]
PUBDATE: 19881101
A vast experience in the introduction of modern mathematical methods into research activities of the Central Research Roentgenoradiology Institute was accumulated in the Department of Biomathematics. The Information-retrieval System for Storage and Analysis of Data on the Activities of X-ray Service in the USSR, a package of applied programs for statistical analysis of radiation therapy effectiveness, a controlled data base on 6 cancer sites, 2 systems for simulation of radiation effects on heterogeneous cell systems were worked out. Some priority results in the fields of mathematical biology and statistical analysis of incomplete selective data were obtained. The Department is heading the work on the problem "Mathematics and computer technology in radiobiology and radiation biophysics".


1. DOCID:3773 SCORE: 0.00427809812227008
DOCNO: 1104491
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunologic Techniques
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A E Powell AE
AUTHOR: A M Sloss AM
AUTHOR: R N Smith RN
AUTHOR: J T Makley JT
AUTHOR: C A Hubay CA
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Specific responsiveness of leukocytes to soluble extracts of human tumors.
PUBDATE: 19751201
The leukocyte adherence inhibition (LAI) method was studied with respect to its specificity in detecting responses to extracts of tumor tissues or normal lymphocytes. Responses of cells from normal persons were within 10% of each other whether incubation was carried out with culture medium alone or with any of the extracts. The same was true of cells from 78 cancer patients unless the cells were incubated with extracts of the same histologic type as their own. In the latter case, statistically significant responses occurred in 95% of the 110 analyses done. Negative responses were given by cells from 14 patients tentatively diagnosed as having breast carcinoma but whose lesions later proved benign. There was one positive response inconsistent with the diagnosis. Of 29 normal individuals known to have been exposed to tumors or tumor extracts, 11 responded positively and specifically to the relevant tumor extract. Cells from 12 of 30 multiparous female breast-cancer patients responded to extracts of pooled normal lymphocytes. The results establish that the LAI analysis is an extremely specific means of detecting systemic responses to malignant diseases. In addition, analyses have proven positive in 95% of the cases studied.


2. DOCID:15579 SCORE: 0.00410469012867606
DOCNO: 2695654
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: G Dugue G
AUTHOR: G Bock G
AUTHOR: L Molho L
AUTHOR: J W Cordice JW
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the National Medical Association.
COUNTRY: UNITED STATES
TITLE: Breast cancer in the young.
PUBDATE: 19891101
Breast cancer in the young is rare. Some cases can be treated with modest surgical intervention and prognosis is good. We present a report of a 17-year-old black girl with adenocarcinoma of the breast. In our case, the disease pursued a devastatingly rapid course in spite of treatment and the patient died within 6 months of diagnosis. The literature relating to clinical experience with various types of breast carcinoma seen in pre- and postpubertal patients is also reviewed. We conclude that this case, and certain other cases cited, demonstrates the need for a high index of suspicion and earlier and more aggressive intervention in young patients with axillary breast masses.


3. DOCID:8474 SCORE: 0.00252011064353541
DOCNO: 7184463
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Plasma Exchange
QUALIFIER: therapy
QUALIFIER: secondary
AUTHOR: T Kamano T
AUTHOR: H Kishino H
AUTHOR: K Mizukami K
AUTHOR: N Azuma N
AUTHOR: J Tamura J
AUTHOR: T Kidokoro T
AUTHOR: S Yuasa S
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Plasma exchange therapy in colonic cancer with hepatic metastasis]
PUBDATE: 19820901
The plasma exchange using Carcino embryonic Antigen (CEA) value as an index was performed for 3 colonic cancer patients with liver metastasis. A remarkable regression of hepatomegaly in two cases with rectal cancer was obtained and a significant decrease of CEA was observed in all patients.


4. DOCID:14945 SCORE: 0.00230115264610243
DOCNO: 3593337
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: L G Baggetto LG
AUTHOR: A L Lehninger AL
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Isolated tumoral pyruvate dehydrogenase can synthesize acetoin which inhibits pyruvate oxidation as well as other aldehydes.
PUBDATE: 19870501
Oxidation of 1 mM pyruvate by Ehrlich and AS30-D tumor mitochondria is inhibited by acetoin, an unusual and important metabolite of pyruvate utilization by cancer cells, by acetaldehyde, methylglyoxal and excess pyruvate. The respiratory inhibition is reversed by other substrates added to pyruvate and also by 0.5 mM ATP. Kinetic properties of pyruvate dehydrogenase complex isolated from these tumor mitochondria have been studied. This complex appears to be able to synthesize acetoin from acetaldehyde plus pyruvate and is competitively inhibited by acetoin. The role of a new regulatory pattern for tumoral pyruvate dehydrogenase is presented.


5. DOCID:3145 SCORE: 0.00217915054639121
DOCNO: 412099
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
AUTHOR: W T Hughes WT
AUTHOR: S Kuhn S
AUTHOR: S Chaudhary S
AUTHOR: S Feldman S
AUTHOR: M Verzosa M
AUTHOR: R J Aur RJ
AUTHOR: C Pratt C
AUTHOR: S L George SL
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: The New England journal of medicine.
COUNTRY: UNITED STATES
TITLE: Successful chemoprophylaxis for Pneumocystis carinii pneumonitis.
PUBDATE: 19771201
In a randomized, double-blind, placebocontrolled study to evaluate the efficacy of trimethoprim-sulfamethoxazole for the prevention of Pneumocystis carinii pneumonia, we studied 160 patients with cancer who were at high risk for this pneumonia over a two-year period. Seventeen of the 80 patients receiving a placebo acquired P. carinii pneumonitis, whereas none of the 80 given 150 mg of trimethoprim and 750 mg of sulfamethoxazole per square meter per day had the infection P less than 0.01). Bacterial sepsis, pneumonia other than that caused by P. carinii, acute otitis media, upper-respiratory-tract infections, sinusitis and cellulitis occurred less frequently in recipients of the drug than in the placebo group (P less than 0.01 in each case). Oral candidiasis was the only adverse effect ecountered from trimethoprim-sulfamethoxazole administration. The study shows the combination to be highly effective in the prevention of P. carinii pneumonitis.


6. DOCID:11681 SCORE: 0.00211009588155456
DOCNO: 6748244
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Coitus
DESCRIPTOR: Urination
QUALIFIER: surgery
QUALIFIER: physiopathology
AUTHOR: S Kodaira S
AUTHOR: T Teramoto T
AUTHOR: J Kuromizu J
AUTHOR: M Ikoma M
AUTHOR: O Abe O
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Radical operation for rectal cancer to preserve anorectal, urinary and sexual function]
PUBDATE: 19840501
Recently, preservation of physiological functions have become to be considered in the operative treatment for rectal cancer. Dysfunction caused following radical operation for rectal cancer is divided into two parts as follows, (1) disturbance or loss of anorectal function due to sacrifice of the anus in abdomino-perineal resection and decrease function as fecal reservoir following anal sphincter preserving resection of the rectum. (2) anorectal, urinary and sexual dysfunction following surgical injury to the autonomic nerves by pelvic lymph nodes dissection. Our conceptions of the indication for sphincter preserving operation and for wide dissection of pelvic lymph nodes which cause severe dysfunction of urinary and sexual functions postoperatively were discussed.


7. DOCID:12878 SCORE: 0.00210966436938629
DOCNO: 2657851
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: R F Thoeni RF
AFFILIATION: CT/Gastrointestinal Section, University of California, San Francisco.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: CT evaluation of carcinomas of the colon and rectum.
PUBDATE: 19890701
Computed tomography (CT) has proved to be a powerful tool in the detection and staging of carcinomas of the colon and rectum. It is unsurpassed in the detection of recurrent colon cancer and is particularly useful in patients who have undergone abdominal-perineal resections for rectal neoplasms. The current applications of CT in colon cancer are contrasted with barium studies, endoscopy, and magnetic resonance imaging.


8. DOCID:15091 SCORE: 0.00202810896808167
DOCNO: 3167811
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Kamma H
AUTHOR: K Fujii K
AUTHOR: T Ogata T
AFFILIATION: Department of Pathology, University of Tsukuba, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Lymphocytic infiltration in juvenile thyroid carcinoma.
PUBDATE: 19881101
In this study, the significance of lymphocytic infiltration in juvenile thyroid carcinoma is clarified. We examined nine patients younger than 20 years of age. Histopathologically, there was good correlation between lymphocytic infiltration and the development and spread of carcinoma. It is believed that lymphocytic infiltration around the tumor is an immunologic reaction induced by antigens from the carcinoma itself, and also that the reaction may progress according to tumor development. Immunocytochemically, we determined what type of inflammatory cells infiltrated the thyroid and demonstrated HLA-DR expression in the cancer cells. These findings are similar to autoimmune thyroiditis in which antibody-dependent cellular cytotoxicity (ADCC) works as a main immunomechanism.


9. DOCID:7098 SCORE: 0.00197801529740062
DOCNO: 7421658
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colectomy
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: G L Barnes GL
AUTHOR: P E Campbell PE
AUTHOR: C W Chow CW
AUTHOR: L S Naidoo LS
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: Colectomy and cancer in Melbourne children with ulcerative colitis.
PUBDATE: 19800701
A search of hospital records dating from 1945 to 1977 inclusive identified 67 children with a definite diagnosis of ulcerative colitis, and 26 in whom the diagnosis was suspected, but not proven. Actuarial analysis of follow-up data available in December, 1978, indicated 75% patient survival after 18 years of disease, and 50% colon survival after 12 years of disease. Deaths were due to cancer (2 patients), complications of surgery (four patients) and incidental respiratory tract infection (one patient). Cancer risk was found to be lower than expected, which does not support the argument for prophylactic colectomy in childhood-onset disease. Restricting colectomy to medical indications during childhood will minimize the complications of colectomy without exposing the patient to risks greater than those of surgery itself.


10. DOCID:7096 SCORE: 0.00197318899746372
DOCNO: 7436853
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: C T Chung CT
AUTHOR: D D Rabuzzi DD
AUTHOR: R H Sagerman RH
AUTHOR: G A King GA
AUTHOR: R R Gacek RR
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Radiotherapy for carcinoma of the nasal cavity.
PUBDATE: 19801201
Twenty-five patients with primary epithelial carcinoma of the nasal cavity without nodal or distant metastases were treated by irradiation between 1967 and 1978. Small field, beam-directed techniques delivered 6,000 to 7,000 rads with conventional fractionation. Control of the primary tumor was achieved in 21 (84%) patients after irradiation. All five treatment failures (one infield only, three infield recurrence with lymph node metastases, and one regional cervical node metastasis) were evident within six months; all five patients died of cancer. The adjusted actuarial survival rate at three years was 76%. Failure in the untreated neck was only 5% when the primary carcinoma was controlled and 16% overall. The literature has been reviewed with attention to tumor control rates and survival.


11. DOCID:14968 SCORE: 0.0019441624059837
DOCNO: 3729499
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prostatic Neoplasms
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: N Miyaji N
AUTHOR: M Nakajo M
AUTHOR: K Ueki K
AUTHOR: H Kobayashi H
AUTHOR: S Onohara S
AUTHOR: S Shinohara S
AUTHOR: K Niimura K
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of metastatic brain tumor from prostatic cancer showing remarkable shrinkage following CDDP administration]
PUBDATE: 19860701
A patient with brain metastases from prostatic cancer received chemotherapy using CDDP alone. A dose of 80 mg of CDDP was administered twice intravenously, followed by intra-arterial injections of 70 mg and 50 mg for the primary lesion over the course of three months. The main brain tumor showed a 70% decrease in size when estimated by CT, along with improvement of clinical symptoms related to the brain metastases. Intravenous injection of CDDP may thus have potential therapeutic value against metastatic brain tumors.


12. DOCID:14980 SCORE: 0.00194416240581217
DOCNO: 2876282
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Biological
QUALIFIER: therapy
AUTHOR: A P Forrest AP
AUTHOR: P A Levack PA
AUTHOR: U Chetty U
AUTHOR: R A Hawkins RA
AUTHOR: W R Miller WR
AUTHOR: J F Smyth JF
AUTHOR: T J Anderson TJ
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: A human tumour model.
PUBDATE: 19861001
An approach to the management of patients with large (greater than 4 cm) operable breast cancers is described. The conventional sequence of mastectomy followed by systemic therapy is reversed, allowing accurate measurements of response to individual forms of endocrine therapy or chemotherapy. Such a method not only permits individual selection of appropriate systemic therapy, but also allows clinical response to be related to histological and biochemical tumour parameters. A response was observed in eleven of twenty-three patients to endocrine treatment and in twelve of thirteen to combination chemotherapy. In five of the latter the response was histologically complete.


13. DOCID:9168 SCORE: 0.00193360941158773
DOCNO: 7163527
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Castration
QUALIFIER: secondary
QUALIFIER: therapy
AUTHOR: A Severini A
AUTHOR: J D Tesoro Tess JD
AUTHOR: S Oriana S
PUBTYPE: Journal Article
JOURNALTITLE: La Radiologia medica.
COUNTRY: ITALY
TITLE: [Effect of ovariectomy on bone metastases of breast cancer: analysis of radiographic pictures]
PUBDATE: 19821101
The radiograms of the skeleton of 41 patients with advanced breast cancer treated with bilateral ovariectomy were reviewed. The modifications in the secondary localizations and/or their appearance after castration were compared with the findings of the clinical examination. Appearance and progression of osteolytic lesions, corresponded to a clinical progression of the disease. Osteoblastic evolution of osteolytic lesions and the appearance of osteoblastic lesions in bones undamaged before ovariectomy were signs of a favorable response to therapy.


14. DOCID:6118 SCORE: 0.00189072003722796
DOCNO: 679154
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: S Inutsuka S
AUTHOR: S Araki S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Plasma copper and zinc levels in patients with malignant tumors of digestive organs: clinical evaluation of the C1/Zn ratio.
PUBDATE: 19780801
The plasma copper level (PCL) and plasma zinc level (PZL) were determined in 126 patients: 54 had carcinomas of which 40 were carcinomas of the digestive organs, 37 had benign lesions, and 35 were without disease. The PCL increased and the PZL decreased significantly in the group with carcinoma of the digestive organs. The CuHZn ratio was not only significantly higher than in the normal group, but also was high in cases with advanced carcinoma especially when liver metastasis was present. Therefore, the Cu/Zn ratio may be valuable in estimating the extent of the carcinoma as well as in determining the prognosis of the cancer patients.