0. DOCID:27831 SCORE: 0.00304119400190962
DOCNO: 10222439
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: A Das A
AUTHOR: F H Hochberg FH
AUTHOR: S McNelis S
AFFILIATION: National University of Singapore, Singapore.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of neuro-oncology.
COUNTRY: NETHERLANDS
TITLE: A review of the therapy of paraneoplastic neurologic syndromes.
PUBDATE: 19990101
The therapy of paraneoplastic neurologic syndromes remains unclear and warrants a systematic review of the literature. Reports in English and foreign language literature were abstracted. Data were sorted by the primary paraneoplastic neurologic syndrome, the primary malignancy, and the methods of treatment. Neurologic improvement follows surgical, chemotherapeutic, and radiation treatments. Adjuvant immunosuppressive therapy with steroids, plasmapheresis, or immunoglobulin may help stabilize the progression of neurologic symptoms. Syndromes characterized by inflammation or neurotransmitter production without neuronal loss are most responsive to therapy. While treatment of the underlying cancer with appropriate surgery, chemotherapy, and radiation is recommended, the paraneoplastic syndrome should probably be managed with immunosuppressive therapy.

1. DOCID:26941 SCORE: 0.00265428180805831
DOCNO: 10888265
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: E Bolton E
AUTHOR: J King J
AUTHOR: D L Morris DL
AFFILIATION: University of New South Wales, Department of Surgery, St George Hospital, Sydney, Australia.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: H2-antagonists in the treatment of colon and breast cancer.
PUBDATE: 20000201
Several clinical trials have now been carried out with histamine type 2 receptor antagonists in cancer patients often as an adjunct to surgical resection of the primary tumour While promising results have been obtained in some groups of patients with gastrointestinal cancer, with increased survival and evidence of increased immunological recognition of tumour, results are less encouraging for breast cancer. This may be due to differences in the levels of histamine or the role of histamine in growth of these different tumour types.

2. DOCID:25549 SCORE: 0.00235922353197303
DOCNO: 11910667
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Status
DESCRIPTOR: Menopause
QUALIFIER: complications
AUTHOR: R J Norman RJ
AUTHOR: E McVeigh E
AFFILIATION: Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, University of Adelaide, Australia.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Climacteric : the journal of the International Menopause Society.
COUNTRY: United States
TITLE: Polycystic ovary syndrome and implications for the menopause.
PUBDATE: 19990601
Polycystic ovary syndrome (PCOS) is the most common endocrine condition of premenopausal women and has significant metabolic abnormalities that could have an impact after the menopause. Diabetes mellitus, hyperlipidemia and hyperinsulinemia could potentially affect health in this era of life. Endometrial cancer, due to unopposed estrogen action, is more common where progestins have not been given for menstrual dysfunction. Preventive management earlier in life will avoid postmenopausal problems in PCOS.

3. DOCID:27853 SCORE: 0.00222151942026253
DOCNO: 9674324
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Graft Survival
DESCRIPTOR: Skin Transplantation
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
AUTHOR: R K Caldwell RK
AUTHOR: W C Giles WC
AUTHOR: P T Davis PT
AFFILIATION: Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Ear, nose, & throat journal.
COUNTRY: UNITED STATES
TITLE: Use of foam bolsters for securing facial skin grafts.
PUBDATE: 19980601
Many methods of securing skin grafts to their recipient beds have been described. A review of the senior author's experience with facial skin cancers over a two-year period revealed that reconstruction with full-thickness skin grafts was employed in 60 of more than 500 cases. This series of 60 cases was reviewed. Uses of foam as a bolster has proven to be a simple, time-conserving and reliable technique that produces consistently excellent results with a low complication rate. The technique is reviewed, along with its advantages and disadvantages.

4. DOCID:25259 SCORE: 0.00215176742782958
DOCNO: 11715941
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
DESCRIPTOR: Liposomes
QUALIFIER: therapy
AUTHOR: D D Lasic DD
AUTHOR: J J Vallner JJ
AUTHOR: P K Working PK
AFFILIATION: Liposome Consultations, Newark, CA 94560, USA. Dan.Lasic@roche.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in molecular therapeutics.
COUNTRY: England
TITLE: Sterically stabilized liposomes in cancer therapy and gene delivery.
PUBDATE: 19990401
The introduction of colloidally stable liposomes with low drug leakage rates resulted in a renaissance in liposome applications in cancer therapy. Furthermore, a platform of sterically stabilized liposomes also allows the construction of new generations of drug delivery vehicles. These include targeted liposomes and targeted nucleic acid delivery vehicles, based either on cationic sterically stabilized liposomes or pre-condensed DNA encapsulated in neutral or negatively charged liposomes.

5. DOCID:26335 SCORE: 0.00205853143892001
DOCNO: 10559762
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genetic Predisposition to Disease
DESCRIPTOR: Mass Screening
QUALIFIER: physiopathology
QUALIFIER: diagnosis
QUALIFIER: genetics
AUTHOR: C L Clericuzio CL
AFFILIATION: University of New Mexico Pediatrics, ACC3, Albuquerque, NM 87131-5311, USA. ccleri@salud,unm.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of medical genetics.
COUNTRY: UNITED STATES
TITLE: Recognition and management of childhood cancer syndromes: a systems approach.
PUBDATE: 19990601
Recognition of congenital anomalies that predispose to childhood cancer allows for the institution of a cancer surveillance program, identification of relatives with increased cancer risk, and recurrence risk counseling. In this article, a systems approach to the diagnosis of 21 childhood cancer syndromes is set forth in the format of the pediatric physical examination. In the second part of this article, guidelines are presented for genetic testing, cancer screening, and genetic counseling for the 21 cancer syndromes.

6. DOCID:26825 SCORE: 0.00204477421409696
DOCNO: 11380352
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: psychology
QUALIFIER: etiology
AUTHOR: F J Andrews FJ
AFFILIATION: BreastScreen Victoria Inc., Carlton, Victoria, Australia. fionaa@breastscreen.org.au
PUBTYPE: Journal Article
JOURNALTITLE: Australasian radiology.
COUNTRY: Australia
TITLE: Pain during mammography: implications for breast screening programmes.
PUBDATE: 20010501
Pain experienced during mammography can deter women from attending for breast cancer screening. Review of the current literature on pain experienced during mammography reveals three main areas of interest: reports of the frequency of pain, identification of predictors of pain and strategies for responding to pain. Implications of this literature for breast screening programmes include the need for appropriate measurements of pain during mammography that are valid for screening populations, a further understanding of organizational factors involved in screening programmes that may be predictors of pain and for the development of valid strategies for responding to pain within breast screening programmes.

7. DOCID:27055 SCORE: 0.0020192237361665
DOCNO: 10910149
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: radiotherapy
AUTHOR: C C Lamb CC
AUTHOR: P Meskell P
AUTHOR: E J Holupka EJ
AFFILIATION: Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts, USA. clamb@caregroup.harvard.edu
PUBTYPE: Journal Article
JOURNALTITLE: Journal of endourology / Endourological Society.
COUNTRY: UNITED STATES
TITLE: Analysis of prostate seed loading for permanent implants.
PUBDATE: 20000501
The goal of radioactive seed implantation in prostate cancer is to treat the tumor to the necessary dose while minimizing the dose to adjacent normal structures. The uniform and peripheral loading schemes used in the past have serious limitations. However, with the availability of three-dimensional treatment-planning systems, it has become possible to do custom volume loading based on volumetric ultrasound imaging of the gland. As a result, the dose distributions are more uniform, and the doses to the urethra and rectum are maintained in a safe range.

8. DOCID:26959 SCORE: 0.0019909877571237
DOCNO: 10366135
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Plants, Toxic
QUALIFIER: chemistry
PUBTYPE: Journal Article
JOURNALTITLE: MMWR. Morbidity and mortality weekly report.
COUNTRY: UNITED STATES
TITLE: Determination of nicotine, pH, and moisture content of six U.S. commercial moist snuff products--Florida, January-February 1999.
PUBDATE: 19990501
The use of smokeless tobacco (moist snuff and chewing tobacco) can cause oral cancer and precancerous oral lesions (leukoplakia) and is a risk factor for cardiovascular diseases and nicotine addiction. Despite these adverse effects, smokeless tobacco is used commonly in the United States by young people, especially male high school students. Officials in Florida requested CDC assistance in analyzing six moist snuff products to measure three factors that affect their nicotine dose: pH, nicotine content, and moisture content. This report summarizes the results of the analysis, which indicate that the pH, amount of nicotine, and moisture vary widely among brands.

9. DOCID:24574 SCORE: 0.00192653323743948
DOCNO: 10739716
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fertility
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: J M Andrade JM
AUTHOR: H R Marana HR
AUTHOR: L F Mangieri LF
AUTHOR: A C Matthes AC
AUTHOR: S P Cunha SP
AUTHOR: S Bighetti S
AFFILIATION: Department of Gynecology and Obstetrics of Medical School of Ribeirão Preto, University of São Paulo, SP, Brazil.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Successful preservation of fertility subsequent to a complete pathologic response of a squamous cell carcinoma of the uterine cervix treated with primary systemic chemotherapy.
PUBDATE: 20000401
This is the first report about a successful pregnancy following treatment for advanced cervical cancer.

10. DOCID:26179 SCORE: 0.00185710324326111
DOCNO: 11794059
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymph Node Excision
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: D Chlapík D
AUTHOR: M Gogora M
AFFILIATION: Chirurgické oddelenie NsP, Trencín, Slovenská republika.
PUBTYPE: Journal Article
JOURNALTITLE: Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti.
COUNTRY: Czech Republic
TITLE: [Gastric carcinoma and mediastinal lymph nodes]
PUBDATE: 20011101
The objective of the work was to assess the impact of the shift of gastric cancer in an oral direction in the mediastinal lymph nodes. For this purpose a new miniinvasive lower mediastinoscopy was used in 30 patients. The method is safe and can be used also in other situations. Mediastinal metastases may occur in cancer in the distal and medium third of the stomach. They need not be present when cancer is in the upper third. The shift of gastric carcinoma did not influence the mediastinal nodes.

11. DOCID:26171 SCORE: 0.00185710239984376
DOCNO: 9759681
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: therapy
PUBTYPE: Guideline
PUBTYPE: Journal Article
PUBTYPE: Practice Guideline
PUBTYPE: Review
JOURNALTITLE: Archives of internal medicine.
COUNTRY: UNITED STATES
TITLE: Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults.
PUBDATE: 19980901
An estimated 97 million adults in the United States are overweight or obese, a condition that substantially raises their risk of morbidity from hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis, sleep apnea and respiratory problems, and endometrial, breast, prostate, and colon cancers. Higher body weights are also associated with increases in all-cause mortality. Obese individuals may also suffer from social stigmatization and discrimination. As a major contributor to preventive death in the United States today, overweight and obesity pose a major public health challenge.

12. DOCID:27547 SCORE: 0.00183785184444254
DOCNO: 11222105
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: methods
AUTHOR: C Lee C
AUTHOR: D Gisselsson D
AUTHOR: C Jin C
AUTHOR: A Nordgren A
AUTHOR: D O Ferguson DO
AUTHOR: E Blennow E
AUTHOR: J A Fletcher JA
AUTHOR: C C Morton CC
AFFILIATION: Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA 02115, USA.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of human genetics.
COUNTRY: United States
TITLE: Limitations of chromosome classification by multicolor karyotyping.
PUBDATE: 20010401
Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schröck et al.1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful in prenatal, postnatal, and cancer cytogenetics. However, these technologies have inherent limitations that, in certain situations, may result in chromosomal misclassification. In this report, we present nine cases, which fall into five categories, in which multicolor karyotyping has produced erroneous interpretations. Most errors appear to have a similar mechanistic basis.

13. DOCID:27467 SCORE: 0.00176867936831906
DOCNO: 10855376
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Analgesia
DESCRIPTOR: Analgesics, Opioid
DESCRIPTOR: Methadone
AUTHOR: S Donnadieu S
AFFILIATION: Unité d'Evaluation et de Traitement de la Douleur, Hôpital Laennec, Paris.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annales de médecine interne.
COUNTRY: FRANCE
TITLE: [Use of methadone as analgesic]
PUBDATE: 20000401
Methadone is a synthetic opioid agonist which is mostly used for drug maintenance therapy in opioid addicts. It has also proven to be a powerful analgesic four times more powerful than oral morphine. The main indication is cancer pain as an alternative to oral morphine in case of tolerance or side effects due to accumulation of active metabolites. Methadone however shows wide inter-individual variability in half-life necessitating a carefully scheduled administration scheme. Side effects are similar for morphine and methadone. Methadone might be a safe and effective analgesic in patients with renal disease because its metabolites are almost exclusively excreted in the feces.

14. DOCID:26255 SCORE: 0.00165169618770886
DOCNO: 9650020
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diet
DESCRIPTOR: Nutrition
QUALIFIER: etiology
AUTHOR: D D Hensrud DD
AUTHOR: D C Heimburger DC
AFFILIATION: Division of Preventive Medicine, Mayo Medical School, Rochester, Minnesota, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastroenterology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Diet, nutrients, and gastrointestinal cancer.
PUBDATE: 19980601
Tobacco and alcohol use are strong risk factors for cancer of the upper gastrointestinal tract. Saturated fat and red meat intake also appear to increase the risk of colorectal cancer. The strongest and most consistent dietary protective factors for gastrointestinal cancer are vegetables and fruits. Some micronutrients show beneficial effects, but the degree of protection is less than that observed from whole plant foods. Substantial decreases in the morbidity and mortality from gastrointestinal cancer could occur with more widespread adoption of dietary guidelines designed for cancer prevention.