0. DOCID:22749 SCORE: 0.00361311674335455
DOCNO: 7867546
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: J A Adwok JA
AFFILIATION: Department of Surgery, College of Health Sciences, University of Nairobi, Kenya.
PUBTYPE: Journal Article
JOURNALTITLE: East African medical journal.
COUNTRY: KENYA
TITLE: Treatment of thyroid cancer.
PUBDATE: 19940801
The management of differentiated thyroid cancer remains controversial. A consecutive series of 234 thyroidectomies done by one surgeon in various Nairobi Hospitals from July 1990 to June 1993 were studied. 18 patients were operated on for thyroid cancer. The procedures ranged from lobectomy to total thyroidectomy. Young adults from 20-40 years of age were mainly affected, with a male/female sex ratio of 8:1. The immediate and subsequent morbidity of the operation of total thyroidectomy, in our opinion, overweighs its advantages of improved disease control. This is particularly so when low socio-economic standards lead to lack of compliance with replacement therapy.


1. DOCID:23090 SCORE: 0.00321378100738071
DOCNO: 7962737
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: etiology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T T Kirchmann TT
AUTHOR: B R Smoller BR
AUTHOR: J McGuire J
AFFILIATION: Department of Dermatology, Stanford University Medical Center, Palo Alto, CA 94304.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the American Academy of Dermatology.
COUNTRY: UNITED STATES
TITLE: Cutaneous angiosarcoma as a second malignancy in a lymphedematous leg in a Hodgkin's disease survivor.
PUBDATE: 19941101
Angiosarcoma is a rare and highly malignant neoplasm. Cutaneous angiosarcoma not associated with postmastectomy lymphedema is rare. There are only eight reported cases of development of cutaneous angiosarcoma in a lymphedematous extremity in a patient with preexisting malignancy other than breast cancer. This is the first reported case of development of cutaneous angiosarcoma in a lymphedematous extremity in a Hodgkin's disease survivor. A review of cutaneous angiosarcoma associated with lymphedema and a discussion of the pathogenesis of angiosarcoma are included.


2. DOCID:23072 SCORE: 0.00296581631623704
DOCNO: 9080214
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Interleukin-6
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: T Chard T
AFFILIATION: Department of Reproductive Physiology, St Bartholomew's Hospital Medical College, London, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Human reproduction update.
COUNTRY: ENGLAND
TITLE: Cytokines in implantation.
PUBDATE: 19950701
The process of implantation in the human involves 'invasion' of the maternal endometrium by the trophoblast surrounding the developing blastocyst, in response to which there is a cellular reaction in the endometrium. The overall situation has some features analogous to invasion by a tumour and some which are more characteristic of an inflammatory response. In addition, and also in common with cancer and inflammation, there is a release of biologically active molecules, including cytokines, at and around the implantation site. It is believed that these cytokines may play an important role in the successful establishment of the pregnancy; the evidence for this belief is examined in this review.


3. DOCID:23197 SCORE: 0.00288613814766123
DOCNO: 8689512
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: biosynthesis
AUTHOR: K Nishimura K
AUTHOR: M Higashino M
AUTHOR: T Hara T
AUTHOR: T Oka T
AFFILIATION: Department of Urology, Minoh City Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: Bladder cancer producing granulocyte colony-stimulating factor: a case report.
PUBDATE: 19960301
A rare case of bladder cancer producing granulocyte colony-stimulating factor (G-CSF) is reported. A 63-year-old man with a progressive, grade 3 transitional cell bladder carcinoma, showed marked leukocytosis (maximum 181,800/mm3) and an elevated serum G-CSF to 131.7 pg/mL. After radical cystectomy and neoadjuvant chemotherapy, the tumor recurred locally. Immunohistochemical examination with monoclonal antibody specific for G-CSF revealed positive staining in the local recurrent tumor. To our knowledge, there have been only seven cases reported of bladder cancer producing G-CSF.


4. DOCID:23141 SCORE: 0.00288612305358963
DOCNO: 8948553
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: C Müller C
AUTHOR: C Schinkel C
AUTHOR: H Hoffmann H
AUTHOR: H Dienemann H
AUTHOR: F W Schildberg FW
AFFILIATION: Department of Surgery, Klinikum Grosshadern, Ludwig-Maximilians University, München, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: The Thoracic and cardiovascular surgeon.
COUNTRY: GERMANY
TITLE: Bronchoplastic resection for non-small-cell lung cancer.
PUBDATE: 19961001
During the past 12 years, among 1478 operations for non-small-cell lung cancer (NSCLC), 102 (6.9%) bronchosplastic resections were performed. There were 74 lobectomies, 19 bilobectomies, and 9 pneumonectomies done by means of 72 sleeve-, 28 wedge resections, and 2 resections of the tracheal bifurcation. Atelectasis was observed in 6%, whereas anastomotic dehiscence occurred in 4%. Local complete resection was achieved in 81%. The 30-day mortality amounted to 4%. Our results demonstrate that bronchoplastic procedures represent a safe therapeutic option in the operative treatment of central NSCLC.


5. DOCID:23731 SCORE: 0.00258654068581103
DOCNO: 9055043
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bayes Theorem
DESCRIPTOR: Neural Networks (Computer)
QUALIFIER: diagnosis
QUALIFIER: methods
AUTHOR: C E Kahn CE
AUTHOR: L M Roberts LM
AUTHOR: K A Shaffer KA
AUTHOR: P Haddawy P
AFFILIATION: Department of Radiology, Medical College of Wisconsin, Milwaukee 53226, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Computers in biology and medicine.
COUNTRY: UNITED STATES
TITLE: Construction of a Bayesian network for mammographic diagnosis of breast cancer.
PUBDATE: 19970101
Bayesian networks use the techniques of probability theory to reason under uncertainty, and have become an important formalism for medical decision support systems. We describe the development and validation of a Bayesian network (MammoNet) to assist in mammographic diagnosis of breast cancer. MammoNet integrates five patient-history features, two physical findings, and 15 mammographic features extracted by experienced radiologists to determine the probability of malignancy. We outline the methods and issues in the system's design, implementation, and evaluation. Bayesian networks provide a potentially useful tool for mammographic decision support.


6. DOCID:22427 SCORE: 0.00250263089907143
DOCNO: 9342508
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: congenital
QUALIFIER: complications
AUTHOR: G Gherardini G
AUTHOR: N Bhatia N
AUTHOR: S Stal S
AFFILIATION: Department of Plastic Surgery, Texas Children's Hospital, Houston, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinics in plastic surgery.
COUNTRY: UNITED STATES
TITLE: Congenital syndromes associated with nonmelanoma skin cancer.
PUBDATE: 19971001
Syndromes associated with nonmelanoma skin cancer are part of a group of inherited disorders characterized by a wide variety of clinical manifestations including palmar and plantar pitting, calcification of the dura, jaw cysts, and skeletal abnormalities. The syndromes have in common skin lesions progressing to basal or squamous cell cancers. In addition to skin tumors, bone and visceral tumors are common. Early diagnosis, genetic counseling, and treatment of skin lesions are appropriate tools for the management of patients with these syndromes. Surgical procedures generally involve total resection combined with reconstructive efforts.


7. DOCID:23703 SCORE: 0.00229729624298603
DOCNO: 9411996
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adenoviruses, Human
DESCRIPTOR: Apoptosis
DESCRIPTOR: Gene Therapy
DESCRIPTOR: Gene Transfer Techniques
DESCRIPTOR: Genes, p16
DESCRIPTOR: Genes, p53
AUTHOR: B V Sandig BV
AUTHOR: K Brand K
AUTHOR: S Herwig S
AUTHOR: J Lukas J
AUTHOR: J Bartek J
AUTHOR: M Strauss M
AFFILIATION: Max-Planck-Gesellschaft, Berlin.
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [p16 and p53 genes transferred with the help of adenovirus to induce apoptic tumor cell death]
PUBDATE: 19971101
Based on studies of the cell cycle in tissue cultures of cancer cell lines and cells from normal tissue interference in the regulatory network of pRB/cdk4/cyclin D1/p16 in combination with the tumour suppressor gene p53 was investigated. It was shown that overexpression of p53 and p16, but not p53 on its own, induced apoptotic cell death only in tumour cells. Gene transfer of the same two genes to tumours transplanted subcutaneously in mice also caused fast regression of some of the tumours.


8. DOCID:23416 SCORE: 0.00228916403035647
DOCNO: 8904385
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: K Kwekkeboom K
AFFILIATION: University of Wisconsin Hospital and Clinics, Madison, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer nursing.
COUNTRY: UNITED STATES
TITLE: Postmastectomy pain syndromes.
PUBDATE: 19960201
Pain associated with cancer and its treatment continues to be a significant concern for those persons diagnosed with the illness. This article will focus on pain syndromes associated with surgical interventions for women with breast cancer. Postmastectomy pain syndromes including postaxillary dissection pain and phantom breast pain will be described in terms of their nature, incidence, and temporal course based on current literature findings. Treatment strategies and implications for nursing interventions employed in caring for these women will also be discussed. Nurses can use information about postmastectomy pain syndromes to educate their patients, to cooperate in successfully managing effects of the disease and treatment, and to help women cope after breast cancer surgery.


9. DOCID:23864 SCORE: 0.00200192755807297
DOCNO: 7627835
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: K Koiso K
AUTHOR: H Akaza H
AUTHOR: M Ohtani M
AUTHOR: N Miyanaga N
AUTHOR: K Aoyagi K
AFFILIATION: Department of Urology, University of Tsukuba, Ibaraki, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: A new tumor marker for bladder cancer.
PUBDATE: 19940301
Biochemical assay and immunohistochemical staining of neutral endopeptidase were performed on bladder cancer cells. In superficial bladder cancer the enzyme activity and immunohistochemical intensity of staining were high, while invasive bladder cancer showed only a low level of activity. This finding suggests that neutral endopeptidase is expressed at a certain stage of cell differentiation, during the neoplastic process in the bladder. Gene expression is assumed to be closely correlated with this mechanism. From the results of this study neutral endopeptidase will serve as a new tumor marker for bladder cancer as well as acute lymphatic leukemia.


10. DOCID:23898 SCORE: 0.0020019193533162
DOCNO: 7992713
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: surgery
AUTHOR: T Miki T
AUTHOR: S Saki S
AUTHOR: T Kotake T
AFFILIATION: Department of Urology, Osaka University Hospital.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [The role of salvage surgery following chemotherapy in advanced testicular cancer]
PUBDATE: 19941001
Twenty-seven patients with advanced testicular cancer underwent cisplatin-based combination chemotherapy and followed by salvage surgery. Complete necrosis and/or fibrosis (necrosis) was found in 12 (44%) operative specimens, mature teratoma in 5 (19%) and residual cancer in 10 (37%) patients. Ten of the 12 (83%) patients with necrosis and all 5 with mature teratoma were rendered disease-free (NED). Only 6 of the 10 (60%) patients with residual cancer were continuously NED. These findings suggest that if carcinoma is found in the resected specimen, further salvage chemotherapy is required. Salvage surgery should be avoided in patients with elevated serum tumor marker levels.


11. DOCID:22832 SCORE: 0.00194945412991014
DOCNO: 7807042
AUTHOR: D G Ferris DG
AUTHOR: M J Messing MJ
AUTHOR: J H Crosby JH
AFFILIATION: Department of Family Medicine, Medical College of Georgia, Augusta 30912-3500.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of family practice.
COUNTRY: UNITED STATES
TITLE: Vaginal intraepithelial neoplasia III detected after hysterectomy for benign conditions.
PUBDATE: 19950101
Because primary vaginal cancer is rare, many experts discourage routine cytologic sampling of the vaginal vault following hysterectomy for benign circumstances. The following report describes a case of vaginal intraepithelial neoplasia III (VAIN III) detected by a vaginal vault Papanicolaou smear obtained from an asymptomatic 57-year-old woman 23 years after she had a total abdominal hysterectomy for a benign condition. As VAIN III is a true vaginal cancer precursor, the innocent disregard of recommended screening practices averted significant morbidity and possibility mortality for this otherwise healthy woman.


12. DOCID:22650 SCORE: 0.00188689065902696
DOCNO: 8592802
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Saguinus
QUALIFIER: veterinary
QUALIFIER: analysis
QUALIFIER: veterinary
QUALIFIER: analysis
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: M Brack M
AFFILIATION: German Primate Center, Göttingen, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Veterinary pathology.
COUNTRY: UNITED STATES
TITLE: Lectin histochemistry and carcinoembryonic antigen in spontaneous colonic cancers of cotton-top tamarins (Saguinus oedipus).
PUBDATE: 19951101
The glycoconjugate-binding properties and the expression of carcinoembryonic antigen in colonic cancers of cotton-top tamarins at the German Primate Center are described. Deviating from findings in non-tumorous colonic epithelia of cotton-top tamarins was the presence of UEA-, SBA-, or DBA-binding sites in the infranuclear cytoplasm of colonic epithelial cells, staining of entire cells, and the occurrence of subepithelial extracellular glycoconjugates in and adjacent to colonic cancers. Carcinoembryonic antigen, which normally was limited to the fuzzy coat of the colonic epithelium, was demonstrated in the cytoplasm of the cancer cells.


13. DOCID:23768 SCORE: 0.0018543006485315
DOCNO: 7728740
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: drug effects
AUTHOR: O Larsson O
AUTHOR: H Blegen H
AFFILIATION: Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer biochemistry biophysics.
COUNTRY: ENGLAND
TITLE: Inhibitory effect of mevalonate on the EGF mitogenic signaling pathway in human breast cancer cells in culture.
PUBDATE: 19941001
The relationship between the effects of EGF and mevalonate on proliferation of the breast cancer cell line Hs578T was investigated. When Hs578T cells were depleted of serum their proliferation was drastically retarded. This was partially counteracted by insulin or IGF-1 but not by EGF. However, if the activity of HMG-CoA reductase was inhibited, there was a significant increase in DNA synthesis of EGF-treated cells. This effect was not seen in cells stimulated by insulin or IGF-1, and was prevented by addition of mevalonate. The results suggest that mevalonate, or some of its products, inhibits steps in the EGF signal pathway.


14. DOCID:20751 SCORE: 0.00180249825716814
DOCNO: 10174019
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Professional-Patient Relations
DESCRIPTOR: Social Support
QUALIFIER: psychology
QUALIFIER: standards
AUTHOR: P Harvey P
AFFILIATION: Birmingham Oncology Centre, Queen Elizabeth Hospital, UK.
PUBTYPE: Journal Article
JOURNALTITLE: The Health service journal.
COUNTRY: ENGLAND
TITLE: Cancer services. Minding body and soul.
PUBDATE: 19971101
The psychosocial impact of cancer on patients' families and carers, as well as patients themselves, needs to be considered at all stages of diagnosis and treatment. The Calman-Hine report specified this principle but did not state how it should be put into action. Everyone who comes into contact with people with cancer should have the confidence to ask: 'How do you feel?' Standards should be incorporated into contracts.