0. DOCID:14257 SCORE: 0.00439816417793561
DOCNO: 2935793
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: R N Everett RN
AUTHOR: F L Jones FL
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Warfarin-induced skin necrosis. A cutaneous sign of malignancy?
PUBDATE: 19860201
Patchy necrosis of the skin is a rare and unpredictable complication of oral anticoagulant therapy. Of the four patients that we have seen with this disorder, three had metastatic adenocarcinoma; in two, this was an unexpected finding. The association of a malignant neoplasm with warfarin-induced skin necrosis has not been emphasized previously. Whether such necrosis represents a clue to the presence of cancer or occurs only coincidentally in patients requiring anticoagulant therapy because of adenocarcinoma-associated thrombophlebitis must await further experience. A congenital or acquired deficiency of protein C may be the primary initiating factor.

1. DOCID:14220 SCORE: 0.00439816233035121
DOCNO: 3421412
AUTHOR: K R Mittal KR
AUTHOR: K W Barwick KW
AFFILIATION: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of surgical pathology.
COUNTRY: UNITED STATES
TITLE: Diffusely infiltrating adenocarcinoma of the endometrium. A subtype with poor prognosis.
PUBDATE: 19881001
We studied cases of stage I endometrial adenocarcinoma encountered at our institution during the period 1970-80. Five out of 164 of these tumors showed a diffusely infiltrating pattern of growth. Two of the five patients died of cancer within 5 years, with a 5-year mortality of 40%. A control group of 15 patients seen over the same period showed a 5-year mortality of 13.3%. Thus, the diffusely infiltrating pattern of growth was indicative of poor prognosis in endometrial carcinoma in stage I disease.

2. DOCID:15056 SCORE: 0.00431419113343557
DOCNO: 3004727
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: M Huberman M
AUTHOR: J Lokich J
AUTHOR: R Greene R
AUTHOR: S Paul S
AUTHOR: D Phillips D
AUTHOR: H Sonneborn H
AUTHOR: T Zipoli T
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Vinblastine plus cisplatin in advanced non-small cell lung cancer: lack of advantage for vinblastine infusion schedule.
PUBDATE: 19860201
We have evaluated 31 patients with advanced non-small cell lung cancer treated by short-term 5-day vinblastine infusion combined with bolus cisplatin. Nine of 31 patients (29%) had partial and complete responses. Although five of nine (55%) of the responders were alive at greater than or equal to 1 year, three of the 31 patients experienced drug-related mortality. Our experience, as well as a review of previously reported trials in the literature, suggests that the infusion schedule of vinblastine offers no advantage over the bolus schedule.

3. DOCID:14978 SCORE: 0.00315892546768394
DOCNO: 3126708
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Postoperative Care
QUALIFIER: therapeutic use
QUALIFIER: analogs & derivatives
QUALIFIER: therapy
AUTHOR: K Yoshinaka K
AUTHOR: T Tanaka T
AUTHOR: S Takagami S
AUTHOR: T Saeki T
AUTHOR: M Nishiyama M
AUTHOR: T Toge T
AUTHOR: M Niimoto M
AUTHOR: T Hattori T
AFFILIATION: Dept. of Surgery, Hiroshima University.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Prospective randomized controlled study of bestatin in gastric cancer surgery]
PUBDATE: 19880301
The effectiveness of bestatin combined with mitomycin C and tegafur as an adjuvant to surgery for gastric cancer was investigated in a prospective randomized controlled study. All patients underwent curative gastrectomy during the period from November 1980 to April 1984. Five-year survival rate revealed no significant difference between groups with or without bestatin. The effectiveness of bestatin was suggested in postoperative peritoneal recurrence in cases with positive histological invasion into the veins of the stomach wall.

4. DOCID:14958 SCORE: 0.00315892328472547
DOCNO: 3779619
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: F K Kozak FK
AUTHOR: J G Hall JG
AUTHOR: P A Baird PA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Familial breast cancer in males. A case report and review of the literature.
PUBDATE: 19861201
The occurrence of breast cancer in two related males, an uncle and nephew is reported. A review of previously reported cases of male breast cancer occurring in families and the association with other cancers in other family members is included. In previous reports on breast cancer in males, familial or hereditary factors have not generally been recognized as a major contributing factor. Of ten families reported (including our own) where there is sufficient information given, six families (60%) had females with breast cancer. It appears there are some families in which males as well as females have an increased risk of developing breast cancer.

5. DOCID:15101 SCORE: 0.0031139540179002
DOCNO: 2838290
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: secondary
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: P E Kristjansen PE
AUTHOR: H H Hansen HH
AFFILIATION: Department of Oncology ONB, Finsen Institute, Copenhagen.
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: Brain metastases from small cell lung cancer treated with combination chemotherapy.
PUBDATE: 19880301
Ten patients with metastatic small cell lung cancer (SCLC) in the brain, shown by CT scan at time of diagnosis, were treated with systemic combination chemotherapy. Repeated CT scans were performed every 4 weeks. Seven patients were evaluable, since three patients died during the first 2-3 weeks. Significant responses on CT scans as well as neurologic improvement were demonstrated in all evaluable patients. Four of seven patients obtained a complete response in the brain, while three had partial remissions. The impact of this observation on the overall treatment strategies in SCLC has further to be defined.

6. DOCID:15680 SCORE: 0.00307628887567933
DOCNO: 2515763
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: N Mikata N
AUTHOR: S Imao S
AUTHOR: Y Tanaka Y
AUTHOR: D Horiuchi D
AUTHOR: G Matsumoto G
AUTHOR: K Hasegawa K
AFFILIATION: Department of Urology, Tokyo Metropolitane Bokutoh Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [A case of renal cancer complicated with acute hypercalcemia and acute pancreatitis]
PUBDATE: 19891101
A 55-year-old man who had liver metastasis after undergoing surgery for renal cancer was hospitalized immediately on May 4, 1987 with complaints of general malaise, epigastric pain, nausea and vomiting. Because of abnormally high levels of blood calcium 15.6 mg/dl and serum amylase 2,069 IU/l, the case was diagnosed as hypercalcemic crisis and acute pancreatitis. Following recovery from the critical stage with administration of elcatonin and FOY, therapy for cancer initiated. We report the clinical course of this patient and discuss about hypercalcemia and acute pancreatitis as cases of oncologic emergency.

7. DOCID:15273 SCORE: 0.00300450865084621
DOCNO: 3412210
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Food Habits
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: adverse effects
AUTHOR: T F Warner TF
AUTHOR: E A Azen EA
AFFILIATION: Department of Pathology, University of Wisconsin, University Hospital, Madison 53792.
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Tannins, salivary proline-rich proteins and oesophageal cancer.
PUBDATE: 19880601
No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properties of tannins and extracts of tannin-rich plants have been demonstrated experimentally. It is proposed herein that salivary proline-rich proteins (PRPs) by binding ingested tannins protect the oesophagus from the carcinogenic effects of the latter. It is also possible that genetic variants of PRPs may influence the incidence of oesophageal cancer in different populations.

8. DOCID:14600 SCORE: 0.00279780882277665
DOCNO: 3700283
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: K V Rolston KV
AUTHOR: B LeBlanc B
AUTHOR: D H Ho DH
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of antimicrobial chemotherapy.
COUNTRY: ENGLAND
TITLE: In-vitro activity of RU 28965, a new macrolide, compared to that of erythromycin.
PUBDATE: 19860201
The activity of a novel macrolide, RU 28965, was compared to that of erythromycin against Gram-positive organisms isolated mainly from cancer patients. RU 28965 was active against streptococci including Streptococcus pneumoniae and streptococcal groups A, B and G. It was also active against methicillin-susceptible staphylococci, Bacillus cereus and Listeria monocytogenes. Its activity against these organisms was generally equal to that of erythromycin. RU 28965 was moderately active against enterococci and inactive against JK diphtheroids and three different species of coagulase-negative staphylococci. Organisms resistant to erythromycin were also resistant to RU 28965.

9. DOCID:15925 SCORE: 0.00258130792152146
DOCNO: 3770054
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: J Main J
AUTHOR: R A Clark RA
AUTHOR: A Hutcheon A
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: Vindesine and mitomycin C in inoperable non-small cell lung cancer.
PUBDATE: 19860801
Twenty-nine patients with inoperable non-small cell lung cancer were treated as out-patients with vindesine and mitomycin C. Eight patients had a complete response, and nine a partial response. Response was generally associated with either stable or improving ECOG and symptom scores. The incidence of serious side-effects was low--only two patients' white cell count fell below 3000 cells/mm2, only one patient's platelet count fell below 100,000 cells/mm2, and two patients developed vomiting associated with treatment. The combination of vindesine and mitomycin C appears to be effective in the treatment of inoperable non-small cell lung cancer. Side effects were generally well tolerated and allowed out-patient treatment.

10. DOCID:15398 SCORE: 0.00250478996795163
DOCNO: 2681905
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: adverse effects
AUTHOR: R Koike R
AUTHOR: M Sasaki M
AUTHOR: K Kuroda K
AFFILIATION: Department of Thoracic Surgery, Hirakata Municipal Hospital, Osaka, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: Lung cancer coexisting with bullae.
PUBDATE: 19890701
Scattered reports have suggested the association of cancer with bullous disease. We report herein, two surgical cases of lung cancer arising from bullae. Both the patients were males who smoked heavily and the generation of cancer was found simultaneously with the discovery of the bulla. At thoracotomy, it was found that the cancer had arisen from the firm, scarred and contracted area adjacent to the bulla wall. On the basis of this experience and review of the literature, it is suggested that physicians should always pay careful attention to the generation and complication of cancer while treating bullous disease in heavy smoking individuals.

11. DOCID:15906 SCORE: 0.00250456371931585
DOCNO: 3624562
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ethnology
AUTHOR: G K Leong GK
AUTHOR: J L Stone JL
AUTHOR: E R Farmer ER
AUTHOR: J Scotto J
AUTHOR: G T Reizner GT
AUTHOR: T S Burnett TS
AUTHOR: D J Elpern DJ
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Academy of Dermatology.
COUNTRY: UNITED STATES
TITLE: Nonmelanoma skin cancer in Japanese residents of Kauai, Hawaii.
PUBDATE: 19870801
A prospective 3-year survey of nonmelanoma skin cancer in Japanese-American residents of the Hawaiian island of Kauai was conducted beginning in January 1983. The crude rate for basal cell and squamous cell carcinoma was 123/100,000, 88 times higher than the corresponding figure from Japan. This discrepancy may be attributed to an increase in ultraviolet exposure due to lifestyle and latitude, but arsenic exposure may also have played a role. Nonmelanoma skin cancer in Japanese in Hawaii appears to be a significant problem that has not been appreciated because these malignancies are not reportable to tumor registries.

12. DOCID:15982 SCORE: 0.00248425390909167
DOCNO: 3804492
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
QUALIFIER: genetics
AUTHOR: D B Krizman DB
AUTHOR: S Pathak S
AUTHOR: N A Samaan NA
AUTHOR: R C Hickey RC
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: UNITED STATES
TITLE: Genetic instability in fibroblasts of patients with thyroid cancers (TC).
PUBDATE: 19870201
In cultured fibroblasts initiated from fresh tumor biopsies of 11 patients with thyroid tumors, 5 medullary carcinoma of the thyroid (MCT) and 6 papillary follicular, the chromosomes are relatively unstable when compared with those from control fibroblast cultures. Tumor-derived fibroblast samples showed a mean number of cells in metaphase with chromosome abnormalities at a frequency of 9.1% and a range of 6-13%, whereas 5 controls exhibited a mean frequency of 4% and a range of 3-5%. Our results indicate that genetic instability in thyroid cancer patients is present not only in peripheral blood cultures, as reported earlier, but in their fibroblast cultures as well.

13. DOCID:13755 SCORE: 0.0024312703273711
DOCNO: 3760157
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: pharmacology
AUTHOR: J Roosth J
AUTHOR: R B Pollard RB
AUTHOR: S L Brown SL
AUTHOR: W J Meyer WJ
PUBTYPE: Journal Article
JOURNALTITLE: Journal of neuroimmunology.
COUNTRY: NETHERLANDS
TITLE: Cortisol stimulation by recombinant interferon-alpha 2.
PUBDATE: 19861001
Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-alpha 2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-alpha 2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 X 10(6) units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

14. DOCID:15292 SCORE: 0.00241123591802219
DOCNO: 2950846
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Calcium-Binding Proteins
DESCRIPTOR: Eye Proteins
DESCRIPTOR: Lipoproteins
DESCRIPTOR: Nerve Tissue Proteins
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: C E Thirkill CE
AUTHOR: A M Roth AM
AUTHOR: J L Keltner JL
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of ophthalmology.
COUNTRY: UNITED STATES
TITLE: Cancer-associated retinopathy.
PUBDATE: 19870301
Antiretina antibodies have been found in the serum samples of four patients with cancer experiencing concomitant loss of vision (cancer-associated retinopathy [CAR] syndrome). These immunoglobulins bound an antigen from normal pooled retina having a molecular weight of 23,000 daltons, which we describe as the CAR antigen. No corresponding antibodies could be found in serum samples obtained from patients with cancer not experiencing vision loss, from patients having retinitis pigmentosa, or from normally sighted individuals who did not have cancer. The early detection of rising antibody titers against the CAR antigen could prove important in the identification of patients likely to suffer from CARs.