0. DOCID:5067 SCORE: 0.00407784256822278
DOCNO: 7227331
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prostatectomy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: U Seppelt U
PUBTYPE: Journal Article
JOURNALTITLE: Endoscopy.
COUNTRY: GERMANY, WEST
TITLE: Therapeutic approaches to postoperative contracture of the vesical neck.
PUBDATE: 19810301
Postoperative contracture is a rare cause of the secondary obstructions of the vesical neck, besides remnants of prostatic adenomas, recurrent adenoma and prostatic cancer. It appears morphologically either as circumscribed sclerosis, as so-called sphincter sclerosis, or as extensive contracture of the entire prostatic urethra. Severe postoperative contracture with an iris-shaped membrane at the site of the internal sphincter is the most frequent form up to one year after primary surgery. The overall incidence has been given as 1.37%, of which 13.6% were refractory to therapy and recurred. Special forms of therapy are discussed.

1. DOCID:6325 SCORE: 0.00398028716341284
DOCNO: 7397669
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude to Health
DESCRIPTOR: Mass Screening
DESCRIPTOR: Motivation
QUALIFIER: prevention & control
AUTHOR: P Strax P
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Strategy (motivation) for detection of early breast cancer.
PUBDATE: 19800801
For successful strategy to increase motivation for mass screening for detection of early breast cancer, three elements are needed: 1) women at risk must be taught the necessity of the examination; 2) they must be made aware of the existence of the facility, which must be made easily accessible; and 3) they must be reassured that the examination is simple, effective, and safe. Mass screening for breast cancer is the only proven method that has the potential to reduce the stationary death rate from the disease. Until true primary prevention is developed, it is necessary to make mass screening ever more efficient, economical, and safe. At the same time, increasing efforts must be made to motivate women to accept such mass screening.

2. DOCID:7497 SCORE: 0.00388362734301836
DOCNO: 630038
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: False Negative Reactions
DESCRIPTOR: Mass Screening
AUTHOR: J D Goldberg JD
AUTHOR: J T Wittes JT
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: The estimation of false negatives in medical screening.
PUBDATE: 19780301
In a medical screening program for early detection of disease, one or more screening modes are administered to an apparently healthy population. Knowledge of the true disease status for all screened individuals would allow estimation of the false negative and false positive rates for each mode of detection and for the program as a whole. This paper develops capture-recapture methods applicable to programs as a whole. This paper develops capture-recapture methods applicable to programs when follow-up of individuals negative on screening is not performed or is incomplete. The methods require at least two independent modes of detection. Data from a breast cancer screening program illustrate the procedure. The results of four screening examinations at approximately one-year intervals and the long-term follow-up of all screened individuals support the usefulness of these methods in the evaluation of a screening program.

3. DOCID:7906 SCORE: 0.00350153104692827
DOCNO: 537638
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: European Continental Ancestry Group
QUALIFIER: epidemiology
AUTHOR: D F Austin DF
AUTHOR: M King M
AUTHOR: K Roe K
PUBTYPE: Journal Article
JOURNALTITLE: National Cancer Institute monograph.
COUNTRY: UNITED STATES
TITLE: Cancer incidence trends in white women of the San Francisco Bay Area.
PUBDATE: 19791101
The 10% increase in the incidence of all cancer observed in the total white population of the San Francisco Bay Area during 1970-75 is mostly due to the 19% increase in cancer among white females. The latter is largely a result of increased incidence of cancer of the corpus uteri, breast, and lung, and of malignant melanoma. Cancer of these four sites constitutes 85% of the increase in white women. The rise in uterine corpus cancer is limited to women over 50 years of age. An incidence peak in 1974 of breast cancer was followed by a substantial decrease in 1975. The 50% rise in female lung cancer is an extension of the increase that began in 1965. The almost 70% increase in melanoma among women since 1975 accompanies a comparable increase in melanoma among males after a decade of stable incidence rates.

4. DOCID:7028 SCORE: 0.00341986131172543
DOCNO: 638979
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: H E Skipper HE
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Adjuvant chemotherapy.
PUBDATE: 19780301
In this brief presentation, an attempt was made to illustrate why it is not possible to carry over chemotherapeutic trial results from one animal cancer to another or one human cancer to another without corrections for differences in (a) staging, (b) dose response, and (c) tumor regrowth rates. Interrelation of quantitative information on these same three variables has provided useful guidance in the planning and interpretation of experimental therapeutic trials. For example, such integration analyses show that selection and overgrowth of specifically and permanently drug-resistant tumor cells is a major cause of chemotherapeutic failure in cancers that initia-ly respond. Surgery followed by optimum chemotherapy improves the "cure rate" of all metastatic solid animal cancers that have been studied to date. However, surgery followed by chemotherapy fails in those animals in which the residual tumor cell burden (after surgery) is too large for the chemotherapy now available.

5. DOCID:6988 SCORE: 0.0034198372674445
DOCNO: 6938127
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Multiple Primary
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A D Mosijczuk AD
AUTHOR: F B Ruymann FB
PUBTYPE: Journal Article
JOURNALTITLE: American journal of diseases of children (1960)
COUNTRY: UNITED STATES
TITLE: Second malignancy in acute lymphocytic leukemia. Review of 33 cases.
PUBDATE: 19810401
Improved survival in childhood cancer resulting from advances in therapy is frequently associated with long-term morbidity, including the potential for second malignancy. In a review of the literature in the English language, we found 33 cases of acute lymphocytic leukemia (ALL) followed by a second neoplasm. Second tumors in this group of patients with ALL include seven cases of histiocytic medullary reticulosis, four cases of Hodgkin's disease, nine cases of acute myelocytic leukemia, four cases of chronic myelocytic leukemia, and nine cases of solid tumors. The appearance of subsequent malignancies may be related to a combination of therapy-induced immunosuppression, a direct carcinogenic effect resulting from therapy, and/or constitutional factors. Physicians should be alert to the possibility of subsequent malignant neoplasms in survivors of cancer.

6. DOCID:7828 SCORE: 0.00337693548737043
DOCNO: 728871
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: M McKenzie M
AUTHOR: T McLemore T
AUTHOR: P Rankin P
AUTHOR: R R Martin RR
AUTHOR: N Wray N
AUTHOR: E Cantrell E
AUTHOR: D Busbee D
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: A human plasma component that binds benzo(a)pyrene.
PUBDATE: 19781201
A component capable of binding benzo(a)pyrene was measured in plasma from cigarette smokers and nonsmokers. This plasma fraction was found to have a high specificity of binding to benzo(a)pyrene, bound benzanthracene competitively with benzo(a)pyrene, and was positively correlated (r = 0.861, p less than 0.001) with the capacity of the individual subject's lymphocytes to be induced for AHH activity in culture. An inverse correlation (r = -0.957, p less than 0.001) between the presence of the plasma component in lung cancer patients and the capacity of lung cancer patients' lymphocytes to be induced in culture is unexplained at this time. A benzo(a)pyrene-binding fraction was not found in induced or uninduced cultured lymphocytes from smokers or nonsmokers, or in homogenates of lung excisional tissue from smokers with or without primary lung cancer.

7. DOCID:7529 SCORE: 0.00337408533990723
DOCNO: 93183
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: P J Selby PJ
AUTHOR: R L Powles RL
AUTHOR: B Janeson B
AUTHOR: H E Kay HE
AUTHOR: J G Watson JG
AUTHOR: R Thornton R
AUTHOR: G Morgenstern G
AUTHOR: H M Clink HM
AUTHOR: T J McElwain TJ
AUTHOR: H G Prentice HG
AUTHOR: R Corringharn R
AUTHOR: M G Ross MG
AUTHOR: A V Hoffbrand AV
AUTHOR: D Brigden D
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Parenteral acyclovir therapy for herpesvirus infections in man.
PUBDATE: 19791201
Acyclovir is a new antiviral agent which is highly active against herpesviruses in vitro and in laboratory animals. Twenty-three cancer patients with cutaneous and/or systemic herpes zoster or herpes simplex infections were treated with parenteral acyclovir. All had received previous specific treatment for their malignant disease and ten had undergone bone-marrow transplantation. The drug seemed to arrest the progress of the infections and was most effective when given early. Although two patients showed transient increases in blood-urea, possibly the result of acyclovir, the drug was remarkably non-toxic in the doses used.

8. DOCID:7743 SCORE: 0.0033223080525741
DOCNO: 77562
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinoma, Squamous Cell
DESCRIPTOR: Esophageal Neoplasms
QUALIFIER: pharmacology
AUTHOR: R M Saunders RM
AUTHOR: J J Alexander JJ
PUBTYPE: Journal Article
JOURNALTITLE: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
COUNTRY: SOUTH AFRICA
TITLE: In vitro effects of bleomycin on a carcinoma of the oesophagus cell line.
PUBDATE: 19780201
A dose of 10 microgram/ml bleomycin inhibited the growth of oesophageal carcinoma cells and non-squamous cells in vitro. Drug concentration, density of cells and the time of exposure to the drug were important variables. The oesophagus cancer cells increased in volume by 2,5 +/- 0,2% per hour until the onset of lysis at 96 hours. The effects of the drug were irreversible even when the exposure time was only 24 hours. A certain proportion of the cell population was resistant to bleomycin and these cells remained resistant when the drug was removed for 48 hours and then replaced. No drug inactivation or uptake could be detected with the use of microbiological assay after 4 days of incubation with 3 cell types. There is poor correlation between in vitro and in vivo results.

9. DOCID:7573 SCORE: 0.00311767469562599
DOCNO: 7438112
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: M S Sasaki MS
AUTHOR: Y Tsunematsu Y
AUTHOR: J Utsunomiya J
AUTHOR: J Utsumi J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Site-directed chromosome rearrangements in skin fibroblasts from persons carrying genes for hereditary neoplasms.
PUBDATE: 19801201
Chromosomal variability was studied in cultured skin fibroblasts in members of two unrelated families associated with hereditary neoplasms, one with familial childhood leukemia and the other with medullary thyroid cancer syndrome. Nonconstitutional chromosome rearrangements occurred with consistent frequency in the patients and obligate carriers. The G-banding analysis showed that th chromosome rearrangements were not random, and site of rearrangements tended to cluster to band p22 of chromosome 1 in the carriers of childhood leukemia gene and to band q23 of chromosome 17 in the patient with medullary thyroid cancer. The de novo rearrangements of chromosomes and their tendency to cluster to particular chromosomal sites strongly point to the possibility that the procancer type-dominant mutations responsible for these diseases have a mutator function analogous to the property of some insertion mutations or transposable elements.

10. DOCID:7234 SCORE: 0.00296852402231853
DOCNO: 7296498
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: analysis
AUTHOR: J C Chang JC
AUTHOR: G Wergowske G
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Correlation of estrogen receptors and response to chemotherapy of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) in advanced breast cancer.
PUBDATE: 19811201
Thirty-six patients with advanced breast cancer were treated with the regimen of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF). Their response to the combination chemotherapy and their survival were correlated in respect to estrogen-receptor (ER) status. No patient had received any form of hormonal therapy or other chemotherapeutic agents prior to the CMF treatment. Overall response rate, both complete and partial, to chemotherapy was 60% (21/36): 88% in the ER+ group and seven months in the ER--. Median duration of survival was 27 months in ER+ patients and nine months in ER-- patients after initiation of chemotherapy. These data suggest ER+ status has a beneficial effect in the responsiveness of advanced breast cancer to CMF chemotherapy and is prognostic of better survival.

11. DOCID:5976 SCORE: 0.0028823727691785
DOCNO: 230434
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aftercare
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: A Pfleiderer A
AUTHOR: D Richter D
AUTHOR: P Thiessen P
AUTHOR: U Kissel U
AUTHOR: B Tibi B
AUTHOR: P Nowara P
PUBTYPE: Journal Article
JOURNALTITLE: Onkologie.
COUNTRY: SWITZERLAND
TITLE: [Pressing problems of after care of patients with cancers of the cervix and corpus uteri]
PUBDATE: 19790401
A modern and optimal follow-up treatment of patients with uterine cancer requires a detailed knowledge of this disease and its sequelae. Incidence and localisation of cervical and endometrial cancers as well as kind and incidence of therapeutical side effects are demonstrated in the cases of the Gynecological University Hospital of Freiburg, GFR. A study of the psychosexual situation 2--4 years after therapy of uterine cancer is reported. Actual state of social assurances for cancer patients in the German Federal Republic is pointed out. The dates allow to draw conclusions for the follow-up of individual cases.

12. DOCID:6102 SCORE: 0.00279818316582343
DOCNO: 379697
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: methods
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: F Di Padova F
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [A new approach to immunotherapy: the transfer factor]
PUBDATE: 19790501
The transfer factor is a tiny molecule capable of transferring the function of the T lymphocytes (immunological memory and retarded hypersensitivity) from a sensitized to a non-sensitized individual. The exact structure and action modalities of the molecule have not yet been precisely established. The difficulties involved in the study of the transfer factor are aggravated by the lack of any suitable experimental model. The attention of immunologists is attracted by this factor which opens up new prospects for the treatment of cancer, immunological deficiencies and certain infectious and autoimmune diseases. More profound research would appear useful to evaluate if and in what cases a potentiation of the immune mechanism can represent an alternative to immunosuppression.

13. DOCID:7594 SCORE: 0.00275949945626175
DOCNO: 262590
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude to Health
DESCRIPTOR: Smoking
QUALIFIER: etiology
AUTHOR: R G Rawbone RG
AUTHOR: C A Keeling CA
AUTHOR: A Jenkins A
AUTHOR: A Guz A
PUBTYPE: Journal Article
JOURNALTITLE: Journal of epidemiology and community health.
COUNTRY: ENGLAND
TITLE: Cigarette smoking among secondary schoolchildren in 1975. Prevalence of respiratory symptoms, knowledge of health hazards, and attitudes to smoking and health.
PUBDATE: 19780301
A questionnaire relating to smoking habits, respirator symptoms, and health attitudes was administered to 10 498 secondary schoolchildren in 1975. The results reported in this paper indicate that children who smoke regularly have a higher prevalence of upper respiratory tract infections and a higher incidence of the respiratory symptoms, cough, phlegm production with a cold, and shortness of breath, compared with non-smokers. Children are aware of the risks of lung cancer when smoking, but less aware of the other more immediate health risks, and this is particularly so in the younger age groups. It is suggested that health education should be directed towards younger children and that more use should be made of the fact that smoking clearly makes them less healthy.

14. DOCID:6983 SCORE: 0.00273704577477087
DOCNO: 7248897
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lung Neoplasms
QUALIFIER: diagnostic use
QUALIFIER: secondary
QUALIFIER: radionuclide imaging
QUALIFIER: analogs & derivatives
AUTHOR: M A Quraishi MA
AUTHOR: J J Costanzi JJ
AUTHOR: S Balachandran S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Iodocholesterol adrenal scanning for the detection of adrenal metastases in lung cancer and its clinical significance.
PUBDATE: 19810801
Detection of adrenal metastases is difficult. Since metastatic growth fails to destroy sufficient adrenal tissue to produce clinical symptoms of adrenal insufficiency, and since adrenal metastases have been reported in 28--36% of autopsied patients with primary lung cancer, the authors studied 25 patients with lung cancer by using iodocholesterol adrenal scans. Six patients (24%) were found to have abnormal scans suggestive of adrenal metastases by this technique. Two of these patients were confirmed by biopsy to have adrenal metastases. Four of the six patients died within a mean of six weeks of the positive scan. Iodocholesterol adrenal scanning appears to be a promising noninvasive technique in the detection of adrenal metastases. The prognostic significance of adrenal metastases is discussed.