0. DOCID:31483 SCORE: 0.00349820909882922
DOCNO: 16305905
OWNER: NLM
STATUS: In-Process
AUTHOR: Taku Okamoto T
AUTHOR: Daiki Masuya D
AUTHOR: Takashi Nakashima T
AUTHOR: Shinya Ishikawa S
AUTHOR: Yasumichi Yamamoto Y
AUTHOR: Cheng-Long Huang CL
AUTHOR: Hiroyasu Yokomise H
AFFILIATION: Second Department of Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: The Annals of thoracic surgery.
COUNTRY: Netherlands
TITLE: Successful treatment for lung cancer associated with pulmonary sequestration.
PUBDATE: 20051201
We encountered a 69-year-old man with lung adenocarcinoma and pulmonary sequestration. The cancer lesion was located in the left upper lobe, with sequestration of the left lower lobe. Left upper lobectomy was performed after induction chemoradiotherapy, but the sequestered lung lobe was preserved because the preoperative respiratory function was poor. Preservation of the sequestered lung during surgery for lung cancer should be considered in patients who have poor respiratory function and no signs of respiratory infection.

1. DOCID:31522 SCORE: 0.00309082467174557
DOCNO: 15280398
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: M R Hussein MR
AFFILIATION: Department of Pathology, Assiut University Hospitals, Egypt. mrh17@swissfo.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of clinical pathology.
COUNTRY: England
TITLE: Genetic pathways to melanoma tumorigenesis.
PUBDATE: 20040801
The incidence of cutaneous malignant melanomas is growing faster than that of any other cancer and therefore posing a major heath threat worldwide. In melanocytic skin tumours, the feasibility of correlating a specific pathological stage with a corresponding genetic alteration provides a remarkable opportunity to study the multistep tumorigenesis model. This multistep melanoma tumorigenesis is best described as a continuum of transformation of the melanocytes, melanocytic dysplasia, and melanoma formation. These steps involve genotypic alterations including loss of tumour suppressor genes, microsatellite instability, and alterations of the mismatch repair system. This review seeks to examine melanoma tumorigenesis based on these genetic changes.

2. DOCID:27831 SCORE: 0.00304119400190962
DOCNO: 10222439
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: A Das A
AUTHOR: F H Hochberg FH
AUTHOR: S McNelis S
AFFILIATION: National University of Singapore, Singapore.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of neuro-oncology.
COUNTRY: NETHERLANDS
TITLE: A review of the therapy of paraneoplastic neurologic syndromes.
PUBDATE: 19990101
The therapy of paraneoplastic neurologic syndromes remains unclear and warrants a systematic review of the literature. Reports in English and foreign language literature were abstracted. Data were sorted by the primary paraneoplastic neurologic syndrome, the primary malignancy, and the methods of treatment. Neurologic improvement follows surgical, chemotherapeutic, and radiation treatments. Adjuvant immunosuppressive therapy with steroids, plasmapheresis, or immunoglobulin may help stabilize the progression of neurologic symptoms. Syndromes characterized by inflammation or neurotransmitter production without neuronal loss are most responsive to therapy. While treatment of the underlying cancer with appropriate surgery, chemotherapy, and radiation is recommended, the paraneoplastic syndrome should probably be managed with immunosuppressive therapy.

3. DOCID:31730 SCORE: 0.00303734838743482
DOCNO: 16556007
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Jingwu Xie J
AFFILIATION: University of Texas Medical Branch at Galveston, Sealy Centers for Cancer Cell Biology and Environmental Health, Department of Pharmacology and Toxicology, 301 University Blvd, Galveston, TX 77555-1048, USA. jinxie@utmb.edu.
PUBTYPE: Journal Article
JOURNALTITLE: Future oncology (London)
COUNTRY: England
TITLE: Hedgehog signaling in prostate cancer.
PUBDATE: 20050601
Prostate cancer is the most common malignancy and the second leading cancer-related cause of death in men in the USA. Despite enormous efforts in understanding the molecular basis of prostate cancer, very little progress has been made in prevention and treatment of this often lethal cancer. Recent studies have demonstrated that hedgehog signaling is frequently activated in advanced or metastatic prostate cancers. With small molecule inhibitors available to analyze the hedgehog signaling pathway, a novel rationale for prostate cancer therapy can be devised.

4. DOCID:31727 SCORE: 0.00303734748638192
DOCNO: 16366091
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: Rana Sherwani R
AUTHOR: Sabina Khan S
AUTHOR: Nazoora Khan N
AUTHOR: Mohd Kamran M
AUTHOR: Musharraf Husain M
AFFILIATION: Department of Pathology & General Surgery, J.N. Medical College, Aligarh Muslim University, Aligarh. ranasherwani@yahoo.com
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of pathology & microbiology.
COUNTRY: India
TITLE: Significance of apoptosis in prostatic intraepithelial neoplasia and carcinoma.
PUBDATE: 20051001
This study was carried out to assess the significance of apoptosis in prostatic intraepithelial neoplasia (PIN) and prostate cancer. A total of 120 prostatic specimens were studied in the department of Pathology [corrected] JNMC, Aligarh. The rate of apoptosis in PIN and prostate cancer was examined by quantifying the number of apoptotic bodies per hundred cells (apoptotic index) on haematoxylin and eosin stained histological sections [corrected] A significant correlation was noted between increasing apoptotic indices and increasing Gleason grades within a cancer.

5. DOCID:26941 SCORE: 0.00265428180805831
DOCNO: 10888265
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: E Bolton E
AUTHOR: J King J
AUTHOR: D L Morris DL
AFFILIATION: University of New South Wales, Department of Surgery, St George Hospital, Sydney, Australia.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: H2-antagonists in the treatment of colon and breast cancer.
PUBDATE: 20000201
Several clinical trials have now been carried out with histamine type 2 receptor antagonists in cancer patients often as an adjunct to surgical resection of the primary tumour While promising results have been obtained in some groups of patients with gastrointestinal cancer, with increased survival and evidence of increased immunological recognition of tumour, results are less encouraging for breast cancer. This may be due to differences in the levels of histamine or the role of histamine in growth of these different tumour types.

6. DOCID:30895 SCORE: 0.0025308109815898
DOCNO: 16340833
OWNER: NLM
STATUS: In-Process
AUTHOR: J-M Bréchot JM
AFFILIATION: Service d'Oncologie Médicale, Hôpital Avicenne, Bobigny, France. anne-marie.brechot@avc.ap-hop-paris.fr
PUBTYPE: Journal Article
JOURNALTITLE: Revue des maladies respiratoires.
COUNTRY: France
TITLE: [Thrombosis and lung cancer]
PUBDATE: 20051201
Venous thromboembolism (TE) is a frequent occurrence in lung cancer patients and can be precipitated by venous stasis, the activation of clotting cascades by pro-coagulant tumour factors and by vascular injury due to chemotherapy and central venous catheters. Subcutaneous low molecular weight heparin (LMWH) has replaced intravenous unfractionated heparin in the treatment of acute TE. The use of long-term LMWH is recommended to prevent the recurrence of TE. Prophylactic treatment is indicated in patients undergoing surgery or hospitalised. Heparin appears to have distinct anti-neoplastic as well as anticoagulant effects, which benefit overall survival.

7. DOCID:30036 SCORE: 0.00253077191698614
DOCNO: 16274993
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: Kathleen I Pritchard KI
AFFILIATION: Clinical Trials & Epidemiology, Toronto Sunnybrook Regional Cancer Centre, 2075 Bayview Avenue, Toronto, Ont., Canada M4N 3M5. Kathy.Pritchard@sw.ca
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Breast (Edinburgh, Scotland)
COUNTRY: Scotland
TITLE: Adjuvant endocrine therapies for pre-/perimenopausal women.
PUBDATE: 20051201
Endocrine therapy in the form of ovarian ablation was developed over a century ago. It remains nonetheless one of the most effective and most clearly targeted form of systemic therapy for breast cancer. Endocrine or hormonal therapy has an effect on virtually only those women whose tumors are positive for estrogen receptors (ER) and/or progesterone receptors (PgR). The presence of these steroid hormone receptors remains the most useful predictive factor in selecting therapy for breast cancer.

8. DOCID:31928 SCORE: 0.00250335569436317
DOCNO: 12623037
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: organization & administration
QUALIFIER: organization & administration
AUTHOR: C J Garvey CJ
AUTHOR: R Seymour R
AUTHOR: L Wright L
AFFILIATION: Department of Radiology, Royal Liverpool University Hospital, UK. conall.garvey@rlbuh-tr.nwest.nhs.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinical radiology.
COUNTRY: England
TITLE: Radiology and the Cancer Services Collaborative--an opportunity awaits.
PUBDATE: 20030201
The principles and methodologies used by the Cancer Services Collaborative (CSC) are particularly relevant for radiology departments. A radiology project looking at the provision of barium enema examinations is used to highlight how the principles can be applied to a radiology department. Advice on how to access available CSC literature is offered. The CSC principles and methodologies are an important part of the NHS modernization agenda, and offer an exciting vehicle to improve patient care. It is important that radiologists understand the opportunities offered and the challenges posed by the modernization agenda.

9. DOCID:25549 SCORE: 0.00235922353197303
DOCNO: 11910667
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Status
DESCRIPTOR: Menopause
QUALIFIER: complications
AUTHOR: R J Norman RJ
AUTHOR: E McVeigh E
AFFILIATION: Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, University of Adelaide, Australia.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Climacteric : the journal of the International Menopause Society.
COUNTRY: United States
TITLE: Polycystic ovary syndrome and implications for the menopause.
PUBDATE: 19990601
Polycystic ovary syndrome (PCOS) is the most common endocrine condition of premenopausal women and has significant metabolic abnormalities that could have an impact after the menopause. Diabetes mellitus, hyperlipidemia and hyperinsulinemia could potentially affect health in this era of life. Endometrial cancer, due to unopposed estrogen action, is more common where progestins have not been given for menstrual dysfunction. Preventive management earlier in life will avoid postmenopausal problems in PCOS.

10. DOCID:31079 SCORE: 0.00228423593457191
DOCNO: 15157343
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunotherapy
QUALIFIER: immunology
QUALIFIER: therapy
QUALIFIER: immunology
AUTHOR: Ying Liu Y
AFFILIATION: Department of Pediatric Internal Medicine, General Hospital of PLA, Beijing 100853, China.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology.
COUNTRY: China
TITLE: [Tumor antigen-specific cytotoxic T lymphocytes and cancer immunotherapy - review]
PUBDATE: 20040401
Tumor antigen-specific cytotoxic T lymphocytes are important anti-cancer cells. The focuses of this review are to introduce the molecular basis of antigen presentation and CTL recognition, to summarize the identification of tumor associated antigens and their T cell epitopes, to highlight the current insights into the immunogenicity of TAA peptides and the principles of peptide-based vaccines against cancer, and to comment on future prospects for CTL therapy.

11. DOCID:30775 SCORE: 0.00227949326122087
DOCNO: 14601526
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: Stéphane Paul S
AFFILIATION: Transgene SA, 2 Rue Adolphe Hirn, Strasbourg 67082, France. paul@transgene.fr
PUBTYPE: Clinical Trial
PUBTYPE: Controlled Clinical Trial
PUBTYPE: Evaluation Studies
PUBTYPE: Journal Article
JOURNALTITLE: Current opinion in molecular therapeutics.
COUNTRY: England
TITLE: Technology evaluation: CpG-7909, Coley.
PUBDATE: 20031001
Coley Pharmaceutical (formerly CpG ImmunoPharmaceuticals) is developing CpG-7909 (ProMune) for use in the potential treatment of cancer and as a vaccine adjuvant. By April 2000, CpG-7909 had entered phase I/II trials for cancer and in March 2002, Coley initiated a phase I trial in non-Hodgkin's lymphoma in combination with rituximab (Rituxan). By October 2002, CpG-7909 was in phase II trials as a vaccine adjuvant. Cpg-7909 is currently also undergoing phase II trials for melanoma.

12. DOCID:30766 SCORE: 0.00227949002794619
DOCNO: 12108349
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: Karim Kellou K
AUTHOR: Franz Hering F
AFFILIATION: Clinique d'Urologie, Centre Hospitalier Biel/Bienne, Suisse. karimkellou@yahoo.fr
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie.
COUNTRY: France
TITLE: [Secondary tumors of the kidney]
PUBDATE: 20020401
The frequency of secondary tumours of the kidney is underestimated, especially as their diagnosis is often delayed, after nephrectomy or autopsy. The authors present the case of a 59-year-old patient presenting with renal metastases from lung cancer operated two years previously and review about forty cases published in the literature over the last twelve years. The diagnosis by percutaneous needle biopsy can avoid useless surgery and improve patient management. The specificity and sensitivity of this method need to be evaluated.

13. DOCID:27853 SCORE: 0.00222151942026253
DOCNO: 9674324
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Graft Survival
DESCRIPTOR: Skin Transplantation
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
AUTHOR: R K Caldwell RK
AUTHOR: W C Giles WC
AUTHOR: P T Davis PT
AFFILIATION: Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Ear, nose, & throat journal.
COUNTRY: UNITED STATES
TITLE: Use of foam bolsters for securing facial skin grafts.
PUBDATE: 19980601
Many methods of securing skin grafts to their recipient beds have been described. A review of the senior author's experience with facial skin cancers over a two-year period revealed that reconstruction with full-thickness skin grafts was employed in 60 of more than 500 cases. This series of 60 cases was reviewed. Uses of foam as a bolster has proven to be a simple, time-conserving and reliable technique that produces consistently excellent results with a low complication rate. The technique is reviewed, along with its advantages and disadvantages.

14. DOCID:25259 SCORE: 0.00215176742782958
DOCNO: 11715941
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
DESCRIPTOR: Liposomes
QUALIFIER: therapy
AUTHOR: D D Lasic DD
AUTHOR: J J Vallner JJ
AUTHOR: P K Working PK
AFFILIATION: Liposome Consultations, Newark, CA 94560, USA. Dan.Lasic@roche.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in molecular therapeutics.
COUNTRY: England
TITLE: Sterically stabilized liposomes in cancer therapy and gene delivery.
PUBDATE: 19990401
The introduction of colloidally stable liposomes with low drug leakage rates resulted in a renaissance in liposome applications in cancer therapy. Furthermore, a platform of sterically stabilized liposomes also allows the construction of new generations of drug delivery vehicles. These include targeted liposomes and targeted nucleic acid delivery vehicles, based either on cationic sterically stabilized liposomes or pre-condensed DNA encapsulated in neutral or negatively charged liposomes.