0. DOCID:14257 SCORE: 0.00439816417793561
DOCNO: 2935793
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: R N Everett RN
AUTHOR: F L Jones FL
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Warfarin-induced skin necrosis. A cutaneous sign of malignancy?
PUBDATE: 19860201
Patchy necrosis of the skin is a rare and unpredictable complication of oral anticoagulant therapy. Of the four patients that we have seen with this disorder, three had metastatic adenocarcinoma; in two, this was an unexpected finding. The association of a malignant neoplasm with warfarin-induced skin necrosis has not been emphasized previously. Whether such necrosis represents a clue to the presence of cancer or occurs only coincidentally in patients requiring anticoagulant therapy because of adenocarcinoma-associated thrombophlebitis must await further experience. A congenital or acquired deficiency of protein C may be the primary initiating factor.


1. DOCID:14220 SCORE: 0.00439816233035121
DOCNO: 3421412
AUTHOR: K R Mittal KR
AUTHOR: K W Barwick KW
AFFILIATION: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of surgical pathology.
COUNTRY: UNITED STATES
TITLE: Diffusely infiltrating adenocarcinoma of the endometrium. A subtype with poor prognosis.
PUBDATE: 19881001
We studied cases of stage I endometrial adenocarcinoma encountered at our institution during the period 1970-80. Five out of 164 of these tumors showed a diffusely infiltrating pattern of growth. Two of the five patients died of cancer within 5 years, with a 5-year mortality of 40%. A control group of 15 patients seen over the same period showed a 5-year mortality of 13.3%. Thus, the diffusely infiltrating pattern of growth was indicative of poor prognosis in endometrial carcinoma in stage I disease.


2. DOCID:15056 SCORE: 0.00431419113343557
DOCNO: 3004727
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: M Huberman M
AUTHOR: J Lokich J
AUTHOR: R Greene R
AUTHOR: S Paul S
AUTHOR: D Phillips D
AUTHOR: H Sonneborn H
AUTHOR: T Zipoli T
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Vinblastine plus cisplatin in advanced non-small cell lung cancer: lack of advantage for vinblastine infusion schedule.
PUBDATE: 19860201
We have evaluated 31 patients with advanced non-small cell lung cancer treated by short-term 5-day vinblastine infusion combined with bolus cisplatin. Nine of 31 patients (29%) had partial and complete responses. Although five of nine (55%) of the responders were alive at greater than or equal to 1 year, three of the 31 patients experienced drug-related mortality. Our experience, as well as a review of previously reported trials in the literature, suggests that the infusion schedule of vinblastine offers no advantage over the bolus schedule.


3. DOCID:10323 SCORE: 0.00388469591690129
DOCNO: 7108937
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: metabolism
AUTHOR: C Scully C
AUTHOR: T Barkas T
AUTHOR: P Boyle P
AUTHOR: I A McGregor IA
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical & laboratory immunology.
COUNTRY: ITALY
TITLE: Circulating immune complexes detected by binding of radiolabelled protein A in patients with oral cancer and oral premalignant lesions.
PUBDATE: 19820601
Circulating immune complexes were determined in 48 patients with oral squamous cell cancer, 17 patients with oral keratosis and 49 controls, using a rapid sensitive assay using a Staphylococcus aureus immunoadsorbent. Concentrations of immune complexes were significantly higher in patients with oral cancer and in patients with oral keratosis than in controls, but the levels in those with oral cancer were not significantly different from those in keratosis. Immune complexes might be responsible for the cell-mediated immune defect in patients with cancer in the head and neck.


4. DOCID:11343 SCORE: 0.00351625467832948
DOCNO: 6544829
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: W B Povah WB
AUTHOR: W Beecroft W
AUTHOR: I Hodson I
AUTHOR: H Yazdi H
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of otolaryngology.
COUNTRY: CANADA
TITLE: Malignant lympho-epithelial lesion--the Manitoba experience.
PUBDATE: 19840601
A retrospective study was carried out utilizing the Records Department of the Health Sciences Centre, St. Boniface General Hospital, and the Manitoba Cancer Treatment and Research Foundation. Seventeen cases of malignant lympho-epithelial lesion were found. The pathology of all cases was reviewed. There were 12 females and five males. Sixteen cases involved the parotid gland and one the submandibular gland. The ages ranged from 17-65 years with the peak incidence in the fourth decade of life. Fifteen of the patients were Eskimos, all residing in the Northwest Territories; two patients were Caucasian. Most patients were treated with a combined modality of surgery with postoperative radiation. The clinical features, pathology, treatment, and final outcome are reviewed.


5. DOCID:10201 SCORE: 0.0033231420024305
DOCNO: 2856957
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: J S Tobias JS
AUTHOR: M H Tattersall MH
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Doing the best for the cancer patient.
PUBDATE: 19850101
An overview is presented of special dilemmas facing the cancer clinician as a result of changes in the nature of cancer care, such as the trends toward multidisciplinary cancer management and toward involving patients in treatment decisions. The desire to introduce experimental treatments may conflict with the welfare of the patient. Informed consent documents are often barely comprehensible and are frequently geared toward legal considerations. A patient needs a reasonable understanding of treatment goals in order to make decisions regarding quantity and quality of survival. Priorities for allocating limited resources must be evaluated, with careful consideration being given to the diverting of funds from unsuccessful therapies to disease prevention.


6. DOCID:11856 SCORE: 0.00323771781394108
DOCNO: 6834843
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: methods
QUALIFIER: diagnostic use
QUALIFIER: diagnostic use
AUTHOR: I L Avis IL
AUTHOR: F P Avis FP
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: A modification of the (75Se) selenomethionine assay for the detection of complement-dependent antibody in human tumor systems.
PUBDATE: 19830401
A modification of Brook's prelabeling (75SE) selenomethionine assay was developed and evaluated for detection of complement-dependent antibody (CDA) in a human tumor system. CDA was indeed detected in some breast cancer patients' sera. To determine whether the assay was reliable and reproducible, xenoantibodies were raised in rabbits by immunization with a human breast cancer line, Sk-Br-3, and tested against that line and five other unrelated human cancer lines. Multiple tests were performed on separate days. It can be concluded from the data that the assay is reliable and reproducible. The assay has wide application in investigating the biologic role of complement-dependent antibody activity in human and experimental animal tumor systems.


7. DOCID:11275 SCORE: 0.00316703377122916
DOCNO: 6150277
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Menopause
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
AUTHOR: R C Coombes RC
AUTHOR: P Goss P
AUTHOR: M Dowsett M
AUTHOR: J C Gazet JC
AUTHOR: A Brodie A
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: 4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer.
PUBDATE: 19841201
4-hydroxyandrostenedione, a potent inhibitor of the aromatase (oestrogen synthetase) system, was given to 11 patients with metastatic breast cancer. After a single 500 mg intramuscular injection a sustained reduction of serum oestradiol was observed for at least 1 week in all patients in whom the steroid was measured. 4 patients responded to treatment for periods of up to 4 months, and healing of bone metastases and reduction in size of soft-tissue metastases was evident. The only side-effects were pain at the injection site and hot flushes. 4-hydroxyandrostenedione is a new and specific aromatase inhibitor which shows promise in the treatment of patients with metastatic breast cancer.


8. DOCID:14978 SCORE: 0.00315892546768394
DOCNO: 3126708
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Postoperative Care
QUALIFIER: therapeutic use
QUALIFIER: analogs & derivatives
QUALIFIER: therapy
AUTHOR: K Yoshinaka K
AUTHOR: T Tanaka T
AUTHOR: S Takagami S
AUTHOR: T Saeki T
AUTHOR: M Nishiyama M
AUTHOR: T Toge T
AUTHOR: M Niimoto M
AUTHOR: T Hattori T
AFFILIATION: Dept. of Surgery, Hiroshima University.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Prospective randomized controlled study of bestatin in gastric cancer surgery]
PUBDATE: 19880301
The effectiveness of bestatin combined with mitomycin C and tegafur as an adjuvant to surgery for gastric cancer was investigated in a prospective randomized controlled study. All patients underwent curative gastrectomy during the period from November 1980 to April 1984. Five-year survival rate revealed no significant difference between groups with or without bestatin. The effectiveness of bestatin was suggested in postoperative peritoneal recurrence in cases with positive histological invasion into the veins of the stomach wall.


9. DOCID:14958 SCORE: 0.00315892328472547
DOCNO: 3779619
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: F K Kozak FK
AUTHOR: J G Hall JG
AUTHOR: P A Baird PA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Familial breast cancer in males. A case report and review of the literature.
PUBDATE: 19861201
The occurrence of breast cancer in two related males, an uncle and nephew is reported. A review of previously reported cases of male breast cancer occurring in families and the association with other cancers in other family members is included. In previous reports on breast cancer in males, familial or hereditary factors have not generally been recognized as a major contributing factor. Of ten families reported (including our own) where there is sufficient information given, six families (60%) had females with breast cancer. It appears there are some families in which males as well as females have an increased risk of developing breast cancer.


10. DOCID:15101 SCORE: 0.0031139540179002
DOCNO: 2838290
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: secondary
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: P E Kristjansen PE
AUTHOR: H H Hansen HH
AFFILIATION: Department of Oncology ONB, Finsen Institute, Copenhagen.
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: Brain metastases from small cell lung cancer treated with combination chemotherapy.
PUBDATE: 19880301
Ten patients with metastatic small cell lung cancer (SCLC) in the brain, shown by CT scan at time of diagnosis, were treated with systemic combination chemotherapy. Repeated CT scans were performed every 4 weeks. Seven patients were evaluable, since three patients died during the first 2-3 weeks. Significant responses on CT scans as well as neurologic improvement were demonstrated in all evaluable patients. Four of seven patients obtained a complete response in the brain, while three had partial remissions. The impact of this observation on the overall treatment strategies in SCLC has further to be defined.


11. DOCID:15680 SCORE: 0.00307628887567933
DOCNO: 2515763
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: N Mikata N
AUTHOR: S Imao S
AUTHOR: Y Tanaka Y
AUTHOR: D Horiuchi D
AUTHOR: G Matsumoto G
AUTHOR: K Hasegawa K
AFFILIATION: Department of Urology, Tokyo Metropolitane Bokutoh Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [A case of renal cancer complicated with acute hypercalcemia and acute pancreatitis]
PUBDATE: 19891101
A 55-year-old man who had liver metastasis after undergoing surgery for renal cancer was hospitalized immediately on May 4, 1987 with complaints of general malaise, epigastric pain, nausea and vomiting. Because of abnormally high levels of blood calcium 15.6 mg/dl and serum amylase 2,069 IU/l, the case was diagnosed as hypercalcemic crisis and acute pancreatitis. Following recovery from the critical stage with administration of elcatonin and FOY, therapy for cancer initiated. We report the clinical course of this patient and discuss about hypercalcemia and acute pancreatitis as cases of oncologic emergency.


12. DOCID:11272 SCORE: 0.00304810156541769
DOCNO: 3964880
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: blood
QUALIFIER: therapy
AUTHOR: S Rössner S
AUTHOR: P O Hedlund PO
AUTHOR: T Jogestrand T
AUTHOR: U Säwe U
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Treatment of prostatic cancer: effects on serum lipoproteins and the cardiovascular system.
PUBDATE: 19850101
We studied 32 patients with prostatic cancer before, and after 1 and 6 months of treatment with orchiectomy, estramustine phosphate or conventional estrogens (polyestradiol phosphate plus ethinyl estradiol). Lipid metabolism was evaluated by lipoprotein analysis and the intravenous fat tolerance test. Effects on the cardiovascular system were studied by exercise electrocardiography, blood volume estimation and thoracic electrical impedance measurement, a sensitive method to detect early signs of fluid retention. Present treatment programs for prostatic cancer seem to result in effects on lipoprotein metabolism that probably are of minor importance for the development of atherosclerotic manifestations. Measurement of thoracic impedance may be of value to detect fluid retention in individual patients.


13. DOCID:15273 SCORE: 0.00300450865084621
DOCNO: 3412210
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Food Habits
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: adverse effects
AUTHOR: T F Warner TF
AUTHOR: E A Azen EA
AFFILIATION: Department of Pathology, University of Wisconsin, University Hospital, Madison 53792.
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Tannins, salivary proline-rich proteins and oesophageal cancer.
PUBDATE: 19880601
No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properties of tannins and extracts of tannin-rich plants have been demonstrated experimentally. It is proposed herein that salivary proline-rich proteins (PRPs) by binding ingested tannins protect the oesophagus from the carcinogenic effects of the latter. It is also possible that genetic variants of PRPs may influence the incidence of oesophageal cancer in different populations.


14. DOCID:10275 SCORE: 0.00292206787718271
DOCNO: 3888336
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R J Steele RJ
AUTHOR: A P Forrest AP
AUTHOR: T Gibson T
AUTHOR: H J Stewart HJ
AUTHOR: U Chetty U
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: The efficacy of lower axillary sampling in obtaining lymph node status in breast cancer: a controlled randomized trial.
PUBDATE: 19850501
Four hundred and seventeen patients with operable breast cancer treated by simple mastectomy were randomly allocated to have node sampling or total axillary clearance. There was no significant difference in the incidence of node positivity. One hundred and thirty-five patients had node sampling and were randomized at the completion of this procedure to have axillary clearance or to have no further surgery. All node positive patients who went on to have a clearance had positive samples, confirming the accuracy of the sampling technique.