0. DOCID:23519 SCORE: 0.00298148239942095
DOCNO: 9627713
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: genetics
AUTHOR: A Kamb A
AFFILIATION: Myriad Genetics, Inc., Salt Lake City, UT 84108, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research.
COUNTRY: UNITED STATES
TITLE: Human melanoma genetics.
PUBDATE: 19960401
Melanoma is an important human cancer, the etiology of which has been the subject of much study. Recently a gene for familial melanoma, MLM, has been mapped and isolated. This gene encodes the cell-cycle regulator p16 and is mutated in a variety of sporadic human cancers in addition to melanoma. The isolation of MLM answers some questions in the area of melanoma biology, but raises others. Identification of p16 and other genes that contribute to melanoma development may be viewed as one step in the attempt to understand, diagnose, and treat this malignant disease.


1. DOCID:22771 SCORE: 0.00239672124160819
DOCNO: 8906048
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: C W Cummings CW
AFFILIATION: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Outpatient Center, Baltimore, Md, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology--head & neck surgery.
COUNTRY: UNITED STATES
TITLE: Is reengineering of head and neck cancer treatment indicated? Absolutely.
PUBDATE: 19961101
A review of the table of contents of the program for the fourth International Conference on Head and Neck Cancer permits one to conclude that there is high energy in virtually every aspect of either the diagnosis or therapy concerning head and neck cancer. There is, in addition, an emerging interest (in fact, emphasis) on a more global restitution of the head and neck cancer patient, such that rehabilitation, both physical and emotional, as well as a greater acceptance of the benefits of less orthodox methods for treatment can be seen affecting outcomes.


2. DOCID:22752 SCORE: 0.00239671887555038
DOCNO: 7529702
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: epidemiology
AUTHOR: K Hemminki K
AUTHOR: G Pershagen G
AFFILIATION: Center for Nutrition and Toxicology, Karolinska Institute, Stockholm, Sweden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Cancer risk of air pollution: epidemiological evidence.
PUBDATE: 19941001
Epidemiological studies on the effect of urban air pollution on lung cancer were surveyed. Overall, the studies from many countries point to a smoking-adjusted risk in urban areas over countryside areas that is higher by a factor of up to 1.5. The extent to which urban air pollution contributes to this excess remains unknown. Studies on diesel-exposed occupational groups show that urban air pollution may have a causative role in lung cancer. Model calculations on unit risk factors of known human carcinogens were carried out to rank carcinogens according to their current ambient air concentrations.


3. DOCID:20795 SCORE: 0.00228014462466979
DOCNO: 8311485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: T Yamaguchi T
AUTHOR: T Takahashi T
AFFILIATION: First Dept. of Surgery, Kyoto Prefectural University of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Application of monoclonal antibody for cancer therapy]
PUBDATE: 19940201
Immunoconjugates composed of mouse monoclonal antibody and anticancer drug was applied for the treatment of patients with colorectal cancer. Administration of mouse antibody raised human anti-mouse antibody that may interfere with the effect of immunoconjugates. To resolve this problem, human/mouse chimeric antibody was prepared and immunoconjugate of chimeric antibody and anticancer drug was developed. The characteristics of this new immunoconjugate were described.


4. DOCID:20799 SCORE: 0.00228014428745961
DOCNO: 8150774
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: M A Friedman MA
AFFILIATION: Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: New directions for breast cancer therapeutic research.
PUBDATE: 19940201
For the past two decades, attempts to improve chemotherapy for patients with breast cancer have emphasized the use of currently available agents. Research by drug discovery programs of the National Cancer Institute has identified a number of clinically promising novel agents. Conceivably, within the next several years there could be a doubling of the chemotherapy armamentarium for breast cancer--more than 30 active cytotoxic agents.


5. DOCID:23809 SCORE: 0.00210341699748382
DOCNO: 9263334
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
AUTHOR: S D Yeh SD
AUTHOR: M P La Quaglia MP
AFFILIATION: Department of Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in pediatric surgery.
COUNTRY: UNITED STATES
TITLE: 131I therapy for pediatric thyroid cancer.
PUBDATE: 19970801
The treatment of differentiated thyroid cancer occurring in children and young adults remains controversial. Because the mortality rate associated with this disease is extremely low and recurrence can develop many years after primary therapy, it is impossible to perform randomized trials that answer therapeutic questions. In previous issues, the topic of thyroid cancer from the surgical perspective has been addressed. Herein the authors discuss the techniques and applicability of radioactive iodine therapy in the treatment of patients with differentiated thyroid cancer. Topics included are indications for treatment as well as short- and long-term complications. A discussion of secondary malignancies is also provided.


6. DOCID:22068 SCORE: 0.00206759060453806
DOCNO: 8720977
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Proteins
QUALIFIER: metabolism
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: E A Torre EA
AUTHOR: R A Fulco RA
AFFILIATION: Istituto Nazionale per la Ricerca sul Cancro, Genova.
PUBTYPE: Journal Article
JOURNALTITLE: Minerva ginecologica.
COUNTRY: ITALY
TITLE: [pS2 protein and breast cancer]
PUBDATE: 19951201
pS2 is a small protein (7000 daltons) that is prevalently expressed in human breast cancer positive for estrogen receptors: protein is, in fact, induced by estrogen stimulation. Studies indicate that pS2 protein is a marker for hormone-dependent breast tumors and that its expression is helpful in the prognosis. The presence of pS2, in fact, besides being associated in 96% of the cases to the positivities for estrogen receptors, is associated with longer overall, and disease free, survival. The pS2 protein is also expressed in normal stomach mucosa; its physiological function is unknown.


7. DOCID:22747 SCORE: 0.00186530364056846
DOCNO: 7719485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: metabolism
QUALIFIER: analysis
AUTHOR: T M Phillips TM
AFFILIATION: Immunochemistry Laboratory, George Washington University Medical Center, Washington, D.C. 20037.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chromatography. B, Biomedical applications.
COUNTRY: NETHERLANDS
TITLE: Immunoaffinity measurement of recombinant granulocyte colony stimulating factor in patients with chemotherapy-induced neutropenia.
PUBDATE: 19941201
A high-performance immunoaffinity chromatographic technique has been developed for the measurement of recombinant human granulocyte colony stimulating factor in human patients receiving this agent, following neutropenia, arising from cancer chemotherapy. The technique employs a short, biocompatible polymer column packed with minute, antibody-coated glass beads. This system was applied to the analysis of recombinant human granulocyte colony stimulating factor in three different human body fluids. A reasonable degree of correlation was achieved when comparing the immunoaffinity technique to a conventional immunoassay, although the immunoaffinity technique displayed greater specificity.


8. DOCID:22825 SCORE: 0.00186024134840072
DOCNO: 7774494
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: analysis
AUTHOR: A W Martin AW
AUTHOR: D D Davey DD
AFFILIATION: Department of Pathology, University of Louisville School of Medicine, KY, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Diagnostic cytopathology.
COUNTRY: UNITED STATES
TITLE: Comparison of immunoreactivity of neu oncoprotein in fine-needle aspirates and paraffin-embedded materials.
PUBDATE: 19950301
Expression of the neu oncogene has been extensively examined in frozen and paraffin section breast cancers; however, very few studies examine neu oncoprotein oncoprotein expression in fine-needle aspirates. To this effect, we compared the expression of neu oncoprotein in formalin-fixed paraffin-embedded breast cancers and the corresponding fine-needle aspirates of these cancers. There was 100% correlation between the expression of neu oncoprotein in the paraffin-embedded breast cancers and the fine-needle aspirates, indicating the suitability of fine-needle aspirates for the expression of neu oncoprotein in breast cancers.


9. DOCID:22851 SCORE: 0.00186023816192145
DOCNO: 8844291
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Pelvis
DESCRIPTOR: Neoplasms, Multiple Primary
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: M Ando M
AUTHOR: C Arisawa C
AUTHOR: T Okano T
AFFILIATION: Department of Urology, East Tokyo Metropolitan Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: A case of renal cell carcinoma associated with synchronous contralateral renal pelvic cancer and bladder tumor.
PUBDATE: 19960701
We report a case of renal cell carcinoma associated with synchronous contralateral renal pelvic cancer and bladder tumor. The patient underwent total nephroureterectomy for the left renal pelvic cancer with transurethral resection of the bladder tumor. After 2 courses of combination chemotherapy, we performed surgical enucleation of the right renal cell carcinoma. Although transurethral resection of the recurrent bladder tumors was undergone 17 months after the last operation, the patient retains normal renal function.


10. DOCID:22852 SCORE: 0.00186023763048043
DOCNO: 7773901
AUTHOR: A Mullens A
PUBTYPE: Journal Article
JOURNALTITLE: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
COUNTRY: CANADA
TITLE: The Dutch experience with euthanasia: lessons for Canada?
PUBDATE: 19950601
Anne Mullens used a recent fellowship provided by the Atkinson Foundation to take an in-depth look at euthanasia in the Netherlands. During her time in Holland, she discussed the issue with doctors who support and oppose euthanasia. She accompanied a doctor as he visited a patient who was dying of cancer and was beginning to consider the possibility of euthanasia. She talked to a nonphysician who is adamantly opposed to euthanasia and carries a card stating that. She visited a hospital in Amsterdam that has received requests from foreigners seeking euthansia. Mullens offers a comprehensive look at an issue that continues to provoke strong feelings among Canadian physicians and patients.


11. DOCID:22754 SCORE: 0.00182149808191119
DOCNO: 7968998
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
PUBTYPE: Journal Article
JOURNALTITLE: MMWR. Morbidity and mortality weekly report.
COUNTRY: UNITED STATES
TITLE: Prevalence of overweight among adolescents--United States, 1988-91.
PUBDATE: 19941101
Among adults, overweight is associated with increased risk for death, coronary heart disease, diabetes mellitus, gallbladder disease, joint disease, and certain cancers (1), and overweight during adolescence is associated with increased risk for overweight as an adult (2). CDC's third National Health and Nutrition Examination Survey (NHANES III) provides data to monitor changes in the dietary, nutritional, and health status of the U.S. population (3) and to track progress toward achieving the year 2000 national health objectives, including those related to prevalence of overweight (4). This report presents findings from NHANES III, Phase 1 (1988-91), on the prevalence of overweight among U.S. adolescents (ages 12-19 years).


12. DOCID:23320 SCORE: 0.00179181290964193
DOCNO: 9053759
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Erythrocyte Transfusion
DESCRIPTOR: Leukocyte Transfusion
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Brand A
AUTHOR: D J van Rhenen DJ
AFFILIATION: Rode Kruis Bloedbank Leidsenhage, Leiden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nederlands tijdschrift voor geneeskunde.
COUNTRY: NETHERLANDS
TITLE: [Immunological effects of erythrocyte and leukocyte transfusion. Work Group Blood Group Serology of the Medical Advisory Commission of the College for Blood Transfusion of the Netherlands Red Cross]
PUBDATE: 19970101
Immunological consequences of blood transfusion are less well-known than infectious complications although they occur more frequently. In many cases the effects in individual patients are hardly visible although fatal transfusion reactions may occur: Transfusion of red cells may induce acute or delayed haemolytic transfusion reactions. Transfusion of leukocytes may suppress the function of the immune system of the recipient (with consequences for immune tolerance in transplant patients, cancer surveillance and the occurrence of postoperative infections) but also may induce graft versus host disease.


13. DOCID:20863 SCORE: 0.00171473650686694
DOCNO: 14732055
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: K L Manchester KL
AFFILIATION: Dept of Biochemistry, University of the Witwatersrand, Johannesburg, South Africa.
PUBTYPE: Journal Article
JOURNALTITLE: Trends in cell biology.
COUNTRY: England
TITLE: Theodor Boveri and the origin of malignant tumours.
PUBDATE: 19951001
As long ago as 1914, Theodor Boveri suggested that there is an inhibitory mechanism in every normal cell that prevents the process of cell division until the inhibition has been overcome by a special stimulus. From his work on abnormal mitoses in the eggs of echinoderms, Boveri also suggested that the inhibitor resided in the chromosomes. The relevance of Boveri's ideas to modern cancer research is discussed in this Retrospective article.


14. DOCID:23607 SCORE: 0.00169915084431888
DOCNO: 9225960
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: chemistry
QUALIFIER: administration & dosage
QUALIFIER: chemistry
AUTHOR: J M Terwogt JM
AUTHOR: B Nuijen B
AUTHOR: W W Huinink WW
AUTHOR: J H Beijnen JH
AFFILIATION: Department of Medical Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer treatment reviews.
COUNTRY: ENGLAND
TITLE: Alternative formulations of paclitaxel.
PUBDATE: 19970301
Paclitaxel, a novel antitumour agent, is active clinically against advanced ovarian and breast cancer and under investigation for various other cancers. One of the problems associated with the intravenous administration of paclitaxel is its low solubility in water. The current pharmaceutical formulation consists of a 1:1 (v/v) mixture of ethanol and Cremophor EL. This formulation, however, has been demonstrated to cause some severe hypersensitivity reactions. Therefore the development of a safer intravenous formulation devoid of Cremophor EL is an important investigational issue. This review deals with some of the most promising formulation alternatives.