0. DOCID:15608 SCORE: 0.00268391444086744
DOCNO: 3062286
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Heart Transplantation
QUALIFIER: chemically induced
QUALIFIER: surgery
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: S Ballhaus S
AUTHOR: G Grevers G
AFFILIATION: HNO-Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Laryngologie, Rhinologie, Otologie.
COUNTRY: GERMANY, WEST
TITLE: [Laryngeal cancer in immunosuppressive therapy with cyclosporin A]
PUBDATE: 19880701
As a serious side effect of immunosuppressive therapy following organ transplantation, the incidence of malignancies shows a significant threefold increase compared with the age-matched general population. Under treatment with conventional immunosuppressive drugs (azathioprine, steroids and antilymphocyte globulin) patients are supposed to be susceptible to skin and lip cancers (40%) whereas the recently introduced new immunosuppressive drug cyclosporine A shows a comparable incidence of non-Hodgkin lymphomas (41%) and the patients seem to develop more potentially life threatening tumours of internal organs. In the present paper we report on a case of laryngeal carcinoma following immunosuppressive treatment with cyclosporine A 10 months after heart transplantation.


1. DOCID:14950 SCORE: 0.00221163041610595
DOCNO: 3803120
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: P J O'Dwyer PJ
AUTHOR: C Mojzisik C
AUTHOR: D P McCabe DP
AUTHOR: B J Sickle-Santanello BJ
AUTHOR: W B Farrar WB
AUTHOR: E W Martin EW
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Diseases of the colon and rectum.
COUNTRY: UNITED STATES
TITLE: Variation in recognition of recurrent colonic cancer by different CEA assays.
PUBDATE: 19870201
Forty-six patients were followed with serial CEA determinations by two CEA assays after curative resection of a primary or recurrent colonic cancer. Thirteen have had a histologically proven recurrence, of which only six (46 percent) were predicted by both assays, while seven (54 percent) were predicted by one assay only. The assays appear complementary in indicating tumor recurrence, and preliminary findings suggest that it may be beneficial to follow patients with more than one CEA assay after resection of a primary or recurrent colonic cancer.


2. DOCID:14459 SCORE: 0.00212333341599423
DOCNO: 2432963
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: N N Mamaev NN
AUTHOR: A A Mikhaĭlov AA
AUTHOR: S I Irzhanov SI
AUTHOR: I V Bykhovets IV
PUBTYPE: Journal Article
JOURNALTITLE: Biulleten' eksperimental'noĭ biologii i meditsiny.
COUNTRY: USSR
TITLE: [Activity of the nucleolar organizers of the cells in epithelial tumors of the human large intestine]
PUBDATE: 19861201
Normal, adenoma and cancer cell nucleoli have been studied by silver impregnation in 13 cancer patients, 48 patients with adenoma (14-tubular, 35-tubulovillous and villous) and 15 controls. It has been shown that the content of silver granules per cell was significantly higher (34.0 +/- 9.7) in cancer cells than in the control (12.3 +/- 3.1). Adenoma cells were heterogeneous. Most villous adenomas, like adenocarcinomas, had high content of Ag granules per cell. The importance of these findings for theoretical and clinical oncology is discussed.


3. DOCID:15446 SCORE: 0.00191841872159949
DOCNO: 3646459
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Division
DESCRIPTOR: Models, Biological
QUALIFIER: pathology
AUTHOR: B Jenkin B
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: A conceptual model of cell division in neoplasia.
PUBDATE: 19870201
A model of cell division as it occurs in the neoplastic cell is presented. The two basic features of the model are that firstly cell division is autonomous and secondly it is incomplete because not all of the processes which take place during normal division occur in the disordered division of neoplasia. As a result cellular structures may not be replicated along with the rest of the cell and they are therefore deficient. The deficiency of particular structures is then used to explain certain observations made of neoplastic cells eg. disturbances of metabolism and morphology, heterogeneity of the cell population, malignancy and immortalisation. Oncogenes are then introduced into the model in an attempt to understand their role in the development of cancer.


4. DOCID:15773 SCORE: 0.00190150525713437
DOCNO: 2511322
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: R A Smith RA
AUTHOR: M W Lockey MW
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Mississippi State Medical Association.
COUNTRY: UNITED STATES
TITLE: Carcinoma in situ and T-1 squamous cell carcinoma of the glottis: the Mississippi Baptist Medical Center experience.
PUBDATE: 19891101
This report is a retrospective analysis of 62 patients treated for early glottic carcinoma during the six-year period of January 1982 through December 1987. The authors report that the cancer has been controlled in 100% of patients. For invasive stage 1 tumors the radiation cure rate is 42 of 45 patients or 93%, and voice quality after treatment was usually normal. Surgically treated tumors are usually confined to one vocal cord. Primary surgery with laser or cord stripping ultimately led to tumor control and voice preservation in all eleven patients treated although two required salvage with radiotherapy and mild but acceptable hoarseness was a usual sequel.


5. DOCID:14531 SCORE: 0.00187577406792124
DOCNO: 3947586
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Electricity
DESCRIPTOR: Power Plants
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: S Törnqvist S
AUTHOR: S Norell S
AUTHOR: A Ahlbom A
AUTHOR: B Knave B
PUBTYPE: Journal Article
JOURNALTITLE: British journal of industrial medicine.
COUNTRY: ENGLAND
TITLE: Cancer in the electric power industry.
PUBDATE: 19860301
A cohort study of 3358 power linesmen and 6703 power station operators classified in the 1960 population census in Sweden was undertaken. The cancer incidence between 1961 and 1979 was calculated in relation to all male blue collar workers. The relative risk of cancer (all sites) was 1.1, (1.0-1.2, 90% confidence limit) in the group of power linesmen and 1.0 (0.9-1.0) for power station operators. No consistent excess risk of leukaemia or brain tumour was found in the two occupational groups. In both groups a tendency towards an excess risk of cancer of the urinary organs was found.


6. DOCID:14504 SCORE: 0.00183597503223484
DOCNO: 3664431
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: D Scrivner D
AUTHOR: R W Oxenhandler RW
AUTHOR: M Lopez M
AUTHOR: C Perez-Mesa C
AFFILIATION: Department of Pathology, Ellis Fischel State Cancer Center, Columbia, MO 65201.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Plantar lentiginous melanoma. A clinicopathologic study.
PUBDATE: 19871101
Twenty cases of plantar melanoma treated at Ellis Fischel State Cancer Center (EFSCC) since 1940 are analyzed to determine the clinical and histologic features of prognostic significance. The EFSCC experience confirms and extends the observations made in other recent studies of plantar melanoma. This clinical pathologic study suggests that one of the histologic patterns, the lentiginous growth pattern, shares some biologic features with lentigo maligna, namely the relatively indolent growth phase. Plantar melanomas may remain latent for a number of years making these patients good candidates for therapeutic cures if detected early.


7. DOCID:15543 SCORE: 0.00175918687615152
DOCNO: 3028600
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: S Nomura S
AUTHOR: T Kanoh T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Immune hemolytic anemia associated with streptococcal preparation OK-432.
PUBDATE: 19870401
In the course of administration of an immunopotentiator, streptococcal agent OK-432, a patient with lung cancer was found to have severe anemia and a strongly positive antiglobulin test. In the absence of the drug, eluates from the patient's erythrocytes reacted strongly by the indirect antiglobulin test with a panel of washed Group O erythrocyte samples. The eluated antibody was composed of monoclonal IgG1-lambda. Upon discontinuing the drug the patient's hemoglobin level increased slowly with concomitant normalization of the reticulocyte count. Although very rare, drug-induced immune hemolytic anemia should be included in the list of adverse effects of immunopotentiators. This is the first reported case of immune hemolytic anemia associated with OK-432.


8. DOCID:14188 SCORE: 0.00173269453017816
DOCNO: 3697948
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: K M Bang KM
AUTHOR: C A Laing CA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: NETHERLANDS
TITLE: Lymphocytopenia in high cancer risk population: evidence in automobile pattern makers.
PUBDATE: 19860301
A total of 1454 automobile pattern makers were studied to determine the degree of lymphocyte reduction. These occupational workers have been known to be at high risk for colorectal cancer. As a group, pattern makers had significantly lower lymphocyte counts than the comparison group. The proportion of lymphocytopenia (less than 1500/mm3) in pattern makers was 26.2% as compared with 5.6% in the comparison group. Continuous monitoring of lymphocyte reduction in pattern makers may be worthwhile to evaluate whether these workers face a high risk for deficiency in lymphocytes in association with their risk for high rates of colorectal cancer.


9. DOCID:13101 SCORE: 0.00169775538670203
DOCNO: 2909185
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: L D Saunders LD
AFFILIATION: Bureau of Communicable Disease Control, San Francisco Department of Public Health, CA 94102.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of public health.
COUNTRY: UNITED STATES
TITLE: Differences in the timeliness of diagnosis, breast and cervical cancer, San Francisco 1974-85.
PUBDATE: 19890101
Cancer registry data for San Francisco (1974-85) were used to identify women at greater risk of late diagnoses for breast and cervical cancers by age and ethnicity. For breast cancer, Black women were at greater risk for late diagnoses. For cervical cancer, women of all ethnic groups ages 50-69 years and Japanese and Filipino women were at greater risk for late diagnoses.


10. DOCID:15827 SCORE: 0.00167749448378502
DOCNO: 3570802
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nuclear Warfare
DESCRIPTOR: Radiation Effects
AUTHOR: H Kato H
AUTHOR: W J Schull WJ
AUTHOR: A Awa A
AUTHOR: M Akiyama M
AUTHOR: M Otake M
PUBTYPE: Journal Article
JOURNALTITLE: Health physics.
COUNTRY: UNITED STATES
TITLE: Dose-response analyses among atomic bomb survivors exposed to low-level radiation.
PUBDATE: 19870501
An analysis of the dose response within the low-dose range (as here defined, doses of less than 50 cGy (50 rad) was conducted among A-bomb survivors in the ABCC-RERF cohort in an attempt to detect the phenomenon of radiation hormesis, if it is present. These studies include as endpoints cancer mortality, cancer incidence, the frequency of cells with chromosomal aberrations, the phytohemagglutinin response of peripheral lymphocytes and the frequency of mental retardation among survivors exposed in utero. In general, the dose response for these indices of radiation damage varied among comparison groups within the low-dose range, but failed to suggest the existence of radiation hormesis.


11. DOCID:15856 SCORE: 0.0016774881018326
DOCNO: 2420279
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: Y Kori Y
AUTHOR: M Koyama M
AUTHOR: M Kato M
AUTHOR: Y Honda Y
AUTHOR: Y Kawata Y
AUTHOR: S Arai S
AUTHOR: T Ito T
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Clinical study of chemotherapy (PPM therapy) with cisplatin, peplomycin and mitomycin C in squamous cell lung cancer]
PUBDATE: 19860301
The effect of PPM therapy, consisting of cisplatin, peplomycin and mitomycin C, was evaluated in 15 cases of squamous cell lung cancer. Ten partial responses were achieved in primary cases and the response rate was 66.7%. Nephrotoxicity was well controlled with a continuous infused drip and FOM. The nausea and vomiting were reasonably well controlled with methylprednisolone and metoclopramide. Severe interstitial pneumonitis occurred in 5 cases (33.3%). PPM therapy is considered to be a very useful combination chemotherapy for squamous cell lung cancer but careful attention must be paid to pulmonary toxicity.


12. DOCID:14585 SCORE: 0.00167431739524487
DOCNO: 3588560
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Epidemiologic Methods
DESCRIPTOR: Statistics
AUTHOR: S D Stellman SD
PUBTYPE: Journal Article
JOURNALTITLE: Preventive medicine.
COUNTRY: UNITED STATES
TITLE: Workshop on guidelines to the epidemiology of weak associations. Confounding.
PUBDATE: 19870301
The magnitude of confounding is examined in nine case studies of two "weak" relationships: between artificial sweeteners and bladder cancer, and between oral contraceptives and cervical dysplasia. Confounding had little or no influence on the results of any published study. The responsible epidemiologist must always consider the possibility of confounding, no less when associations are weak than when they are strong. Identification of potentially confounding variables is an integral part of good epidemiologic practice. Rarely, however, does confounding itself, especially from unidentified sources, live up to its reputation for introducing seriously spurious associations. An investigator is more likely to be led astray by undetected biases than by pure confounding.


13. DOCID:13983 SCORE: 0.00158100338503627
DOCNO: 2980112
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T Nagayo T
AFFILIATION: Aichi Cancer Center, Nagoya, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Histology and histopathology.
COUNTRY: SPAIN
TITLE: Gastric cancer preceded by severe dysplasia.
PUBDATE: 19860401
For elucidation of histogenesis of gastric cancer derived from relatively flat mucosa, 77 cases of surgically resected stomachs with lesions of severe dysplasia in cancerous mucosae or with cancerous changes in severely dysplastic mucosae were detected out of 380 recently examined cases of early gastric cancer. Several examples of early gastric cancer of the superficial type, showing histological changes indicating that they had developed on the preexisted dysplastic mucosal lesions, have been presented, together with the background data. The frequency for detecting such changes was higher in the slightly elevated lesions than in the depressed or eroded ones.


14. DOCID:15702 SCORE: 0.00154684548835711
DOCNO: 2462748
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: J E Groopman JE
AFFILIATION: Department of Medicine, New England Deaconess Hospital, Boston, MA 02215.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Clinical applications of colony-stimulating factors.
PUBDATE: 19881201
The colony-stimulating factors (CSFs) are polypeptide hormones that regulate myeloid proliferation and differentiation. Granulocyte-macrophage CSF (GM-CSF) has been used in leukopenic acquired immunodeficiency syndrome (AIDS) patients, myelodysplastic syndrome patients, and cancer patients after intensive chemotherapy. Its hematologic activity results in an increase in neutrophil, monocyte, and eosinophil counts. Recombinant GM-CSF effectively restores granulopoiesis in AIDS patients and appears capable of improving myelopoiesis and, in some cases, erythropoiesis in subjects with myelodysplastic syndrome. It accelerates bone marrow recovery after chemotherapy. Similarly, granulocyte CSF has demonstrated the capacity to reduce the granulocyte nadir after single agent or combination chemotherapy. Thus, CSFs have considerable promise for therapy for bone marrow failure states.