0. DOCID:23519 SCORE: 0.00298148239942095
DOCNO: 9627713
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: genetics
AUTHOR: A Kamb A
AFFILIATION: Myriad Genetics, Inc., Salt Lake City, UT 84108, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research.
COUNTRY: UNITED STATES
TITLE: Human melanoma genetics.
PUBDATE: 19960401
Melanoma is an important human cancer, the etiology of which has been the subject of much study. Recently a gene for familial melanoma, MLM, has been mapped and isolated. This gene encodes the cell-cycle regulator p16 and is mutated in a variety of sporadic human cancers in addition to melanoma. The isolation of MLM answers some questions in the area of melanoma biology, but raises others. Identification of p16 and other genes that contribute to melanoma development may be viewed as one step in the attempt to understand, diagnose, and treat this malignant disease.


1. DOCID:22771 SCORE: 0.00239672124160819
DOCNO: 8906048
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: C W Cummings CW
AFFILIATION: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Outpatient Center, Baltimore, Md, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology--head & neck surgery.
COUNTRY: UNITED STATES
TITLE: Is reengineering of head and neck cancer treatment indicated? Absolutely.
PUBDATE: 19961101
A review of the table of contents of the program for the fourth International Conference on Head and Neck Cancer permits one to conclude that there is high energy in virtually every aspect of either the diagnosis or therapy concerning head and neck cancer. There is, in addition, an emerging interest (in fact, emphasis) on a more global restitution of the head and neck cancer patient, such that rehabilitation, both physical and emotional, as well as a greater acceptance of the benefits of less orthodox methods for treatment can be seen affecting outcomes.


2. DOCID:22752 SCORE: 0.00239671887555038
DOCNO: 7529702
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: epidemiology
AUTHOR: K Hemminki K
AUTHOR: G Pershagen G
AFFILIATION: Center for Nutrition and Toxicology, Karolinska Institute, Stockholm, Sweden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Cancer risk of air pollution: epidemiological evidence.
PUBDATE: 19941001
Epidemiological studies on the effect of urban air pollution on lung cancer were surveyed. Overall, the studies from many countries point to a smoking-adjusted risk in urban areas over countryside areas that is higher by a factor of up to 1.5. The extent to which urban air pollution contributes to this excess remains unknown. Studies on diesel-exposed occupational groups show that urban air pollution may have a causative role in lung cancer. Model calculations on unit risk factors of known human carcinogens were carried out to rank carcinogens according to their current ambient air concentrations.


3. DOCID:20795 SCORE: 0.00228014462466979
DOCNO: 8311485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: T Yamaguchi T
AUTHOR: T Takahashi T
AFFILIATION: First Dept. of Surgery, Kyoto Prefectural University of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Application of monoclonal antibody for cancer therapy]
PUBDATE: 19940201
Immunoconjugates composed of mouse monoclonal antibody and anticancer drug was applied for the treatment of patients with colorectal cancer. Administration of mouse antibody raised human anti-mouse antibody that may interfere with the effect of immunoconjugates. To resolve this problem, human/mouse chimeric antibody was prepared and immunoconjugate of chimeric antibody and anticancer drug was developed. The characteristics of this new immunoconjugate were described.


4. DOCID:20799 SCORE: 0.00228014428745961
DOCNO: 8150774
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: M A Friedman MA
AFFILIATION: Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: New directions for breast cancer therapeutic research.
PUBDATE: 19940201
For the past two decades, attempts to improve chemotherapy for patients with breast cancer have emphasized the use of currently available agents. Research by drug discovery programs of the National Cancer Institute has identified a number of clinically promising novel agents. Conceivably, within the next several years there could be a doubling of the chemotherapy armamentarium for breast cancer--more than 30 active cytotoxic agents.


5. DOCID:23809 SCORE: 0.00210341699748382
DOCNO: 9263334
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
AUTHOR: S D Yeh SD
AUTHOR: M P La Quaglia MP
AFFILIATION: Department of Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in pediatric surgery.
COUNTRY: UNITED STATES
TITLE: 131I therapy for pediatric thyroid cancer.
PUBDATE: 19970801
The treatment of differentiated thyroid cancer occurring in children and young adults remains controversial. Because the mortality rate associated with this disease is extremely low and recurrence can develop many years after primary therapy, it is impossible to perform randomized trials that answer therapeutic questions. In previous issues, the topic of thyroid cancer from the surgical perspective has been addressed. Herein the authors discuss the techniques and applicability of radioactive iodine therapy in the treatment of patients with differentiated thyroid cancer. Topics included are indications for treatment as well as short- and long-term complications. A discussion of secondary malignancies is also provided.


6. DOCID:17952 SCORE: 0.00209622165963215
DOCNO: 2255267
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: G M Lower GM
AFFILIATION: Department of Medical Research, Gundersen Medical Foundation, Ltd., La Crosse, Wisconsin 54601.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Human carcinogenesis: a disciplinary perspective.
PUBDATE: 19900901
With the emergence of significant national efforts to comprehend and control the human cancers during the early 1970's, the existing biomedical disciplines of cellular pathology, virology and immunology seemed destined to play a central role in these efforts. Since that time, however, new biomedical disciplines, e.g., molecular toxicology, molecular epidemiology and molecular pathology/genetics, have emerged. Integration of the knowledge embraced by these disciplines provides a view of human cancer from natural historical perspectives embracing the causal chain, a view relevant to national priorities and policies in approaching cancer comprehension and control.


7. DOCID:22068 SCORE: 0.00206759060453806
DOCNO: 8720977
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Proteins
QUALIFIER: metabolism
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: E A Torre EA
AUTHOR: R A Fulco RA
AFFILIATION: Istituto Nazionale per la Ricerca sul Cancro, Genova.
PUBTYPE: Journal Article
JOURNALTITLE: Minerva ginecologica.
COUNTRY: ITALY
TITLE: [pS2 protein and breast cancer]
PUBDATE: 19951201
pS2 is a small protein (7000 daltons) that is prevalently expressed in human breast cancer positive for estrogen receptors: protein is, in fact, induced by estrogen stimulation. Studies indicate that pS2 protein is a marker for hormone-dependent breast tumors and that its expression is helpful in the prognosis. The presence of pS2, in fact, besides being associated in 96% of the cases to the positivities for estrogen receptors, is associated with longer overall, and disease free, survival. The pS2 protein is also expressed in normal stomach mucosa; its physiological function is unknown.


8. DOCID:18030 SCORE: 0.00194977069229042
DOCNO: 8313748
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: J Cheng J
AFFILIATION: Second Affiliated Hospital of Hubei Medical University, Wuhan.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua fu chan ke za zhi.
COUNTRY: CHINA
TITLE: [Clinical application of extraperitoneal ovarian transposition in cervical cancer]
PUBDATE: 19930901
Ten young patients with cervical cancer were treated by extraperitoneal ovarian transposition. All patients received pelvic irradiation post operatively. Sex hormone were analysed after treatment. 10 cervical cancer patients who were irradiated only were analysed as control. Our data suggested that extraperitoneal ovarian transposition has definite significance for reserving ovarian function in young patients with cervical cancer and improve the quality of operation. This operation is chiefly suited for young patients with early cervical cancer who were operated extra-peritoneally, also for young patients who are irradiated alone or before operation.


9. DOCID:17434 SCORE: 0.0018720618847036
DOCNO: 2011141
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: A A Sandberg AA
AFFILIATION: Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Mutation research.
COUNTRY: NETHERLANDS
TITLE: Chromosome abnormalities in human cancer and leukemia.
PUBDATE: 19910401
The meaning and application of chromosomal (cytogenetic, karyotypic) changes in human leukemia and cancer have been succinctly reviewed in this article. Thus, the usefulness of these changes in the diagnosis, classification and prognosis of various leukemic conditions and, more recently, of solid tumors is stressed and their application to molecular studies indicated. The meaning of primary (specific) and additional (secondary) karyotypic changes in malignant and benign tumors is discussed. Tables containing the common cytogenetic changes in leukemias and tumors, including benign ones, are included.


10. DOCID:22747 SCORE: 0.00186530364056846
DOCNO: 7719485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: metabolism
QUALIFIER: analysis
AUTHOR: T M Phillips TM
AFFILIATION: Immunochemistry Laboratory, George Washington University Medical Center, Washington, D.C. 20037.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chromatography. B, Biomedical applications.
COUNTRY: NETHERLANDS
TITLE: Immunoaffinity measurement of recombinant granulocyte colony stimulating factor in patients with chemotherapy-induced neutropenia.
PUBDATE: 19941201
A high-performance immunoaffinity chromatographic technique has been developed for the measurement of recombinant human granulocyte colony stimulating factor in human patients receiving this agent, following neutropenia, arising from cancer chemotherapy. The technique employs a short, biocompatible polymer column packed with minute, antibody-coated glass beads. This system was applied to the analysis of recombinant human granulocyte colony stimulating factor in three different human body fluids. A reasonable degree of correlation was achieved when comparing the immunoaffinity technique to a conventional immunoassay, although the immunoaffinity technique displayed greater specificity.


11. DOCID:22825 SCORE: 0.00186024134840072
DOCNO: 7774494
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: analysis
AUTHOR: A W Martin AW
AUTHOR: D D Davey DD
AFFILIATION: Department of Pathology, University of Louisville School of Medicine, KY, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Diagnostic cytopathology.
COUNTRY: UNITED STATES
TITLE: Comparison of immunoreactivity of neu oncoprotein in fine-needle aspirates and paraffin-embedded materials.
PUBDATE: 19950301
Expression of the neu oncogene has been extensively examined in frozen and paraffin section breast cancers; however, very few studies examine neu oncoprotein oncoprotein expression in fine-needle aspirates. To this effect, we compared the expression of neu oncoprotein in formalin-fixed paraffin-embedded breast cancers and the corresponding fine-needle aspirates of these cancers. There was 100% correlation between the expression of neu oncoprotein in the paraffin-embedded breast cancers and the fine-needle aspirates, indicating the suitability of fine-needle aspirates for the expression of neu oncoprotein in breast cancers.


12. DOCID:22851 SCORE: 0.00186023816192145
DOCNO: 8844291
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Pelvis
DESCRIPTOR: Neoplasms, Multiple Primary
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: M Ando M
AUTHOR: C Arisawa C
AUTHOR: T Okano T
AFFILIATION: Department of Urology, East Tokyo Metropolitan Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: A case of renal cell carcinoma associated with synchronous contralateral renal pelvic cancer and bladder tumor.
PUBDATE: 19960701
We report a case of renal cell carcinoma associated with synchronous contralateral renal pelvic cancer and bladder tumor. The patient underwent total nephroureterectomy for the left renal pelvic cancer with transurethral resection of the bladder tumor. After 2 courses of combination chemotherapy, we performed surgical enucleation of the right renal cell carcinoma. Although transurethral resection of the recurrent bladder tumors was undergone 17 months after the last operation, the patient retains normal renal function.


13. DOCID:22852 SCORE: 0.00186023763048043
DOCNO: 7773901
AUTHOR: A Mullens A
PUBTYPE: Journal Article
JOURNALTITLE: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
COUNTRY: CANADA
TITLE: The Dutch experience with euthanasia: lessons for Canada?
PUBDATE: 19950601
Anne Mullens used a recent fellowship provided by the Atkinson Foundation to take an in-depth look at euthanasia in the Netherlands. During her time in Holland, she discussed the issue with doctors who support and oppose euthanasia. She accompanied a doctor as he visited a patient who was dying of cancer and was beginning to consider the possibility of euthanasia. She talked to a nonphysician who is adamantly opposed to euthanasia and carries a card stating that. She visited a hospital in Amsterdam that has received requests from foreigners seeking euthansia. Mullens offers a comprehensive look at an issue that continues to provoke strong feelings among Canadian physicians and patients.


14. DOCID:22754 SCORE: 0.00182149808191119
DOCNO: 7968998
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
PUBTYPE: Journal Article
JOURNALTITLE: MMWR. Morbidity and mortality weekly report.
COUNTRY: UNITED STATES
TITLE: Prevalence of overweight among adolescents--United States, 1988-91.
PUBDATE: 19941101
Among adults, overweight is associated with increased risk for death, coronary heart disease, diabetes mellitus, gallbladder disease, joint disease, and certain cancers (1), and overweight during adolescence is associated with increased risk for overweight as an adult (2). CDC's third National Health and Nutrition Examination Survey (NHANES III) provides data to monitor changes in the dietary, nutritional, and health status of the U.S. population (3) and to track progress toward achieving the year 2000 national health objectives, including those related to prevalence of overweight (4). This report presents findings from NHANES III, Phase 1 (1988-91), on the prevalence of overweight among U.S. adolescents (ages 12-19 years).