0. DOCID:23519 SCORE: 0.00298148239942095
DOCNO: 9627713
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: genetics
AUTHOR: A Kamb A
AFFILIATION: Myriad Genetics, Inc., Salt Lake City, UT 84108, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research.
COUNTRY: UNITED STATES
TITLE: Human melanoma genetics.
PUBDATE: 19960401
Melanoma is an important human cancer, the etiology of which has been the subject of much study. Recently a gene for familial melanoma, MLM, has been mapped and isolated. This gene encodes the cell-cycle regulator p16 and is mutated in a variety of sporadic human cancers in addition to melanoma. The isolation of MLM answers some questions in the area of melanoma biology, but raises others. Identification of p16 and other genes that contribute to melanoma development may be viewed as one step in the attempt to understand, diagnose, and treat this malignant disease.


1. DOCID:26495 SCORE: 0.00268013360597462
DOCNO: 10700909
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: T Sasaki T
AFFILIATION: Dept. of Chemotherapy, Tokyo Metropolitan Komagome Hospital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Combination of levofolinate calcium and 5-fluorouracil]
PUBDATE: 20000201
It has been determined that in the combination of Leucovorin (LV) and 5-fluorouracil (5-FU), LV potentiates the cytotoxic effect of 5-FU based on biochemical modulation. Many data suggest that LV/5-FU is a very effective combination, and most clinicians worldwide now regard it as the standard therapy for colorectal cancer. In Japan, clinical examinations of this combination using Levofolinate calcium (I-LV) have shown its effectiveness, and I-LV/5-FU for gastric and colorectal cancer was authorized by the Ministry of Public Welfare in Oct. 1999.


2. DOCID:27996 SCORE: 0.002512246047023
DOCNO: 9679358
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Education, Medical, Continuing
DESCRIPTOR: Health Knowledge, Attitudes, Practice
DESCRIPTOR: Program Evaluation
QUALIFIER: education
QUALIFIER: complications
QUALIFIER: therapy
AUTHOR: C Hines C
AUTHOR: J Bingham J
AUTHOR: N Muirden N
AUTHOR: M Beavis M
AFFILIATION: Peter MacCallum Palliative Care Grants Program. hine0014@baggins.cc.flinders.edu.au
PUBTYPE: Journal Article
JOURNALTITLE: Australian family physician.
COUNTRY: AUSTRALIA
TITLE: Evaluation of a cancer pain education program for general practitioners.
PUBDATE: 19980701
OBJECTIVE: To evaluate a cancer pain education program. METHOD: Participants in the program completed an evaluation form covering various aspects of the program's design. RESULTS: All participants who completed the program were glad that they had done so. The most and least useful aspects are included in the article. Participants were satisfied with the program and eager to participate in similar ones. CONCLUSION: The education program was both successful at improving participants' knowledge of cancer pain management and provided in a manner acceptable to the participants. Ideas for future similar projects are included.


3. DOCID:22771 SCORE: 0.00239672124160819
DOCNO: 8906048
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: C W Cummings CW
AFFILIATION: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Outpatient Center, Baltimore, Md, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology--head & neck surgery.
COUNTRY: UNITED STATES
TITLE: Is reengineering of head and neck cancer treatment indicated? Absolutely.
PUBDATE: 19961101
A review of the table of contents of the program for the fourth International Conference on Head and Neck Cancer permits one to conclude that there is high energy in virtually every aspect of either the diagnosis or therapy concerning head and neck cancer. There is, in addition, an emerging interest (in fact, emphasis) on a more global restitution of the head and neck cancer patient, such that rehabilitation, both physical and emotional, as well as a greater acceptance of the benefits of less orthodox methods for treatment can be seen affecting outcomes.


4. DOCID:22752 SCORE: 0.00239671887555038
DOCNO: 7529702
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: epidemiology
AUTHOR: K Hemminki K
AUTHOR: G Pershagen G
AFFILIATION: Center for Nutrition and Toxicology, Karolinska Institute, Stockholm, Sweden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Cancer risk of air pollution: epidemiological evidence.
PUBDATE: 19941001
Epidemiological studies on the effect of urban air pollution on lung cancer were surveyed. Overall, the studies from many countries point to a smoking-adjusted risk in urban areas over countryside areas that is higher by a factor of up to 1.5. The extent to which urban air pollution contributes to this excess remains unknown. Studies on diesel-exposed occupational groups show that urban air pollution may have a causative role in lung cancer. Model calculations on unit risk factors of known human carcinogens were carried out to rank carcinogens according to their current ambient air concentrations.


5. DOCID:25764 SCORE: 0.00239209843324997
DOCNO: 10627999
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Electromagnetic Fields
QUALIFIER: radiation effects
AUTHOR: M Babincová M
AUTHOR: P Sourivong P
AUTHOR: D Leszczynska D
AUTHOR: P Babinec P
AFFILIATION: Department of Biophysics and Chemical Physics, Comenius University, Bratislava, Slovakia. babincova@fmph.uniba.sk
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Naturforschung. C, Journal of biosciences.
COUNTRY: GERMANY
TITLE: Activation of hematoporphyrin in alternating magnetic field: possible implications for cancer treatment.
PUBDATE: 19991101
A new mechanism of cell damage by alternating magnetic field with hematoporphyrin is described. C6 glioblastoma cell suspensions were exposed to an alternating magnetic field with frequency 180 kHz up to 60 min in the presence of hematoporphyrin in H2O and in D2O. The results presented suggest that an alternating magnetic field is able to activate hematoporphyrin, and this method may be a basis for cancer treatment.


6. DOCID:20795 SCORE: 0.00228014462466979
DOCNO: 8311485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: T Yamaguchi T
AUTHOR: T Takahashi T
AFFILIATION: First Dept. of Surgery, Kyoto Prefectural University of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Application of monoclonal antibody for cancer therapy]
PUBDATE: 19940201
Immunoconjugates composed of mouse monoclonal antibody and anticancer drug was applied for the treatment of patients with colorectal cancer. Administration of mouse antibody raised human anti-mouse antibody that may interfere with the effect of immunoconjugates. To resolve this problem, human/mouse chimeric antibody was prepared and immunoconjugate of chimeric antibody and anticancer drug was developed. The characteristics of this new immunoconjugate were described.


7. DOCID:20799 SCORE: 0.00228014428745961
DOCNO: 8150774
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: M A Friedman MA
AFFILIATION: Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: New directions for breast cancer therapeutic research.
PUBDATE: 19940201
For the past two decades, attempts to improve chemotherapy for patients with breast cancer have emphasized the use of currently available agents. Research by drug discovery programs of the National Cancer Institute has identified a number of clinically promising novel agents. Conceivably, within the next several years there could be a doubling of the chemotherapy armamentarium for breast cancer--more than 30 active cytotoxic agents.


8. DOCID:30672 SCORE: 0.00226190130579264
DOCNO: 11823691
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: analogs & derivatives
QUALIFIER: chemically induced
AUTHOR: Manuel F Rosado MF
AUTHOR: Daniel H Kett DH
AUTHOR: Roland M H Schein RM
AUTHOR: Francisco J Baraona FJ
AUTHOR: Kasi S Sridhar KS
AFFILIATION: Department of Medicine, Jackson Memorial Hospital, University of Miami School of Medicine, 1611 NW 12th Avenue, Miami, FL 33136-1094, U.S.A.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: United States
TITLE: Severe pulmonary toxicity in a patient treated with gemcitabine.
PUBDATE: 20020201
Gemcitabine is a pyrimidine analog of deoxycytidine with activity against nonhematologic and hematologic malignancies. Its pulmonary toxicity is usually mild and self-limiting. We describe a male patient with lung cancer in whom severe dyspnea and interstitial infiltrates developed after the administration of gemcitabine.


9. DOCID:30666 SCORE: 0.00226190090317772
DOCNO: 12113243
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: therapeutic use
QUALIFIER: diagnosis
QUALIFIER: enzymology
QUALIFIER: analysis
QUALIFIER: antagonists & inhibitors
QUALIFIER: analysis
QUALIFIER: antagonists & inhibitors
AUTHOR: L Austin Doyle LA
AUTHOR: W Edward Highsmith WE
AFFILIATION: Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA. adoyle@umm.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert review of anticancer therapy.
COUNTRY: England
TITLE: Telomerase as a diagnostic and therapeutic target for cancer.
PUBDATE: 20020401
Telomerase is a ribonucleoprotein enzyme responsible for the elongation of telomeres at the ends of chromosomes. It is widely expressed in most cancers, while absent from most normal somatic cells. Telomerase is partially responsible for the cellular immortalization that allows human cancers to progress indefinitely. Due to its widespread occurrence in cancer and its crucial role in the maintenance of the tumor, telomerase is an attractive target for cancer diagnosis and treatment.


10. DOCID:27100 SCORE: 0.00223473772569844
DOCNO: 9601170
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Competence
DESCRIPTOR: General Practice, Dental
QUALIFIER: etiology
AUTHOR: J Yellowitz J
AUTHOR: A M Horowitz AM
AUTHOR: H S Goodman HS
AUTHOR: M T Canto MT
AUTHOR: N S Farooq NS
AFFILIATION: University of Maryland, Baltimore College of Dental Surgery, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Dental Association (1939)
COUNTRY: UNITED STATES
TITLE: Knowledge, opinions and practices of general dentists regarding oral cancer: a pilot survey.
PUBDATE: 19980501
The authors mailed a pilot survey to 500 randomly selected general dentists. Although most dentists reported their knowledge of oral cancer to be current, their actual knowledge of oral cancer risk factors and signs and symptoms was inconsistent. Conflicting data were also found between their level of knowledge and their provision of oral cancer examinations. Most respondents agreed that patients should undergo an oral cancer examination annually, yet many do not provide this service.


11. DOCID:31904 SCORE: 0.00223004196501014
DOCNO: 14529309
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: therapeutic use
QUALIFIER: methods
AUTHOR: M F Moyers MF
AUTHOR: D W Miller DW
AFFILIATION: Loma Linda University Medical Center, Loma Linda, California 92354, USA. moyers@proton.llumc.edu
PUBTYPE: Journal Article
JOURNALTITLE: Technology in cancer research & treatment.
COUNTRY: United States
TITLE: Range, range modulation, and field radius requirements for proton therapy of prostate cancer.
PUBDATE: 20031001
The Loma Linda University Proton Treatment Facility has treated over 5,000 patients for prostate cancer. Other institutions may find information regarding field size and range requirements for this population of patients useful for designing new proton beamlines. The maximum range, range modulation, and maximum field radius for 240 fields of prostate patients undergoing treatment were sampled and analyzed. Most fields required a range less than 290 mm of water, a modulation width less than or equal to 120 mm, and a radius less than 75 mm.


12. DOCID:30445 SCORE: 0.00218127478313463
DOCNO: 11919208
AUTHOR: F X Bosch FX
AUTHOR: A Lorincz A
AUTHOR: N Muñoz N
AUTHOR: C J L M Meijer CJ
AUTHOR: K V Shah KV
AFFILIATION: Institut Català d'Oncologia, Servei d'Epidemiologia i Registre del Càncer, Gran Via Km 2.7 s/n 08907 L'Hospitalet de Llobregat, 08907 Barcelona, Spain. x.bosch@ico.scs.es
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of clinical pathology.
COUNTRY: England
TITLE: The causal relation between human papillomavirus and cervical cancer.
PUBDATE: 20020401
The causal role of human papillomavirus infections in cervical cancer has been documented beyond reasonable doubt. The association is present in virtually all cervical cancer cases worldwide. It is the right time for medical societies and public health regulators to consider this evidence and to define its preventive and clinical implications. A comprehensive review of key studies and results is presented.


13. DOCID:26827 SCORE: 0.00213548625958297
DOCNO: 11280894
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: S Aoki S
AUTHOR: K Tanaka K
AUTHOR: T Ohori T
AUTHOR: E Nishikawa E
AUTHOR: Y Yamada Y
AUTHOR: N Honda N
AUTHOR: H Fukatsu H
AFFILIATION: Department of Urology, Nagoya Ekisaikai Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: Japan
TITLE: [A case of transitional cell carcinoma of the bladder in a juvenile patient]
PUBDATE: 20010201
A 15-year-old male was referred to our hospital with the chief complaint of gross hematuria. Cystoscopic examination revealed a papillary tumor on the posterior wall. Transurethral resection of the bladder tumor was performed. Histological examination of the excised tumor showed transitional cell carcinoma, grade 1, pTa. Recurrence has not been observed for about 2 years after the operation. We investigated 54 previously reported Japanese cases of bladder cancer before age twenty including the present case.


14. DOCID:29647 SCORE: 0.00212002717432058
DOCNO: 14607373
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: Deborah McCaffrey Boyle DM
AFFILIATION: Banner Good Samaritan Medical Center, 1111 E. McDowell Road, Phoenix, AZ 85006, USA. deborah.boyle@bannerhealth.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Critical reviews in oncology/hematology.
COUNTRY: Ireland
TITLE: Establishing a nursing research agenda in gero-oncology.
PUBDATE: 20031101
Expanding the evidence base of cancer in the elderly is critical to advance the specialty of geriatric oncology nursing. This article will propose topics for nursing investigation relative to prevention and early detection, response to disease and treatment, and psychosocial responses in the elderly at risk for, or having cancer. International considerations for undertaking nursing research with this special population are also described. Current dilemmas requiring investigation and future demographic implications are highlighted.