0. DOCID:7786 SCORE: 0.00331753552260543
DOCNO: 652985
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: pathology
AUTHOR: H Creutzig H
PUBTYPE: Journal Article
JOURNALTITLE: Der Radiologe.
COUNTRY: GERMANY, WEST
TITLE: [Staging of patients with carcinoma of the breast by bone scans? [author's transl)]
PUBDATE: 19780501
Bone scans were performed in 170 patients with widespread breast cancer and metastases which were confirmed by the clinical course. In 82% a positive x-ray and in 95% a positive bone scan could be demonstrated. In 43 patients without bone metastases the ratio of false positive scans was 5%. Seventeen out of 50 patients with early cancer had abnormal scans. In 12 cases there were metastases proven by follow-up of at least 18 months. Assuming an incidence of 25% for bone metastases in patients with early breast cancer, bone scans with a sensitivity and specificity of 95% will be valid in staging. To validate this high incidence we investigated a second group of 97 patients with early cancer in a prospective study: in only 3 cases there was an abnormal scan. Using this low incidence bone scanning is calculated to be not valid for staging of breast cancer.

1. DOCID:3091 SCORE: 0.0029248542899575
DOCNO: 986259
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Galactosemias
QUALIFIER: blood
QUALIFIER: analysis
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: J E Mrochek JE
AUTHOR: S R Dinsmore SR
AUTHOR: D C Tormey DC
AUTHOR: T P Waalkes TP
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Protein-bound carbohydrates in breast cancer. Liquid-chromatographic analysis for mannose, galactose, fucose, and sialic acid in serum.
PUBDATE: 19760901
We describr high-resolution chromatographic analysis for protein-bound sialic acid in serum, with use of a cerate oxidimetric detector. Values for sera from normal women averaged 680.5 mg/liter, with a coefficient of variation of 23%. Including data obtained by previously developed chromatographic procedures for protein-bound mannose, galactose, and fucsoe, we assessed sera from breast-cancer patients whose malignancy had been categorized as either stable, responsive, or progressive (based on clinical observations spaced from two to five months apart). All of 12 responsive patients had decreases of protein-bound fucose averaging 34.5% (SD, 16.1) and all of 10 patients with progressive disease had increases averaging 38.3% (SD 21.5). Changes in fucose averaged less than 6.7% (SD, 4.9) for eight patients with clinically stable breast cancer. Changes in protein-bound mannose, galactose, and sialic acid did not correlate as well as did fucose with the clinical disease status of the patients.

2. DOCID:3447 SCORE: 0.00283961804650379
DOCNO: 1203838
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
AUTHOR: C R Smart CR
AUTHOR: L B Townsend LB
AUTHOR: W J Rusho WJ
AUTHOR: H J Eyre HJ
AUTHOR: J M Quagliana JM
AUTHOR: M L Wilson ML
AUTHOR: C B Edwards CB
AUTHOR: S J Manning SJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Phase I study of ftorafur, an analog of 5-fluorouracil.
PUBDATE: 19750701
Ftorafur, a furanyl analog of 5-fluorouracil (5-FU), is reported to be five to six times less toxic and possibly more effective in cancer of the breast and colon than 5-FU. The drug was synthesized, formulated, and utilized in toxicologic studies, and then in 24 patients with advanced incurable malignancies. When Ftorafur is given by intravenous push, it results in immediate flushing, dizziness, nausea, retching, and in some cases transient hypotension. These immediate side effects are largely eliminated by administering the drug slowly by infusion. In patients, 60 mg/kg of Ftorafur given i.v. daily for up to 10 days resulted in mild toxicity. However, 80 mg/kg given i.v. daily for 7 days resulted in severe toxicity, with nausea, vomiting, stomatitis, leukopenia, and thrombocytopenia. These studies confirm those of the Russian investigators as to toxicity and dosage, even with a different method of administration more convenient for therapy. Phase II studies are presently being carried out to compare the effectiveness of Ftorafur and 5-FU.

3. DOCID:15608 SCORE: 0.00268391444086744
DOCNO: 3062286
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Heart Transplantation
QUALIFIER: chemically induced
QUALIFIER: surgery
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: S Ballhaus S
AUTHOR: G Grevers G
AFFILIATION: HNO-Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Laryngologie, Rhinologie, Otologie.
COUNTRY: GERMANY, WEST
TITLE: [Laryngeal cancer in immunosuppressive therapy with cyclosporin A]
PUBDATE: 19880701
As a serious side effect of immunosuppressive therapy following organ transplantation, the incidence of malignancies shows a significant threefold increase compared with the age-matched general population. Under treatment with conventional immunosuppressive drugs (azathioprine, steroids and antilymphocyte globulin) patients are supposed to be susceptible to skin and lip cancers (40%) whereas the recently introduced new immunosuppressive drug cyclosporine A shows a comparable incidence of non-Hodgkin lymphomas (41%) and the patients seem to develop more potentially life threatening tumours of internal organs. In the present paper we report on a case of laryngeal carcinoma following immunosuppressive treatment with cyclosporine A 10 months after heart transplantation.

4. DOCID:3951 SCORE: 0.00250412129350623
DOCNO: 1117595
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: J Utsunomiya J
AUTHOR: H Gocho H
AUTHOR: T Miyanaga T
AUTHOR: E Hamaguchi E
AUTHOR: A Kashimure A
PUBTYPE: Journal Article
JOURNALTITLE: The Johns Hopkins medical journal.
COUNTRY: UNITED STATES
TITLE: Peutz-Jeghers syndrome: its natural course and management.
PUBDATE: 19750201
Two hundred and twenty-two patients with Peutz-Jeghers syndrome were ascertained in Japan between 1961 and 1974 through two nationwide surveys, medical literature, and personal examinations. Genetic analysis was made of this group as well as 102 follow-up cases. The average age at diagnosis was 23 in males and 26 in females, with male to female ratio of 1:1.13. Presenting complaints of 170 patients included obstruction (42.8 per cent of patients), abdominal pain (23.4 per cent), rectal bleeding (13.5 per cent), extrusion of polyp (7.2 percent). Diagnosis of 52 patients was based on melanin pigmentation. Intussusception occurred in 46.9 per cent of the patients, most often in the small intestine. Polyps occurred in the stomach in 108 patients (48.6 per cent), small intestine, 142 patients (64 per cent), colon, 118 patients (53.2 per cent) and rectum, 71 patients (32 per cent). Among the 222 patients, cancer was histologically verified in 28. Fifteen early cancers occurred (3 gastric, 8 small intestine, 4 colon), and 11 advanced cancers (3 gastric, 1 small intestine, 6 colon, and 1 both colon and small intestine). Mortality was lower than in patients with familial polyposis coli but higher than in the general population. Conservative surgical management, planned medical follow-up, and the need for a national registration system are stressed.

5. DOCID:2766 SCORE: 0.00249814451526523
DOCNO: 912870
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: blood
AUTHOR: L M Silverman LM
AUTHOR: G B Dermer GB
AUTHOR: Z A Tökes ZA
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Electrophoretic patterns for serum glycoproteins reflect the presence of human breast cancer.
PUBDATE: 19771101
We describe a group of glycoproteins that are synthesized and released by human breast tumors maintained in organ culture and similar glycoproteins released by a human breast carcinoma cell line (BT-20). The electrophoretic mobility of these glycoproteins on cellulose acetate is consistent with increased glycoprotein-staining material present in the alpha2- to beta-globulin region of serum glycoprotein electropherograms from patients with breast cancer. Moreover, after mastectomy, this glycoprotein material in serum decreases to concentrations seen in a control population of patients with benign breast lesions. Patients with proven metastatic breast cancer have patterns reflecting their clinical status: those who respond to treatment have glycoprotein electropherograms similar to the group of patients with benign breast lesions, while those who do not have increased amounts of alpha2- beta-glycoprotein. We believe serum glycoprotein measurements in breast-cancer patients reflect the presence of glycoproteins that are released by the malignant cells and enter the circulation.

6. DOCID:3095 SCORE: 0.0024546325723032
DOCNO: 1192361
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radioactive Fallout
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: T Ishimaru T
AUTHOR: R W Cihak RW
AUTHOR: C E Land CE
AUTHOR: A Steer A
AUTHOR: A Yamada A
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Lung cancer at autopsy in A-bomd survivors and controls, Hiroshima and Nagasaki, 1961-1970. II. Smoking, occupation, and A-bomb exposure.
PUBDATE: 19751101
The apparent effect of ionizing radiation on lung cancer in A-bomb survivors has not been large enough to still doubts as to its validity. It has seemed essential to determine whether the apparent radiation effect could have resulted from a confounding of heavy smoking and high radiation dose, or if the occupational exposure of high-dose subjects with lung cancer was suggestive of the influence of environmental hazards other than radiation. The available series consists of 204 subjects with lung cancer verified by autopsy, 61 of whom were low-dose (less than 1 rad) and 13 high-dose (200 + rads) subjects. No evidence could be found that the influence of either smoking or occupational exposure upon lung cancer was exerted so as to suggest that the apparent radiation effect is other than real. The study also provides additional evidence of the relationship between lung cancer and smoking in Japanese.

7. DOCID:7439 SCORE: 0.00245161661672291
DOCNO: 634505
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
AUTHOR: C Mor C
AUTHOR: S Orefice S
AUTHOR: F Rocco F
AUTHOR: R Accinni R
AUTHOR: A Bartorelli A
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Direct radioimmunological determination of plasma CEA in 1704 patients]
PUBDATE: 19780201
An original technique for the direct radioimmunological measurement of plasma CEA has been prepared. Compared to the other in use, this has the advantage of a very low incidence of false positivity. 1704 patients make up the series: the percentage of positivity in 247 suffering from gastroenteric adenocarcinoma was 66.8%, in 60 with lung cancer 30%, in 243 with malignant tumours in various sites 7.4%, in 199 with chronic liver diseases 29.6% while in 598 cases of other non-neoplastic diseases it was only 2.5%. 212 patients who underwent radical surgery for gastroenteric adenocarcinoma were also followed up and the test provided early diagnosis of the clinical re-onset of the neoplastic lesion. It is considered that plasma CEA measurement represents a useful aid to the clinician althouth it cannot be employed at present to screen gastroenteric adenocarcinomas.

8. DOCID:6936 SCORE: 0.00239496651449236
DOCNO: 6777904
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: A Yajima A
AUTHOR: H Higashiiwai H
AUTHOR: A Sato A
AUTHOR: M Watanabe M
AUTHOR: T Mori T
AUTHOR: M Suzuki M
AUTHOR: T Hanyu T
AUTHOR: K Suzuki K
AUTHOR: H Kinii H
AUTHOR: T Moritsuka T
AUTHOR: N Igarashi N
AUTHOR: M Nakano M
AUTHOR: K Nagasawa K
AUTHOR: S Sato S
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Combination chemotherapy in advanced ovarian cancer.
PUBDATE: 19801001
Among the 95 cases of ovarian cancer treated by us between May, 1975 and August, 1978, only 33 were suitable for complete resection. The remaining 62 cases underwent incomplete resection, followed by F.Q.C. combination chemotherapy (1-(2-tetrahydrofuryl)-5-fluorouracil, carbazilquinone, cytosine arabinoside); 54.8% showed an antitumor response. The median survival time of the responders was 13.2 months, whereas it was 7.4 months for the non-responders. The survival rate after 24 months, however, was 13% and 4%, respectively. Side effects of the drugs, including leucopenia, thrombocytopenia, nausea and vomiting, were found in roughly one half of the cases.

9. DOCID:3413 SCORE: 0.00235878686136082
DOCNO: 963170
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Biological
DESCRIPTOR: Mortality
DESCRIPTOR: Probability
DESCRIPTOR: Stochastic Processes
AUTHOR: S W Lagakos SW
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: A stochastic model for censored-survival data in the presence of an auxiliary variable.
PUBDATE: 19760901
In clinical trials and other investigations of survival time, information is often available on a time-dependent event other than survival. An example of such an auxiliary event in cancer studies is objective progression of disease. While some patients expire without experiencing objective disease progression, others die after progression is observed. This paper proposes a stochastic model which utilizes this type of information in the evaluation of survival time. Our intentions in presenting this model are to provide a means of relating survival and another time-dependent event to one another (each of which may be used in the evaluation of a patient's condition), and to obtain more precise estimates of survival time by exploiting its relationship with this other event. The intrinsic aspects of the model are related to the semi-Markov model proposed by Weiss and Zelen [1965]. An important difference is that the present model incorporates incomplete (censored) observations as well as covariante variables. Analysis of the model via the method of maximum likelihood and its testability are discussed. The methods are applied to the results of a recent lung cancer study.

10. DOCID:2611 SCORE: 0.00230483389416861
DOCNO: 171226
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigen-Antibody Reactions
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: G de-Thé G
AUTHOR: J H Ho JH
AUTHOR: D V Ablashi DV
AUTHOR: N E Day NE
AUTHOR: A J Macario AJ
AUTHOR: M C Martin-Berthelon MC
AUTHOR: G Pearson G
AUTHOR: R Sohier R
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Nasopharyngeal carcinoma. IX. Antibodies to EBNA and correlation with response to other ebv antigens in chinese patients.
PUBDATE: 19751101
Ninety-five sera from Chinese NPC patients in different stages of the disease, 38 sera from Chinese patients with other cancers, and 50 normal Chinese sera, were titrated for EBNA, VCA, EA and complement-fixing (CF/S) EBV-specific antibodies. The geometric mean (GMT) EBNA antibody titre of patients with NPC at stage I was found to be four times higher than that of normal individuals and increased in parallel with clinical deterioration. Antibody titres against EBNA did not correlate with either VCA or EA antibodies but, in general, correlated with CF/S antibodies. EA antibodies correlated relatively well with VCA antibodies and discriminated better than EBNA titre between NPC at stage I and controls.

11. DOCID:3427 SCORE: 0.00225888560793465
DOCNO: 324696
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diagnosis, Computer-Assisted
QUALIFIER: diagnosis
AUTHOR: F Wiener F
AUTHOR: L Lev L
AUTHOR: A Kovant A
AUTHOR: E Robinson E
PUBTYPE: Journal Article
JOURNALTITLE: Clinical radiology.
COUNTRY: ENGLAND
TITLE: Computer-aided tumour classification and treatment selection in breast cancer.
PUBDATE: 19770501
In order to provide a common basis for treatment decisions and the future evaluation of breast cancer therapy, the breast cancer protocol used in our clinic was formulated for the computer. A system for the simulation of clinical reasoning was used which allows the physician to express the medical logic as a series of inferences to be confirmed or rejected on the basis of Boolean combinations of medical criteria. The system enables the physician to rearrange these criteria into a questionnaire for complete and accurate recording of patient data. These data are then fed into the computer to produce a patient status report and treatment recommendations. The data from 26 patients in various stages of breast cancer have been processed by the computer and the computer's conclusions compared to the assessment made by a junior physician in our department. In three cases the staging was not identical, in 15 cases the treatment decisions were not identical and in all cases investigations were left out by the physician. The system has been of considerable value in standardising patient examination and treatment and in training inexperienced physicians.

12. DOCID:14950 SCORE: 0.00221163041610595
DOCNO: 3803120
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: P J O'Dwyer PJ
AUTHOR: C Mojzisik C
AUTHOR: D P McCabe DP
AUTHOR: B J Sickle-Santanello BJ
AUTHOR: W B Farrar WB
AUTHOR: E W Martin EW
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Diseases of the colon and rectum.
COUNTRY: UNITED STATES
TITLE: Variation in recognition of recurrent colonic cancer by different CEA assays.
PUBDATE: 19870201
Forty-six patients were followed with serial CEA determinations by two CEA assays after curative resection of a primary or recurrent colonic cancer. Thirteen have had a histologically proven recurrence, of which only six (46 percent) were predicted by both assays, while seven (54 percent) were predicted by one assay only. The assays appear complementary in indicating tumor recurrence, and preliminary findings suggest that it may be beneficial to follow patients with more than one CEA assay after resection of a primary or recurrent colonic cancer.

13. DOCID:7228 SCORE: 0.0021818391368153
DOCNO: 97968
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radiography, Abdominal
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
AUTHOR: A H Robbins AH
AUTHOR: R D Pugatch RD
AUTHOR: S G Gerzof SG
AUTHOR: L J Faling LJ
AUTHOR: W C Johnson WC
AUTHOR: D H Sewell DH
PUBTYPE: Journal Article
JOURNALTITLE: AJR. American journal of roentgenology.
COUNTRY: UNITED STATES
TITLE: Observations on the medical efficacy of computed tomography of the chest and abdomen.
PUBDATE: 19780701
In a retrospective study of 687 computed tomographic (CT) examinations of the chest and abdomen performed over a 1 year period, 16% of the examinations produced information not otherwise available which altered patient diagnosis, prognosis, or therapy. Sixteen thoracotomies and 18 laparotomies were avoided as a result of information available only from CT examinations. CT was of particular value in the evaluation of mediastinal masses, in the assessment of suspected or proven lung cancer, and in the evaluation of pleural and extrapleural masses. It was of notable clinical value in evaluating patients with intraabdominal abscesses, pancreatic disease, staging of malignancies for radiation therapy and surgery, and excluding the presence of suspected masses.

14. DOCID:3469 SCORE: 0.00217043119740703
DOCNO: 194665
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: P J DiSaia PJ
AUTHOR: C P Morrow CP
AUTHOR: B J Haverback BJ
AUTHOR: B J Dyce BJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Carcinoembryonic antigen in cancer of the female reproductive system. Serial plasma values correlated with disease state.
PUBDATE: 19770601
The results of plasma carcinoembryonic antigen (CEA) determinations done over 600 patients with gynecologic malignancy will be presented. It would appear from this extensive survey that the likelihood of a patient having a positive value is increased with advancing stage and bulk of disease. The incidence of positive values in patients with clinical recurrence is quite impressive and presents a possible mode of follow-up for patients after standard treatment techniques have been administered for cervical cancer. Most interesting is the effect of radiation therapy or surgery on squamous cell cancer of the cervix and vulva in patients who have a positive value of the onset. Treatment of the disease by either modality appears to be associated with a precipitous drop in plasma value of CEA. Unfortunately, the presence or absence of CEA is not reliable and to date it is impossible to predict which patients with gynecologic malignancy will manifest a positive plasma value. Comments will be made concerning retro-de-differentiation and de-repression as a mechanism for the production of this antigen in patients with gynecologic cancer.